- Case report
- Open Access
- Open Peer Review
Giant nonfunctioning adrenal tumors: two case reports and review of the literature
© The Author(s). 2018
- Received: 5 May 2018
- Accepted: 8 October 2018
- Published: 10 November 2018
The Correction to this article has been published in Journal of Medical Case Reports 2018 12:361
There are an estimated 1–2 cases per million per year of adrenocortical carcinoma in the USA. It represents a rare and aggressive malignancy; it is the second most aggressive endocrine malignant disease after anaplastic thyroid carcinoma. Non-secretory adrenal masses are diagnosed late due to a mass effect or metastatic disease or found incidentally (adrenal incidentalomas).
The first case report describes a 39-year-old Greek woman who presented to our department with complaints of repeated symptoms of flatulence and epigastric discomfort over a few months. The second case report is about a 67-year-old Greek woman who presented to our department after being evaluated for fatigue, mass effect, and epigastric discomfort. Both of them were diagnosed as having a nonfunctioning adrenocortical carcinoma and underwent open adrenalectomy.
Approximately 60% of patients with adrenocortical carcinoma present with symptoms and signs of hormonal secretion. Our cases’ adrenocortical carcinomas were not functional. Hormone secretion is not a discriminating feature between benign and malignant adrenocortical masses. The silent clinical nature of nonfunctioning adrenocortical carcinoma results in late diagnosis, while the majority of patients present with locally advanced and/or metastatic disease.
Adrenocortical carcinoma is a rare endocrine tumor with a poor prognosis that can be diagnostically challenging and demands high clinical suspicion. The work-up for adrenal masses must include determination of whether the mass is functioning or nonfunctioning and whether it is benign or malignant.
- Adrenal tumors
- Adrenocortical carcinoma (ACC)
- Case report
- Hormone secretion
There are an estimated 1–2 cases per million per year of adrenocortical carcinoma (ACC) in the USA . ACC represents a rare and aggressive malignancy ; it is the second most aggressive endocrine malignant disease after anaplastic thyroid carcinoma. ACC is more common in the female population; it has a bimodal age distribution of 5 to 20 years and 40 to 50 years . Out of all the adrenal masses, 60% are hyper-functioning (hormone-secreting) and the rest, 40%, are nonfunctioning (non-hormone secreting) .
Functional ACC can clinically manifest early with virilization, feminization, or Cushing’s syndrome, while non-secretory adrenal masses are diagnosed late and incidentally (adrenal incidentalomas) due to a mass effect or metastatic disease . Nonfunctioning ACC is correlated with a poor prognosis due to the late diagnosis, local invasion, or recurrence and distant metastases [1, 3, 4].
On the other hand, adrenal cysts are usually benign lesions with a discovery at autopsy range of 0.064–0.18%, in which adrenal pseudocysts account for an extremely small amount .
We present the cases of two women who were referred to our Department of surgery and were diagnosed as having a large nonfunctioning ACC. Both women underwent open adrenalectomy.
Laboratory testing for case report 1
WBC (white blood cells) × 109/L
PLT (platelet count) × 103/μL
Uric acid (mg/dl)
LDH (lactate dehydrogenase; U/L)
CRP (C-reactive protein; mg/dl)
A functional adrenal work-up was performed and included: measurement of serum aldosterone, potassium, renin, and adrenocorticotrophic hormone levels; a dexamethasone suppression test; and measurement of 24-hour urinary metanephrine levels. All results were within the reference ranges. A fine-needle core biopsy revealed ACC.
A metastatic work-up included CT scans of her head and chest and a bone scan and they were negative for metastases. During laparotomy the giant tumor was removed completely with its own capsule, without the need for excision of adherent organs as there were no infiltrations.
A 67-year-old Greek woman, a retired high-school teacher, presented to our department after an evaluation for fatigue, mass effect, epigastric discomfort in liver cirrhosis, and hypothyroidism. Her past medical history was also remarkable for arterial hypertension. She was on double anti-hypertensive medication and she was also receiving levothyroxine 100 μG once daily. She was a heavy tobacco smoker (>1pack/day) for 35 years and a social alcohol consumer. She was afebrile at the time of admission. Her neurological examination was normal; her blood pressure was 145/97 mmHg, her pulses were 95 beats/minute, and her temperature was 36.4 °C. Her mother died from breast cancer.
Laboratory testing for case report 2
WBC (white blood cells) × 109/L
PLT (platelet count) ×103/μL
Uric acid (mg/dl)
LDH (lactate dehydrogenase; U/L)
CRP (C-reactive protein; mg/dl)
The overall 5-year survival rate of ACC ranges from 16 to 44% . However, a more recent study recorded a 5-year overall survival rate that reached 60% and concerned patients with a 34% range of synchronous metastatic disease. Positive prognostic factors that could improve overall survival are early-stage disease in the absence of lymph node and distant metastases, an age of < 40 years, and negative resection margins (Ro), as in our case [1, 4].
On the other hand, adrenal pseudocysts are cystic lesions surrounded by a fibrous tissue wall with an absence of a recognizable epithelial or endothelial lining layer that characterizes true cysts. Adrenal pseudocysts are associated with malignant ACC in 7% of cases .
Approximately 60% of patients with ACC present with symptoms and signs of hormonal secretion. Our cases’ ACC were not functional. Hormone secretion is not a discriminating feature between benign and malignant adrenocortical masses. The silent clinical nature of nonfunctioning ACC results in poor outcomes, while the majority of patients present with locally advanced and/or metastatic disease. The work-up for adrenal masses must include determination of whether the mass is functioning or nonfunctioning and whether it is benign or malignant [1, 5].
Radiographic studies in the form of CT or magnetic resonance imaging (MRI) can help define the size of the mass and rule out metastases. Emerging evidence suggests that fluorodeoxyglucose positron emission tomography (FDG-PET) with CT is superior to CT alone . However, FDG-PET/CT is still considered a complementary study and is not recommended for ACC work-up .
Large tumors of > 4 cm raise high clinical suspicion of malignancy, as in our cases, and favor radical adrenalectomy [7, 8]. To the best of our knowledge, the first of our two case reports describes one of the largest nonfunctioning ACCs reported in the literature in the past 10 years.
Despite the poor prognosis in this patient group, chemotherapy has a limited role in the treatment of ACC, and surgical resection has been shown to have the best outcomes [9, 10]. However, recent studies have shown a role for adjuvant chemotherapy in prolonging recurrence-free survival and overall survival . There is no established duration of adjuvant chemotherapy.
Allolio et al. considered that complete surgical resection (Ro excision) offers the best chance for long-term survival in patients with stage I–III ACC, although these patients should be candidates for chemo-irradiation in order to increase disease-free survival . In cases of recurrence, surgery should be considered a first-line option. However, mitotane has a valuable role in stage IV cases or in the presence of recurrent disseminated disease [12, 13].
Studies demonstrated mitotane’s associated toxicity and its ability in: (1) inhibition of adrenocortical steroid biosynthesis by inhibiting cholesterol side chain cleavage and 11 β-hydroxylation, and (2) induction of hepatic clearance affecting extra-adrenal disposition of cortisol . Concerning the routine use of mitotane, there is a lot of controversy as partial response occurs for 5–30% of patients with ACC treated with this anticancer agent. High-risk patients are currently being treated for 5 years with mitotane.
Alternatively, in patients with proven lung metastasis, the published evidence suggests that en bloc excision of involved organs and pulmonary metastasectomy could improve overall survival.
Postoperative surveillance for recurrence should be performed every 3 months for the first 2 years and then every 6 months for 5 years.
Adrenal pseudocysts most commonly arise from hemorrhage within the adrenal gland, secondary to extreme stress, birth, trauma, surgery, or malignancy. The differential diagnosis of adrenal pseudocysts is from endothelial epithelial and parasitic cysts and rarely from mesothelial cysts, lymphangiomas, dermoid cysts, or cystic adrenal carcinomas.
Most pseudocysts on CT reveal well-demarcated, round or oval masses with fluid density with content of septa, blood, and soft tissue components. The wall of a pseudocyst seems to have occasional calcification on CT. MRI is pathognomonic for visualizing the complicated intracystic components .
Regarding surgical treatment, the open approach is preferable if the patient is symptomatic, the mass is > 6 cm, or there is a possibility of malignancy. Laparoscopic surgery is indicated for small tumors or pseudocysts provided there is no peri-adrenal infiltration and subsequent capsular disruption [15, 16].
ACC is a rare and aggressive malignancy. Non-secretory adrenal masses are diagnosed late by a mass effect, metastatic disease, or found incidentally. The work-up for adrenal masses must include determination of whether the mass is functioning or nonfunctioning and whether it is benign or malignant.
We present the cases of two women who presented to our department after being evaluated for fatigue, mass effect, and epigastric discomfort. Both of them were diagnosed as having a nonfunctioning ACC and underwent open adrenalectomy. To the best of our knowledge, the first case’s nonfunctioning ACC is considered to be one of the biggest that has ever been described in the literature.
Availability of data and materials
The data and materials/figures used in the current study are available from the corresponding author on reasonable request.
GC wrote and corrected the manuscript for its scientific basis. IP wrote the manuscript and collected the data. D-RB and DG collected the data for the study. AK revised the manuscript for grammar and syntax mistakes. KI was one of the consultant surgeons who operated on these cases. IT provided the radiographic/CT images. DP did the histopathological analysis. PS is the director of the Department of Surgery and the consultant surgeon who provided the cases. All authors read and approved the final manuscript.
Ethics approval and consent to participate
Our case report obtained ethics approval from the ethics committee of our hospital and the patients gave their informed consent to participate.
Consent for publication
Written informed consent was obtained from the patients for publication of this case report and any accompanying images. A copy of the written consents is available for review by the Editor-in-Chief of this journal.
The authors declare that they have no competing interests.
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