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Transhepatic ultrasound guided embolization as a successful novel technique in treatment of pediatric complex intrahepatic arterioportal fistula: a case report and review of the literature

Journal of Medical Case Reports volume 17, Article number: 412 (2023) Cite this article

Abstract

Introduction

Intrahepatic vascular shunts “IHVS” are abnormal communications between intra-hepatic vasculature involving the arterial, portal, or hepatic venous system. Arterio-portal fistula “APF” is an intrahepatic communication between the hepatic arterial system and the portal venous system without any communication with the systemic venous circulation. APF is considered a rare cause of portal hypertension and gastrointestinal bleeding in infancy.

Case presentation

A 3-month-old Mediterranean female with known cardiac congenital anomalies presented to us with abdominal distension and diarrhea. Ultrasonography revealed massive ascites and computerized tomography (CT) abdomen with intravenous (IV) contrast revealed a left hepatic lesion. On further evaluation, an intrahepatic arterio-portal vascular malformation was detected. Attempted trans arterial embolization failed and radiology team successfully carried out direct trans hepatic ultrasound guided coiling of the aneurysmal venous sac followed by successful resection of segment 4 of the liver with the vascular malformation avoiding life threatening intra operative bleeding.

Conclusion

Any child with recurrent gastrointestinal bleeding, failure to thrive, vomiting, diarrhea, steatorrhea, splenomegaly, or ascites should be investigated for intrahepatic arterio-portal fistula “IAPF”. Our novel technique of direct trans hepatic ultrasound guided coiling is an alternative method if trans arterial embolization “TAE” failed.

Peer Review reports

Introduction

Arterio-portal fistula “APF” is an intrahepatic communication between the hepatic arterial system and the portal venous system without any communication with the systemic venous circulation. The etiology of APF may be congenital “Primary” or acquired “Secondary”. The acquired form is most often due to trauma [1], surgical procedures [2,3,4] or rupture hepatic artery aneurism [5], transhepatic intervention [6] or biopsy [7, 8]. On the other hand, congenital arterioportal fistulae are rare, with only a small number of case reports describing this entity in children—44 cases—we report here the 45th case of a congenital APF which is a complex type of IHAPF and treated with a Novel technique due to failure of intrahepatic arterial embolization. Surgical treatment was not considered the first option because of the aberrant vasculature and the major concern about uncontrolled intraoperative bleeding.

This case is unique because it highlights the importance of preoperative radiological interventions preoperative to reduce risks of fatal intraoperative bleeding, even in failed attempts of radiological interventions there are novel techniques to achieve ideal preoperative control.

Case presentation

A 3-month-old Mediterranean female, full term after cesarean section “CS”, Apgar score of 8 which was normal and normal birth weight. with cardiac anomalies in the form of atrial septal defect “ASD”—3 × 3.5 ml—and patent foramen ovale “PDA” -closed spontaneously-, presented with failure to thrive, abdominal distention and diarrhea. Physical examination showed hepatomegaly and superficial dilated veins which are suggestive of portal hypertension. Ultrasound revealed massive ascites.

On at admission the child weight was 2.5 kg and length 49 cm both were on the low centile for age.

There was negative family history of medical diseases and negative consanguinity hemoglobin was 8.6 g/dl, albumin was 2.8 g/dl, and prealbumin 13.6 mg/dl. Laboratory values were white blood cell count 10.6 × 103/mm3, platelet count 500 × 103/mm3, normal prothrombin and partial thromboplastin times, serum sodium 120 mmol/l, potassium 6.2 mmol/l, chloride 80 mmol/l, CO2 22 mmol/l, urea 26 mg/dl, creatinine 0.5 mg/dl, aspartate aminotransferase 105 U/l, alanine aminotransferase 65 U/l, alkaline phosphatase 248 U/l, γ-glutamyl transferase 167 U/l, total bilirubin 0.8 mg/dl.

CT abdomen with IV contrast was done and revealed a well-defined lesion at the left lobe of the liver, which was suspected to be hemangioendothelioma, all liver and kidney functions were normal. MSCT angiography and portography “Multi-slice computed tomography” was done and revealed complex intrahepatic arterio-portal vascular malformation (Figs. 1, 2, 3) in segment 4 between an apparent atypical branch of the hepatic artery proper and the left portal vein, the apparent branch was communicating with a dilated venous cystic structure which was communicating with left main portal vein there was an associated solid component showing up as a parenchymal stain. The patient was referred to the interventional radiology department for embolization (Fig. 4a–d) using an endovascular micro-catheter through the celiac trunk and pancreaticoduodenal arcade, but both failed which is thought to be due to hyper-dynamic circulation related thrombosis of the proper hepatic artery which was replaced by multiple collaterals.

Fig. 1
figure 1

Multislice CT hepatic angiography and portography; a soft tissue enhancing mass (Green arrow), b intensely enhancing cystic lesion (vascular space) enhancing during the arterial phase vascular arterial lesion (red arrow)

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Fig. 2
figure 2

Portal phase showing early opacification of portal vein. The arrow is pointing at the portal vein on (Computerised tomography scan with intravenous contrast)

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Fig. 3
figure 3

MSCT showing right aberrant hepatic artery (red arrow) communicating with vascular sac (Astrix) with communication to left portal vein (blue arrow) representing a complex intrahepatic arterioportal malformation that is no direct communication

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Fig. 4
figure 4

a–d Angiography; a right hepatic artery (red arrow), aberrant hepatic artery (green arrow), filling of portal vein (blue arrow); b direct ultrasound guided injection of glue (histoacryle) into the cystic malformation using 20 G needle and coiling (c). d controlled angiography revealed successful embolization of the vascular component of the malformation. e Post-operative CT appearance after resection of segment 4

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The usual trans arterial route embolization through this complex vascularity was impossible therefore using a direct ultrasound guided using an 18G spinal needle trans hepatic obliteration of the cystic (the aneurysmal venous sac) component by histo-acryl which is a glue ratio 1:3 (histoacryl: lipiodol) and coiling as well a single coil 15 mm × 30 cm detachable coil while the second component the intraparenchymal multiple channels between the artery and vein at segment 4 was obliterated by gel foam. Follow-up controlled angiography showed that the vascular communication (cystic component) was closed. The remaining solid intraparenchymal component was surgically removed two days later by left medial segmentectomy -segment 4- since not all the channels were obliterated by gel foam (Fig. 4e).

The patient was discharged to the ICU postoperatively, then the patient was transferred to the department and then discharged with an uneventful post-operative period. After 4 months of follow-up, the portal hypertension symptoms -ascites completely resolved, but there were very small residuals for follow-up every 6 months and the patient is completely asymptomatic. Weight on follow up at 2 years of age is 16 kg which is 75th centile for age.

Discussion

Preoperative radiologic interventions prior to liver resections with vascular malformations is necessarily to reduce risk of fatal intraoperative bleeding, but when vasculature is so aberrant and embolisation fails, novel approaches still need to be sought to reduce intraoperative risk of bleeding, reports on successful trans hepatic ultrasound guided embolisation are very few, in this case report we report a successful case which was managed preoperatively with this novel approach.

Congenital intrahepatic arterio-portal fistula “IAPF” was first reported approximately 50 years ago by Gryboski et al. [9] but its etiology remains unclear. Now it is defined as an intrahepatic communication between the hepatic artery and the portal venous system. IAPF is an uncommon cause of presinusoidal portal hypertension (PH) and is believed to be the result of increased blood flow in the portal system. Congenital IAPF is a rare entity and is always diffuse or multiple [10], whereas a solitary fistula is always acquired. IAPF identified in adulthood is difficult to diagnose as congenital [10]. Based on a study that was made by Vauthey et al. only 10% of IAPF is congenital [11]. Until now, only 45 cases -including our case- of congenital IAPF have been reported in the literature, mostly occurring in infants.

Norton-Jacobson classified IAPF (Table 1) based primarily on the observations that therapeutic occlusion is normally directed at the arterial side and that outcome after various treatments is heavily influenced by the arterial vascular anatomy [12] so they classified IAPF according to the afferent vessels supplying them into unilateral, bilateral or complex. A unilateral IAPF (type 1) is supplied by only one of the right, left, or main hepatic arteries. Bilateral lesions (type 2) include supply from both of the parent hepatic arteries or their branches. Complex lesions (type 3), as in our case, consist typically of a plexiform vascular nidus with multiple feeding arteries, including supply from arteries other than the hepatic arteries.

Table 1 Norton-Jacobson classification of IAPF [12]
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Most symptoms and signs of IAPF (Table 2) are caused by the development of portal hypertension [13,14,15,16]. The commonest symptom and signs are upper GI bleeding (63% of cases), And Splenomegaly (54% of cases) In 20% (n = 9) of affected patients, they have trisomy 21, however, a relationship between both of them is not defined yet. The only other association as in our case was congenital heart disease (n = 3, 6.7%) as atrial, ventricular septal defects, and patent ductus arteriosus.

Table 2 Summarises the demographic data and symptoms and signs of IAPF based on reports published in literature about this condition
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Complications of IAPF include hemorrhagic shock from variceal bleeding [21], high output congestive heart failure “CHF” in very young infants [9, 11, 16, 22] because of left to right shunt through a patent ductus venosus [23], as flow is otherwise restricted by hepatic sinusoids interposed between the fistula and the right heart [1, 10, 24]. CHF occurs more commonly in hepatic arteriovenous malformation “AVM”, a communication between a systemic artery and a hepatic vein, as well as hepatic hemangiomata and hemangioendotheliomas [25], which are abnormal multiple connections between the hepatic artery and hepatic vein. Congenital IAPF differs from these lesions because it does not communicate directly with systemic venous circulation. Thrombocytopenia [21, 26], coagulopathy [21, 26], bacterial peritonitis [21] can be observed in some cases. High flow-related Thrombosis of the arterial part of the IAPF can also be a complication that may cause the failure of catheterization as observed in our case.

Laboratory investigations (Table 2) mostly show anemia in the affected children (73.5% of cases), hypoalbuminemia (16%) and occult blood in the stools (14%).

Hyperbilirubinemia has also been noted [26]. Ultrasonography is considered the first line of investigation to be done. Hepatic angiography can be done later to confirm the diagnosis and identify the vascular malformation. CT “computerized tomography” can be a useful diagnostic modality with the recent advances in radiomics [52,53,54,55,56] which is using algorithms and images to enhance diagnostic accuracy and differentiate from various congenital anomalies which might lead to GIT bleeding and other associated vascular malformations.

The different presentations of IAPF as illustrated before are due to the different sizes and locations of the shunt [12]. The more blood shunted, the more severe the symptoms and signs of IAPF [11]. Mesenteric vascular congestion is the reason behind gastrointestinal hemorrhage, chronic malabsorption, diarrhea, and steatorrhea [9, 12, 23, 28, 33]. Furthermore protein-losing enteropathy, steatorrhea, and fat malabsorption may occur secondary to small bowel ischemia and can lead to malnutrition and failure to thrive of the affected individuals [34, 49]. Another mechanism for fat malabsorption is hypo-pancreatism and lymphatic vessel leakage secondary to abnormal portal circulation [33, 34, 57]. With antegrade flow in the portal vein being decreased, there is an associated increase in hepatic arterial flow. It has been suggested that this results in a “steal” phenomenon with a decrease in blood flow in the aortic branches distal to the celiac trunk that led to worsening of small bowel edema and hemorrhage [16, 32, 33]. Intestinal biopsy of affected children may be normal [28] or may show some vascular dilatation, intestinal edema, and fibrosis of the lamina propria [23].

In the literature, treatment modalities of IAPF include radiological embolization, surgery (for example arterial ligation or portocaval shunt), liver resection (for example lobectomy), or liver transplantation. Combined approaches can be done as embolization and later ligation or resection.

Table 3 summarizes the intervention type and outcome of the 45 patients of IAPF in literature (Table 3), overall, 37 patients were treated primarily by embolization with a success rate of almost 65% (n = 24), while only 13 needed surgical intervention whether arterial ligation, portocaval shunt, liver resection or liver transplantation. Details of surgical intervention are summarized in Table 3.

Table 3 Summarises different management approaches of IAPF of reported in literature
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In unilateral IAPF: Only one case needed liver resection after the failure of arterial ligation [47]. Given this percentage, transarterial embolization “TAE” is very likely to be effective for unilateral lesions if only one feeding artery is present.

In bilateral IAPF: all t patients were initially managed by embolization with a success rate of 55.6% only (n = 5). Two patients were successfully managed by arterial ligation and another two went through liver resection to relieve the symptoms. Some authors [11, 50, 51] have proposed that bilateral lesions should be treated by ligation of feeding arteries, with embolization affording only short-term palliation. However, repeated endovascular interventions are often necessary to be curative, particularly if multiple bilateral feeding arteries are present or if collaterals subsequently develop [15, 18, 43]..

On reviewing the 14 reported cases (including our patient) of complex IAPF, only 5 cases were successfully managed by embolization (35.7%). Three patients underwent arterial ligation and another one had portportocavalnt with a success rate of 100% (n = 4). Another three cases were managed successfully by liver resection and the last two cases with liver transplantation.

In our patient, Trans arterial embolization “TAE” through celiac and pancreaticoduodenal arcade failed, likely due to hyper-dynamic circulation-related thrombosis of the proper hepatic artery. That is why we used a novel technique to reach the IAPF with a different method other than TEA.

Overall, TAE is the main management in most children with non-complex congenital IAPF [11, 12, 21, 24, 29, 37, 39, 48] and is curative alone in more than 70% of such cases. After several trials of embolization, a surgical approach should be considered for fistulae that do not resolve [15, 21, 32, 42]. Until sufficient comparative data are available, surgery should be considered as the initial treatment of patients with complex IAPF.

All patients with IAPF after appropriate management have survived except for the first published case (Table 4). Most of the diagnosed children (86.7%, n = 39) showed regression of the symptoms, normalization of the portal circulation, preservation of liver functions, and catching up with their growth curves. Only 11% (n = 5) of the affected children had persistent portal hypertension [15, 21, 29, 41, 48]. All of them had complex IAPF. Four of them [15, 21, 29, 41] were younger than 4 months and the last one [48] was 7 months, which suggests that younger onset and presentation of complex (type 3) IAPF have a negative effect on prognosis.

Table 4 Outcome of patients with IAPF reported in literature
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Conclusion

Congenital intra-hepatic arterio-portal fistula is a rare, but treatable cause of portal hypertension in children. Early diagnosis and management will prevent further complications. Any child with recurrent gastrointestinal bleeding, failure to thrive, vomiting, diarrhea, steatorrhea, splenomegaly, or ascites should be investigated for IAPF. Doppler ultrasonography is the first line of investigation in such cases. Treatment modalities depend on the type and size of IAPF as mentioned before. Direct trans hepatic ultrasound guided coiling is a novel technique and an alternative method if TAE failed. Non-complex lesions usually respond to radiological embolization while complex lesions usually need surgical intervention.

Availability of data and materials

A comprehensive search was done using PUBMED, MEDLINE, GOOGLE SCHOLAR and a reference list of different case reports about congenital intrahepatic arterioportal fistula from the period 1967 to 2020. We reviewed the papers published and ensured that there are no duplicates and that all met the required criteria. (1) Must include pediatric patients, (2) primary diagnosis of included patients was IAPF. Any case that did not meet the criteria was excluded from our search. The full text of each included article was obtained where possible. Summary tables were made for all the extracted papers including gender, type (unilateral, bilateral, and complex), age, symptoms, signs, laboratory investigations, management, and outcome. We collected all this data and started adding it together to reach gender percentage, type percentage, mean age, common symptoms, signs, and investigations. Management was further classified into categories to reach the percentage of patients that underwent each treatment modality and each success rate of all of them. The outcome of all 45 cases reported (including our case) was added together to reach a final prognosis of the IAPF.

Abbreviations

IHVS:

Intrahepaticatic vascular shunts

APF:

Arterio-portal fistula

CS:

Cesarean section

ASD:

Atrial septal defect

PDA:

Patent foramen ovale

MSCT:

Multi-slice computed tomography

IAPF:

Intrahepatic arterio-portal fistula

CHF:

Congestive heart failure

AVM:

Arteriovenous malformation

TAE:

Trans arterial embolization

References

  1. Davenport M, Redkar R, Howard ER, Karani J. Arterioportal hypertension: a rare complication of partial hepatectomy. Pediatr Surg Int. 1999;15(8):543–5. https://doi.org/10.1007/s003830050666.

    Article  PubMed  CAS  Google Scholar 

  2. Tanaka H, Iwai A, Sugimoto H, Yoshioka T, Sugimoto T. Intrahepatic arterioportal fistula after blunt hepatic trauma: case reports. J Trauma. 1991;31(1):143–6. https://doi.org/10.1097/00005373-199101000-00029.

    Article  PubMed  CAS  Google Scholar 

  3. Eastridge BJ, Minei JP. Intrahepatic arterioportal fistula after hepatic gunshot wound: a case report and review of the literature. J Trauma. 1997;43(3):523–6. https://doi.org/10.1097/00005373-199709000-00024.

    Article  PubMed  CAS  Google Scholar 

  4. English WP, Johnson MB, Borman KR, Turner WW. Mesenteric ischemia: an unusual presentation of traumatic intrahepatic arterioportal fistula. 2001;67(9):865–7.

  5. Lumsden AB, Allen RC, Sreeram S, Atta H, Salam A. Hepatic arterioportal fistula. Am Surg. 1993;59(11):722–6.

    PubMed  CAS  Google Scholar 

  6. Kim TK, Choi BI, Han JK, Chung JW, Park JH, Han MC. Nontumorous arterioportal shunt mimicking hypervascular tumor in cirrhotic liver: two-phase spiral CT findings. Radiology. 1998;208(3):597–603. https://doi.org/10.1148/radiology.208.3.9722834.

    Article  PubMed  CAS  Google Scholar 

  7. Okuda K, Musha H, Nakajima Y, Takayasu K, Suzuki Y, Morita M, Yamasaki T. Frequency of intrahepatic arteriovenous fistula as a sequela to percutaneous needle puncture of the liver. Gastroenterology. 1978;74(6):1204–7.

    Article  PubMed  CAS  Google Scholar 

  8. Gabriel S, Maroney TP, Ringe BH. Hepatic artery-portal vein fistula formation after percutaneous liver biopsy in a living liver donor. Transplant Proc. 2007;39(5):1707–9. https://doi.org/10.1016/j.transproceed.2007.03.099.

    Article  PubMed  CAS  Google Scholar 

  9. Gryboski JD, Clemett A. Congenital hepatic artery aneurysm with superior mesenteric artery insufficiency: a steal syndrome. Pediatrics. 1967;39(3):344–7.

    Article  PubMed  CAS  Google Scholar 

  10. Van Way CW, Crane JM, Riddell DH, et al. Arteriovenous fistula in the portal circulation. Surgery. 1971;70(6):876–90.

    PubMed  Google Scholar 

  11. Vauthey JN, Tomczak RJ, Helmberger T, et al. The arterioportal fistula syndrome: clinicopathologic features, diagnosis, and therapy. Gastroenterology. 1997;113(4):1390–401. https://doi.org/10.1053/gast.1997.v113.pm9322535.

    Article  PubMed  CAS  Google Scholar 

  12. Norton SP, Jacobson K, Moroz SP et al. J Pediatr Gastroenterol Nutr. 2006;43(2):248-255. https://doi.org/10.1097/01.mpg.0000221890.13630.ad.

  13. Heaton ND, Davenport M, Karani J, et al. Congenital hepatoportal arteriovenous fistula. Surgery. 1995;117(2):170–4. https://doi.org/10.1016/s0039-6060(05)80081-9.

    Article  PubMed  CAS  Google Scholar 

  14. Stringer MD, McClean P, Heaton ND, et al. Congenital hepatic arterioportal fistula [letter]. J Pediatr Gastroenterol Nutr. 1999;29(4):487–8. https://doi.org/10.1097/00005176-199910000-00026.

    Article  PubMed  CAS  Google Scholar 

  15. Meunier C, Dabadie A, Darnault P, et al. Congenital intrahepatic arterio-portal fistula: diagnostic and therapeutic aspects. Pediatrie. 1993;48(3):211–6.

    PubMed  CAS  Google Scholar 

  16. Bakker J, Robben SGF, Hazebroek FWJ, et al. Congenital arterioportal fistula of the liver with reversal of flow in the superior mesenteric vein. Pediatr Radiol. 1994;24(3):198–9. https://doi.org/10.1007/BF02012190.

    Article  PubMed  CAS  Google Scholar 

  17. D’Agostino D, Monaco RG, Alonso V, Inon A, Ciardullo M, de Santibanes E. Liver transplantation as treatment for arterioportal fistulae. J Pediatr Surg. 1998;33:938–40.

    Article  PubMed  Google Scholar 

  18. Kumar N, de Goyet JV, Sharif K, et al. Congenital, solitary, large, intrahepatic arterioportal fistula in a child: management and review of the literature. Pediatr Radiol. 2003;1(33):20–3.

    Article  Google Scholar 

  19. Tarazov PG. Intrahepatic arterioportal fistulae: role of transcatheter embolization. Cardiovasc Intervent Radiol. 1993;16(6):368–73. https://doi.org/10.1007/BF02603142.

    Article  PubMed  CAS  Google Scholar 

  20. Foley WJ, Turcotte JG, Hoskins PA, Brant R, Ause R. Intra- hepatic arteriovenous fistulae between the hepatic artery and portal vein. Ann Surg. 1971;174(5):849–55. https://doi.org/10.1097/00000658-197111000-00017.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  21. Chaudry G, Lillis AP, Shaikh R, Padua HM, Chewning RH, Alomari AI. Endovascular treatment of congenital arterioportal fistulas. Cardiovasc Intervent Radiol. 2018;41(7):1021–8. https://doi.org/10.1007/s00270-018-1924-1.

    Article  PubMed  Google Scholar 

  22. Cheung YF, Leung MP. Coil embolization of hepatoportal arteriovenous fistula in a neonate. Clin Cardiol. 1999;22(10):675–6. https://doi.org/10.1002/clc.4960221017.

    Article  PubMed  CAS  Google Scholar 

  23. Marchand V, Uflacker R, Baker SS, et al. Congenital hepatic arterioportal fistula in a 3-year-old child. J Pediatr Gastroenterol Nutr. 1999;28(4):435–41.

    Article  PubMed  CAS  Google Scholar 

  24. Fellows KE, Hoffer FA, Markowitz RI, O’Neill JA Jr. Multiple collaterals to hepatic infantile hemangioendotheliomas and arteriovenous malformations: effect on embolization. Radiology. 1991;181(3):813–8. https://doi.org/10.1148/radiology.181.3.1947103.

    Article  PubMed  CAS  Google Scholar 

  25. Boon LM, Burrows PE, Paltiel HJ, et al. Hepatic vascular anomalies in infancy: a twenty-seven-year experience. J Pediatr. 1996;129(3):346–54. https://doi.org/10.1016/s0022-3476(96)70065-3.

    Article  PubMed  CAS  Google Scholar 

  26. Angelico R, Paolantonio G, Paoletti M, et al. Combined endovascular-surgical treatment for complex congenital intrahepatic arterioportal fistula: a case report and review of the literature. World J Hepatol. 2020;12(4):160–9. https://doi.org/10.4254/wjh.v12.i4.160.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Machado MCC, da Cunha JEM, Bacchella T, Lima SS, Toporovski J. Congenital intrahepatic arteriovenous fistula associated with portal hyper- tension and digestive bleeding. Rev Hosp Clin Fac Med Sao Paulo. 1979;34(6):285–8.

    PubMed  CAS  Google Scholar 

  28. Inon AE, D’Agostino D. Portal hypertension secondary to congenital arterioportal fistula. J Pediatr Gastroenterol Nutr. 1987;6(3):471–3. https://doi.org/10.1097/00005176-198705000-00027.

    Article  PubMed  CAS  Google Scholar 

  29. Routh WD, Keller FS, Cain WS, et al. Transcatheter embolization of a highflow congenital intrahepatic arterial-portal venous malformation in an infant. J Pediatr Surg. 1992;27:511–4.

    Article  PubMed  CAS  Google Scholar 

  30. Fiane AE, Gjestvang FT, Smevik B. Hepatoportal arteriovenous fistula and bleeding oesophageal varices in a child. Eur J Surg. 1993;159(3):185–6.

    PubMed  CAS  Google Scholar 

  31. Lamireau T, Chateil J-F, Petit P, Portier F, Panuel M, Grenier N. Successful embolization of congenital intrahepatic arterioportal fistula in two infants. J Pediatr Gastroenterol Nutr. 1999;29(2):211–4. https://doi.org/10.1097/00005176-199908000-00021.

    Article  PubMed  CAS  Google Scholar 

  32. Helikson MA, Shapiro DL, Seashore JH. Hepatoportal arterio- venous fistula and portal hypertension in an infant. Pediatrics. 1977;60(6):920–4.

    Article  PubMed  CAS  Google Scholar 

  33. D’Agostino D, Orsi M. Congenital hepatic arterioportal fistula [letter]. J Pediatr Gastroenterol Nutr. 1999;29(4):487. https://doi.org/10.1097/00005176-199910000-00024.

    Article  PubMed  Google Scholar 

  34. Agarwala S, Dutta H, Bhatnagar V, et al. Congenital hepatoportal arteriovenous fistula: report of one case. Surg Today. 2000;30(3):268–71. https://doi.org/10.1007/s005950050057.

    Article  PubMed  CAS  Google Scholar 

  35. Altuntaz B, Erden A, Karakurt C, Kut A, Senbil N, Yurdakul M. Severe portal hypertension due to congenital hepatoportal arteriovenous fistula associated with intrahepatic portal vein aneurysm. J Clin Ultrasound. 1998;26(7):357–60. https://doi.org/10.1002/(sici)1097-0096(199809)26:7%3c357::aid-jcu6%3e3.0.co;2-8.

    Article  Google Scholar 

  36. Lin S, Lee C, Kong M, Lu C, You C. Congenital hepatic arterioportal fistula complicated with gastrointestinal bleeding treated with transcatheter embolization: case report. Chang Gung Med J. 1999;22(1):106–10.

    CAS  Google Scholar 

  37. Raghuram L, Korah I, Jaya V, Athyal R, Thomas A, Thomas G. Coil embolization of a solitary congenital intrahepatic hepatoportal fistula. Abdom Imaging. 2001;26(2):194–6. https://doi.org/10.1007/s002610000116.

    Article  PubMed  CAS  Google Scholar 

  38. Alkim C, Yahin T, Oguz P, et al. A case of congenital intrahepatic arterioportal fistula. Am J Gastroenterol. 1999;94(2):523–5. https://doi.org/10.1111/j.1572-0241.1999.00805.x.

    Article  PubMed  CAS  Google Scholar 

  39. Akpek S, Ilgit ET, Cekirge S, Yücel C. High-flow arterioportal fistula: treatment with detachable balloon occlusion. Abdom Imaging. 2001;26(3):277–80. https://doi.org/10.1007/s002610000174.

    Article  PubMed  CAS  Google Scholar 

  40. Gorenflo M, Waldschmidt J, Bein G, Flocken W, Vogel M. Arterioportal fistula in infancy. J Pediatr Gastroenterol Nutr. 1993;16(1):87–9. https://doi.org/10.1097/00005176-199301000-00017.

    Article  PubMed  CAS  Google Scholar 

  41. Fasching G, Schimpl G, Sauer H, et al. Necrotizing enterocolitis due to congenital arterioportal fistulas in an infant. Pediatr Surg Int. 1993;8:264–7.

    Article  Google Scholar 

  42. Billing J, Jamieson N. Hepatic arterioportal fistula: a curable cause of portal hypertension in infancy. HPB Surg. 1997;10(5):311–4. https://doi.org/10.1155/1997/58026.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  43. Cil B. Transhepatic embolization of a recanalized congenital hepatic arterioportal fistula with NBCA and coils. Cardiovasc Intervent Radiol. 2004;27(2):172–4. https://doi.org/10.1007/s00270-003-0152-4.

    Article  PubMed  Google Scholar 

  44. Protheroe S, Tanner M, Bolia A. Ultrasound demonstration and transhepatic embolization of congenital aortoportal fistula with hepatoportal arteriovenous malformation in an infant. J Interv Radiol. 1993;7:157–62.

    Google Scholar 

  45. Kang T, Lee H, Yang F, Wang N. Idiopathic hepatic arterio- portal fistula: report of one case. Acta Paediatr Taiwan. 2002;43(2):102–5.

    PubMed  Google Scholar 

  46. Aarts R, Ijland M, de Blaauw I, Hoogeveen Y, Boetes C, van Proosdij M. Severe gastrointestinal tract bleeding in a two-month-old infant due to congenital intrahepatic arterioportal fistula. Eur J Radiol. 2006;59(1):25–8. https://doi.org/10.1016/j.ejrad.2006.03.014.

    Article  PubMed  CAS  Google Scholar 

  47. Tannuri A, Tannuri U, Lima F, Ricardi L, Leal A, da Silva M. Congenital intrahepatic arterioportal fistula presenting as severe undernutrition and chronic watery diarrhea in a 2-year-old girl. J Pediatr Surg. 2009;44(10):e19-22. https://doi.org/10.1016/j.jpedsurg.2009.07.027.

    Article  PubMed  Google Scholar 

  48. Wu L, Zhao L, Lu Y, He L, Hu X. Interventional embolization of congenital intrahepatic shunts in children. Pediatr Radiol. 2016;46(4):541–7. https://doi.org/10.1007/s00247-015-3497-3.

    Article  PubMed  Google Scholar 

  49. Zuidema GD, Turcotte JG, Wolfman EF Jr, Child CG III. Metabolic studies in acute small-bowel ischemia. Arch Surg. 1962;85(1):130–5. https://doi.org/10.1001/archsurg.1962.01310010134018.

    Article  CAS  Google Scholar 

  50. Heaton ND. Hepatic arterioportal fistulas: surgical ligation or embolization? [reply]. Surgery. 1996;119:237.

    Article  Google Scholar 

  51. Stringer MD, McClean P, Heaton ND, et al. Congenital hepatic arterioportal fistula [letter]. J Pediatr Gastroenterol Nutr. 1999;29:487–8.

    Article  PubMed  CAS  Google Scholar 

  52. Taher H, Grasso V, Tawfik S, Gumbs A. The challenges of deep learning in artificial intelligence and autonomous actions in surgery: a literature review. Art Int Surg. 2022;2:144–58. https://doi.org/10.20517/ais.2022.11.

    Article  Google Scholar 

  53. Taher HMA, Fares A, Wishahy AMK. Laparoscopic resurrection of an old technique: a new approach for total urogenital separation and rectal pull-through in patients with long common channel cloacal malformation. J Endourol. 2022;36(9):1177–82. https://doi.org/10.1089/end.2021.0724.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Azzam A, Abdulkarim AN, Shehata AEM, Mahran I, Arafa A, Arafat A, Tawfik S, Shaban M, Anache A, Kaddah S, Taher H. A report of two infant cases operated for jejunal duplication cyst associated with malrotation and volvulus. Int J Surg Case Rep. 2020;67:227–30. https://doi.org/10.1016/j.ijscr.2020.02.009.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Taher H, Abdellatif M, Tarek M, El Tagy G. Torsion of wandering spleen in an infant associated with hamartomatous vascular malformation. J Pediatric Surg Case Rep. 2019. https://doi.org/10.1016/j.epsc.2018.10.001.

    Article  Google Scholar 

  56. Taher H, Elboraie A, Fares A, Tawfiq S, Elbarbary M, Abdullateef KS. Laparoscopic inguinal hernia repair in bladder exstrophy, a new modified solution to an old problem: a cohort study. Int J Surg Case Rep. 2022;95:107252. https://doi.org/10.1016/j.ijscr.2022.107252.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Gumbs AA, Gogol M, Spolverato G, Taher H, Chouillard EK. Systematic review of the integrative medicine recommendations for patients with pancreatic cancer. Surgeries. 2021;2:216–30. https://doi.org/10.3390/surgeries2020022.

    Article  Google Scholar 

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Authors and Affiliations

  1. Pediatric Surgery Department, Specialized Pediatric Hospital, Cairo University Kasr Al Einy, Faculty of Medicine, 1 Abou El Rish Sq., El Sayeda Zeinab, Cairo, Egypt

    Heba Taher, ElSayed Kidr, Ahmed Kamal, Muayad Shaban, Haytham Eltantawi & Khaled S. Abdullateef

  2. Department of Radiology, Cairo University Kasr Al Einy, Faculty of Medicine, Cairo, Egypt

    Mohamed ElGobashy, Shady Mashhour, Amr Nassef & Gamal El Tagy

  3. Pathology Department, Ministry of Health, Cairo, Egypt

    Sherifa Tawfik

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  1. Heba Taher
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  2. ElSayed Kidr
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  11. Khaled S. Abdullateef
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Contributions

HT: drafting manuscript and supervisor, operating. EK: gathering history and drafting manuscript operating. AK: searching the literature, drafting the manuscript, and gathering data for patient follow-up. ME: revision and labeling radiology data, interventional radiology. SM: gathering radiology data interventional radiology. AN: drafting radiology data interventional radiology. ST: researching data and discussing pathology input. GET: drafting following up with the patient lead surgeon. SM: collecting clinical data and patient follow up. HE: reviewing the manuscript and researching data. AK: final reviewer, data collection and literature review.

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Correspondence to Heba Taher.

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Taher, H., Kidr, E., Kamal, A. et al. Transhepatic ultrasound guided embolization as a successful novel technique in treatment of pediatric complex intrahepatic arterioportal fistula: a case report and review of the literature. J Med Case Reports 17, 412 (2023). https://doi.org/10.1186/s13256-023-04047-0

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Journal of Medical Case Reports

ISSN: 1752-1947