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Extra-ampullary Peutz–Jeghers polyp causing duodenal intussusception leading to biliary obstruction: a case report
© The Author(s). 2016
Received: 10 April 2016
Accepted: 24 June 2016
Published: 15 July 2016
Duodenal Peutz–Jeghers polyp is a rare cause of duodenal or biliary obstruction. However, a sporadic Peutz–Jeghers polyp leading to simultaneous biliary and duodenal obstruction has not been reported.
We report a case of a 25-year-old Sri Lankan woman presenting with features of recurrent upper small intestinal obstruction and biliary obstruction. She had clinical as well as biochemical evidence of intermittent biliary obstruction. Evidence of duodenal intussusception was found in a computed tomography enterogram and a duodenal polyp was noted as the lead point. Marked elongation and distortion of her lower common bile duct with intrahepatic duct dilatation was also noted and the ampulla was found to be on the left side of the midline pulled toward the intussusceptum. Open polypectomy and reduction of intussusception were done and she became fully asymptomatic following surgery. Histology of the resected specimen was reported as a typical “Peutz–Jeghers polyp”. As there was not enough evidence to diagnose Peutz–Jeghers syndrome this was considered to be a sporadic Peutz–Jeghers polyp.
Rare benign causes such as a duodenal polyp should be considered and looked for in initial imaging, when the cause for concurrent biliary and intestinal obstruction is uncertain, particularly in young individuals.
Duodenal polyps are commonly found as an incidental finding during endoscopic evaluations of the upper gastrointestinal (GI) tract. The prevalence of duodenal polyposis in routine upper GI endoscopies is 1.5 % . These polyps rarely obstruct the lumen of the duodenum or become the lead point of a duodenal intussusception. Literature on such lesions resulting in biliary obstruction together with intestinal obstruction is rare. Peutz–Jeghers polyps occur as sporadic lesions or as a part of Peutz–Jeghers syndrome (PJS). They account for 1.8 % of all duodenal polyps . Diagnosis of these polyps is readily made as they show characteristic histological features. Here we report our management experience of a young woman with a sporadic Peutz–Jeghers polyp causing a duodenal intussusception with simultaneous duodenal and biliary obstruction.
A 25-year-old Sri Lankan woman presented with several episodes of central abdominal pain, abdominal fullness, and non-projectile vomiting for 1-week duration. The vomitus was non-bilious, with undigested food particles and was noted particularly 1 to 2 hours after meals. Episodes of vomiting were accompanied with colicky central abdominal pain but these symptoms were only mild and between attacks she was completely asymptomatic. As she had had at least five similar episodes over the last 3 years, she sought medical advice. Most of those episodes were self-limiting, but she had a couple of hospital admissions during which she was managed conservatively. During one episode, she had noticed pruritus and darkening of urine as well, which again resolved spontaneously. She had undergone an upper GI endoscopy 1 year earlier which did not provide a positive finding. She had a past history of rectal polypectomy, at the age of 16 years, when she was investigated for painless per rectal bleeding, the histology of which was consistent with a tubular adenoma. Follow-up colonoscopies had not detected any further polyps.
On examination, she had a body mass index of 20.3 kg/m2. She had a few scratch marks on her trunk and upper limbs confirming pruritus. She was not icteric or febrile. An abdominal examination was unremarkable and her gall bladder was not palpable. Succussion splash was not elicited. There was no mucocutaneous pigmentation.
Our patient became completely asymptomatic following surgery. She is followed up in general surgical clinic and is scheduled for routine upper GI endoscopy surveillance every 3 years.
A non-ampullary duodenal polyp is a rare cause of biliary obstruction [3–6]. In several case reports juxta-ampullary polyps have caused both biliary and duodenal obstruction due to their large size [3–5]. Gentile et al. have reported a case of ampullary distortion following open duodenal polypectomy, as the culprit for biliary obstruction . Duodenal intussusception due to Peutz–Jeghers polyposis has also been reported [3, 6]. However, to the best of our knowledge a case of a Peutz–Jeghers polyp causing duodenal intussusception resulting in both duodenal and biliary obstruction at the same time has not been reported. In our patient, the ampulla was distorted by the pull from the intussusceptum. The pull on the ampulla was so marked that the lower half of her CBD was found on the left side of the midline in a CT scan.
PJS is diagnosed if two out of the three diagnostic criteria (family history, mucocutaneous pigmentation, and intestinal hamartomatosis with typical Peutz–Jeghers-type histology) are fulfilled. In cases in which patients had a Peutz–Jeghers polyp that caused biliary obstruction, the patients had been diagnosed as having PJS [3–6]. Our patient did not have any of the other features for the diagnosis of PJS [7, 8]. STK11 gene testing which can be done to confirm PJS in complement with previous criteria is not available in Sri Lanka [9, 10]. Thus, this lesion was considered a sporadic Peutz–Jeghers polyp.
An initial upper GI endoscopy of our patient did not detect any abnormality. This was probably because the lesion originated beyond the ampulla of Vater and the main bulk of the polyp was in the proximal jejunum as the lead point of the intussusception. Since upper GI endoscopies are commonly carried out only up to the second part of duodenum, evidence of polyps can be missed. This necessitated a CT enterogram to detect the exact abnormality.
Treatment options adopted previously for similar cases were open polypectomy , limited duodenectomy , Whipple procedure , and endoscopic resection . Data on the safety and efficacy of endoscopic resection of duodenal polyps are sparse . The size of successfully resected polyps from a reported case series is only 15.1 ± 5.1 mm . Because our patient had an intussusception in addition to the polyp this option was not considered.
Patients with PJS have a risk of GI malignancy and so do patients with sporadic Peutz–Jeghers polyps. Guidelines are available for the surveillance of patients with PJS, but not for patients with sporadic polyps. Our patient is scheduled for follow-up upper GI endoscopy every 3 years according to the guidelines for PJS .
New onset obstructive jaundice is not common in young individuals in the absence of gallstones. When such symptoms are associated with features of upper intestinal obstruction, early CT/MR imaging would help to localize a structural anomaly. As there are no specific guidelines available to manage sporadic foregut polyps each case requires tailor-made management.
ALP, alkaline phosphatase; CBD, common bile duct; CT, computed tomography; GI, gastrointestinal; MRCP, magnetic resonance cholangiopancreatogram; PJS, Peutz–Jeghers syndrome
The authors wish to acknowledge Dr H. Nagenthiram and Dr D. A. Herath for taking photographs of specimens, providing images, and processing figures.
WSLD followed up the patient, compiled the patient details, and wrote the manuscript. AAP, BDG, DSM, JB, and WSLD were involved in the surgery and the decision making in patient management. UK reported on the histology of the specimen. AAP and BJ revised and restructured the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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