- Case report
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Aphonia induced by simultaneous bilateral ischemic infarctions of the putamen nuclei: a case report and review of the literature
© Senatorov et al.; licensee BioMed Central Ltd. 2013
- Received: 28 August 2012
- Accepted: 14 February 2013
- Published: 19 March 2013
Isolated aphonia induced by acute stroke is a rare phenomenon with only a few cases reported in the literature.
We report an unusual case of a 44-year-old African-American man with a history of hypertension, smoking and cocaine use who developed acute aphonia secondary to simultaneous ischemic infarctions of the bilateral putamen nuclei.
We describe the clinical presentation of acute aphonia induced by bilateral putamen nuclei ischemic infarctions, correlating clinical symptoms with injury localization. We further highlight the anatomic and functional organization of the neural pathways involved.
- Vocal Fold
- Internal Capsule
- Primary Motor Cortex
- Lentiform Nucleus
Isolated aphonia induced secondary to simultaneous acute ischemic infarctions of the bilateral basal ganglia is a rare phenomenon. Most often, acute ischemic lesions involving the basal ganglia present with multiple symptoms including motor weakness and pseudobulbar signs, among others. We report an unusual case of a 44-year-old African-American man with a history of hypertension, smoking and cocaine abuse who presented with isolated acute onset aphonia after experiencing isolated ischemic infarctions involving the bilateral putamen nuclei.
A 44-year-old African-American man with a previous medical history of uncontrolled hypertension (noncompliant with antihypertensive medications), smoking cigarettes, and chronic alcohol and cocaine abuse presented to an outside hospital with the complaint of altered speech that had waxed and waned for one week. On presentation to the outside hospital, his National Institutes of Health Stroke Scale (NIHSS) was 2 for isolated dysarthria. His blood pressure was 285/185mmHg. After treatment with hydralazine, his systolic blood pressure decreased to about 130mmHg and he became acutely aphonic. He remained alert and followed all commands, but was unable to produce speech. With maximal effort, our patient was able to produce short breathy sounds. His NIHSS increased to 9, primarily based upon his inability to verbally respond to questions. Given his severe speech deficit, our patient was treated with intravenous tissue plasminogen activator with a subsequent improvement in NIHSS, returning to 2. He was transferred to our hospital for further workup.
These findings were compatible with acute ischemic infarcts within the regions supplied by the distal lateral lenticulostriate arteries. Magnetic resonance imaging fluid attenuated inversion recovery was also consistent with the acute ischemia seen on the diffusion-weighted imaging and apparent diffusion coefficient sequences, with a slightly more superior cut (Figure 1B) demonstrating the chronic lacunar infarct in his right basal ganglia, as seen on the initial head computed tomography. Our patient was hospitalized at our facility for five days; throughout this time he remained grossly aphonic and developed no further symptoms. He was started on daily statin and aspirin therapy and his blood pressure slowly normalized. He was counseled to quit smoking and discontinue all cocaine use. He was discharged home under 24-hour supervision.
While at home approximately two weeks after discharge, our patient experienced two episodes of transient right eye vision loss. The first episode lasted for approximately 30 minutes and resolved spontaneously; the second episode occurred two days later and our patient was again hospitalized. On presentation to our Emergency Department, he was hypotensive with a blood pressure of 101/68mmHg. His vision loss resolved spontaneously within five hours after aggressive hydration. Our patient's hypertensive medications, lisinopril and hydrochlorothiazide, were held. He was seen by our Ophthalmology Department, who suggested transient retinal ischemia in the setting of significant hypertensive retinopathy and potential medication-related hypotension. Our patient’s ability to speak had improved since his prior admission although his speech remained extremely hoarse and dysarthric. No other neurological deficits were noted. Our patient was evaluated by our Otolaryngology Department, who carried out an endoscopic examination and described decreased bilateral vocal fold (cord) function, more so on the right than left. Our patient was again discharged home with close follow-up.
At a follow-up visit to our neurology clinic approximately one month after the onset of the primary aphonic event, our patient continued to have moderately severe hoarseness and dysarthria, although his speech had improved in comparison to his second hospital admission. Our patient had experienced no further neurological events in the interim.
Acute unilateral infarctions limited to the lenticular nuclei are quite common and are often an accidental finding on imaging scans in patients with microangiopathy. Such lesions rarely cause clinical symptoms, representing just 1.6% of all deep cerebral infarcts leading to clinical symptoms of stroke . Symmetrical acute lesions involving both basal ganglia as supplied by the perforating lenticulostriate arteries have rarely been reported. Such lesions have been associated with diffuse hypoxic injury , cardiogenic emboli  and cocaine or heroin toxicity . The few reported cases that do describe acute bilateral infarctions as limited to both lenticular nuclei typically describe additional clinical deficits beyond aphonia, making our case unusual. To the best of our knowledge, there is only one prior report of a patient with isolated aphonia caused by simultaneous bilateral lenticulostriate artery territory infarctions .
Somatotopical organization of the putamen has been relatively well-studied in electrophysiological and neuroanatomical experiments involving the monkey . To summarize, the motor territory of the striatum belongs to the caudal aspect of the putamen and only the lateral putamen receives projections from the primary motor cortex. In the lateral putamen, the corticostriatal projections from hindlimb, forelimb and orofacial representations are arranged from dorsal to ventral. The caudal putamen projects to the ventral two-thirds of the caudal globus pallidus. Neurons responding to the orofacial, forelimb and hindlimb regions of the primary motor cortex are located along the ventral-to-dorsal axis in the external and internal segments of the globus pallidus. The internal segment of the globus pallidus sends output to the oral part of the ventrolateral thalamic nucleus. The ventrolateral thalamic nucleus then sends fibers back to the primary motor cortex. Although much less is known about the somatotopy of the human putamen, imaging studies suggest similar somatotopical organization . Available data correspond well with the locations of the lesions and the symptoms presented in our case.
Vocal fold paralysis induced by stroke is most commonly associated with ischemia in the brainstem; however, isolated vocal paralysis is an uncommon manifestation of stroke . The vocal folds are regulated by the Xth cranial nerve (vagus), with the muscles of the larynx (voice box) controlled by the branchial motor component of the vagus originating in the nucleus ambiguus in the medulla. As there is no direct connection from the lentiform nuclei to the nucleus ambiguus, the upper motor neuron innervations to the nucleus ambiguus controlling voice are provided by the corticobulbar tract originating from the bilateral laryngeal motor cortex [8, 9].
Because the nucleus ambiguus receives bilateral input from the motor cortex, a unilateral lesion of the corticobulbar tract prior to the ambiguus nucleus should not paralyze the unilateral vocal fold. Although unilateral corticobulbar tract lesions are not typically associated with vocal fold palsies, there are several cases reported describing altered phonation with injury to a dominant hemispheric projection from the contralateral corticobulbar tract to the vocal fold. For instance, Takase et al.  reported a right vocal fold paresis caused by hypoperfusion of the left hemisphere in the setting of severe stenosis of the left middle cerebral artery (MCA). Interestingly, in our patient, we found more decreased function in the right vocal fold as a possible consequence of a larger lesion in the left putamen.
As described, both acute lesions were symmetrically located in the posterolateral region of the putamen nuclei, near the posterior limb of the internal capsule. However, there was no indication that the lesions might have affected the internal capsule. There is some controversy regarding the somatotopy of the pyramidal tract in the human internal capsule, and experimental studies have shown the lack of a direct corticoambigual projection in rhesus monkey as well as in several other animal species . Many believe that direct corticoambigual projections are a very recent acquisition in hominid evolution, reflecting speech development in humans. Current consensus is that corticospinal fibers of hand and foot representation pass in the posterior limb of the internal capsule; however, the pyramidal tract does not maintain a fixed position in the internal capsule and is shifting from the middle part of the posterior limb in the superior portion of the capsule to the posterior third of the posterior limb in the inferior portion of the capsule . At the same time, the corticobulbar tract of head and neck representation occupies the genu [8, 9]. The disruption of the corticobulbar tract by focal ischemic lesions in the genu of the internal capsule has been found to cause orofacial and laryngeal paresis . Simonyan et al. , who studied spasmodic dysphonia (a neurological disorder characterized by involuntary spasm in the laryngeal muscles during speech production) using diffusion tensor imaging and neuropathological studies, reported bilateral changes in both the lentiform nucleus and the right genu of the internal capsule. The ischemic lesions in our case are close to the posterior portion of the posterior limb of the internal capsule, but far from the genu. If there was involvement of the internal capsule, it would produce symptoms associated with corticospinal injury but not corticobulbal tract lesions.
Thus, the isolated bilateral lentiform nuclei infarctions seen in our patient appear to have induced the vocal fold paralysis. As such, our case indicates that the putamen, and specifically its caudal part, appears to be necessary for phonation independent of any other injury. Physicians observing voice changes associated with weakness or paralysis of the vocal folds should consider possible injury to the lentiform nuclei of the brain. Lastly, physicians evaluating patients with stroke should be aware of the risks of overly aggressive treatment of hypertension in patients with acute stroke and a high risk for cerebral microangiopathy with multiple poorly controlled vascular risk factors.
We describe the clinical presentation of acute aphonia induced by bilateral infarctions of the putamen, further correlating clinical symptoms with injury localization. We highlight the anatomic and functional organization of the neural pathways involved, suggesting that the regions of the lentiform nuclei supplied by the lateral lenticulostriate arteries may be necessary for vocal cord function, and that these regions appear to be particularly sensitive to fluctuations in blood pressure and the toxic effects of cocaine.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
JWC was supported in part by the Department of Veterans Affairs, Baltimore, Office of Research and Development, Medical Research Service; the Department of Veterans Affairs Stroke Research Enhancement Award Program; the University of Maryland General Clinical Research Center (Grant M01 RR 165001), General Clinical Research Centers Program, National Center for Research Resources; and the National Institutes of Health - National Institute of Neurological Disorders and Stroke grant U01 (U01 NS069208-01).
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