This article has Open Peer Review reports available.
Hybrid video-assisted thoracoscopic surgery lobectomy of fissureless congenital cystic adenomatoid malformation: a case report
© Nakata et al.; licensee BioMed Central. 2015
Received: 18 September 2014
Accepted: 10 December 2014
Published: 5 February 2015
Thoracoscopic lobectomy for congenital pulmonary airway malformation has been indicated from the neonatal period to adolescence. However, it is difficult to approach the pulmonary artery for lobectomy in congenital lung malformations with incomplete or absent interlobar fissures. Multidetector computed tomographic images and computed tomography pulmonary angiography gave us helpful information before the operation. We performed thoracoscopic lobectomy for congenital pulmonary airway malformations with absent interlobar fissures and adhesions in accordance with information from multidetector computed tomographic images.
A 14-year-old Japanese girl received a diagnosis of congenital pulmonary airway malformation when she presented with pneumonia. Using multidetector computed tomography and three-dimensional reconstruction provides meticulous characterization of the anatomy in pediatric patients. We confirmed that her left A4+5 artery arose from her left pulmonary artery medial to A6. Her left pulmonary artery was divided just proximal to the A6 origin before the lobes were separated safely. We took advantage of using a stapler to divide the fissureless thick parenchyma. Perioperative diagnosis was congenital cystic adenomatoid malformation.
We used preoperative multidetector computed tomography to outline the bronchovascular anatomy and guide hybrid video-assisted thoracoscopic surgery for a congenital cystic adenomatoid malformation in a fissureless left lung.
Congenital pulmonary airway malformation (CPAM) has been historically diagnosed in a broad range of age groups, from the prenatal period to adulthood. The spectrum of CPAM requiring surgery includes congenital cystic adenomatoid malformation (CCAM), intra- and extrapulmonary sequestration, and symptomatic congenital lobar emphysema. The indications for surgery of asymptomatic CPAM are controversial . The risk of infection in the first 3 months after birth is low. Stanton et al. reported that asymptomatic antenatally diagnosed infants developed symptoms at a median age of 6.9 months (range, 2 to 10 months) . Pelizzo et al. reported chronic inflammation in 50% of asymptomatic CPAMs resected at 3 months of age . This suggests that lobectomy in neonates or infants is desirable, even in asymptomatic cases. Although there are still few reports of thoracoscopic lobectomy in children, thoracoscopic lobectomy for CPAM has been indicated from the neonatal period to adolescence [4–6]. However, adhesions and incomplete or absent interlobar fissures make thoracoscopic surgery difficult, even in adults .
In this paper, we describe using multidetector computed tomography (MDCT) three-dimensional reconstructions to guide a hybrid video-assisted thoracoscopic surgery (VATS) lobectomy safely in a patient with absence of the interlobar fissure, and provide a brief review of the existing literature.
A 14-year-old Japanese girl received a diagnosis of CPAM when she presented with pneumonia. Volumetric thin-section high-resolution computed tomography (CT) revealed almost complete absence of the left interlobar fissure (Figure 1). A lesion was detected in the basal segment of her left lower lobe, consisting of multiple cysts but no abnormal vessels. The preoperative diagnosis was CCAM.
CT pulmonary angiography with three-dimensional reconstructions of her pulmonary vessels was performed. Images were acquired using a 16-slice scanner (LightSpeed Ultra; GE Healthcare, Milwaukee WI, USA). Iohexol (400mg I/kg of contrast medium, to a maximum of 100mL) was injected intravenously at a rate of 2mL/second. Images revealed her left lingual artery to be the first branch of her left main pulmonary artery, which is the so-called mediastinal lingual artery (Figure 2).
Thoracoscopic lobectomy for CPAMs in pediatric patients is practical and safe. Patients are generally pleased with the cosmetic result. The good view of the hilar area ensures less blood loss. Nasr and Bass reported that there was no significant difference between thoracoscopic and open procedures in the rate of overall complications and the duration of surgery by meta-analysis . Our operation was hampered by adhesions (probably due to previous infections)  and an atretic interlobar fissure.
In the case of incomplete interlobar fissures or fused fissures it is difficult to determine the arterial anatomy, and forcible division of fused fissures risks vessel injury and prolonged air leakage .
We selected hybrid VATS. A minithoracotomy combined with video assist performed predominantly via direct visualization was a secure, integrated, minimally invasive approach to the large fused fissure and the severe adhesion .
Preoperative imaging studies are essential for assessing not only the congenital lung disease but also the anatomy of vessels, bronchi, and fissures. Using MDCT and three-dimensional reconstruction provides meticulous characterization of the anatomy in pediatric patients. According to Lee et al., types and location of congenital lung disease and anomalous vessels associated with congenital lung anomalies were detected with high accuracy . In our case, we knew that the left A4+5 artery was the mediastinal lingual artery and the left pulmonary artery was divided just proximal to the A6 origin before the fissures were separated.
During the operation it may be necessary to produce a fissural separation. Inadvertent separation results in prolonged air leakage. It has been reported that the use of various devices, such as staplers, bipolar thermofusion, biodegradable sealant, and ultrasonically activated scalpels  can prevent prolonged air leakage. Automatic stapling devices have been often used for interlobar fissure division for pulmonary lobectomy. Thomas et al. explained how to use staplers safely to divide fissures . Using staplers is helpful in dividing thick parenchyma with no fissure. Nomori et al. reported that there was no postoperative air leakage in the patients after lobectomy with large fused fissures divided by staplers. They defined the steps of the procedures according to each lobectomy . Thomas et al. introduced the technique of dividing the parenchyma with staplers to expose the pulmonary arteries .
In neonates and infants the operative field is too small to use a stapler. Albanese et al. recommended bipolar electrocoagulation (LigaSure™ Covidien, Mansfield MA, USA) for sealing pulmonary vessels and dividing fissures during lobectomy in infants. In their series, they used this on both arteries and veins less than 7mm in diameter because of the low pressure pulmonary circulation in small children . Santini et al. assessed the efficacy and safety of bipolar electrocoagulation in experimental studies with animals and humans; they found it was useful in dividing fissures . Kaneko et al. suggested that bipolar electrocoagulation seemed to have a weaker sealing effect under wet conditions, and there was an increased risk of hemorrhage .
In summary, we reported hybrid video-assisted thoracoscopic surgical lobectomy of fissureless CCAM for a 14-year-old girl. Thoracoscopic lobectomy for CPAM has been indicated from the neonatal period to adolescence. However, it is difficult to approach the pulmonary artery for lobectomy in congenital lung malformations with incomplete or absent interlobar fissures. MDCT and CT pulmonary angiography gave us helpful information before the operation. We confirmed that her mediastinal lingual artery arose medial to A6. Her left pulmonary artery was divided just proximal to the A6 origin before the lobes were separated safely. We took advantage of using a stapler to divide the fissureless thick parenchyma. We performed safely hybrid VATS lobectomy on an essentially fissureless lung using staplers, guided by preoperative MDCT and CT pulmonary angiography.
Written informed consent was obtained from the patient’s parent for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The authors have no disclosures to make and have had no source of funding in the preparation of this manuscript. We would like to thank Dr Shigetoshi Yoshida for his technical support.
- Laje P, Liechty KW: Postnatal management and outcome of prenatally diagnosed lung lesions.Prenat Diagn 2008, 28:612–8. 10.1002/pd.1966View ArticlePubMedGoogle Scholar
- Stanton M, Njere I, Ade-Ajayi N, Patel S, Davenport M: Systematic review and meta-analysis of the postnatal management of congenital cystic lung lesions.J Pediatr Surg 2009, 44:1027–33. 10.1016/j.jpedsurg.2008.10.118View ArticlePubMedGoogle Scholar
- Pelizzo G, Barbi E, Codrich D, Lembo MA, Zennaro F, Bussani R, Schleef J: Chronic inflammation in congenital cystic adenomatoid malformations. An underestimated risk factor?J Pediatr Surg 2009, 44:616–9. 10.1016/j.jpedsurg.2008.10.064View ArticlePubMedGoogle Scholar
- Vu LT, Farmer DL, Nobuhara KK, Miniati D, Lee H: Thoracoscopic versus open resection for congenital cystic adenomatoid malformations of the lung.J Pediatr Surg 2007, 43:35–9.View ArticleGoogle Scholar
- Sundararajan L, Parikh DH: Evolving experience with video-assisted thoracic surgery in congenital cystic lung lesions in a British pediatric center.J Pediatr Surg 2007, 42:1243–50. 10.1016/j.jpedsurg.2007.02.016View ArticlePubMedGoogle Scholar
- Garrett-Cox R, MacKinlay G, Munro F, Aslam A: Early experience of pediatric thoracoscopic lobectomy in the UK.J Laparoendosc Adv Surg Tech A 2008, 18:457–9. 10.1089/lap.2007.0038View ArticlePubMedGoogle Scholar
- Nomori H, Ohtsuka T, Horio H, Naruke T, Suematsu K: Thoracoscopic lobectomy for lung cancer with a largely fused fissure.Chest 2003, 123:619–22. 10.1378/chest.123.2.619View ArticlePubMedGoogle Scholar
- Nasr A, Bass J: Thoracoscopic vs open resection of congenital lung lesions: a meta-analysis.J Pediatr Surg 2012, 47:857–61. 10.1016/j.jpedsurg.2012.01.036View ArticlePubMedGoogle Scholar
- Abel G-C, Maria Jose Roca C, Juan Torres L, Ryan C, Pedro C, Pascual P: The approach of fused fissures with fissureless technique decreases the incidence of persistent air leak after lobectomy.Eur J Cardio-thorac Surg 2007, 31:203–8. 10.1016/j.ejcts.2006.11.030View ArticleGoogle Scholar
- Okada M, Sakamoto T, Yuki T, Mimura T, Miyoshi K, Tsubota N: Hybrid surgical approach of video-assisted minithoracotomy for lung cancer: significance of direct visualization on quality of surgery.Chest 2005, 128:2696–701. 10.1378/chest.128.4.2696View ArticlePubMedGoogle Scholar
- Lee EY, Tracy DA, Mahmood SA, Weldon CB, David Z, Boiselle PM: Preoperative MDCT evaluation of congenital lung anomalies in children: comparison of axial, multiplanar, and 3D images.Am J Roentgenol 2011, 196:1040–6. 10.2214/AJR.10.5357View ArticleGoogle Scholar
- Droghetti A, Schiavini A, Muriana P, Folloni A, Picarone M, Bonadiman C, Sturani C, Paladini R, Muriana G: A prospective randomized trial comparing completion technique of fissures for lobectomy: stapler versus precision dissection and sealant.J Thorac Cardiovasc Surg 2008, 136:383–91. 10.1016/j.jtcvs.2008.04.014View ArticlePubMedGoogle Scholar
- Thomas Temes R, Willms CD, Endara SA, Wernly JA: Fissureless lobectomy.Ann Thorac Surg 1998, 65:282–4. 10.1016/S0003-4975(97)01268-XView ArticleGoogle Scholar
- Albanese CT, Sydorak RM, Tsao KJ, Lee H: Thoracoscopic lobectomy for prenatally diagnosed lung lesions.J Pediatr Surg 2003, 38:553–5. 10.1053/jpsu.2003.50120View ArticlePubMedGoogle Scholar
- Santini M, Vicidomini G, Baldi A, Gallo G, Laperuta P, Busiello L, Marino MPD, Pastore V: Use of an electrothermal bipolar tissue sealing system in lung surgery.Eur J Cardiothorac Surg 2006, 29:226–30. 10.1016/j.ejcts.2005.11.017View ArticlePubMedGoogle Scholar
- Kaneko K, Ono Y, Tainaka T, Sumida W, Kawai Y, Ando H: Thoracoscopic lobectomy for congenital cystic lung diseases in neonates and small infants.Pediatr Surg Int 2010, 26:361–5. 10.1007/s00383-010-2556-yView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.