Chikungunya fever is a mosquito-borne illness of humans caused by the chikungunya virus, a type of alphavirus. Aedes aegypti and Aedes albopictus mosquitoes are the main vectors of chikungunya in Asia and the Indian Ocean islands. The virus was first reported in 1952 in Tanzania. Since then it has been attributed to many outbreaks in a number of countries. The virus is geographically distributed in Africa, Southeast Asia and India. Sporadic cases are regularly reported from different countries in the affected regions [1]. During December 2008, an investigation team from the Institute of Epidemiology, Disease Control and Research (IEDCR) and International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) investigated the first outbreak of chikungunya fever in the Rajshahi and Chapianawabganj districts of Bangladesh [2], which was in fact the third outbreak [3] in the whole of Bangladesh. We identified six cases of chikungunya fever in the last year.

The name chikungunya is derived from a local language of Tanzania meaning "that which bends up" or "stooped walk" because of the incapacitating arthralgia caused by the disease. Multiple outbreaks beyond West Africa have been described. Since 2004 chikungunya has spread widely, causing massive outbreaks with explosive onset in the Indian Ocean region, India and other parts of Asia [4, 5]. The first outbreak in Bangladesh was observed in December 2008 when 32 cases were identified [3]. Since then sporadic cases were reported from different parts of Bangladesh. Our case series is an example of sporadic chikungunya infection.

The most significant manifestation of chikungunya fever is the severe joint pain occurring in virtually every clinical case [6]. In our cases, we observed the same manifestation. The arthralgia is most commonly symmetrical and peripheral, being noted in the small joints of the hands and other large joints. The joints exhibit extreme tenderness and swelling with patients frequently reporting incapacitating pain that lasts for weeks to months. Most infections completely resolve within weeks or months but there have been documented cases of chikungunya fever-induced arthralgia persisting for several years [7]. In our case series only two patients had residual joint pain for two to three months after recovering from the initial infection.

The symptoms of infection are quite similar to those caused by many other infectious agents in the endemic areas. One particular difficulty in identifying infection is its overlapping distribution with dengue virus. It has been postulated that many cases of dengue virus infection are misdiagnosed and in practice the incidence of chikungunya infection is much higher than reported [8]. Diagnosis of chikungunya is based on two cardinal signs in the acute phase; fever and arthralgia has a specificity of 99.6% and positive predictive value of 84.6% [9]. However, as the clinical manifestations of chikungunya fever resemble those of dengue and other fevers caused by arthropod-borne viruses, confirmation of chikungunya fever should be based on: isolation of the virus, molecular methods, detection of IgM antibody, and demonstration of a rising titer of the IgG antibody [10]. In Bangladesh, only detection of IgM Ab is so far possible in Dhaka city. We confirmed our diagnosis by detecting IgM Ab against chikungunya virus. A specific antiviral agent or vaccine against chikungunya was not available till now. Treatment is supportive, involving rest, proper diet, movement and mild exercise. Combinations with mild pain relief medication, such as naproxen, ibuprofen, acetaminophen or paracetamol, may relieve the fever and aches. Re-evaluation and closer monitoring are advised in chronic ailments. Chikungunya virus infection provides immunity against the disease [11].

Chikungunya fever is not uncommon in Bangladesh as evidenced by this short case series. Most of the cases remain undiagnosed or misdiagnosed due to lack of awareness and diagnostic facilities, the self-limiting nature of the disease and, most importantly, the prevalence of another arthropod-borne disease, dengue fever, in Bangladesh. Clinically, it can be distinguished from dengue fever but laboratory diagnosis is a prerequisite for confirmation.

Written informed consents were obtained from our patients for publication of this case report. Copies of the written consents are available for review by the Editor-in-Chief of this journal.