Skip to main content

Chronic intracranial subdural hematoma after spinal anesthesia for a cesarean section: a case report



Subdural hematoma is a rare, potentially devastating, yet curable complication of spinal anesthesia. Differentiation between post-dural puncture headache and subdural hematoma can be difficult, resulting in a delay in diagnosis.

Case presentation

We present a 28-year-old Ethiopian female patient who underwent elective cesarean section under spinal anesthesia and returned to the emergency department after 1 month with a worsening headache. Brain computed tomography revealed a chronic subdural hematoma with a significant midline shift. The patient recovered completely after surgical evacuation.


A high index of suspicion and close attention to the pattern and characteristics of the headache, coupled with a meticulous neurologic examination and neuroimaging, can help to achieve timely diagnosis of this serious entity. Investigation with head computed tomography or magnetic resonance imaging is vital.

Peer Review reports


Spinal anesthesia is a safe and effective alternative to general anesthesia for cesarean delivery. Post-dural puncture headache (PDPH) is one of the common complications of spinal anesthesia that is usually managed with bed rest in a flat position, hydration, and simple analgesics [1]. PDPH is usually a benign self-limited condition, but it may also be a sign of a rarer but more serious complication like intracranial hemorrhage [2, 3]. Patients with complaints of PDPH often seek treatment and usually respond to conservative measures like bed rest, oral analgesics, and hydration. If the PDPH is persistent and/or is having associated neurologic findings, the patient should be investigated for an intracranial hemorrhage. Subdural hematoma after neuraxial anesthesia or dural puncture is a relatively rare complication, with around 50 cases being reported in the literature [4, 5]. Here, we present a case of a chronic subdural hematoma (CSDH) diagnosed 31 days after spinal anesthesia for cesarean delivery.

Case presentation

A 28-year-old Ethiopian pregnant (G2, P1) woman presented to our emergency obstetrics department with a complaint of a worsening headache and easy fatigability for 3 days. It was a continuous vague type of global headache that became worse over 24 hours and was associated with easy fatigability, generalized malaise, and nausea. She had undergone an elective cesarean section at our hospital 31 days before her current presentation with an indication of “previous cesarean scar and big baby.” She had a normal pregnancy with an uneventful antenatal follow-up. She had no history of any known chronic medical illness like hypertension, diabetes, cardiac or renal disease, coagulopathy, or any bleeding tendency. She has no history of primary headache, migraine, or any trauma.

For her cesarean delivery, spinal anesthesia was given in a sitting position with a 22-gauge Quincke spinal needle at the L3–L4 interspace using 12.5 mg of 0.5% isobaric bupivacaine. The puncture was successful on the first attempt, and the course of anesthesia was without incident. Her intraoperative vital signs were stable, and the surgery was completed uneventfully. She had a smooth postoperative course and was discharged on the third day. She had no headache at the time of discharge. She was in a relative resting state being cared for by her family and did not return to work. She had no history of trauma or fall accident. About 8 days later, she developed a mild global headache for which she was managing herself with rest and paracetamol per os as needed. The headache increased gradually and became associated with nausea and easy fatigability.

Upon presentation, on the 31st postoperative day, she complained of severe global headache with worsening over 3 days that was not position dependent and was unrelieved with rest and analgesics. On physical examination, there was no vital sign derangement. She was fully conscious and oriented with no mental status change. All meningeal signs were negative, and her motor function was intact bilaterally.

Laboratory data revealed normal complete blood count, prothrombin time (PT), partial prothrombin time (PTT), and international normalized ratio (INR). CT scan of the head revealed a layered hypodense crescent-shaped extra-axial left frontoparietal collection with areas of linear and crescentic hyperdensities (Hounsfield unit of 50). There was a mass effect on the underlying brain resulting in a midline shift of 13 mm. The width of the lesion measured 15 mm at the level of the bodies of the lateral ventricles. The finding was consistent with chronic subdural hematoma with areas of acute bleeds (Fig. 1a).

Fig. 1
figure 1

Pre- and postoperation Axial precontrast CT scan: a large left frontoparietal chronic subdural hematoma with areas of acute bleeds (a) that shows significant improvement after operation (b)

After emergent consultation with a neurosurgeon, the patient was admitted to the neurosurgical ward, and hematoma evacuation was achieved using burr-hole placement. She had a smooth immediate postoperative course and was discharged home 3 days later. Follow-up CT showed a crescentic left frontoparietal hyperdense extra-axial collection with a width of 3.8 mm and midline shift of 2.2 mm at the level of the bodies of the lateral ventricle (Fig. 1b), a finding suggestive of a largely improved left frontoparietal subdural hematoma. Clinically, she had an uneventful recovery with full resolution of her symptoms. On subsequent follow-up at 6 months, the patient had no residual symptoms or neurologic deficit.

Discussion and conclusions

We presented a case of subdural hematoma that occurred more than 1 month after spinal anesthesia lumbar puncture was done for cesarean section. The case demonstrates the importance of having a high index of suspicion and the need for timely investigation with imaging in patients with suggestive symptoms.

Spinal anesthesia is a commonly used method to achieve anesthesia in obstetric patients [6, 7]. It has the advantage of avoidance of complications of general anesthesia and a more direct experience of childbirth. But it has complications such as hypotension, post-dural puncture headache, nerve damage, meningitis, intracerebral hemorrhage, spinal, and cranial hematoma. Intracranial subdural hematoma is a rare but potentially lethal complication that can occur after neuraxial anesthesia or myelography. An incidence of 1 in 500,000 obstetric procedures has been estimated for intracranial SDH following spinal anesthesia, but most authors believe that the true incidence of SDH after dural puncture might be higher as many cases go unreported [8].

The exact mechanism for PDPH is not known, but continued cerebrospinal fluid (CSF) leakage, leading to a reduction in CSF pressure, is often blamed [1, 4, 9]. Predisposing factors for PDPH and subsequent development of subdural hematoma include pregnancy, dehydration, multiple dural punctures, using large gauge needles, coagulopathy, cerebral vascular abnormalities, brain atrophy, and alcohol consumption [4]. In reviewing 35 cases of intracranial hemorrhage following spinal anesthesia, Amorim et al. found that there were no apparent predisposing factors in 15 of these patients. Among those who did have such risk factors, the most common were pregnancy, multiple punctures, use of anticoagulants, intracranial vascular abnormalities, and brain atrophy [10]. The contributing factors in our patient could be the pregnancy and the large bore needle used for the puncture.

Severe headache after spinal anesthesia in a pregnant patient has a broad differential diagnosis, including post-dural puncture headache and intracranial pathologies, so a high index of suspicion and early investigation for patients having a persistent headache is lifesaving. It is not easy to differentiate between the neurological symptoms of intracranial hypotension of PDPH and SDH. In the SDH cases presented by Amorim, in addition to headache as the chief complaint, 89% of the patients presented with at least one of the following signs: vomiting, diplopia, cognitive changes, or altered mental status, or focal neurologic signs [10]. Also, the change in the headache characteristics from postural to nonpostural has been mentioned as a warning sign that intracranial hemorrhage may be complicating simple intracranial hypotension. Our case illustrates the importance of early and careful assessment of post-spinal headache as it could be more serious than just benign PDPH. The International Headache Society has developed a list of criteria to help differentiate PDPH from other, more serious complications of dural puncture [11]. Accordingly, in PDPH, the pain worsens or develops within 15 minutes of assuming an upright position and improves within a similar period after the individual lies down, and it develops within 5 days after the puncture and disappears spontaneously within 1 week, or up to 48 hours after an epidural blood patch is employed. If the clinical presentation is apart from these criteria, one should consider the more severe possibilities and proceed to imaging modalities like CT scan, MRI, and angiography. On a head CT, acute SDH is readily visualized on as a high-density crescentic collection across the hemispheric convexity, while subacute and chronic SDH appear as isodense and hypodense crescent-shaped lesions, respectively. Brain MRI is more sensitive than head CT for the detection of intracranial hemorrhage. MRI has also the additional advantage for the detection of small SDH and tentorial and interhemispheric SDH. Noninvasive angiography (such as MRA or CTA) or conventional cerebral angiography may be indicated for evaluation of SDH, particularly when there is no history of trauma and no obvious cause. In our patient, headache was nonpostural and persistent for more than a month, which mandates imaging.

As with any other SDH, the management is either conservative or surgical. Various treatments for chronic SDH after dural puncture have been reported, including observation, surgical resection of the hematoma, epidural blood patch, or both surgical resection and epidural blood patch [12,13,14,15]. The management is decided based on the patient’s neurological symptoms and the size of the hematoma. Small hematomas often resolve spontaneously, and therefore the risk of surgical evacuation is not justified. Early blood patching after the presentation of PDPH may decrease the risk of subdural bleeding through the prevention of CSF loss [16]. Surgical evacuation of the clot is indicated in cases of larger hematomas. In the Amorim study, 27 of the 35 cases required surgical drainage [10], and in the Zeidan series, surgery was performed in 20 of 25 patients [4]. In our patient, severe headache refractory for conservative management, the size of the mass, and significant cerebral shifting on brain imaging were clear indications for surgical intervention.

In conclusion, SDH is a rare, serious yet curable complication of spinal anesthesia, and pregnant women seem to be more susceptible to the development of SDH after spinal anesthesia. Differentiation between PDPH and SDH is difficult, and a high index of suspicion is crucial for timely diagnosis. All patients developing PDPH not relieved by conservative measures, as well as the change of PDPH from postural to nonpostural, require careful assessment and follow-up for early diagnosis and management of possible SDH. Such patients should be investigated with a head CT or MRI.

Availability of data and materials

Not applicable



Cerebrospinal fluid


Computed tomography


Computed tomography angiography


International normalized ratio


Magnetic resonance angiography


Magnetic resonance imaging


Post-dural puncture headache


Prothrombin time


Partial prothrombin time


Subdural hematoma


  1. Wrobel M, Volk T. Post-dural puncture headache. Anesth Pain Med. 2012;1(4):273–4.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Schweiger V, Zanconato G, Lonati G, Baggio S, Gottin L, Polati E. Intracranial subdural hematoma after spinal anesthesia for cesarean section. Case Rep Obstet Gynecol. 2013;2013:253408.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Machurot PY, Vergnion M, Fraipont V, Bonhomme V, Damas F. Intracranial subdural hematoma following spinal anesthesia: case report and review of the literature. Acta Anaesthesiol Belg. 2010;61(2):63–6.

    CAS  PubMed  Google Scholar 

  4. Zeidan A, Farhat O, Maaliki H, Baraka A. Does postdural puncture headache left untreated lead to subdural hematoma? Case report and review of the literature. Int J Obstet Anesth. 2006;15(1):50–8.

    Article  CAS  PubMed  Google Scholar 

  5. Nakanuno R, Kawamoto M, Yuge O. Intracranial subdural hematoma following dural puncture. Masui. 2007;56:395–403.

    PubMed  Google Scholar 

  6. Azmude A, Agha’amou S, Yousefshahi F, Berjis K, Mirmohammad’khani M, Sadaat’ahmadi F, et al. Pregnancy outcome using general anesthesia versus spinal anesthesia for in vitro fertilization. Anesth Pain Med. 2013;3(2):239–42.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Lak M, Forouzanmehr M, Doudangeh F. Spinal versus epidural anesthesia complications, outcomes and pain relieving capacity. Trauma Mon. 2008;13(2):153–61.

    Google Scholar 

  8. Scott DB, Hibbard BM. Serious non-fatal complications associated with extradural block in obstetric practice. Br J Anaesth. 1990;64(5):537–41.

    Article  CAS  PubMed  Google Scholar 

  9. Valenca MM, Amorim JA, Moura TP. Why don’t all individuals who undergo dura mater/arachnoid puncture develop postdural puncture headache? Anesth Pain Med. 2012;1(3):207–9.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Amorim JA, Remigio DS, Damazio Filho O, de Barros MA, Carvalho VN, Valenca MM. Intracranial subdural hematoma post-spinal anesthesia: report of two cases and review of 33 cases in the literature. Rev Bras Anestesiol. 2010;60(6):620–9.

    Article  PubMed  Google Scholar 

  11. Headache Classification Subcommittee of the International Headache Society. The international classification of headache disorders: 2nd edition. Cephalalgia. 2004;24 Suppl 1:9–160.

    Article  Google Scholar 

  12. Loo CC, Dahlgren G, Irestedt L. Neurological complications in obstetric regional anaesthesia. Int J Obstet Anesth. 2000;9:99–124.

    Article  CAS  PubMed  Google Scholar 

  13. Kale A, Emmez H, Pişkin Ö, Durdağ E. Postdural puncture subdural hematoma or postdural puncture headache?: two cases report. Korean J Anesthesiol. 2015;68:509–12.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Zhang J, Jin D, Pan KH. Epidural blood patch for spontaneous intracranial hypotension with chronic subdural haematoma: a case report and literature review. J Int Med Res. 2016;44:976–81.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Girgis F, Shing M, Duplessis S. Thoracic epidural blood patch for spontaneous intracranial hypotension: case report and review of the literature. Turk Neurosurg. 2015;25(2):320–5.

    Article  PubMed  Google Scholar 

  16. Reynolds AF, Slavin L. Postpartum acute subdural hematoma; a probable complication of saddle block analgesia. Neurosurgery. 1980;7(4):398–9.

    Article  CAS  PubMed  Google Scholar 

Download references


The authors would like to acknowledge all those involved in the management of the patient.


No funding from an external source supported the publication of this case report.

Author information

Authors and Affiliations



MB and DB conceived the idea of reporting the case. MB drafted the manuscript. DB contributed to the review and editing of the manuscript. AB contributed to the review and editing of the manuscript. All authors were involved in the clinical management of the patient. All authors read and approved the final manuscript.

Authors’ information

Delayehu Bekele (MD, MPH)—Associate professor of obstetrics and gynecology and maternal fetal medicine, Department of Obstetrics and Gynecology, Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Mehari Bayable (MD)—Assistant professor of obstetrics and gynecology, Department of Obstetrics and Gynecology, Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Alemayehu Bedane (MD)—Assistant professor of radiology, Department of Radiology, Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Corresponding author

Correspondence to Delayehu Bekele.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal

Competing interests

The authors declare that they have no competing interest to declare.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bekele, D., Bayable, M. & Bedane, A. Chronic intracranial subdural hematoma after spinal anesthesia for a cesarean section: a case report. J Med Case Reports 15, 492 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: