Open Access
Open Peer Review

This article has Open Peer Review reports available.

How does Open Peer Review work?

Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature

  • Vito Emanuele Catania1Email author,
  • Michele Vecchio2,
  • Michele Malaguarnera3,
  • Roberto Madeddu4,
  • Giulia Malaguarnera3 and
  • Saverio Latteri1
Journal of Medical Case Reports201711:79

https://doi.org/10.1186/s13256-017-1241-3

Received: 5 July 2016

Accepted: 13 February 2017

Published: 24 March 2017

Abstract

Background

This case report describes a spontaneous tumor lysis syndrome due to a rare solid tumor.

Case presentation

A 65-year-old white woman had tumor lysis syndrome, which represent a dangerous oncological emergency. This syndrome occurs usually with a hematological tumor, but in this case our patient had a solid tumor, which was a rare extraskeletal osteosarcoma, localized in her pelvic region. She also had lung metastases and bilateral hydronephrosis.

After spontaneous tumor lysis syndrome, she had acute renal insufficiency, which was treated with hemodialysis and successively with rasburicase, Kayexalate (sodium polystyrene sulfonate), and febuxostat.

Conclusion

Tumor lysis syndrome represents an oncological emergency, which must be suspected and treated as soon as possible.

Keywords

Tumor lysis Osteosarcoma Case report Uricemia Kalemia Rasburicase

Background

Tumor lysis syndrome (TLS) is one of the major oncological emergencies; disruption is caused by massive tumor cell lysis in which the contents of the lysed tumor cells are released into the bloodstream [1]. It is a potential fatal complication of the treatment of hematological tumors and, less frequently, of solid aggressive tumors. Hematologic malignancies comprise the vast majority of TLS, which is believed to be secondary to treatment sensitivity and rapid proliferative rates [2, 3]. Patients with a solid tumor usually show TLS after intensive chemotherapy (treatment-induced TLS), but sometimes it can appear before the treatment (spontaneous TLS) especially in cases of bulky tumors with wide necrotic areas. TLS can alter the body’s homeostatic mechanisms and cause hyperuricemia, hyperkalemia, hyperphosphatemia, and uremia [4].

Extraskeletal osteosarcoma (ESOS) is a rare subtype of osteosarcoma without attachment to bone or periosteum. It accounts for less than 4% of all osteosarcomas and approximately 1 to 2% of all soft tissue sarcomas (STSs) [5]. The clinical features of patients with this tumor differ significantly from the clinical features of patients with skeletal osteosarcoma, including older age, propensity for axial tumors, and female preponderance.

Although ESOS has been found to develop in all organs, the most common locations are limbs. In the case of abdominal or pelvic lesions the diagnosis can be very difficult, thus it requires confirmation after exploratory laparotomy and histopathology. Such tumors may reach an enormous size before detection, because the enlarging mass may not be associated with pain. ESOS may be one of the differential diagnoses to be considered in the case of calcified masses arising in retroperitoneal space [5, 6].

In previous studies, the total number of patients reported with both tumor lysis and sarcoma was five: three males and two females and their age spanned from 9 years to 66 years. All of them had evidence of advanced and metastatic disease [510]. One patient was reported to have normal baseline values of creatinine and phosphorus, whereas another patient had elevated baseline values of creatinine and lactate dehydrogenase (LDH). Three cases were preceded by chemotherapy; the other two cases were represented by spontaneous TLS. All the cases taken in consideration had baseline elevation of uric acid and phosphorus.

Clinical tumor lysis occurred more frequently in patients with pre-treatment renal insufficiency than in patients with normal renal function. The development of uremia is correlated with high pre-treatment serum LDH concentrations [4].

Case presentation

A 65-year-old white woman was hospitalized for a right hypochondrium colicky pain radiating to the ipsilateral subscapularis region. Her pain was not related to food and posture. It appeared during the previous week and persisted despite nonsteroidal anti-inflammatory medication. A clinical examination showed that her abdomen was swollen in the right iliac fossa and the presence of voluminous palpable mass that was hard, fixed to the deep layers, and sore to touch.

An abdominal ultrasound (US) examination revealed her liver with gallbladder stones, a heterologous formation in her right iliac fossa with internal calcification, which compressed the iliac vessels, and a bilateral hydronephrosis more marked on the right than on the left.

Laboratory tests revealed significant alterations (Table 1). Her blood pressure was above 180 mmHg. A chest X-ray showed the presence of multiple metastases placed in both lung fields. A total body computed tomography scan (CT) without contrast confirmed the presence of lung metastases, bilateral hydronephrosis, and a mass in her right iliac fossa invading her ureter and her iliac artery.
Table 1

Laboratory tests before and after hemodialysis

Laboratory tests

Before dialysis

After dialysis

Reference range

Alkaline phosphatase IU/l

1460

670

20–140

Urea nitrogen mg/dl

196.2

58.3

10–50

Creatinine mg/dl

7.89

1.36

0.60–1.50

Phosphorus mg/dl

4.9

4.2

2.6–4.5

Calcium mg/dl

7.5

7.7

8.5–10.5

Sodium mmol/l

144

136

135–145

Potassium mmol/l

6.1

4.2

3.4–4.8

Lactate dehydrogenase U/l

1120

870

110–210

Uric acid mg/dl

11.4

6.7

3.6–8.5

There was also a mass in the right iliac mass but with a reduced size in the left iliac fossa invading her psoas muscle. The internal structure of the masses was homogeneous, apart from the centrally located amorphous high-attenuation areas. There was no fat inside the lesion.

She underwent hemodialysis and infusion therapy with rasburicase (Fasturtec ®; Table 1).

Prompt dialysis is necessary when treatment fails to normalize electrolytes or establish urinary flow. Hemodialysis removes excess circulating uric acid. Before the dialysis our patient was hyperuricemic and oliguric. After the dialysis, we observed that she developed diuresis, associated with the consequent resolution of hyperuricemia, hyperazotemia, hyperphosphatemia, and normalization of electrolytes.

After 10 days she underwent surgery. An exploration of her abdominal cavity detected a retroperitoneal mass in her right iliac region which involved the last ileal loop besides compressing the iliac vessels and infiltrating her ureter. Another mass in her left iliac fossa caused a compression of the left iliac vessels and ureter without infiltration. As a result of the inoperability of the mass in her right iliac region, an ileotransversostomy was performed with enucleation of the left mass and cholecystectomy.

An histological examination performed on the mass diagnosed an ESOS infiltrating her psoas muscle, her internal iliac artery, and her bladder wall. On macroscopic examination the mass had a hard consistency, was whitish-gray in color, and there were large central calcified parts and areas of hemorrhagic-necrotic tissue. The mass was osteoblastic histological type, consisting of osteoblasts producing an osteoid material. The lesional cells showed great cytological atypia, high mitotic activity, and permeative growth pattern (Fig. 1).
Fig. 1

Round and multinucleated cells separated by osteoid material (×200)

The tumor massively invaded our patient’s abdominal cavity and metastasized in both lung fields. According to these parameters, she was in a very poor prognostic subgroup, due to a very bulky and high growth rate tumor. This tumor was only partially resectable because she was over 60-years old and showed multiple metastatic lesions, multiorgan impairment, and increased alkaline phosphatase (ALP) levels. A CT scan showed large soft tissue masses with focal or massive areas of calcification and no osseous involvement. Magnetic resonance (MR) images showed intermediate signal intensity on T1-weighted images and a low-to-hyperintense signal on T2-weighted images.

The diagnosis of osteoblastic ESOS was confirmed by the tumor localization within the soft tissue, without attachment to bony structures, and the presence of abundant osteoid. There was no history of radiation or trauma in our patient, but there was an anamnestic finding of hysterectomy just 6 months before the diagnosis of ESOS.

The most common presentation of ESOS is a gradually enlarging mass that varies in size from 1 to 50 cm in diameter and does not always imply pain. Very large and bulky tumors often develop in the retroperitoneum before their detection as in our case. Thus the presence of metastatic lesions, the patient’s age, and the size were the major prognostic factors; in addition, patients with very large lesions have a worse clinical outcome.

Discussion

ESOS is a high-grade malignant mesenchymal neoplasm with very aggressive behavior. The tumor is typically located in the deep soft tissues, without attachment to skeletal bones. The most common affected site is the thighs, followed by upper extremities, retroperitoneum, and buttocks.

The etiology of ESOS is essentially unknown, even though there have been reported cases of radiation-induced ESOS, a history of previous trauma, intramuscular injection at the tumor site, and malignant transformation of myositis ossification. ESOS has also been shown to develop in unusual sites, such as mediastinum, hand, cerebellum, heart, skin, pleura, larynx, scalp, tongue, penis, gallbladder, breast, and mesentery.

The treatment of choice for ESOS is amputation or a wide surgical resection of the tumor for local control and to prevent a possible recurrence. Chemotherapy and radiation therapy can be combined to surgery although their role in neoadjuvant or adjuvant therapy has not been clearly defined yet. Nevertheless, classical high-grade ESOS still remains a very aggressive rare tumor with a poor prognosis.

Our patient had a spontaneous TLS, with an acute renal insufficiency, treated with hemodialysis (Table 1). After this treatment, TLS was treated with rasburicase, Kayexalate (sodium polystyrene sulfonate), abundant hydration, and febuxostat (Fig. 1) [11, 12].

Risk factors for TSL include: (1) presence of bulky disease, particularly with pluri-metastatic sites (especially abdominal metastases), bulky adenopathy, and hepatosplenomegaly; (2) high leucocyte count; (3) elevated pre-treatment LDH; (4) elevated pre-treatment uric acid; (5) compromised renal function; and (6) history of use of potentially nephrotoxic drugs [7].

The most frequent serological alteration is: hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. Both hyperuricemia and hyperphosphatemia can evolve in renal failure and they can also cause cardiologic complications. The contemporaneous presence of the two electrolytic alterations may cause a fall in cardiologic function [810]. Hyperuricemia results from the release and breakdown of purine nucleic acids. Uric acid is poorly soluble in water and, when normal limits of excretion are surpassed, precipitation of crystals occurs in the renal tubules leading to renal insufficiency and, potentially, failure [13].

Malignant cells often have a higher phosphate concentration than normal cells. Rapid lysis can lead to hyperphosphatemia when the normal homeostatic mechanisms are overwhelmed. Excretion of phosphate may be further impaired because of acute kidney injury either from uric acid crystal deposition or from tumor involvement of the kidneys [14]. In the setting of hyperphosphatemia, calcium phosphate precipitation may also occur in renal tubules, contributing further to acute kidney injury [15]. Hyperphosphatemia may also cause nausea, vomiting, diarrhea, lethargy, or seizures. Hypocalcemia in TLS is a consequence of hyperphosphatemia, causing calcium phosphate precipitation in tissues.

TLS may be clinically asymptomatic, but hyperkalemia and hypocalcemia may cause neurologic, cardiovascular, or muscular symptoms including seizures, arrhythmias (typically with a longer QT space), and tetany. Hyperkalemia is a potentially life-threatening consequence of TLS, occurring when large quantities of potassium are released from necrotic tumor cells. Acute kidney injury, if present, can worsen hyperkalemia. A rapid increase in serum potassium levels may result in cardiac arrhythmia and cardiac arrest [1618].

In neoplastic patients, acute tumor lysis may be a cause of acute renal failure (ARF) due to severe metabolic derangement. Acute TLS has rarely been investigated and most patients developed spontaneous and oliguric ARF before therapy. The cause of renal failure is now recognized as acute uric acid nephropathy, due to increased uric acid production and hyperuricosuria resulting from a high tumor cell turnover rate. A key distinction between spontaneous tumor lysis and TLS is the lack of hyperphosphatemia in the spontaneous form occurring after therapy.

Search strategy

We searched PubMed/Medline, Scopus, Embase, and Web of Sciences articles that focused on TLS in patients with osteosarcomas published from 1960 to September 2016. The search methodology was adapted from scientific search guidelines published in 2011.

Conclusions

Previous studies have shown a reduced incidence of significant post-treatment hyperuricemia and hyperphosphatemia as the most common laboratory abnormalities associated with post-treatment ARF. Prospective investigations are required to compare conservative treatment with pre-emptive dialysis and to develop reliable clinical profiles identifying patients at risk of developing renal failure and increasing the potential of TLS.

Acute TLS often represents a fatal complication in treated and non-treated tumors. A prompt treatment of TLS in ESOS and in others tumor reduces complications and can improve prognosis and quality of life (Fig. 2).
Fig. 2

Cause, prevention, and treatment of tumor lysis syndrome

Abbreviations

ALP: 

Alkaline phosphatase

ARF: 

Acute renal failure

CT: 

Computed tomography

ESOS: 

Extraskeletal osteosarcoma

LDH: 

Lactate dehydrogenase

MR: 

Magnetic resonance

STS: 

Soft tissue sarcoma

TLS: 

Tumor lysis syndrome

US: 

Ultrasound

Declarations

Acknowledgements

Not applicable.

Funding

None.

Availability of data and materials

We have no data to share.

Authors’ contributions

All the authors contributed in the realization of the manuscript. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Ethics approval and consent to participate

Not applicable.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Medical-Surgical Sciences, and Advanced Technologies “G. F. Ingrassia”, University of Catania
(2)
UOC Centre of Physical Medicine and Rehabilitation, AOU “O.V.E-Policlinico”
(3)
Research Centre “The Great Senescence”, University of Catania
(4)
Department of Biomedical Sciences, University of Sassari

References

  1. Howard SC, Jones DP, Pui CH. The tumor lysis syndrome. N Engl J Med. 2011;364(19):1844–54.View ArticlePubMedPubMed CentralGoogle Scholar
  2. Pumo V, Sciacca D, Malaguarnera M. Tumor lysis syndrome in elderly. Crit Rev Oncol Hematol. 2007;64(1):31–42.View ArticlePubMedGoogle Scholar
  3. Burns RA, Topoz I, Reynolds SL. Tumor lysis syndrome: risk factors, diagnosis, and management. Pediatr Emerg Care. 2014;30(8):571–6.View ArticlePubMedGoogle Scholar
  4. Hande KR, Garrow GC. Acute tumor lysis syndrome in patients with high-grade non-Hodgkin’s lymphoma. Am J Med. 1993;94(2):133–9.View ArticlePubMedGoogle Scholar
  5. Thampi S, Matthay KK, Boscardin WJ, Goldsby R, DuBois SG. Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma. Sarcoma. 2014;2014:902620.View ArticlePubMedPubMed CentralGoogle Scholar
  6. Mc Auley G, Jagannathan J, O’Regan K, Krajewski KM, Hornick JL, Butrynski J, Ramaiya N. Extraskeletal osteosarcoma: spectrum of imaging findings. AJR Am J Roentgenol. 2012;198(1):W31–7.View ArticlePubMedGoogle Scholar
  7. Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD. Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors. Rheumatol Int. 2011;31(11):1409–17.View ArticlePubMedGoogle Scholar
  8. Khan J, Broadbent VA. Tumor lysis syndrome complicating treatment of widespread metastatic abdominal rhabdomyosarcoma. Pediatr Hematol Oncol. 1993;10(2):151–5.View ArticlePubMedGoogle Scholar
  9. Gold JE, Malamud SC, LaRosa F, Osband ME. Adoptive chemoimmunotherapy using ex vivo activated memory T-cells and cyclophosphamide: tumor lysis syndrome of a metastatic soft tissue sarcoma. Am J Hematol. 1993;44(1):42–7.View ArticlePubMedGoogle Scholar
  10. Qian KQ, Ye H, Xiao YW, Bao YY, Qi CJ. Tumor lysis syndrome associated with chemotherapy in primary retroperitoneal soft tissue sarcoma by ex vivo ATP-based tumor chemo-sensitivity assay (ATP-TCA). Int J Gen Med. 2009;2:1–4.PubMedPubMed CentralGoogle Scholar
  11. Rampello E, Fricia T, Malaguarnera M. The management of tumor lysis syndrome. Nat Clin Pract Oncol. 2006;3(8):438–47.View ArticlePubMedGoogle Scholar
  12. Hsu HH, Chan YL, Huang CC. Acute spontaneous tumor lysis presenting with hyperuricemic acute renal failure: clinical features and therapeutic approach. J Nephrol. 2004;17(1):50–6.PubMedGoogle Scholar
  13. Bien E, Maciejka-Kapuscinska L, Niedzwiecki M, Stefanowicz J, Szolkiewicz A, Krawczyk M, Maldyk J, Izycka-Swieszewska E, Tokarska B, Balcerska A. Childhood rhabdomyosarcoma metastatic to bone marrow presenting with disseminated intravascular coagulation and acute tumour lysis syndrome: review of the literature apropos of two cases. Clin Exp Metastasis. 2010;27(6):399–407.View ArticlePubMedPubMed CentralGoogle Scholar
  14. El-Husseini A, Sabucedo A, Lamarche J, et al. Acute kidney injury associated with tumor lysis syndrome: a paradigm shift. Am J Emerg Med. 2012;30:390. e393–e396.Google Scholar
  15. Mukherjee E, Mukherji D, Jayawardene SA, et al. Tumor lysis syndrome and acute renal failure—an increasing spectrum of presentations. Clin Nephrol. 2007;68:186–9.View ArticlePubMedGoogle Scholar
  16. Lobe TE, Karkera MS, Custer MD, et al. Fatal refractory hyperkalemia due to tumor lysis during primary resection for hepatoblastoma. J Pediatr Surg. 1990;25:249–50.View ArticlePubMedGoogle Scholar
  17. Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol. 2004;127:3–11.View ArticlePubMedGoogle Scholar
  18. Malaguarnera G, Giordano M, Malaguarnera M. Rasburicase for the treatment of tumor lysis in hematological malignancies. Expert Rev Hematol. 2012;5(1):27–38.View ArticlePubMedGoogle Scholar

Copyright

© The Author(s). 2017

Advertisement