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  1. Immune checkpoint inhibitors and mitogen-activated protein kinase inhibitors have become the standard of care in patients with advanced melanoma bearing V600 mutations. However, little is known about their nep...

    Authors: Periklis Kyriazis, Abhinav Tiwary, Jonathan Freeman, Daniel Landry and Gregory Braden

    Citation: Journal of Medical Case Reports 2021 15:186

    Content type: Case report

    Published on:

  2. Clear-cell carcinoma arising from the surgical cesarean section scar is very infrequent. The present study reports two patients with clear-cell carcinoma arising from an abdominal wall scar 20 and 23 years aft...

    Authors: Seyedeh Razieh Hashemi, Mahdi Morshedi, Houshyar Maghsoudi, Arezoo Esmaeilzadeh and Ibrahim Alkatout

    Citation: Journal of Medical Case Reports 2021 15:146

    Content type: Case report

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  3. Mondor’s disease of the breast (MDB) is a rare and benign disorder of the breast. It is characterized by thrombophlebitis of the superficial veins of the chest wall. Clinically, it manifests as a cord-like ind...

    Authors: K. Ben Hamida, M. Ghalleb, A. Triki, I. Jebir, R. Makhlouf and H. Touinsi

    Citation: Journal of Medical Case Reports 2021 15:188

    Content type: Case report

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  4. Urinary retention is a condition in which impaired emptying of the bladder results in postvoid residual urine. It can be acute or chronic urinary retention. There have been only scattered case studies that hav...

    Authors: Ayotunde Olumide Ojo, Adesegun Lawrence Ajasa, Rilwan Babatunde Oladipupo and Nicholas Oluwaseyi Aderinto

    Citation: Journal of Medical Case Reports 2021 15:183

    Content type: Case report

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  5. Rhopressa (netarsudil) has recently been added to the arsenal of treatment for open-angle glaucoma. It is an effective norepinephrine transporter and Rho-associated protein kinase (ROCK) inhibitor used to decr...

    Authors: Matthew J. Chu, Michael Song, Trisa Palmares, Alice Song and Julia Song

    Citation: Journal of Medical Case Reports 2021 15:182

    Content type: Case report

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  6. A central retinal artery occlusion (CRAO) is an ophthalmic emergency due to its strong association with cerebrovascular and cardiovascular morbidity and mortality. A timely diagnosis is necessary but difficult...

    Authors: Timothy M. Janetos, Olga German and Rukhsana Mirza

    Citation: Journal of Medical Case Reports 2021 15:145

    Content type: Case report

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  7. Unilateral pulmonary artery discontinuity is a rare malformation that is associated with other intracardiac abnormalities. Cases accompanied by other cardiac abnormalities are often missed on prenatal echocard...

    Authors: Hyun-Hwa Cha, Hae Min Kim and Won Joon Seong

    Citation: Journal of Medical Case Reports 2021 15:190

    Content type: Case report

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  8. Despite an otherwise robust national antenatal clinic program, maternal and congenital syphilis remains an important public health issue in Zambia. This case series reports the clinical presentation of seven i...

    Authors: Nsofwa Sukwa, Michelo Simuyandi, Masuzyo Chirwa, Yvonne Mutombo Kumwimba, Obvious N. Chilyabanyama, Natasha Laban, Aybüke Koyuncu and Roma Chilengi

    Citation: Journal of Medical Case Reports 2021 15:149

    Content type: Case report

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  9. Heart failure is usually associated with a low-cardiac-output state; however, a minority of these patients are characterized by a high-output cardiac state, described as a cardiac index of > 4 L/minute/m2. Usuall...

    Authors: Laura J. Albak, Ashish H. Shah and James W. Tam

    Citation: Journal of Medical Case Reports 2021 15:177

    Content type: Case report

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  10. Diagnosis of intestinal tuberculosis poses a dilemma to physicians due to nonspecific symptoms like abdominal pain, fever, nausea, and a change in bowel habit. In particular, the distinction between inflammato...

    Authors: Daniel Sasse, Christoph D. Spinner, Kathrin Rothe, Jochen Schneider, Jochen Gaa and Silvia Würstle

    Citation: Journal of Medical Case Reports 2021 15:144

    Content type: Case report

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  14. Diagnosis of chronic pulmonary aspergillosis (CPA) is based on a combination of clinical symptomatology, compatible chest imaging findings, evidence of Aspergillus infection and exclusion of alternative diagnosis...

    Authors: Richard Kwizera, Andrew Katende, Felix Bongomin, Lydia Nakiyingi and Bruce J. Kirenga

    Citation: Journal of Medical Case Reports 2021 15:140

    Content type: Case report

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  15. Pheochromocytomas are a subset of paragangliomas, which are a rare group of neural crest cell-derived tumors. Malignant cases of both pheochromocytomas and paragangliomas are even rarer, and currently there is...

    Authors: Robin Raquel Rodriguez, Saleha Rizwan, Khaled Alhamad and Gene Grant Finley

    Citation: Journal of Medical Case Reports 2021 15:172

    Content type: Case report

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  16. Perampanel (PER) is a novel antiepileptic drug (AED) which employs a completely different mechanism of action compared to existing medications. Overall, PER is considered to be safe up to a dose of 12 mg per d...

    Authors: Kanitpong Phabphal and Prut Koonalintip

    Citation: Journal of Medical Case Reports 2021 15:147

    Content type: Case report

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  17. Gram-negative bacteria are an uncommon etiology of spontaneous community-acquired adult meningitis and meningoencephalitis. Escherichia coli is a Gram-negative bacterium that is normally present in the intestinal...

    Authors: V. Pota, M. B. Passavanti, F. Coppolino, F. Di Zazzo, L. De Nardis, R. Esposito, M. Fiore, G. S. R. C. Mangoni di Santostefano, C. Aurilio, P. Sansone and M. C. Pace

    Citation: Journal of Medical Case Reports 2021 15:138

    Content type: Case report

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  18. Reversible cerebral vasoconstriction syndrome is characterized by severe headache with reversible segmental constriction of the cerebral arteries. We present details on a patient with reversible cerebral vasoc...

    Authors: Rijo Hayashi, Shimmin Hayashi and Shigeki Machida

    Citation: Journal of Medical Case Reports 2021 15:175

    Content type: Case report

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  19.  Patients with lymphoproliferative disorders following hematopoietic stem cell transplant (HSCT) most commonly present with fever and lymphadenopathy within the first 5 months of transplant. Pulmonary post-tra...

    Authors: Ritika Dutta, Susanna Y. Miao, Paul Phan, Sebastian Fernandez-Pol, Parveen Shiraz, Dora Ho, Gabriel N. Mannis and Tian Y. Zhang

    Citation: Journal of Medical Case Reports 2021 15:170

    Content type: Case report

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  20. Mixed gonadal dysgenesis (MGD) is a subtype of the disorders of sex development (DSD) associated with sex chromosome abnormalities characterized by abnormal external genitalia, short stature, and primary ameno...

    Authors: Yoshiko Kurose, Tomonori Nagai, Kousuke Shigematsu, Takahiro Uotani, Taichi Akahori, Yasushi Takai and Hiroyuki Seki

    Citation: Journal of Medical Case Reports 2021 15:165

    Content type: Case report

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  21. Vulvar Paget’s disease (VPD) is a rare malignant disorder originating in the external genitalia. It occasionally invades into urethral or vaginal mucosa of female, making surgical treatment more complicating. ...

    Authors: Masaki Nakamura, Yuji Hakozaki, Shohei Iwata, Yusuke Sato, Katsuhiro Makino, Taketo Kawai, Yuta Yamada, Daisuke Yamada, Motofumi Suzuki, Jun Omatsu, Masanobu Abe, Kazuto Hoshi, Haruki Kume and Yasuhiko Igawa

    Citation: Journal of Medical Case Reports 2021 15:136

    Content type: Case report

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  22. Traditional coronary artery disease risk factors are well established and help risk stratify most patients presenting with chest pain syndromes. Young patients (under age 30 years) without other risk factors a...

    Authors: Nafeesah Ali, Kandace Baggan, Shari S. Khan, Paramanand Maharaj and Ronan G. Ali

    Citation: Journal of Medical Case Reports 2021 15:166

    Content type: Case report

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  23. The concept of using a gonadotropin-releasing hormone agonist (GnRH-a) instead of human chorionic gonadotropin for triggering ovulation in patients treated with an antagonist protocol for in vitro fertilization (...

    Authors: A. Smirnova, M. Anshina, E. Shalom Paz and A. Ellenbogen

    Citation: Journal of Medical Case Reports 2021 15:134

    Content type: Case report

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  24. The pandemic of this century has overwhelmed the healthcare systems of affected countries, and all resources have been diverted to coronavirus disease 2019. At the onset, coronavirus disease 2019 can present a...

    Authors: Abdullah Isneen Hilmy, Rajib Kumar Dey, Hisham Ahmed Imad, Abdul Azeez Yoosuf, Ali Nazeem and Ali Abdulla Latheef

    Citation: Journal of Medical Case Reports 2021 15:171

    Content type: Case report

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  25. Patients with Marfan syndrome commonly require spinal deformity surgery. The purpose of this case report is to present a rare thoracotomy complication. We present the management of such a patient.

    Authors: Saeid Safaei, Ahmadreza Mirbolook, Parisa Azimi, Mirbahador Athari, Farhad Hamzehzadeh and Taravat Yazdanian

    Citation: Journal of Medical Case Reports 2021 15:167

    Content type: Case report

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  26. Paraneoplastic neurological syndrome is an immune-mediated phenomenon where antibodies from tumor cells are produced against neuronal proteins. Amphiphysin antibody is an onconeural antibody linked to the diag...

    Authors: Vineet Kwatra, Michail Charakidis and Narayan V. Karanth

    Citation: Journal of Medical Case Reports 2021 15:158

    Content type: Case report

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  27. Neurolymphomatosis is rare. Neoplastic lymphocytes are seen to invade nerves (cranial or peripheral), nerve roots or other related structures in patients with hematological malignancy. It is a separate entity ...

    Authors: S. Alazawi, H. Elomri, R. Taha, M. Bakr, M. T. Abdelhamid, L. Szabados, M. Yassin, H. El Sabah, K. Aboudi, A. Ellahie, A. Fadul, A. Gameil, A. Al Battah and L. J. Fernyhough

    Citation: Journal of Medical Case Reports 2021 15:133

    Content type: Case report

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  28. The outcomes of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) can improve with allogeneic hematopoietic stem cell transplantation (HSCT) during the first complete remission after tr...

    Authors: Junichiro Yuda, Nobuhiko Yamauchi, Ayumi Kuzume, Yong-Mei Guo, Nobue Sato and Yosuke Minami

    Citation: Journal of Medical Case Reports 2021 15:164

    Content type: Case report

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  29. Spontaneous Pneumomediastinum is a rare disease. It could be a simple and self-limited condition or be a life-threatening complication of underlying diseases. The therapeutic options also differ by the cause. ...

    Authors: Berhanu N. Alemu, Ephraim T. Yeheyis and Abraham G. Tiruneh

    Citation: Journal of Medical Case Reports 2021 15:157

    Content type: Research article

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  30. Primary adrenal insufficiency (Addison's disease) is a rare medical condition usually associated with hyperkalemia or normokalemia. We report a rare case of Addison's disease, coexisting with hypokalemia, requ...

    Authors: M. Abdalla, J. A. Dave and I. L. Ross

    Citation: Journal of Medical Case Reports 2021 15:131

    Content type: Case report

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  31. Limbic encephalitis (LE), a variant of autoimmune encephalitis, is inflammation of the limbic system of the brain. The disorder presents with subacute impairment of short-term memory, psychiatric manifestation...

    Authors: Ismail Ibrahim Ismail, Fahad Alnaser and Jasem Y. Al-Hashel

    Citation: Journal of Medical Case Reports 2021 15:130

    Content type: Case report

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  32. We present a minimal skin wound abdominal hysterectomy for patients with leiomyomas and describe the characteristics of this technique. The skin wound was made as small as possible, with a maximum length of 6 cm.

    Authors: Wataru Isono and Masanori Maruyama

    Citation: Journal of Medical Case Reports 2021 15:128

    Content type: Research article

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  33. A significant portion of critically ill patients with coronavirus disease 2019 (COVID-19) are at high risk of developing intensive care unit (ICU)-acquired swallowing dysfunction (neurogenic dysphagia) as a co...

    Authors: Marianna Traugott, Wolfgang Hoepler, Reinhard Kitzberger, Sophie Pavlata, Tamara Seitz, Sebastian Baumgartner, Gudrun Placher-Sorko, Daniela Pirker-Krassnig, Urs Ehehalt, Andreas Grasnek, Michaela Beham-Kacerovsky, Emanuela Friese, Christoph Wenisch and Stephanie Neuhold

    Citation: Journal of Medical Case Reports 2021 15:148

    Content type: Case report

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  34. Anti-transcriptional intermediary factor 1 gamma (TIF1γ) antibody is a marker for predicting cancer association in patients with dermatomyositis (DM). The overall survival rate in DM patients with cancer was r...

    Authors: Ryohei Ono, Tomohiro Kumagae, Mari Igasaki, Takaaki Murata, Masaki Yoshizawa and Izumi Kitagawa

    Citation: Journal of Medical Case Reports 2021 15:142

    Content type: Case report

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  35. Abdominal pregnancy accounts for 0.6 to 4% of all ectopic pregnancies. Due to delays in diagnosis and difficulties in the management of abdominal pregnancy, the risk of mortality is significantly higher than f...

    Authors: Abraham Fessehaye, Biruck Gashawbeza, Mekdes Daba, Muhudin Arusi and Tsega Terefe

    Citation: Journal of Medical Case Reports 2021 15:127

    Content type: Case report

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  36. We report a case of pulmonary edema induced by tocolytic agents that was successfully managed with noninvasive positive-pressure ventilation (NPPV) and resulted in extended gestation.

    Authors: Kotaro Takahashi, Koji Nishijima, Masayuki Yamaguchi, Kensuke Matsumoto, Shunya Sugai and Takayuki Enomoto

    Citation: Journal of Medical Case Reports 2021 15:126

    Content type: Case report

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  37. Previous studies have shown that patients who underwent renal transplantation were at a greater risk of developing malignancies. Due to advances in effective surgical techniques and immunosuppressive therapies...

    Authors: Szabolcs Bellyei, Árpád Boronkai, Eva Pozsgai, Dávid Fodor and László Mangel

    Citation: Journal of Medical Case Reports 2021 15:125

    Content type: Case report

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  38. There are limited data on cardiovascular complications of coronavirus disease 2019 in pregnancy, and there are only a few case reports on coronavirus disease 2019 related cardiomyopathy in pregnancy. Different...

    Authors: Rahim Nejadrahim, Sara Khademolhosseini, Hadiseh Kavandi and Reza Hajizadeh

    Citation: Journal of Medical Case Reports 2021 15:143

    Content type: Case report

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  39. May–Thurner syndrome is an anatomical condition characterized by compression of the left common iliac vein by the right common iliac artery, causing venous outflow obstruction. It is an uncommon cause of deep ...

    Authors: Joel Zhen Khang Hng, Shu Su and Noel Atkinson

    Citation: Journal of Medical Case Reports 2021 15:141

    Content type: Case report

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  40. Increasingly widespread use of programmed cell death protein 1 (PD-1) immune checkpoint inhibitors (ICIs) for treatment of a variety of progressive malignancies continues to reveal a range of immune-related ad...

    Authors: Jacobi Hines, Ellen Daily, Anh Khoa Pham, Christopher R. Shea, Urooba Nadeem, Aliya N. Husain, Walter M. Stadler and Pankti Reid

    Citation: Journal of Medical Case Reports 2021 15:124

    Content type: Case report

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  41. Rectal signet ring cell carcinoma is a rare type of colorectal adenocarcinoma characterized by an aggressive biological behavior and poor prognosis. The co-occurrence of colorectal carcinoma and renal cell car...

    Authors: Blagica Krsteska, Rubens Jovanovic, Aleksandar Eftimov, Boro Ilievski, Dragan Hadzi-Mancev, Bujar Osmani and Slavica Kostadinova-Kunovska

    Citation: Journal of Medical Case Reports 2021 15:123

    Content type: Case report

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  42. Neurocysticercosis is the most common parasitic infection of the central nervous system, brain being the most frequent site. Intramedullary location of cysticercus is a rarely described entity in literature. W...

    Authors: Durjoy Lahiri, Abhishek Chowdhury, Souvik Dubey and Biman Kanti Ray

    Citation: Journal of Medical Case Reports 2021 15:139

    Content type: Case report

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  43. Gamma heavy chain disease (γ-HCD) is a monoclonal gammopathy defined by an abnormal clonal and isolated production of incomplete heavy chain gamma (γ), unable to bind with light chains kappa or lambda. This di...

    Authors: Gwenvaël Danic, Thomas Dejoie, Hélène Caillon, Aurélie Achille, Pierre Pottier and Christian Agard

    Citation: Journal of Medical Case Reports 2021 15:121

    Content type: Case report

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  44. Diffuse alveolar hemorrhage (DAH) is a rare, life-threatening condition that can present as a spectrum of nonspecific symptoms, ranging from cough, dyspnea, and hemoptysis to severe hypoxemic respiratory failu...

    Authors: Yumin Jo, Jagyung Hwang, Jieun Lee, Hansol Kang and Boohwi Hong

    Citation: Journal of Medical Case Reports 2021 15:137

    Content type: Case report

    Published on:

  46. Corneal refractive surgeries cause epithelial damage and induce wound healing processes. To promote wound healing after photorefractive keratectomy, the effectiveness of an autologous platelet tissue graft was...

    Authors: Yoshinori Takayanagi, Shigeaki Kato and Masaru Okada

    Citation: Journal of Medical Case Reports 2021 15:122

    Content type: Case report

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  47. Shulman’s disease, or eosinophilic fasciitis (EF), is a rare autoimmune disease, characterized by sclerodermic skin lesions with progressive induration and thickening of the soft tissues. Chronic graft-versus-...

    Authors: Thomas Chalopin, Nicolas Vallet, Marion Morel, Raphael Maguet, Louis d’Alteroche, Gonzague de Pinieux, Olivier Hérault, Emmanuel Gyan, Laurent Sutton and Alban Villate

    Citation: Journal of Medical Case Reports 2021 15:135

    Content type: Case report

    Published on:

  48. Darier–Ferrand dermatofibrosarcoma (DFS) is a rare malignant cutaneous neoplasm characterized by local aggressiveness, high risk of recurrence, and low metastatic potential.

    Authors: A. Triki, M. Aloui, M. Ghalleb, I. Jbir, Ben Naceur, J. Ben Hassouna, R. Chargui and K. Rahal

    Citation: Journal of Medical Case Reports 2021 15:120

    Content type: Case report

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  49. Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of the skin. It is associated with advanced age, ultraviolet (UV) radiation, and Merkel cell polyomavirus. It has a predilection for th...

    Authors: Alex F. Grubb and Elizabeth Hankollari

    Citation: Journal of Medical Case Reports 2021 15:118

    Content type: Case report

    Published on:

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Journal of Medical Case Reports

ISSN: 1752-1947