This article has Open Peer Review reports available.
Gastric adenomyoma in the stomach body: a case report
© Yoon et al.; licensee BioMed Central Ltd. 2014
Received: 12 August 2014
Accepted: 23 September 2014
Published: 24 November 2014
Gastric adenomyoma is a rare benign tumor, known to occur in the antrum or pylorus of the stomach. To the best of our knowledge, this is the first case reported in the literature of a gastric adenomyoma in the stomach body, but not in the antrum.
We report the case of a 79-year-old Korean woman with a gastric subepithelial lesion in the stomach body. The lesion was observed via endoscopy as a bulging mass in the stomach body with a cystic center. It was confirmed via endoscopic ultrasonography. A laparoscopic wedge resection was performed. A biopsy revealed epithelial and smooth muscle proliferation, and a final diagnosis of gastric adenomyoma was made.
Gastric adenomyoma can occur in the stomach body and can be treated completely with surgery.
According to the World Health Organization’s histopathologic classification, gastric adenomyoma is a benign tumor of the stomach characterized by a smooth muscle stroma in the glandular structures of the cuboidal epithelium or columnar epithelium . Magnus-Alsleben first reported this disease in 1903 . Although gastric adenomyoma occurs most frequently in the gallbladder, a few cases in the stomach have been reported. Of the cases in the stomach, 85% occurred in the antrum and 15% occurred in the pylorus . Furthermore, even though some patients may experience non-specific gastrointestinal symptoms such as epigastric pain or vomiting, most cases are asymptomatic [4, 5]. In this report, we describe the case of a patient with a gastric subepithelial lesion in the stomach body that was discovered via endoscopic examination and diagnosed as a gastric adenomyoma. We also present a review of the related literature.
The patient did not develop any noticeable complications following the operation. Oral intake was initiated on the third post-operative day, and the patient was discharged from the hospital on the sixth post-operative day. Currently, the patient’s progress is being monitored in the outpatient clinic.
An adenomyoma is a lesion with observed epithelial and smooth muscle proliferation [1, 6]. The epithelial origin observed in adenomyomas is unclear, but it is thought that embryonic epithelial buds remaining after birth can develop into undifferentiated glandular structures, mature pancreatic tissues, or duodenal tissues depending on the stage of differentiation. Smooth muscle is thought to accompany the embryonic muscle bud during its separation from the epithelial tissue or to be normal muscle tissue created from proliferating mislocated epithelium consequent to stimulation .
The average size of an adenomyoma ranges from 0.6cm to 4.5cm, and these lesions are usually found on the submucosa and sometimes on the muscle layer. This disease can affect patients from 8 months to 82 years of age, and more men are affected than women, albeit this difference is not statistically significant [8, 9]. Although gastric adenomyomas can occur anywhere in the gastrointestinal tract, they are most commonly found in the fundus of the gallbladder; most cases in the stomach occur near the antrum or the pylorus . However, in our patient, the lesion was found in the proximal body of the stomach.
Chu described the characteristics of a gastric adenomyoma observed by EUS . However, the pre-surgical diagnosis of this disease remains difficult. In our patient, EUS revealed that the lesion originated from the submucosal layer and contained a cystic center, thus coinciding with previously reported findings . However, because the lesion was located in the proximal body and its cystic center suggested necrotic changes and malignancy, a decision for surgical treatment was made .
As previously mentioned, although gastric adenomyomas are characterized as benign tumors, there have been reported cases in which these tumors were found alongside adenocarcinomas. Chapple and colleagues were first to report a case of an adenomyoma observed with adenocarcinoma . Kanehira and colleagues reported a case of an associated adenomyoma with a superficial adenocarcinoma centered in an adenomyoma . Zhu and colleagues demonstrated that frozen sections are useful for intraoperative diagnosis and avoiding unnecessarily extensive surgeries . In our patient, the gastric adenomyoma was confirmed by examining a frozen section taken during the operation, followed by wedge resection of the lesion. The patient’s progress has been observed for 26 months after surgery without any apparent symptoms of recurrence.
We report that gastric adenomyoma is a very rare disease with differential malignant characteristics that can be observed using EUS. In our patient, we observed that this disease can occur in the stomach body and can be successfully treated with wedge resection of the lesion without a requirement for extensive surgery.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
We thank Man Hoon Han, MD for his thoughtful insight into the pathology of adenomyoma.
- Ulich TR, Kollin M, Simmons GE, Wilczynski SP, Waxman K: Adenomyoma of the papilla of Vater. Arch Pathol Lab Med. 1987, 111: 388-390.PubMedGoogle Scholar
- Magnus-Alsleben E: Adenomyome des pylorus. Virchows Arch. 1903, 173: 137-155. 10.1007/BF01947878.View ArticleGoogle Scholar
- Chapple CR, Muller S, Newman J: Gastric adenocarcinoma associated with adenomyoma of the stomach. Postgrad Med J. 1988, 64: 801-803. 10.1136/pgmj.64.756.801.View ArticlePubMedPubMed CentralGoogle Scholar
- Takahashi Y, Fukushima J, Fukusato T, Mori S: Adenomyoma with goblet and Paneth cells of the ileum. Pathol Res Pract. 2006, 202: 549-553. 10.1016/j.prp.2006.03.001.View ArticlePubMedGoogle Scholar
- Al-Zahem A, Arbuckle S, Cohen R: Combined ileal heterotopic pancreatic and gastric tissues causing ileocolic intussusceptions in an infant. Pediatr Surg Int. 2006, 22: 297-299. 10.1007/s00383-005-1566-7.View ArticlePubMedGoogle Scholar
- Handra-Luca A, Terris B, Couvelard A, Bonte H, Flejou JF: Adenomyoma and adenomyomatous hyperplasia of the Vaterian system: clinical, pathological, and new immunohistochemical features of 13 cases. Mod Pathol. 2003, 16: 530-536. 10.1097/01.MP.0000073525.71096.8F.View ArticlePubMedGoogle Scholar
- Chung KW, Sun HS, Park SH, Kim JK, Kim JI, Park JH, Kim YJ, Kim HK, Na JS, Han JY: A case of adenomyoma of duodenum. Korean J Gastrointest Endosc. 1997, 17: 200-203.Google Scholar
- Lee JS, Kim HS, Jung JJ, Kim YB: Adenomyoma of the small intestine in an adult: a rare cause of intussusception. J Gastroenterol. 2002, 37: 556-559. 10.1007/s005350200086.View ArticlePubMedGoogle Scholar
- Park HS, Lee SO, Lee JM, Kang MJ, Lee DG, Chung MJ: Adenomyoma of the small intestine: report of two cases and review of the literature. Pathol Int. 2003, 53: 111-114. 10.1046/j.1440-1827.2003.01435.x.View ArticlePubMedGoogle Scholar
- Chu KM: Endosonographic appearance of gastric adenomyoma. Endoscopy. 2002, 34: 682-10.1055/s-2002-33248.View ArticleGoogle Scholar
- Palazzo L, Landi B, Cellier C, Cuillerier E, Roseau G, Barbier JP: Endosonographic features predictive of benign and malignant gastrointestinal stromal cell tumours. Gut. 2000, 46: 88-92. 10.1136/gut.46.1.88.View ArticlePubMedPubMed CentralGoogle Scholar
- Kanehira E, Kawaura Y, Ohta Y, Tanaka I, Kawada N, Nonomura A: Adenomyoma in association with early gastric carcinoma. Gan No Rinsho. 1990, 36: 2475-2479.PubMedGoogle Scholar
- Zhu HN, Yu JP, Luo J, Jiang YH, Li JQ, Sun WY: Gastric adenomyoma presenting as melena: a case report and literature review. World J Gastroenterol. 2010, 16: 1934-1936. 10.3748/wjg.v16.i15.1934.View ArticlePubMedPubMed CentralGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.