Ocular metastasis from breast carcinoma simulating anterior scleritis: a case report
© The Author(s). 2017
Received: 20 April 2017
Accepted: 20 July 2017
Published: 28 August 2017
Breast cancer is one of the commonest sources of ocular metastasis. Patients with ocular metastatic disease can present with a variable clinical picture. Patients with a history of breast cancer presenting with any eye symptom should be evaluated with consideration of ocular metastasis.
We report a case of ocular metastasis in a 46-year-old Brahmin woman presenting with right eye pain. She had been treated for stage IIIc left-sided breast cancer 2 years ago with six cycles of chemotherapy with docetaxel, adriamycin, and cyclophosphamide after undergoing modified radical mastectomy. An ophthalmic examination revealed a tender subconjunctival swelling superotemporally on retracting right upper eyelid. This finding alone indicated anterior scleritis. On examining fundus under mydriasis, an amelanotic subretinal mass could be visualized in the posterior pole superotemporal to macula. An orbital magnetic resonance imaging revealed a mass of 2 × 1 cm in size in the subretinal space of her right eye. Computed tomography of her chest was then done and showed multiple metastases in both lungs.
This case report highlights the fact that any unusual ocular presentation, even one simulating anterior scleritis, in a patient with a history of breast cancer should raise suspicion of metastasis.
KeywordsAnterior scleritis Breast cancer Case report Ocular metastasis Subretinal mass
Ophthalmic involvement can occur in up to one-fourth of patients with known metastatic breast carcinoma . Although almost any structure of the eye and orbit can be the site for metastasis, the most favored site is the choroid; the choroid is predominantly affected with an incidence of nearly 80% of total ocular metastasis .
As survival of patients with breast carcinoma prolongs, the incidence of ocular metastasis and range of ocular morbidity is bound to increase . Although uncommon, ocular metastasis can represent the initial manifestation of an undiagnosed primary tumor . Hence, ophthalmologists in close association with oncologists can play a vital role in detecting an ocular metastasis from a known primary tumor or a primary tumor when an ophthalmic symptom is the initial manifestation of breast cancer.
Ocular metastasis from breast cancer can mimic a variety of conditions depending on the site of metastasis . Here we report a rare case of choroidal metastasis extending anteriorly causing a tender subconjunctival swelling similar to anterior scleritis. This case report serves as an indication that any signs of anterior scleritis in a patient with underlying breast cancer could be associated with ocular metastasis.
A 46-year-old Brahmin woman with a history of a hormone receptor-negative invasive ductal type of adenocarcinoma of her left breast (stage pT3N3aM0) presented with pain and blurring of vision of her right eye.
Diagnosis of left-sided stage IIIc breast carcinoma was made 2 years ago when she developed pain in her left arm. She subsequently underwent a left-sided modified radical mastectomy. Postoperatively she started treatment with docetaxel 80 mg, adriamycin 60 mg, and cyclophosphamide 600 mg. After completion of six cycles of chemotherapy, external beam radiation of her thoracic wall was performed once a week for 8 weeks.
In females, breast cancer is the most common primary tumor and it is responsible for nearly half of the occurrences of ocular metastasis . The uveal tissue, especially the choroid, is the primary ocular site of breast cancer metastases accounting for 81% of total ocular metastasis . The possible explanation for such high metastatic dissemination to the choroid could be its high vascularity . Although most cases of choroidal metastasis are asymptomatic, the most common symptom on presentation is diminution of vision with or without metamorphopsia which can be either due to serous detachment of fovea or macular involvement by malignant lesion [7, 8].
The intraocular anatomical distribution of tumors arising from breast cancer involves mainly the superotemporal quadrant of the fundus . Choroidal foci of metastases typically appear as a homogenous, creamy yellow plateau-shaped lesion located between macula and equator , but they can occasionally present with choroidal detachment simulating uveal effusion syndrome or, when advanced, can cause exophthalmos, glaucoma, and uveitis . One unusual reported case presented as scleritis with exudative retinal detachment in a 36-year-old white man; he was diagnosed as having ocular metastasis when enucleation was done to demonstrate small cell carcinoma on histopathological examination after there was no response to treatment and he developed a painful blind eye .
Since the present case was a known case of breast carcinoma under routine follow-ups for the last 2 years, diagnosis was much easier. Ocular metastasis usually presents in patients with breast cancer 20 to 40 months after initial diagnosis . Diagnosis of ocular metastatic disease is mainly clinical. When in doubt, investigative modalities such as optical coherence tomography (OCT), fundus fluorescein angiography (FFA), B-scan, and MRI can be helpful. At the time of diagnosis of ocular metastasis, 85% of patients already have lung metastasis . Hence treatment of ocular metastasis is almost always palliative. Prognosis of patients with metastatic ocular tumor is rather poor with a median survival of 9 months . External beam radiation therapy is very effective in patients with blurred vision secondary to foveal involvement and metastatic tumor regression has been reported in 63 to 83% of cases [7, 13].
Breast cancer is a common source of ocular metastasis. Any ocular features, no matter how subtle or unusual, should raise a suspicion of tumor spread to the eye. As in this case, ocular metastasis can be the first sign of tumor dissemination and thus can aid in further evaluation of systemic involvement.
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RKS drafted the manuscript. SL helped to draft the manuscript, participated in the sequence alignment, and the final editing of the manuscript as well as the submission of the manuscript. Both authors read and approved the final manuscript.
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Ethical approval was taken from the Institutional Review Board (IRB) of Institute of Medicine (IOM).
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Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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- Mewis L, Young SE. Breast carcinoma metastatic to the choroid. Analysis of 67 patients. Ophthalmology. 1982;89(2):147–51.View ArticlePubMedGoogle Scholar
- Shields JA, Shields CL. Metastatic tumors to the intraocular structures. In: Shields JA, Shields CL, editors. Intraocular tumors. Philadelphia: Saunders; 1992. p. 207–38.Google Scholar
- Wickremasinghe S, Dansingani KK, Tranos P, Liyanage S, Jones A, Davey C. Ocular presentations of breast cancer. Acta Ophthalmol Scand. 2007;85(2):133–42.View ArticlePubMedGoogle Scholar
- Olfa G, Riadh H, Sameh T, Fafani BH, Slim BA. Breast cancer discovered from choroidal metastasis: apropos of a case and review of the literature. Can J Ophthalmol. 2009;44(6):e67.View ArticlePubMedGoogle Scholar
- Freedman MI, Folk JC. Metastatic tumors to the eye and orbit. Patient survival and clinical characteristics. Arch Ophthalmol. 1987;105(9):1215–9.View ArticlePubMedGoogle Scholar
- McCartney A. Intraocular metastasis. Br J Ophthalmol. 1993;77(3):133.View ArticlePubMedPubMed CentralGoogle Scholar
- Kanthan GL, Jayamohan J, Yip D, Conway RM. Management of metastatic carcinoma of the uveal tract: an evidence-based analysis. Clin Exp Ophthalmol. 2007;35(6):553–65.View ArticlePubMedGoogle Scholar
- Konstantinidis L, Rospond-Kubiak I, Zeolite I, Heimann H, Groenewald C, Coupland SE, Damato B. Management of patients with uveal metastases at the Liverpool ocular oncology centre. Br J Ophthalmol. 2014;98(1):92–8.View ArticlePubMedGoogle Scholar
- Demirci H, Shields CL, Chao AN, Shields JA. Uveal metastasis from breast cancer in 264 patients. Am J Ophthalmol. 2003;136(2):264–71.View ArticlePubMedGoogle Scholar
- Ferry AP, Font RL. Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases. Arch Ophthalmol. 1974;92(4):276–86.View ArticlePubMedGoogle Scholar
- Yeo JH, Jakobiec FA, Iwamoto T, Brown R, Harrison W. Metastatic carcinoma masquerading as scleritis. Ophthalmology. 1983;90(2):184–94.View ArticlePubMedGoogle Scholar
- Ferry AP. Metastatic carcinoma of the eye and ocular adnexa. Int Ophthalmol Clin. 1967;7(3):615–58.PubMedGoogle Scholar
- Wiegel T, Bottke D, Kreusel KM, Schmidt S, Bornfeld N, Foerster MH, Hinkelbein W. External beam radiotherapy of choroidal metastases – final results of a prospective study of the German cancer society (ARO 95-08). Radiother Oncol. 2002;64(1):13–8.View ArticlePubMedGoogle Scholar