- Case report
- Open Access
Panniculitis in a patient presenting with a pancreatic tumour and polyarthritis: a case report
© Chee; licensee Cases Network Ltd. 2009
- Received: 11 November 2008
- Accepted: 29 January 2009
- Published: 6 July 2009
Panniculitis is a rare manifestation of pancreatic disease. Rarer still is the association of panniculitis, pancreatitic disease and polyarthritis. A literature search revealed less than five cases of pancreatic panniculitis associated with pancreatic tumour and polyarthritis.
An 84-year-old Caucasian man presented with epigastric pain, weight loss, polyarthritis and multiple discharging nodules. A computed tomography scan revealed a mass in the head of the pancreas. Histology of the cutaneous lesions confirmed the diagnosis of pancreatic panniculitis.
Pancreatic panniculitis can clinically present in many ways to clinicians across a broad scope of specialties. Knowledge and understanding of the association between panniculitis and polyarthritis with pancreatic disease may aid rapid diagnosis and management.
- Pancreatic Tumour
- Pancreatic Disease
- Lipolytic Enzyme
- Pancreatic Pseudocyst
Pancreatic panniculitis is a rare disease involving fat necrosis in the panniculus in association with pancreatic disease. The rarity of this condition is best described by Mullin et al. who reported one case of panniculitis out of 893 patients with various pancreatic diseases . We report a man presenting with panniculitis, pancreatic tumour and polyarthritis with a fatal outcome. Awareness of the rare skin manifestation observed and the potentially fatal consequences, can guide physicians to rapid diagnosis and management.
An 84-year-old Caucasian man presented with a 4-week history of severe abdominal pain radiating to his back and with haematuria. He was receiving long-term warfarin treatment for atrial flutter and his international normalised ratio on admission was 17.6. He complained of nausea and weight loss, but reported no recent change in bowel habit.
On examination, the patient was cachectic and pyrexial. He had epigastric and right upper quadrant tenderness. Of note was swelling of his right carpometacarpal, bilateral thumb and index finger metacarpal joints.
Pancreatic panniculitis affects 2% to 3% of patients with pancreatic disease . This involves fat necrosis in the panniculus and distant foci in pancreatic diseases such as acute or chronic pancreatitis and pancreatic carcinoma. It is less commonly associated with pancreatic pseudocyst, post-traumatic pancreatitis, pancreatic divisum or haemophogocytic syndrome . The pathogenesis is unknown but has been postulated to involve the release of pancreatic enzymes, particularly amylase and lipase from the diseased pancreas, causing subcutaneous fat necrosis . Skin histopathology findings of panniculitis are virtually pathognomonic, described as ghost-like anucleated cells with shadowy walls . Panniculitis manifests as tender erythematous nodules on the lower extremities but can also occur on the arms, trunk or back. These lesions may ulcerate and extrude an oily discharge . Skin lesions are the presenting feature in about 40% of pancreatic panniculitis and in some cases precede development of pancreatic disease . There may be joint manifestations of arthritis or arthralgia . Not much is known of the underlying pathogenesis of arthropathy in pancreatic panniculitis. Some studies postulate that increased levels of lipolytic enzymes of pancreatic origin, once they freely circulate in the tissues, are cytotoxic for many cells including leukocytes and therefore perpetuate inflammation. Synovial fluid of patients with pancreatic arthritis syndrome has been shown to contain elevated concentrations of these lipolytic enzymes [8, 9].
Several cases of a triad of panniculitis, pancreatitis and polyarthritis have been reported. Development of pancreatitis in these cases was related to high levels of alcohol intake -. Treatment is largely supportive but, where possible, should involve treatment of the underlying cause. Pancreatic panniculitis has a high mortality rate unless the underlying pancreatic abnormality is reversed . Several case studies have shown resolution of panniculitis in patients after surgical intervention or medical management of their underlying pancreatic disease [3, 13]. Prognosis is worse in cases of pancreatic panniculitis associated with pancreatic tumour .
In our patient, the clinical finding of panniculitis, pancreatic mass on CT scan, elevated pancreatic enzymes and histological findings of pancreatic panniculitis strengthened the likelihood of a pancreatic tumour in the absence of histopathological and post-mortem biopsies of the pancreatic mass.
As patients may present to practitioners of various medical specialities with differing symptoms or signs, awareness of the relationship between panniculitis lesions, pancreatic disease and arthritis or arthralgia may prevent a delay of prompt diagnosis and management.
As the patient died before the write-up of his case, written informed consent was obtained from the patient's next-of-kin for the publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The author would like to acknowledge Dr A Khan of the Department of Pathology and Dr N Bassi of the Department of Dermatology, Nottingham City Hospital, who contributed towards the acquisition of histopathology and clinical images, respectively.
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