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Hoffmann’s syndrome in the differential work-up of myopathic complaints: a case report



Hoffmann’s syndrome is a rare form of hypothyroid myopathy in adults, which is mainly characterized by muscular weakness and muscular pseudohypertrophy.

Case presentation

We report about a 61-year-old Western European man with myalgia, myxedema and pseudohypertrophy of the calf muscles. Laboratory tests revealed significantly elevated thyroid stimulating hormone (TSH) and creatine kinase (CK). Muscle MRI showed muscular hypertrophy of the lower limbs, but no signs of myositis or myopathy (no gadolinium enhancement, no edema, no fatty degeneration). In addition, electromyography (EMG) detected spontaneous activity. After the beginning of thyroxin-therapy it took six months until the muscle weakness improved and the myalgia regressed.


Here, we focus on diagnostic routines and typical findings to differentiate Hoffmann’s syndrome from other myopathies. Clinical hallmarks of Hoffmann’s syndrome are pseudohypertrophy and weakness of the calf muscles in combination with elevated CK and elevated TSH. EMG is well suited to detect the involvement of the muscles and muscle MRI helps to differentiate it from other myopathies. Hoffmann’s syndrome is a rare myopathy due to hypothyroidism and plays a role in the differential diagnosis of myopathic complaints even if hypothyroidism has not been detected before.

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The thyroid hormone is essential for the cell metabolism of all human organic systems. One of the prevalent malfunctions of the thyroid gland is primary hypothyroidism [1], which can be associated with a rare muscular manifestation, i.e. Hoffmann`s Syndrome in adults and analogously Kocher-Debré-Sémélaigne syndrome in children [2]. Hoffmann`s Syndrome is characterized by (proximal accentuated) weakness of limb muscles with an increase of muscle mass (pseudohypertrophy), muscle stiffness and cramps. It occurs most often in male adults with longstanding untreated hypothyroidism [2, 3]. Muscular pseudohypertrophy is a very rare phenomenon, which predominantly involves the calf muscles (especially the gastrocnemius muscles) [4]. The syndrome was first described in 1896 by the German neurologist Johann Hoffmann (1857–1919) [5, 6].

In addition to classic hypothyroidism-associated symptoms such as somnolence, cold intolerance, depressed mood, and myxedema, muscular symptoms such as exercise intolerance, myalgia, cramps, stiffness, and myoedema are common [7, 8]. It is known that hypothyroidism may be associated with an impairment of peripheral nerves, neuromuscular junction, and muscular fibres [9].

Indicative for hypothyroid myopathy (HM) is the finding of elevated thyroid stimulating hormone (TSH) in combination with elevated creatine kinase (CK) or lactate dehydrogenase (LDH) for at least 2 weeks [10]. The leading cause for HM is Hashimoto thyroiditis [9].

The underlying pathophysiology for HM is still not definitely known. One pathomechanism may be an alteration of glycogen metabolism and oxidative phosphorylation in the muscle [11]. Serum thyroid hormone T3 is one of the major hormonal regulators of glucose metabolism in mitochondria of the skeletal muscle. Thus, patients with hypothyroidism have a reduced glycogenolytic activity in the muscles, which can be proven by low levels of acid alpha-glucosidase in muscle cells and accumulation of glycogen deposits [11]. In addition, the actin-myosin unit is altered. Hypothyroidism leads to an atrophy and loss of type 2 muscle fibres (fast twitch and fast contraction fibres) and hypertrophy of type 1 fibres (slow twitch and slow contraction fibres) [12,13,14,15,16]. The third mechanism is the change of the glycosaminoglycan metabolism due to a higher urinary excretion of glycosaminoglycans in hypothyroid patients [17].

The treatment of HM is a replacement therapy with thyroid hormone (LT4). However, clinical recovery may be incomplete so that some patients have persistent myopathic symptoms over years. The variability of response to LT4 treatment is supposed to depend on the severity of previous muscle damage and the age of the patient [18].

Case presentation

A 61-year-old Western European man applied to our neurological outpatient clinic complaining about swollen hands for 8 weeks, myalgia dependent on physical activity in the lower and upper limbs for 3 months, general muscular weakness, and a hoarse voice without dysphagia. The clinical neurological examination revealed mild dysarthria, hypertrophy of bilateral calf muscles (Fig. 1A) without tenderness on palpation, and hypo-/areflexia with pallhypesthesia of the lower limbs. In addition, the patient reported about paresthesias in the first three fingers and the radial forth finger of the right hand with a positive Phalen’s sign suggestive of carpal tunnel syndrome. Except for mild edema of the limbs the cardiovascular and respiratory system showed no abnormality.

Fig. 1
figure 1

Calf muscles of the patient. A Photograph. B Muscle MRI. C and D Muscle ultrasound

CK was significantly elevated (64 µmol/l*s, normal < 3.2), and electromyography (EMG) showed spontaneous activity (positive sharp waves and fibrillation potentials) in the muscles (right tibialis anterior and left gastrocnemius muscle) but no signs of chronic denervation and no myopathic changes.

Thus, the patient was subjected to our neurological ward at Jena University Hospital. Nerve conduction study showed bilateral carpal tunnel syndrome but no signs of polyneuropathy. Magnetic evoked potentials were normal. The most important finding was an elevated TSH up to 30.5 mU/l (normal range: 0.27–4.20 mU/l), the level of T3 was under 1.50 pmol/l (normal range 3.10–6.80 pmol/l) and the T4 level under 1.30 pmol/l (normal range 12.00–22.00 pmol/l). Thus, manifest hypothyroidism was diagnosed. Anti-thyreoglobulin-antibodies (5671.0 U/ml, normal < 60 U/ml) and anti-TSH-receptor-antibodies (5.4 U/ml, normal < 1.8 U/ml) were increased, and Hashimoto thyroiditis was diagnosed [19]. Myoglobin was elevated to 248 µg/l (normal range 28–72 µg/l). Blood count showed a mild normocytic, normochrome anemia, the liver enzymes were elevated (ALAT up to 1.94 µmol/l*s, normal < 0.83 µmol/l*s; ASAT up to 2.75 µmol/l*s, normal < 0.85 µmol/l*s). Renal function did not show any significant abnormalities. Cerebrospinal fluid showed cytoalbuminologic dissociation without evidence of infection. Rheumatologic parameters, hepatitis serology, lipid profile, and vitamins revealed no pathologic findings.

Electrocardiogram, cardiac ultrasound and pulmonary function testing demonstrated no pathologic findings. Magnetic resonance imaging showed a muscular hypertrophy of the lower limbs (Fig. 1B), but no signs of myositis or myopathy (no gadolinium enhancement, no edema, no fatty degeneration).

Consequently, replacement therapy with levothyroxine (LT4), was initiated starting with 75 µg per day. Myopathic symptoms improved over six months but there was no complete remission of the symptoms. Especially the bilateral calf hypertrophy persisted. Signs of chronic denervation evolved in EMG with elevated amplitudes of muscle unit action potentials (right and left tibialis anterior, left gastrocnemius, and right vastus lateralis muscles), positive sharp waves were still detectable in the right tibialis anterior muscle. Muscle ultrasound revealed a normal to slightly increased echogenicity of the calf muscles (Fig. 1C). The patient reported about a good clinical recovery of muscle strength and decreased myalgia. CK and myoglobin decreased significantly (Table 1).

Table 1 Change of laboratory parameters over time


The prevalence of manifest hypothyroidism varies between 0–7% in the USA and 0–5% in Europe [20]. Decompensated hypothyroidism is a rare condition, with an incidence of 0.22–1.08 cases per million patients per year with women over 60 years of age being most frequently affected [21]. Hoffmann’s syndrome with its characteristic symptoms of muscular (pseudo-) hypertrophy is a rather rare manifestation of hypothyroidism [22].

We collected 21 case reports [3, 4, 18, 23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40] describing 23 patients with Hoffmann’s syndrome (Pubmed, search for: “Hoffmann syndrome hypothyroidism”, 08-25-2022). 20 of the patients were male and three were female with a mean age of 36 years (standard deviation 12.4) which demonstrates a clear male predominance of the syndrome in contrast to the female predominance in decompensated hypothyroidism.

Relative elevations of CK and TSH of the reported patients were calculated by division of each individual measurement by the largest normal value reported in the case reports because normal reference values differ between laboratories. Mean elevation of CK was 19.8fold (standard deviation 14.2) and mean elevation of TSH was 18.5fold (standard deviation 13.6). In 18 cases neurophysiological examinations were described, 6 case reports described muscle biopsy results and 3 described results of muscle MRI. The details are shown in Additional file 1.

Hoffmann’s syndrome with its characteristic symptoms of muscular (pseudo-) hypertrophy is a rather rare manifestation of hypothyroidism [22]. Muscular symptoms as described by hypothyroid patients like myalgia, weakness, stiffness, cramps and easy fatigability are similar to symptoms of other myopathies. More specific to hypothyroidism-associated myopathy are weakness of proximal muscles, myxedema, delay in deep tendon reflex and development of muscle hypertrophy [41]. Hypothyroid myopathy can also lead to rhabdomyolysis [42] and can therefore potentially be life-threatening.

Although there are several case descriptions of Hoffmann’s syndrome in the literature there is no consistent concept for diagnostic work-up with typical findings. Therefore, this case report brings diagnostic routines and possible findings into focus especially to differentiate Hoffmann’s syndrome from other myopathies.

The clinical hallmark of Hoffmann’s syndrome is the pseudohypertrophy of calf muscles as shown in our case and in all reported cases as well. In addition to elevated CK as sign of muscular impairment and elevated TSH levels as expression of hypothyroidism the differential workup of myopathies clearly points to the diagnosis of Hoffmann’s syndrome. Interestingly, there is a positive correlation between CK and TSH but no correlation with clinical severity [43].

Clinical neurophysiological methods were most often used to evaluate patients´ nerve and muscle function. Electromyography showed spontaneous activity such as fibrillation potentials and positive sharp waves in our patient as well as in five of the collected cases and complex repetitive (pseudomyotonic) discharges in three of the collected cases. In addition, low amplitude and polyphasic motor unit action potentials (MUAPs) were found, but also normal MUAPs were described.

Nerve conduction studies (NCS) showed carpal tunnel syndrome in our patient. It has been shown before that a considerable proportion of patients with untreated primary hypothyroidism have carpal tunnel syndrome [44] and hypothyroidism is a risk factor for carpal tunnel syndrome [45].

A study of 24 hypothyroid patients [45] showed clinical muscle weakness in 38%, signs of sensorimotor axonal neuropathy in 42%, and carpal tunnel syndrome in 29%. Short duration of MUAPs were seen in 33%, fibrillation potentials in 17%, and decreased nerve conduction velocity in 17% [46].

In six of the reported cases of Hoffmann’s syndrome muscle biopsy was performed. However, results were described very differently: increased hypertrophic fibres, muscle atrophy, increased nuclei, variation in fibre size, or muscle fibre necrosis. None of the reports found any signs of inflammation. One of the muscle biopsies was normal. In addition, type 1 fibre predominance, type 2 atrophy, glycogen accumulation and damaged mitochondria were described [22]. In addition, a case series of muscle biopsy results in eight patients with hypothyroid myopathy [47] found a dominance of type 2 fibres over type 1 fibres and 'core-like' structures, which disappeared after treatment. In contrast, no individual muscle fibre hypertrophy in the cases with Hoffmann's syndrome could be found [47]. Overall, morphologic changes described in hypothyroid myopathy appear to be largely nonspecific [22], but from the perspective of a differential clinical workup, a muscle biopsy may indicate muscular involvement.

The main finding in muscle MRI is T1 hypertrophy of the calf muscles (Fig. 1B). In addition, affected muscles may show patchy hyperintensities on T2-weighted images [3, 28, 29]. In contrast, muscle MRI shows no gadolinium enhancement, no edema, and no fatty degeneration in Hoffmann’s syndrome and may therefore be useful in the non-invasive differentiation from other myopathies. Muscle ultrasound in our case did not show specific changes (Fig. 1C, D).

There were some tests performed such as motor evoked potentials, when there are no upper motor signs or symptoms, and CSF studies when there are no cerebral of peripheral nerve symptoms. However, although they did not contribute to the diagnosis they were suited to exclude other differential diagnoses.

The therapy of choice is the substitution of thyroid hormones (levothyroxine, LT4) [48]. Most symptoms slowly regress over time after beginning LT4, but the electrophysiologic findings may persist [36, 38].


Clinical hallmarks of Hoffmann’s syndrome are muscular weakness and pseudohypertrophy of the calf muscles in combination with elevated CK and elevated TSH. EMG is well suited to detect the involvement of the muscles and muscle MRI helps to differentiate it from other myopathies. Hoffmann’s syndrome is a rare myopathy due to hypothyroidism and plays a role in the differential diagnosis of myopathic complaints, even when hypothyroidism has not been diagnosed before.

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Open Access funding enabled and organized by Projekt DEAL. BH was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Clinician Scientist Program OrganAge funding number 413668513 and by the Interdisciplinary Center of Clinical Research of the Medical Faculty Jena..

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SW: conceptualization, patient data collection, manuscript writing, literature review. BH: patient data collection. NE: patient data collection. CK: literature review, supervision. HA: conceptualization, manuscript writing, literature review. All authors read and approved the final manuscript.

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Correspondence to Hubertus Axer.

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Supplementary Information

Additional file 1: Table A1.

Case reports of Hoffmann’s syndrome.

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Winter, S., Heiling, B., Eckardt, N. et al. Hoffmann’s syndrome in the differential work-up of myopathic complaints: a case report. J Med Case Reports 17, 473 (2023).

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