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Cornual pregnancy as a complicaton of the use of a levonorgestrel intrauterine device: a case report
© Beltman and de Groot; licensee Cases Network Ltd. 2009
Received: 9 August 2008
Accepted: 2 March 2009
Published: 22 July 2009
Complications of copper load intrauterine devices, including ectopic pregnancies are well reported. Rates of ectopic pregnancy are 0.6 to 1.1% per year. However, the levonorgestrel intrauterine device has been described as more protective against ectopic pregnancies due to the addition of the hormone levonorgestrel. The hormone released from the intrauterine device causes some systemic effects, but local effects such as glandular atrophy and stromal decidualization, in addition to foreign body reaction, are dominant. Few case reports have described ampullary ectopic pregnancies. However, we report, for the first time, a major complication of levonorgestrel intrauterine device: a cornual pregnancy.
A 36-year-old Caucasian nulliparous woman presented with complaints of progressive nausea, abdominal pain and irregular vaginal bleeding for 2 months. For 3 years, she had been using a levonorgestrel intrauterine device. A two-dimensional transvaginal sonogram noted a sac situated external to the endometrial cavity in the right cornua of the uterus with an empty uterus. She was successfully treated with chemotherapy.
Many complications have been described, including ectopic pregnancies, using copper intrauterine devices. The levonorgestrel-releasing intrauterine system is a particularly good choice for adolescents because of associated non-contraceptive benefits such as decreased menstrual bleeding, dysmenorrhea and pain associated with endometriosis . Yet a cornual pregnancy following the use of a levonorgestrel intrauterine device is a complication which, to our knowledge, has not been described before. Physicians prescribing this type of intrauterine device should be aware of this rare event.
Many studies have described ectopic pregnancies as a complication of copper intrauterine devices (IUDs) while other studies suggest the protective role that levonorgestrel IUDs have on the incidence of ectopic pregnancies. In our patient, a cornual pregnancy occurred using a levonorgestrel IUD.
A 36-year-old Caucasian nulliparous healthy woman was referred to our outpatient clinic with a positive pregnancy test and complaints of progressive nausea, abdominal pain and irregular vaginal bleeding for 2 months. For 3 years, she had been using a levonorgestrel-releasing intrauterine device as a contraceptive, which was removed by the general practitioner the same day. She had no history of prior ectopic pregnancy, pelvic inflammatory diseases or previous tubal-uterine surgery, in vitro fertilization or other assisted reproduction procedures. She did not smoke.
The patient was discharged from hospital after signs of resolution of the ectopic pregnancy and was seen for follow-up until hCG levels were <5 mIU/mL and follow-up ultrasound findings did not reveal any abnormalities: normal uterine cavity, no adnexal mass, no abdominal fluid. Hysteroscopic evaluation showed the same: no abnormalities, both uterine openings open to fallopian tubes. There were no side effects to the methotrexate treatment.
Ectopic pregnancies account for 1.5% of all reported pregnancies in western countries -. The terms 'cornual pregnancy' and 'interstitial pregnancy', both types of ectopic pregnancy, are used in the medical literature interchangeably. By definition, a cornual pregnancy refers to the implantation and development of a pregnancy in the lateral upper portion of the uterus, whereas an interstitial pregnancy implants within the myometrium of the proximal and intramural portion of the fallopian tube .
Most of the risk factors of ectopic pregnancies are known. The most common risk factors are: history of pelvic inflammatory disease, smoking, induction of ovulation, history of ectopic pregnancy, previous pelvic surgery and the use of IUDs . Whether salpingitis associated with IUD use is a cause of ectopic pregnancy or whether the IUD prevents intrauterine pregnancies but not ectopic pregnancies remains unknown.
The prevalence of ectopic pregnancies and IUD use differs between studies. In France and Norway, women with IUDs accounted for 25-30% of all ectopic pregnancies [6, 7], whereas in a British study, IUDs accounted for only 14% . These differences may result from differences in the rate of IUD use, differences in the kind of IUD and differences in adequate registration.
Almost all of the literature concerning ectopic pregnancies and IUD use relate to copper IUDs rather than levonorgestrel IUDs. Data on levonorgestrel IUD use complicated by ectopic pregnancies are limited. Only a few studies have investigated the relationship between ectopic pregnancies and levonorgestrel IUD use: in a 5-year follow-up, international comparative study between levonorgestrel-20 and TCu-380(Ag), none of the six pregnancies in 1124 women with the levonorgestrel-IUD-20 were ectopic. In women using the Copper T 380 (n = 1121), two ectopic pregnancies occurred, with a 5-year ectopic pregnancy rate of 0.6 per 1000 woman-years .
In another study that compared the levonorgestrel-IUD-20 with the Nova-T device, after one year of use, the only pregnancy occurring in levonorgestrel-IUD-20 users (n = 1821) was intrauterine, and one of the eight pregnancies occurring in Nova-T users (n = 937) was ectopic. The 3-year ectopic pregnancy rates per 1000 women were 0.3 among the former and 2.5 among the latter (p = 0.02) .
The above studies suggest that the levonorgestrel IUDs may have a protective effect against the incidence of ectopic pregnancy. But there are more advantages: in addition to the long-acting, safe and reversible method of contraception, it also offers a protective effect on pelvic inflammatory disease and has a high level of acceptability with the majority of women requesting effective contraception . However, this case report shows an ectopic pregnancy with levonorgestrel IUD use. In addition, to our knowledge, this is the first case report describing an ectopic, cornual pregnancy with levonorgestrel IUD use.
Although non-surgical treatment of cornual pregnancies faces higher failure rates than treatment of ampullary pregnancies , we adopted this non-surgical management since there was no acute emergency (of a ruptured ectopic pregnancy). In addition, a surgical approach would have had an increased risk of severe hemorrhage with salpingectomy and opening the uterus with possible negative consequences for future pregnancies. Several reports have recommended treating an interstitial pregnancy conservatively. Jermy et al.  suggested that systemic methotrexate is a safe and highly effective treatment for interstitial pregnancy. Surgery can be avoided in the majority of women with this condition. Early recognition of the cornual pregnancy with transvaginal ultrasound is essential. Surgery means cornual resection or hysterectomy thereby compromising reproductive function . Curettage was not considered because of the ectopic aspect from ultrasound.
A nulliparous woman presented with a cornual pregnancy, consistent with 6 weeks of gestation and with cardiac activity. She had been using a levonorgestrel IUD. She was treated successfully with conservative management. One of the reasons not to treat the patient surgically was to avoid severe hemorrhage and to preserve reproductive function.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Gold MA, Johnson LM: Intrauterine devices and adolescents. Curr Opin Obstet Gynecol. 2008, 20: 464-469. 10.1097/GCO.0b013e32830a98f8.View ArticlePubMedGoogle Scholar
- Chow WH, Daling JR, Cates W, Greenberg RS: Epidemiology of ectopic pregnancy. Epidemiol Rev. 1987, 9: 70-94.PubMedGoogle Scholar
- Coste J, Bouyer J, Job-Spira N: Epidémiologie de la grossesse extra-utérine: incidence et facteurs de risque [Epidemiology of ectopic pregnancy: incidence and risk factors]. Contracept Fertil Sex. 1996, 24: 135-139.PubMedGoogle Scholar
- Coste J, Job-Spira N, Aublet-Cuvelier B, Germain E, Bouyer J, Fernandez H: Stability of incidence rates of ectopic pregnancy. Results of a population-based register in France. 21ème Congrès de l'Association des Epidémiologistes de Langue Française. Bruxelles, 3-5 Juin 1996. Arch Public Health. 1996, 53: 32-Google Scholar
- Malinowski , Bates SK: Semantics and pitfalls in the diagnosis of corneal/interstitial pregnancy. Fertil Steril. 2006, 86: 1764-10.1016/j.fertnstert.2006.03.073.View ArticlePubMedGoogle Scholar
- Job-Spira N, Coste J, Aublet-Cuvelier B, Germain E, Fernandez H, Bouyer , Pouly JLl: Fréquence de la grossesse extra-utérine et caractéristiques des femmes traitées. Premiers résultats du registre d'Auvergne [Frequency of ectopic pregnancy and clinical features of treated women. First results of the Auvergne (France) registry]. Presse Méd. 1995, 24: 351-355.PubMedGoogle Scholar
- Sandvei R, Ulstein M, Mollen A: Fertility following ectopic pregnancy with special reference to previous use of an intra-uterine contraceptive device. Acta Obstet Gynecol Scand. 1987, 66: 131-135. 10.3109/00016348709083034.View ArticlePubMedGoogle Scholar
- Aboud E: A five-year review of ectopic pregnancy. Clin Exp Obstet Gynecol. 1997, 24: 127-129.PubMedGoogle Scholar
- Sivin I, el Mahgoub S, McCarthy T, Mishell DR, Shoupe D, Alvarez F, Brache V, Jimenez E, Diaz J, Faundes A: Long-term contraception with the levonorgestrel 20 mcg/day (LNG-20) and the copper T 380Ag intrauterine devices: a five-year randomized study. Contraception. 1990, 42: 361-367. 10.1016/0010-7824(90)90046-X.View ArticlePubMedGoogle Scholar
- Luukkainen T, Allonen H, Haukkamaa M, Holma P, Pyörälä T, Terho J, Toivonen J, Batar I, Lampe L, Andersson K: Effective contraception with the levonorgestrel-releasing intrauterine device: 12-month report of a European multicenter study. Contraception. 1987, 36: 169-179. 10.1016/0010-7824(87)90012-6.View ArticlePubMedGoogle Scholar
- Odlind V: Long-term experience of a levonorgestrel-releasing intrauterine system. Eur J Contracept Reprod Health Care. 1996, 1: 319-323. 10.3109/13625189609150677.View ArticlePubMedGoogle Scholar
- McBroom JW: Medical management of interstitial pregnancy with a retained IUD. A case report. J Reprod Med. 2000, 45: 491-492.Google Scholar
- Jermy K, Thomas J, Doo A, Bourne T: The conservative management of interstitial pregnancy. BJOG. 2004, 111: 1283-1288. 10.1111/j.1471-0528.2004.00442.x.View ArticlePubMedGoogle Scholar
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