A 28-year-old African female with history of three prior pregnancies with full-term deliveries and recent immigration from East Africa presented with a large, tender left axillary mass. The patient noted the initial appearance of the mass 3 years prior, at which time, the mass was small and nontender. The initial appearance of the mass was 6 months after having an etonogestrel implant device placed within the left arm for contraception, 8 months after her most recent pregnancy and delivery, and 2 years after immigrating to the USA from East Africa. The mass continued to grow slowly for 2.5 years without any pain, drainage, overlying skin changes, or changes in sensation or strength of the left arm. The patient did not experience any difficulty with breastfeeding. Six months prior to presentation, the patient noticed rapid growth and increasing tenderness of the axillary mass that prevented full arm adduction. The patient reported having her etonogestrel implant device removed and replaced 2 months prior to the onset of rapid growth. She denied any breast tenderness, abnormal discharge, or arm weakness. The patient also denied any preceding trauma or infection in the area. The patient had no other significant past medical history or family history, and no recent environmental or employment-related exposures. Social history was significant only for immigration from East Africa 5 years prior to presentation. The patient had no alcohol, tobacco, or illicit substance use and took no regular medications other than the etonogestrel implant device. On initial presentation to our clinic, physical examination demonstrated a protruding, nonreducible, mobile, softball-sized mass in the left axillary fossa with overlying skin striations. The patient did not have any cervical or clavicular lymphadenopathy. She had no vascular or neurological deficits of the left arm, and both sensory and motor function were intact. Due to the size of the mass, the patient was unable to fully adduct the left arm and had mild discomfort with adduction. Vital signs, physical examination, and neurological examination were otherwise unremarkable.
Prior to presentation to our clinic, the patient had undergone magnetic resonance imaging (MRI) with and without contrast, which demonstrated a 16 × 11 × 11 cm3 multiloculated subcutaneous cystic lesion in the left axilla. There was displacement but no invasion of surrounding structures, no intrathoracic communication, and no axillary lymphadenopathy. Based on this imaging, lymphangioma was suspected, but hydatid cyst could not be ruled out given the patient’s history of immigration from an endemic location. To further classify the lymphatic and vascular involvement of the mass, MR lymphangiogram was obtained by injecting contrast media subcutaneously into each interdigital web space of the left hand.
Lymphangiogram showed no evidence of active lymphatic communication with the mass. Lymphatics in the left upper extremity drained to nodes overlying the large cystic mass (Fig. 1). Additionally, echinococcal IgG antibody was tested, with equivocal results. Initial laboratory results did not suggest systemic infection and were otherwise unremarkable. Preoperative pharmacotherapy for Echinococcus was considered but deferred since the diagnosis was not confirmed.
After review of the images and laboratory results, treatment options including percutaneous drainage and surgical excision were discussed with the patient. Given the large size of the mass with presence of overlying stretched skin, surgical excision was recommended. The patient consented and underwent complete surgical excision of the mass along with the overlying skin. Given the possibility that the mass was a hydatid cyst, the surgical field was prepared with sterile 20% hypertonic saline-soaked gauze as a protoscolicidal agent, as reentry of immature tapeworms into the patient would cause anaphylaxis. Intraoperatively the mass was found to be translucent with very thin walls, and drainage demonstrated typical yellow cystic fluid. The appearance of the cyst and fluid on direct visualization ruled out hydatid cyst, which would appear with thicker, opaque white walls. Therefore, cultures of the cystic fluid were not sent. After excision of the mass there was a large pocket within the axillary tissue, and a Jackson–Pratt drain was placed to prevent seroma development (Fig. 2).
Gross surgical pathology showed a collapsed cyst measuring 9.5 × 9.0 × 4.0 cm3. Microscopic evaluation of the specimen showed large lymphatic spaces lined by thin epithelium, morphologically most consistent with cystic lymphangioma (Fig. 3). Associated lymph nodes were evaluated and determined to be histologically benign.
Approximately 1 month after surgery, the patient developed a surgical-site infection, which presented as a change in the quality of the JP drain output from serous to purulent. Drain fluid cultures were collected with resulting growth of Pseudomonas aeruginosa and methicillin-sensitive Staphylococcus aureus (MSSA). Blood cultures collected at this time were negative. Based on drain culture susceptibilities, the patient was started on standard dosing of oral amoxicillin/clavulanate and ciprofloxacin, with rapid resolution of infection. The drain was subsequently removed. At 6 month follow-up, the patient does not have any re-accumulation of fluid or signs of infection.