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Emphysematous cystitis presenting as severe confusion and abdominal pain: two case reports
© De Coninck and Michielsen; licensee BioMed Central. 2015
Received: 11 August 2014
Accepted: 20 January 2015
Published: 7 March 2015
Emphysematous cystitis is a very rare complicated urinary tract infection characterized by air in the bladder wall.
We report two clinical cases of emphysematous cystitis of an 83-year-old Caucasian woman with diabetes mellitus and a 78-year-old Caucasian man with no past medical history. They presented with severe confusion and abdominal distension. Emphysematous cystitis was diagnosed in time with a thorough physical examination, urine analysis and computed tomography. The patients were successfully treated with antibiotic therapy and bladder drainage.
This rare disorder should be recognized in time and treated properly to guarantee survival.
KeywordsComputed tomography Diabetes mellitus Emphysematous cystitis Pneumaturia Urinary tract infection
Emphysematous cystitis is a very rare urinary tract infection. Two cases presenting as severe confusion and abdominal pain are described. Patients should be diagnosed in time by performing a thorough physical examination and selecting accurate diagnostic tests.
An 83-year-old Caucasian woman was referred by her general practitioner to our emergency department due to agitation and hallucination. Because of pyuria and haematuria on dipsticks, the general practitioner started ciprofloxacin 5 days earlier.
She had a medical history of Parkinson disease, atrial flutter, rheumatoid arthritis and diabetes mellitus.
A physical examination revealed severe confusion, dehydration, abdominal distension and suprapubic tenderness.
Blood analysis revealed prerenal acute kidney failure (creatinine 2.24mg/dL, urea 98mg/dL), signs of infection (C-reactive protein 30mg/dL, serum white blood count 17200/mm3) and a well-controlled glycaemia (glycated haemoglobin, A1c, 48mmol/mol).
Urine analysis disclosed leukocyturia, bacteriuria and 540 red blood cells per field.
Parenteral ciprofloxacin was continued and a 16 Fr Foley catheter was inserted for optimal drainage. After catheterization, pneumaturia was observed.
After 3 days, Escherichia coli resistant to ciprofloxacin but sensitive to temocillin was cultured at more than 1×106 colony-forming units/mL, so intravenous antibiotics were switched to the latter.
Intravenous ciprofloxacin was started and a bladder catheter was replaced. After catheterization, pneumaturia was not observed. After 3 days, more than 1×106 colony-forming units/mL E. coli sensitive to ciprofloxacin was cultured. His abdominal pain and confusion disappeared after 2 days. After 1 week of treatment with antibiotics and bladder catheterization, his bladder wall returned to normal on computed tomography scanning of his abdomen.
Emphysematous cystitis is a rare disorder characterized by air in the bladder wall and lumen. The triggers and cellular mechanisms of this complicated urinary tract infection are unclear. Gas in the bladder wall is probably produced by natural fermentation of glucose by bacteria.
Older women with uncontrolled diabetes are at highest risk of developing emphysematous cystitis. A 2:1 female to male predominance is noticed and two-thirds of reported cases are diabetics. However, this complicated urinary tract infection should not be overlooked in non-diabetic male patients as presented in the second case. Other risk factors comprise urinary tract obstruction, indwelling urinary catheters, chronic urinary tract infections, neurogenic bladder or immunosuppression .
Presentation can vary from asymptomatic to severe sepsis. More than half of patients present with abdominal pain, classic symptoms of acute cystitis and pneumaturia. Although pneumaturia appears to be a highly specific symptom, it is a rare patient complaint . However, pneumaturia was observed after bladder catheterization in the first case. Both patients presented with severe confusion. This atypical symptom should always be further investigated as it can be the only sign of severe illness.
Urine analyses and Gram staining are essential in managing patients with cystitis emphysematosa. Laboratory testing usually reveals positive urine cultures with E. coli or Klebsiella pneumoniae involving 80% of cases . In the first case accurate treatment was delayed because of E. coli resistance to ciprofloxacin.
The severity and extent of emphysematous cystitis is best defined by computed tomography. Because of the increased use of computed tomography, emphysematous cystitis is often incidentally diagnosed. Images are characterized by multiple gas foci in a diffuse collection of gas within the thickened bladder wall.
When performing ultrasonography or plain films of the abdomen, air surrounding the bladder can be seen in most cases.
Cystoscopy may show submucosal emphysema and can be suggestive for bladder outlet obstruction.
The impeded flow from the bladder to the urethra can be confirmed by uroflowmetry.
Cystography can show irregular thickening of the bladder wall, representing submucosal blebs of air. Furthermore, it is the most sensitive imaging modality to exclude other causes of pneumaturia like enterovesical fistula .
In most cases, this gas-forming infection can be treated with antibiotics and bladder catheterization for optimal drainage. Of course, underlying medical conditions and glycaemic levels in diabetics should be controlled as well. In case of haematuria that includes blood clots or necrotizing tissue, bladder irrigation or transurethral debridement might be necessary. Emphysematous cystitis seldom requires (partial) cystectomy .
If not diagnosed in time, cystitis emphysematosa may result in urosepticaemia and even in death in up to 7% of patients .
Written informed consent was obtained from the patients for publication of this case report and accompanying images. A copy of the written consents is available for review by the Editor-in-Chief of this journal.
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