Swept-source optical coherence tomography and optical coherence tomography angiography in acquired toxoplasmic chorioretinitis: a case report
Journal of Medical Case Reports volume 12, Article number: 358 (2018)
To describe swept-source optical coherence tomography and optical coherence tomography angiography retinal changes in a case of acute toxoplasmic chorioretinitis both at the time of diagnosis and after healing.
A 57-year-old white woman suffering from acquired toxoplasmic chorioretinitis underwent swept-source optical coherence tomography and optical coherence tomography angiography both at the time of diagnosis and after healing. In the acute phase of the disease, swept-source optical coherence tomography clearly showed retinal and choroidal involvement in the superficial retina and in the choroidal swelling. Optical coherence tomography angiography showed a complete loss of deep and superficial capillary networks and of choroidal vessels in the area of the inflammation. After healing, swept-source optical coherence tomography showed a retinal thinning of the area involved, with a subversion of retinal layers and no visible change at the choroid level. On the other hand, optical coherence tomography angiography showed the persistence of a vascular occlusion at the retina and choroid level.
This is the first case in the optical coherence tomography angiography literature that shows the imaging of toxoplasmic chorioretinal lesions. This case confirms the involvement of the retina and choroid in toxoplasmic uveitis and the disruptive potential of such inflammation. The optical coherence tomography angiography performed after healing showed a persistent ablation of the retina, choriocapillaris, and choroidal vessels. The non-invasive optical coherence tomography angiography imaging technique may have diagnostic and prognostic value in regard to toxoplasmic uveitis.
Toxoplasma gondii is a ubiquitous intracellular parasite deemed to be the leading infectious cause of posterior uveitis worldwide . In high T. gondii endemic regions of the USA and Europe, ocular toxoplasmosis is the most frequent cause of posterior uveitis [2, 3]. Recent reports indicated that acquired infections affect a larger ocular portion than congenital ocular toxoplasmosis [4, 5].
Ocular toxoplasmosis is commonly detected by means of standard ophthalmic researches and its diagnosis is obtained through a clinical examination . Seropositivity to T. gondii infection indicates a previous systemic exposure to the parasite. Toxoplasmic chorioretinitis can be congenital or acquired. The congenital form is due to a systemic maternal infection during pregnancy and causes scars in the fetus retina, which are often bilateral with macular involvement . The acquired form appears in most cases (72%) as recurrence of a previous asymptomatic infection, with a concentration of necrotizing retinitis or retinochoroiditis adjacent to a variably pigmented chorioretinal scar. Usually, recurrences affect younger patients (mean age 30 years) with a positive immunoglobulin (Ig) G serology. However, older patients (mean age 51 years), in most cases, experience an acute primary chorioretinal lesion during a primary systemic infection, depending on their serology . Active lesions are associated with symptomatic vitreous inflammation, which is the presenting symptom of ocular toxoplasmosis, which leads to blurred vision. The classical ocular manifestation of toxoplasmosis is a focal necrotizing retinitis or retinochoroiditis. A severe vitritis causes the classic “headlight in the fog” sign .
Swept-source optical coherence tomography (SS-OCT) is the latest milestone in retinal and choroidal imaging. Because its wavelength of 1050 nm, which is superior to the 840 nm of spectral domain optical coherence tomography (SD-OCT), it is able to overcome ocular opacities such as cataracts and vitritis, allowing the retinal and choroidal visualization of eyes whose fundus is not clearly visible.
For the same reason, SS-OCT allows visualization of the retinal and choroidal vascular networks, even in eyes with medium opacity . Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information generating angiographic images. Optical coherence tomography (OCT) angiograms are en face images which can be scrolled outward from the internal limiting membrane (ILM) up to the choroid in order to visualize the individual vascular plexus and segment the inner retina, outer retina, choriocapillaris, or other areas of interest . In this case report we describe the SS-OCT and OCTA imaging techniques used in the case of a 57-year-old white woman suffering from primary acute toxoplasmic chorioretinitis. To the best of our knowledge, such a report has never been done before.
A 57-year-old white woman presented to the emergency department of the hospital in Novara, Italy, with sudden ocular pain and blurred vision in her left eye. The best corrected visual acuity (BCVA) was 20/20 in her right eye and 20/200 in her left eye. Her right eye was normal. Her left eye anterior segment showed an aqueous flare and the presence of cells and keratic precipitates without posterior synechiae. Intraocular pressure was 14 mmHg in her right eye and 20 mmHg in her left eye. A fundus examination showed an intense vitreitis and a focal necrotizing retinochoroiditis above the optic disc (Fig. 1a). As the pigmented chorioretinal scar adjacent to the active lesion was not visible, a clinical diagnosis of suspected primary ocular toxoplasmosis was made. The diagnosis had been confirmed by anamnestic data (our patient adopted a wildcat a few months before). Serology for T. gondii (IgM and IgG) was positive, but it was negative for other common uveal infections. Necrotic herpetic retinopathies, cytomegalovirus retinitis, syphilitic chorioretinitis, and tuberculous chorioretinitis were excluded by serological tests. In addition, a chest X-ray to detect hilar adenopathy of sarcoidosis was performed. The result was negative. After that, a systemic antibiotics combination therapy with pyrimethamine and sulfadiazine was performed and a steroid therapy with prednisone was started. Two months after healing, the inflammation completely disappeared. Analyzing the fundus, a non-pigmented atrophic chorioretinal scar without signs of vitreitis was clearly visible in the primary lesion site and a clinical examination showed that the BCVA was 20/25 in her left eye.
Despite the vitreitis (Fig. 1b–d, f–h), SS-OCT and OCTA (Triton Plus®, Topcon Corporation, Tokyo, Japan) were performed before and after the resolution of the disease. In particular, the SS-OCT showed nerve fiber swelling and choroidal thickening (Fig. 1b). The OCTA performed on the lesion showed an obliteration of the retinal capillary, choriocapillary, and deep choroidal vessels (Fig. 1c, d). Fluorescein angiography (FA) showed a hypofluorescence during the early phase, followed by a progressive hyperfluorescence that developed after the leakage phase; on the other hand, indocyanine green angiography (ICGA) showed a hypofluorescent lesion with characteristic hypofluorescent perilesional satellite lesions.
After healing, an SS-OCT performed on the lesion showed a hyper-reflective dome-shaped intraretinal mass involving the entire retinal thickness, associated with an increasing retinal thickness on the scar site (Fig. 1f). The retinal layers within the mass could no longer be recognized. The choroid had a normal thickness. An OCTA performed on the lesion showed a persistent retinal capillary plexus and a choriocapillaris failure with partial reperfusion of the deep choroidal vessels (Fig. 1g, h).
Non-invasive clinical imaging with SS-OCT and OCTA confirms that toxoplasmic uveitis affects the vitreous and all the retinal layers up to the choroid, causing inflammatory swelling of the retina and choroid. As previously described by Chen et al., despite the presence of intense vitreitis , the use of 1050 nm wavelength SS-OCT can provide better images than SD-OCT and TM-OCT. It also allows us to verify the involvement of the vitreous, retina, and choroid with a single scan image.
In this study we report for the first time OCTA images of toxoplasmic chorioretinitis from an acute stage to a quiescent stage. The OCTA confirmed the results of previous FA and ICGA studies  by showing a vascular obliteration of the retina and choroid, which is typical of toxoplasmic inflammatory lesions. After the resolution of the disease, the vascular obliteration appears to be only partially reversible in the periphery of the lesion, although not in the center. Furthermore, the choriocapillaris texture destruction persists around the obliterated area and only the deep choroidal vessels remain visible.
By performing FA, the chorioretinal vascular network was not clearly visible because it was masked by a rapid loss of dye from the vessels. Instead, the OCTA allowed us to visualize the entire lesion more clearly. In fact, because of the absence of dye, there was no interference due to early leakage. Compared to FA, OCTA has the advantage of determining more accurately which retinal vascular layer is affected.
The non-invasive OCTA and SS-OCT imaging techniques may help a physician to make the correct diagnosis, especially when a pigmented retinal scar is not visible. However, further studies in this regard are needed. Furthermore, OCTA may play a special role as a prognostic tool in regard to toxoplasmic uveitis. In particular, when the toxoplasmic lesion is close to the macula, OCTA may show the macula vascular involvement more effectively than FA. OCTA is also able to detect which retinal vascular layer is affected. In the current situation, in which the vascular obliteration in such pathology seems to be only partially reversible, OCTA may add valuable prognostic information for sight recovery after healing.
Best corrected visual acuity
Indocyanine green angiography
Internal limiting membrane
Optical coherence tomography
Optical coherence tomography angiography
Spectral domain optical coherence tomography
Swept-source optical coherence tomography
Jabs DA. Ocular toxoplasmosis. Int Ophthalmol Clin. 1990;30(4):264–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2228473. [cited 2018 Jan 14]
McCannel CA, Holland GN, Helm CJ, Cornell PJ, Winston JV, Rimmer TG. Causes of uveitis in the general practice of ophthalmology. UCLA Community-Based Uveitis Study Group. Am J Ophthalmol. 1996;121(1):35–46. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8554079. [cited 2018 Jan 14]
Balasundaram MB. Outbreak of acquired ocular toxoplasmosis involving 248 patients. Arch Ophthalmol. 2010;128(1):28. Available from: http://archopht.jamanetwork.com/article.aspx?doi=10.1001/archophthalmol.2009.354. [cited 2018 Jan 14]
Perkins ES. Ocular toxoplasmosis. Br J Ophthalmol. 1973;57(1):1–17. Available from: http://www.ncbi.nlm.nih.gov/pubmed/4574554. [cited 2018 Jan 14]
Atmaca LS, Simsek T, Batioglu F. Clinical features and prognosis in ocular toxoplasmosis. Jpn J Ophthalmol. 2004;48(4):386–91. Available from: http://link.springer.com/10.1007/s10384-003-0069-0. [cited 2018 Jan 14]
Dodds EM. Toxoplasmosis. Curr Opin Ophthalmol. 2006;17(6):557–61. Available from: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00055735-200612000-00013. [cited 2018 Jan 14]
Bosch-Driessen LEH, Berendschot TTJM, Ongkosuwito JV, Rothova A. Ocular toxoplasmosis: clinical features and prognosis of 154 patients. Ophthalmology. 2002;109(5):869–78. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11986090. [cited 2018 Jan 14]
Park Y-H, Nam H-W. Clinical features and treatment of ocular toxoplasmosis. Korean J Parasitol. 2013;51(4):393–9. Available from: http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2013.51.4.393. [cited 2018 Jan 14]
Michalewska ZB, Michalewski J, Nawrocki JE. Swept-source OCT, wide-field simultaneous choroid, retina, and vitreous visualization. Retina Today. 2013;(9):50–6.
Spaide RF, Klancnik JM, Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol. 2015;133(1):45–50.
Chen KC, Jung JJ, Engelbert M. Single acquisition of the vitreous, retina and choroid with swept-source optical coherence tomography in acute toxoplasmosis. Retin Cases Brief Rep. 2016;10(3):217–20. Available from: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=01271216-201601030-00007. [cited 2018 Jan 14]
Atmaca LS, Simsek T, Atmaca Sonmez P, Sonmez K. Fluorescein and indocyanine green angiography in ocular toxoplasmosis. Graefes Arch Clin Exp Ophthalmol. 2006;244(12):1688–91. Available from: http://link.springer.com/10.1007/s00417-006-0345-z. [cited 2018 Jan 14]
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Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. The local ethics committee ruled that no formal ethics approval was required in this particular case.
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Vezzola, D., Allegrini, D., Borgia, A. et al. Swept-source optical coherence tomography and optical coherence tomography angiography in acquired toxoplasmic chorioretinitis: a case report. J Med Case Reports 12, 358 (2018). https://doi.org/10.1186/s13256-018-1902-x