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Acute refractory hypoxemia after chest trauma reversed by high-frequency oscillatory ventilation: a case report
© Charbonney et al.; licensee BioMed Central Ltd. 2013
Received: 16 November 2012
Accepted: 26 March 2013
Published: 15 July 2013
Polytrauma often results in significant hypoxemia secondary to direct lung contusion or indirectly through atelectasis, systemic inflammatory response, large volume fluid resuscitation and blood product transfusion. In addition to causing hypoxemia, atelectasis and acute lung injury can lead to right ventricular failure through an acute increase in pulmonary vascular resistance. Mechanical ventilation is often applied, accompanied with recruitment maneuvers and positive end-expiratory pressure in order to recruit alveoli and reverse atelectasis, while preventing excessive alveolar damage. This strategy should lead to the reversal of the hypoxemic condition and the detrimental heart–lung interaction that may occur. However, as described in this case report, hemodynamic instability and intractable alveolar atelectasis sometimes do not respond to conventional ventilation strategies.
We describe the case of a 21-year-old Caucasian man with severe chest trauma requiring surgical interventions, who developed refractory hypoxemia and overt right ventricular failure. After multiple failed attempts of recruitment using conventional ventilation, the patient was ventilated with high-frequency oscillatory ventilation. This mode of ventilation allowed the reversal of the hemodynamic effects of severe hypoxemia and of the acute cor pulmonale. We use this case report to describe the physiological advantages of high-frequency oscillatory ventilation in patients with chest trauma, and formulate the arguments to explain the positive effect observed in our patient.
High-frequency oscillatory ventilation can be used in the context of a blunt chest trauma accompanied by severe hypoxemia due to atelectasis. The positive effect is due to its capacity to recruit the collapsed alveoli and, as a result, the relief of increased pulmonary vascular resistance and subsequently the reversal of acute cor pulmonale. This approach may represent an alternative in case of failure of the conventional ventilation strategy.
Polytrauma and chest trauma often result in significant hypoxemia secondary to direct or indirect lung injury. Indirect lung injury can result from the systemic inflammatory response to the trauma itself or to the interventions such as large volume fluid resuscitation and blood product transfusion . However, direct injury to the parenchyma often leads to bleeding, contusion and impaction of secretions with subsequent airway obstruction. The consequence is the development of multiple areas of atelectasis. Besides primary intervention, such as pneumothorax or hemothorax drainage, the management of chest injury and hypoxemia requires oxygen supplementation and often mechanical ventilation.
Ventilatory strategies for trauma patients are similar to those for patients with acute respiratory distress syndrome (ARDS). It is generally accepted to apply mechanical ventilation according to the open lung concept, consisting of intermittent recruitment maneuvers and positive end-expiratory pressure (PEEP), along with a low tidal volume to limit end-inspiratory transalveolar pressures . The goals of this strategy are to achieve better oxygenation through alveoli recruitment, while preventing excessive alveolar damage. In addition to causing a mismatch in the ventilation to perfusion ratio, atelectasis and lung injury can lead to right ventricular failure through an acute increase in afterload secondary to increased pulmonary vascular resistance .
The use of high-frequency oscillatory ventilation (HFOV) has been reported in trauma patients as a safe rescue therapy , including in patients sustaining pulmonary contusions [5, 6]. We describe a case of an injured patient with severe blunt chest trauma requiring surgery, who developed refractory hypoxemia during surgery. After multiple failed attempts of recruitment using conventional ventilation (CV) in the Intensive Care Unit (ICU), the patient’s severe hypoxemia was reversed by HFOV. As far as we are aware, this is the first case report of HFOV used as an extremely early rescue therapy shortly after admission to the ICU from the Operating Room (OR). We use this case report to describe the physiological advantages of HFOV in patients with chest trauma and formulate the arguments to explain the positive effect observed in our patient.
A 21-year-old unrestrained Caucasian man, involved in a motor vehicle collision, was ejected after multiple rollovers and was found lying on the ground. His initial vital signs in the field were stable and he was awake and conversing. He was brought to the Emergency Room (ER) by ambulance at 2:30 a.m. His injuries included an open femur fracture, lower limb lacerations and blunt chest trauma.
While he was being assessed, he required 2L of crystalloids and two units of packed red blood cell (PRBC) transfusion to maintain his blood pressure. The focused assessment with sonography for trauma was negative and the first chest radiograph was unremarkable. After he was intubated in the ER for respiratory distress, a whole body computed tomography scan was performed. This examination revealed multiple vertebral fractures (T5 to T8) and a large hemothorax on the right side for which a chest tube was placed. After draining 800mL of blood, the drainage stabilized. The patient’s arterial blood pressure was maintained at 120/75mmHg without vasopressor support, but he was anuric. He was then brought to the ICU at 3:45 a.m. for close observation and continuous resuscitation. One hour later, he became hypotensive (systolic blood pressure <90mmHg) and tachycardic (heart rate >110 beats per minute), which coincided with the rapid drainage of 1.5L of frank blood from his chest tube. He was transferred to the OR for emergent thoracotomy.
The source of the bleeding was the posterior mediastinum in the area of the vertebral fractures. The bleeding was still active and had breached the pleural cavity. To allow for operative access, the anesthetist placed a right bronchial blocker to deflate the right lung. Paravertebral and intercostal vessels were then controlled. The severe bleeding and ongoing coagulopathy necessitated the transfusion of 24 units of PRBCs, 12 units of frozen plasma and 19 units of cryoprecipitate. He was also given recombinant Factor VIIa (7.2mg). Mixed respiratory and metabolic acidosis ensued. Inotropes and vasopressors (epinephrine and norepinephrine), intravenous bicarbonate and calcium gluconate were administered due to hemodynamic instability.
Respiratory, hemodynamic and laboratory parameters
PEEP and/or mean airway pressure (cmH2O)*
Mean arterial pressure (mmHg)
Norepinephrine (μg/kg /minute)
The ICU team next decided to ventilate the patient with HFOV (Sensormedics 3100B, CareFusion, San Diego, USA). The initial settings were: fraction of inspired oxygen (FiO2) 100%, bias flow, 40L/minute; frequency, 4Hz (given the extreme acidosis); inspiration time, 33%; pressure amplitude of oscillation 83cmH2O, and mean airway pressure 38cmH2O (5cm H2O above mean airway pressure on CV). After 45 minutes, the PaO2 had reached 75mmHg and CVP dropped to 18mmHg. Two hours later, the FiO2 was titrated down to 50% and the epinephrine infusion was discontinued with maintenance of norepinephrine. Within a few hours, continuous veno-venous hemodialysis was started due to persistent anuria and hyperkalemia.
HFOV has usually been described and used as “rescue therapy” in intractable ARDS with severe hypoxemia, and its use as early ventilatory support for ARDS is not supported by recent clinical trials [7, 8]. Despite the description of “early” use (0 to 14 days after injury) of HFOV in trauma patients in retrospective series [4, 5], no report of extreme early use has been described.
To the best of our knowledge, the case we describe above is the first report of HFOV as an “extreme early rescue therapy” for refractory hypoxemia after blunt chest trauma. The consequences of the chest trauma and surgery (mainly alveolar atelectasis, but also alveolar edema) had led to severe hypoxemia and adverse heart–lung interactions that were not reversible with CV. The efficacy of recruitment on the collapsed lung provides the explanation for the positive outcome observed once HFOV was started.
After blunt chest trauma, followed by the additional hit of intra-thoracic surgery, the ventilatory and radiographic abnormalities are mainly the consequences of alveolar collapse (atelectasis) and edema due to lung contusion and surfactant alteration . A component of permeability edema due to trauma, polytransfusion, emergency thoracic surgery, and high-pressure ventilation in the OR is probable. However, we believe that the main pathophysiological process was acute cor pulmonale. The latter pathophysiological explanation is supported not only by the elevated CVP and the need of inotropes and vasopressors, but also by the rapid decrease of FiO2 requirement, CVP and inotropic requirement, after lung recruitment by the HFOV. However, measurement of changes in lung mechanics (compliance and resistance) was not possible while the patient was receiving HFOV.
The theoretical advantage of HFOV is the presence of a high continuous distending pressure (mean airway pressure) that decreases from the ventilator to the distal trachea and is associated with less lung inflammation compared to CV with the same measured mean airway pressure . In selected cases, HFOV may recruit lung more rapidly at comparable distending pressures due to prolonged elevation of pressure over time, associated with incremental pressure distribution and oscillations. These characteristics may better exploit pressure-volume hysteresis of collapsing unstable alveolar units than CV, through avoidance of the opening-closing phenomenon [12, 13]. If HFOV achieves faster recruitment than CV, then the deleterious effects of HFOV on right ventricular function  may be reduced or avoided altogether.
Once the effect of afterload reduction by opening the lung and reducing the pulmonary arterial resistance is achieved, acute cor pulmonale should resolve . However, we acknowledge that further improvement of our patient’s oxygenation was due to correction of the hypervolemic state with the continuous veno-venous hemodialysis.
In conclusion, this patient presented with extreme hypoxemia in the context of blunt chest trauma accompanied by atelectasis and ARDS, with subsequent acute cor pulmonale. CV was ineffective in reversing the process. The introduction of HFOV allowed the recruitment of collapsed alveoli and, as a result, the rapid relief of increased pulmonary vascular resistance and subsequently the reversal of acute cor pulmonale. This illustrates the potentially beneficial role of rapid HFOV-mediated lung recruitment in desperate situations on both oxygenation and right ventricular function, notwithstanding recent evidence from landmark clinical trials finding no benefit  or harm  from the routine application of HFOV in patients with early ARDS.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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