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Primary purulent bacterial pericarditis due to Streptococcus intermedius in an immunocompetent adult: a case report
© The Author(s). 2018
- Received: 24 October 2017
- Accepted: 10 January 2018
- Published: 5 February 2018
Acute purulent bacterial pericarditis is of rare occurrence in this modern antibiotic era. Primary involvement of the pericardium without evidence of underlying infection elsewhere is even rarer. It is a rapidly progressive infection with high mortality. We present an extremely rare case of acute purulent bacterial pericarditis in an immunocompetent adult patient with no underlying chronic medical conditions.
A 33-year-old previously healthy white man presented with the complaints of chest pain and dyspnea. He was diagnosed as having acute pericarditis and was discharged home on indomethacin. Over a period of 2 weeks, his symptoms worsened gradually and he was readmitted to our hospital. He was found to have large pericardial effusion with cardiac tamponade. An urgent pericardiocentesis was done with drainage of 550 ml of purulent material. Cultures grew Streptococcus intermedius confirming the diagnosis of acute purulent bacterial pericarditis. No other focus of infection was identified on imaging workup suggesting primary infection of the pericardium. His clinical course was complicated by development of constrictive pericarditis for which he underwent surgical pericardiectomy. He received a total of 7 weeks of intravenously administered antibiotics with complete clinical recovery.
Acute purulent bacterial pericarditis, although rare, should always be kept in mind as a possible cause of pericarditis. Early recognition and prompt intervention are important for a successful outcome.
- Primary bacterial pericarditis
- Acute purulent pericarditis
- Streptococcus intermedius
- Cardiac tamponade
Bacterial pericarditis is a rapidly progressive infection with high mortality. It is rare in the modern antibiotic era and the majority of cases occur in immunocompromised individuals or in individuals with underlying disease of the pericardium [1, 2]. Bacterial pericarditis usually occurs as a secondary infection by contiguous spread from surrounding intrathoracic focus of infection or by hematogenous spread from distant focus of infection [2, 3]. Primary involvement of the pericardium without evidence of underlying infection elsewhere is very rare. We present a case of a 33-year-old immunocompetent previously healthy adult patient who was diagnosed as having primary purulent acute bacterial pericarditis caused by Streptococcus intermedius.
A 33-year-old white man presented to our hospital with sudden onset pleuritic chest pain and dyspnea of 1 day’s duration. The chest pain started when he was lifting a heavy trash bag and described the pain as sharp, constant, and radiating to his back. He also complained of diffuse body aches and chills but denied any fever, cough, hemoptysis, or weight loss. He denied any history of dental caries, recent travel, or exposure to sick contacts. He had no significant past medical history and was not taking any routine medications. He smoked half a pack of cigarettes a day for the past 10 years and denied any alcohol or illicit drug use. He worked as a waste collector in a garbage disposal firm.
We report a case of primary purulent acute bacterial pericarditis in an immunocompetent previously healthy adult patient caused by S. intermedius. Our patient presented with symptoms of dyspnea and chest pain, which gradually progressed over the course of 2 weeks. He was found to have large purulent pericardial effusion with cardiac tamponade and was managed with emergent pericardiocentesis and intravenously administered antibiotics. Further, the disease course was complicated with development of constrictive pericarditis, which was successfully managed with pericardiectomy. Acute pericarditis can be caused by a wide variety of etiologies, which can be infectious or noninfectious . Possible causes include connective tissue disorders, malignancies, radiation, cardiac injury, uremia, and infections (including viral, bacterial, and fungal etiologies) [4, 5]. In a majority of cases (80 to 90%), the cause of pericarditis is not identified [5, 6]. These cases are considered to be idiopathic, most likely due to an undetected underlying virus [5, 6]. Bacterial pericarditis is a rare cause of acute pericarditis in the modern antibiotic era. The reported incidence is < 1% of all cases of pericarditis [7, 8]. The most common organisms implicated are Streptococci, Staphylococci, Haemophilus, and Mycobacterium tuberculosis [3, 9].
Bacterial pericarditis usually occurs as a secondary infection by contiguous spread from surrounding intrathoracic infection, including extension from pulmonary, myocardial, and subdiaphragmatic site of infection or by hematogenous dissemination from a distant infection elsewhere in the body [2, 3]. Among these, direct extension from lung or pleura (pneumonia and pleural empyema) accounts for the majority of cases [3, 10]. Very rarely, it can occur as a primary infection without evidence of underlying infection elsewhere. The common predisposing conditions for bacterial pericarditis are immunosuppression, malignancies, preexisting pericardial effusion, alcoholism, uremia, chest trauma, cardiac and thoracic surgery, and insertion or use of catheters for draining pericardial fluid [9, 10]. Purulent pericarditis is a serious manifestation of bacterial pericarditis characterized by the presence of frank pus in the pericardial cavity. It is an acute fulminant disease with rapid progression. It is associated with high mortality and a large number of cases are identified after death . If not identified and treated promptly the mortality rates can be as high as 100% . Even with treatment, the rate of complications and death is high, with the mortality rate approaching 40% [3, 9]. Death is most likely secondary to cardiac tamponade, constriction, and sepsis [3, 9].
Clinical recognition of bacterial pericarditis can be difficult as classical manifestations of acute pericarditis such as chest pain, pericardial friction rub, and pulsus paradoxus may be absent and a patient may present with nonspecific signs and symptoms of infection. Fever is present in almost all of the patients . Chest pain, which can be pleuritic or nonpleuritic, is seen in 25 to 37% of patients [3, 10]. Pericardial friction rub and pulsus paradoxus are seen in less than 50% of patients [3, 10]. Laboratory workup may show evidence of systemic inflammation with leukocytosis, and elevated CRP and ESR . Elevated troponins are seen in approximately 50% of cases . Chest radiograph usually shows cardiomegaly with abnormal cardiac silhouette. Pulmonary infiltrates, pleural effusion, and mediastinal widening may be identified as well . Electrocardiogram findings of acute pericarditis are present in a majority of patients; however, in 10 to 35% of cases findings may be normal [9, 10]. Echocardiogram is the most sensitive test and shows presence of fluid in the pericardial cavity in almost all the patients. However, it is not possible to differentiate purulent fluid collections from other causes of acute pericarditis based on echocardiogram alone. If purulent pericarditis is suspected an urgent pericardiocentesis should be performed for diagnostic and therapeutic indications and fluid should be sent for cell count, Gram stain, culture, and fungal and acid-fast stain. If tuberculous pericarditis is suspected, then performing polymerase chain reaction and adenosine deaminase activity assays on fluid increase the diagnostic yield . Medical therapy includes immediate initiation of broad-spectrum antibiotics with antistaphylococcal agent and an aminoglycoside, which can be followed by 4 weeks of bactericidal antibiotic as per culture and sensitivities. For critically ill patients the empiric antibiotic should include vancomycin, third generation cephalosporin, and a fluoroquinolone . Surgical pericardiectomy is indicated in selected patients with incomplete resolution and complications of the disease.
Our case is an extremely rare case of primary purulent acute bacterial pericarditis in a previously healthy adult individual with no immunocompromising or chronic medical condition, caused by S. intermedius. S. intermedius is a member of the Streptococcus anginosus group. The S. anginosus group (also called Streptococcus milleri group) is a subgroup of viridans streptococci that includes three streptococcal species: S. anginosus, S. intermedius, and Streptococcus constellatus. Although these organisms are a part of normal commensal of oral cavity, gastrointestinal tract, and genitourinary tract, they are capable of causing various pyogenic infections and abscess formation . They have been associated with abscess formation in the liver, abdomen, brain, and lung but rarely cause purulent pericarditis.
From a search of the medical literature, we identified a total of 22 cases of bacterial pericarditis caused by S. anginosus (milleri) group from 1984 to 2017 [3, 15–34]. Out of these, five cases were attributed to S. intermedius [18, 28, 31, 34]. To the best of our knowledge, this is the sixth reported case of bacterial pericarditis caused by S. intermedius. In our case, the source of S. intermedius infection was unclear and development of pericarditis was spontaneous without evidence of any other infective focus elsewhere. S. intermedius is a part of normal microbial flora of human oral cavity as discussed earlier. We believe that the most likely etiology of infection in our case was transient bacteremia from a mucosal breach in our patient’s oral cavity with hematogenous spread and seeding of bacteria in pericardial cavity leading to purulent pericarditis.
Acute purulent bacterial pericarditis, although rare, should always be kept in mind as a possible cause of pericarditis. As this disease has a rapidly progressive fulminant course, early recognition and prompt intervention are critical for a successful outcome.
No funding was received for this study.
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Study concept and design: MSK and ZK. Acquisition of data: MSK, ZK, BSB, GA, LM, and CG. Drafting of the manuscript: MSK and ZK. Critical revision of manuscript for important intellectual content: all authors. All authors read and approved the final manuscript.
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- Hall IP. Purulent pericarditis. Postgrad Med J. 1989;65(765):444–8.View ArticlePubMedPubMed CentralGoogle Scholar
- Klacsmann PG, Bulkley BH, Hutchins GM. The changed spectrum of purulent pericarditis: an 86 year autopsy experience in 200 patients. Am J Med. 1977;63(5):666–73.View ArticlePubMedGoogle Scholar
- Sagrista-Sauleda J, et al. Purulent pericarditis: review of a 20-year experience in a general hospital. J Am Coll Cardiol. 1993;22(6):1661–5.View ArticlePubMedGoogle Scholar
- Lange RA, Hillis LD. Clinical practice. Acute pericarditis N Engl J Med. 2004;351(21):2195–202.View ArticlePubMedGoogle Scholar
- Little WC, Freeman GL. Pericardial disease. Circulation. 2006;113(12):1622–32.View ArticlePubMedGoogle Scholar
- LeWinter MM. Clinical practice. Acute pericarditis. N Engl J Med. 2014;371(25):2410–6.View ArticlePubMedGoogle Scholar
- Imazio M, et al. Indicators of poor prognosis of acute pericarditis. Circulation. 2007;115(21):2739–44.View ArticlePubMedGoogle Scholar
- Leoncini G, et al. Primary and secondary purulent pericarditis in otherwise healthy adults. Interact Cardiovasc Thorac Surg. 2006;5(5):652–4.View ArticlePubMedGoogle Scholar
- Pankuweit S, et al. Bacterial pericarditis: diagnosis and management. Am J Cardiovasc Drugs. 2005;5(2):103–12.View ArticlePubMedGoogle Scholar
- Rubin RH, Moellering Jr RC. Clinical, microbiologic and therapeutic aspects of purulent pericarditis. Am J Med. 1975;59(1):68–78.View ArticlePubMedGoogle Scholar
- Keersmaekers T, Elshot SR, Sergeant PT. Primary bacterial pericarditis. Acta Cardiol. 2002;57(5):387–9.View ArticlePubMedGoogle Scholar
- Bonnefoy E, et al. Serum cardiac troponin I and ST-segment elevation in patients with acute pericarditis. Eur Heart J. 2000;21(10):832–6.View ArticlePubMedGoogle Scholar
- Mayosi BM, Burgess LJ, Doubell AF. Tuberculous pericarditis. Circulation. 2005;112(23):3608–16.View ArticlePubMedGoogle Scholar
- Whiley RA, et al. Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus (the Streptococcus milleri group): association with different body sites and clinical infections. J Clin Microbiol. 1992;30(1):243–4.PubMedPubMed CentralGoogle Scholar
- Reder RF, et al. Purulent pericarditis caused by Streptococcus anginosus-constellatus. Mt Sinai J Med. 1984;51(3):295–7.PubMedGoogle Scholar
- Akashi K, et al. Purulent pericarditis caused by Streptococcus milleri. Arch Intern Med. 1988;148(11):2446–7.View ArticlePubMedGoogle Scholar
- Hirata K, Asato H, Maeshiro M. A case of effusive constrictive pericarditis caused by Streptococcus milleri. Jpn Circ J. 1991;55(2):154–8.View ArticlePubMedGoogle Scholar
- Muto M, et al. Streptococcus milleri infection and pericardial abscess associated with esophageal carcinoma: report of two cases. Hepatogastroenterology. 1999;46(27):1782–4.PubMedGoogle Scholar
- Snyder RW, Braun TI. Purulent pericarditis with tamponade in a postpartum patient due to group F streptococcus. Chest. 1999;115(6):1746–7.View ArticlePubMedGoogle Scholar
- Marchal LL, Detollenaere M, De Baere HJ. Streptococcus milleri, a rare cause of pericarditis; successful treatment by pericardiocentesis combined with parenteral antibiotics. Acta Clin Belg. 2000;55(4):222–4.View ArticlePubMedGoogle Scholar
- Berek Z, et al. Group-F streptococcal pleuro-pericarditis in a mesothelioma patient after dental surgery (case report). Acta Microbiol Immunol Hung. 2001;48(2):147–50.View ArticlePubMedGoogle Scholar
- Salazar Gonzalez JJ, Sanchez-Rubio Lezcano J, Merchante Garcia P. Purulent pericarditis with pneumopericardium caused by Streptococcus milleri. Rev Esp Cardiol. 2002;55(8):861.View ArticlePubMedGoogle Scholar
- Kaufman J, et al. Esophageal-pericardial fistula with purulent pericarditis secondary to esophageal carcinoma presenting with tamponade. Ann Thorac Surg. 2003;75(1):288–9.View ArticlePubMedGoogle Scholar
- Tomkowski WZ, et al. Effectiveness of intrapericardial administration of streptokinase in purulent pericarditis. Herz. 2004;29(8):802–5.View ArticlePubMedGoogle Scholar
- Kabra R, et al. Bacterial pericarditis due to group F streptococci as a complication of esophagomediastinal fistula. Ann Thorac Surg. 2005;79(6):2132–4.View ArticlePubMedGoogle Scholar
- Tokuyasu H, et al. Purulent pericarditis caused by the Streptococcus milleri group: a case report and review of the literature. Intern Med. 2009;48(12):1073–8.View ArticlePubMedGoogle Scholar
- Li Q, et al. Purulent pericarditis caused by a bad tooth. Eur Heart J. 2013;34(11):862.View ArticlePubMedGoogle Scholar
- Presnell L, et al. A child with purulent pericarditis and Streptococcus intermedius in the presence of a pericardial teratoma: an unusual presentation. J Thorac Cardiovasc Surg. 2014;147(3):e23–4.View ArticlePubMedGoogle Scholar
- Tachjian A, et al. Purulent pericarditis after transbronchial biopsy. Can J Cardiol. 2014;30(10):1250 e19–21.View ArticleGoogle Scholar
- Takayama T, et al. Esophageal cancer with an esophagopericardial fistula and purulent pericarditis. Intern Med. 2013;52(2):243–7.View ArticlePubMedGoogle Scholar
- Tigen ET, et al. Giant purulent pericarditis with cardiac tamponade due to Streptococcus intermedius rapidly progressing to constriction. Echocardiography. 2015;32(8):1318–21.View ArticlePubMedGoogle Scholar
- Maves RC, et al. Pyogenic pericarditis and cardiac tamponade due to Streptococcus anginosus in a combat theater. Open Forum Infect Dis. 2017;4(1):ofw267.PubMedPubMed CentralGoogle Scholar
- Hindi Z. Rare purulent cardiac tamponade caused by Streptococcus constellatus in a young immunocompetent patient: case report and review of the literature. Am J Case Rep. 2016;17:855–9.View ArticlePubMedPubMed CentralGoogle Scholar
- Denby KJ, Byrne RD, Gomez-Duarte OG. Streptococcus intermedius: an unusual case of purulent pericarditis. Case Rep Infect Dis. 2017;2017:5864694.PubMedPubMed CentralGoogle Scholar