Iatrogenic central retinal artery occlusion following retrobulbar anesthesia with adrenaline for vitreoretinal surgery: a case report
Journal of Medical Case Reports volume 16, Article number: 303 (2022)
We describe a patient presenting with central retinal artery occlusion (CRAO) of the right eye after retrobulbar anesthesia with adrenaline for macular pucker surgery.
The patient, a 67-year-old Caucasian man, developed a CRAO postoperatively by the next-day control likely due to the retrobulbar injection of a combination of Xylocaine and Bupivacaine with adrenaline as anesthetic.
The addition of adrenaline to the standard anesthetic solution could be a risk factor for serious complications, such as CRAO.
Central retinal artery occlusion (CRAO) has been reported as a rare complication associated to intraocular surgery in different types of ophthalmic surgery [1,2,3,4]. CRAO associated to anesthesia administration has been reported after sub-tenon [5, 6], peribulbar [7,8,9,10,11] and especially retrobulbar injection [2, 12,13,14,15,16]. Visual recovery is consistently reported to be poor in these patients. Epinephrine (adrenaline) is usually injected either with lidocaine or its derivatives to prolong the effects of a local anesthetic. Adrenaline is generally recognized as also havinga vasoconstrictive effect that decreases bleeding and counteracts the vasodilator effects of lidocaine through its sympathectomy effect. Eye vessels appear to be no exception even when anesthesia is administered outside the orbit [17,18,19,20,21,22]. Here, we report a case of a 1-day postoperative unilateral CRAO after vitreoretinal surgery with anesthetic containing adrenaline delivered by retrobulbar injection.
A 67-year-old Caucasian man with a history of non-pathological myopia underwent uneventful surgery for macular pucker with epiretinal membrane (ERM) peeling in his left eye. Three months later, he underwent the same surgical procedure using the same retrobulbar anesthesia in his right eye. Preoperative best corrected visual acuity (BCVA) was 0.5 (− 1.25 sphere − 0.75 cylinder at axis 50) in the right eye and 0.75 (− 3.25 sphere − 1.75 cylinder at axis 95) in the left eye. Both eyes were pseudophakic at the time of macular pucker diagnosis and underwent the same procedure 3 months apart. The patient underwent surgery under monitored anesthesia care with a retrobulbar block using a 25-gauge (G), 38-mm Atkinson needle containing 5 ml of a 1:1 mixture of 2% Xylocaine containing adrenaline (1:200,000) and Bupivacaine 5 mg/ml. Both eyes were operated by the same experienced surgeon. In both cases the retrobulbar anesthesia was administered by the same experienced ophthalmologist and the same drug combination was used.
Preoperative review of the patient’s medical history showed that the patient was under observation due to a myocardial infarction that he had about 5 years previously. He also was undere rheumatological observation for ankylosing spondylitis. His treatment at the time of surgery consisted of acetylsalicylic acid 75 mg once daily and atorvastatin 40 mg once daily. No other health problems were reported. The patient denied any allergies. The patient’s social history was negative for smoking, alcohol abuse, recreational drug use, and travel abroad. The patient was a doctor who had been worked in the hospital as a clinician for about 30 years. His mother suffered from migraines and died of a heart attack at the age of 70 years. At the age of 69 years, his maternal grandfather suffered a stroke. The patient did not know anything about his father’s side of the family, but there was no other family history of stroke or vascular illness.
Three 25G trocars were placed through a self-sealing sclerotomy construction. Central and peripheral pars plana vitrectomy (PPV) was performed. Preexisting posterior vitreous detachment (PVD) induction was verified. Brilliant Blue G containing dye (ILM-BLUE®; D.O.R.C., Zuidland, the Netherlands) aided visualization of the internal limiting membrane (ILM) and allowed for both ERM and ILM peeling up to the vascular arcades. Peripheral indentation allowed for retinal lesion verification. No breaks were found. BSS intraocular irrigating solution was left in the vitreous chamber. The sclerotomies were self-sealing and no sutures were needed. At the conclusion of the procedure, about 0.2 mg of subconjunctival gentamycin was administered. No gas bubble was instilled, there were no episodes of hypotension during the surgery, and postoperatively the patient did not sleep in the prone position.
The left eye had a regular postoperative course (Fig. 1a, b). On postoperative day 1 the patient was seen by a junior ophthalmologist, and the visual acuity (VA) in the right eye was hand motion. Intraocular pressure (IOP) was 14 mmHg. There was a trace afferent pupillary defect by reverse in the right eye. The posterior segment examination showed retinal whitening in the macula and a cherry-red spot (Fig. 2a, b).
The retina was attached. There was no proptosis or orbital fullness. Optical coherence tomography (OCT) demonstrated inner retinal thickening and hyperreflectivity (Fig. 2c). Fluorescein angiography demonstrated delayed arterial and venous perfusion (not shown).
No further systemic evaluation was performed, the patient was observed and was not referred to a stroke center by the junior ophthalmologist. No blood tests were carried out. No blood pressure, pulse nor temperature was recorded. The patient was not treated with anterior chamber paracentesis, timolol-dorzolamide and brimonidine drops, or 500 mg oral acetazolamide at the first day postoperative control. The patient was alert, attentive, and oriented. Speech was clear and fluent. Cranial nerve assessment, reflexes, sensory perception, coordination, and gait were all normal. No signs of cerebrovascular event were reported.
At 3 months after surgery, the patient felt his central scotoma had improved, and the BCVA had remained stable at 0.05 (− 0.75 to 1.0 axis 60). The anatomical signs of acute ischemia had resolved, and the macular region resulted in atrophic changes with disappearance of the physiological foveal depression (Fig. 3).
At 4 months after surgery, OCT angiography documented a right eye capillary dropout predominantly in the deep capillary plexus (Fig. 4)
Discussion and conclusions
We report a patient with CRAO that occurred in the postoperative period after vitreoretinal surgery with PPV + ERM peeling. Both eyes underwent the same procedure 3 months apart by the same experienced surgeon, but only the second eye showed CRAO.
Many authors have previously described the occurrence of CRAO after retrobulbar anesthesia, as summarized in Table 1.
CRAO is a known, but very rare complication of ocular surgery that can occur after retrobulbar, peribulbar, or sub-Tenon’s anesthesia [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. It is also a known, but very rare complication of adrenaline injection as an adjuvant in anesthesia administration in other parts of the body, especially in ear, nose and throat, oral, and plastic surgery [14,15,16,17,18,19,20]. To our knowledge, this is the first report to associate retrobulbar anesthesia injection combined with adrenaline to CRAO.
We suspect that multiple factors related to the adrenaline injection might have contributed to the development of this case. Since CRAO can happen after retrobulbar anesthetic injection even in absence of adrenaline, however, this might just be one of those rare cases of increased intraorbital pressure in a patient affected by vasculopathy resulting in ischemia.
Since adrenaline can cause CRAO following trigeminal nerve block during oral procedures or local anesthesia of the nasal mucosa during nasal surgery [14,15,16,17,18,19,20], the proposed mechanism is arterial occlusion resulting from either direct or indirect mechanical trauma with subsequent vasospastic events or intraarterially injected adrenaline with retrograde migration [20, 23,24,25,26,27]. The Atkinson needle has a blunt tip and would be expected to cause minimal trauma to the surrounding tissue.
Adrenaline acts peripherally on α-adrenergic receptors , resulting in the constriction of blood vessels. Thus, in our case, retrograde arterial migration of the injected adrenaline into the ophthalmic arterial system might have blocked the ophthalmic artery immediately after injection. Through vasodilation over time, subsequent anterior movement of adrenaline to more distal vessels may have led to vasoconstriction and subsequent vasospasm.
We exclude the hypothesis of allergic reaction to adrenaline, even though sensitization could have happened after the first vitreoretinal operation, because of lack of systemic symptoms.
Adrenaline can lead to CRAO following retrobulbar injection of intraconal administered local anesthetics. Hence, physicians should carefully administer local anesthesia with adrenaline in the intraconal space while considering the possibility that such a complication may occur, or possibly exclude anesthetics containing adrenaline during retrobulbar anesthesia.
Availability of data and materials
Data and material can be found at the Oslo University Hospital, Ophthalmology Department.
Best corrected visual acuity
Central retinal artery occlusion
Internal limiting membrane
Pars plana vitrectomy
Posterior vitreous detachment
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Confalonieri, F., Ladstein, G.E., Stene-Johansen, I. et al. Iatrogenic central retinal artery occlusion following retrobulbar anesthesia with adrenaline for vitreoretinal surgery: a case report. J Med Case Reports 16, 303 (2022). https://doi.org/10.1186/s13256-022-03518-0