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Unusual symptomatic inclusion cysts in a newborn: a case report
© Marini et al.; licensee BioMed Central Ltd. 2014
Received: 12 March 2014
Accepted: 30 July 2014
Published: 21 September 2014
Dental lamina cysts are cysts that occur as white or pink small nodules, often multiple, approximately 1 to 3mm in diameter. They are typically located on the midpalatine raphe and less frequently on the maxillary and mandibular alveolar mucosa; in the latter case these can be appear to be neonatal teeth.
On microscopic examination, these lesions show a stratified squamous epithelium (two to three cell layers); it is possible to find protein, keratin and/or exfoliated epithelial cells in the lumen of the lesions.
Neonatal cysts usually show no particular symptoms. They are associated with an excellent prognosis because they regress spontaneously within a few weeks and are not associated to any complications. However, if pain, bleeding or other symptoms occur, a surgical excision is required.
In this paper, we present an anomalous case of symptomatic dental lamina cyst which affected a 60-day-old male Caucasian newborn. The surgical treatment was elective in this case and 6-month follow-ups were mandatory.
We can underline the successful predictability of the surgical approach; however, we consider that the treatment choice should take place in the light of medical history and clinical considerations, and always be evaluated on a case-by-case basis. Further studies and reviews in this field should be performed in order to suggest guidelines for clinicians, although these cases are rare.
In 1967, according to histogenesis and location in the oral cavity, Fromm classified oral cysts as Epstein’s pearls, Bohn’s nodules and dental lamina cysts. This classification was based on their location and histology: all neonatal cysts are keratin-filled nodules but Epstein’s pearls are predominantly located along the midpalatine raphe and probably derive from residual epithelial cells arising from embryonic palatine processes. Bohn’s nodules derive from palatal salivary glands’ structures and their most common site is the palate. Dental lamina cysts occur as white or pink small nodules, often multiple, approximately 1 to 3mm in diameter. Dental lamina cysts are typically located on the midpalatine raphe and less frequently on the maxillary and mandibular alveolar mucosa; in the latter case these can appear to be neonatal teeth. It is probable that these lesions originate from remnants of the dental lamina.
This case report describes the unusual clinical presentation and management of multiple oral cysts in a newborn baby.
A surgical removal of the lesions was planned in order to solve feeding problems and bleeding.
The dental lamina cyst, also known as gingival cyst of newborn, is considered a true cyst because it is lined by thin epithelium with a lumen usually filled with desquamated keratin and occasionally inflammatory cells[6, 7]. These cysts can easily be wrongly diagnosed as natal teeth, especially if they are located in the newborn’s mandibular anterior ridge. They typically appear as multiple nodules along the alveolar ridge in babies. It is believed that fragments of dental lamina remain within the alveolar ridge mucosa after tooth formation and then proliferate to develop these small, keratinized cysts. However, many of them degenerate, reduce in size or are broken spontaneously in the oral cavity within 2 weeks to 5 months of postnatal life[8–11].
It is more difficult to elucidate the method of their disappearance. In a study of 32 human fetal heads from 8 to 22 weeks of fetal age, not more than 20 midpalatal raphe cysts were found in any fetus by week 14, and they did not increase in frequency with time. The authors suggested that as the cysts developed, the epithelium differentiated, fused with the oral epithelium and the contents discharged. Some cysts may produce keratin, enlarge, extend to the surface and rupture during the first few months after birth[12–14].
As regards the prevalence of oral cysts in newborns, George et al. in a study of 1038 newborn Indian babies, found that gingival cysts were present in 143 neonates (13.8%): 112 (10.8%) on the alveolar region, 19 (1.8%) palatally and 12 (1.2%) on both regions; moreover, in 5 cases, gingival cysts were present on the mandibular ridge. Epstein’s pearls were present in 365 newborn (35.2%), and were located in the midline within the median raphae of the hard palate in the maxilla. Bohn’s nodules were present in 492 newborn (47.4%), which were located at the junction of the hard and soft palate, adjacent to the midpalatal raphae. Fromm reported cysts in 75.9% of 1367 neonates less than 48-hours old and Cataldo and Berkman, in a study of 209 neonates between 1 and 5 days of age, reported that the most common location for the cysts was along the median palatal raphe (65.1%) and the least common site was the mandibular alveolar mucosa (9.9%). Jorgensen et al. found palatal cysts in 73% of 596 White children in the USA and alveolar cysts in 53.5%. Cetinkaya et al., through an oral examination of 2021 newborn Turkish children, registered that palatally located oral mucosal cysts were the most common findings (29%).
Whereas some authors reported a female predilection[10, 15], others found no gender differences. Moreover, in some surveys[7, 11, 15] an increased incidence has been noticed in Caucasian as opposed to Negro children; our patient was a Caucasian newborn.
Donley and Nelson demonstrated that oral cysts are correlated with gestational age and weight at birth. They are less frequent in preterm newborns or those with weight at birth of less than 2500g. A greater frequency of submucous cysts with less clinical prevalence or greater difficulty in clinical exploration of preterm infants could explain these differences. Our patient was a full-term baby with weight at birth of 2900g.
The particularity of this case is due to two unusual features that occur in this patient: the presence of symptoms and the different onset time of the lesions. In fact, all the cysts showed spontaneous bleeding and tenderness to palpation. In addition, during the first observation only the mandibular cysts were present; after 30 days the maxillary lesion also appeared.
The treatment options have been: no treatment and follow up, marsupialization or surgical extraction. In this case the surgical treatment was mandatory because of the inability of the baby to feed properly.
The role of histopathology in establishing the final diagnosis is not essential because the treatment was required by the symptomatology of the newborn; however, it is important to prevent any misdiagnosis, such as hemangioma, melanoma, unicystic ameloblastoma, keratinizing cystic odontogenic tumor and mucocele[16–18].
Inclusion cysts may be associated to natal or neonatal teeth like in this case. When natal or neonatal teeth interfere with feeding, have high mobility, and/or are poorly developed, there is the indication to remove them.
The present case of inclusion cysts was successfully managed by the surgical excision of the lesions and the extraction of the neonatal tooth, in order to promote the baby’s natural breastfeeding, without hurting his mother. The parents were well informed about the pathology and its implications. After surgery, both the child and his mother had no complications during feeding; normal eruption of primary teeth occurred by the 6th month. Although for this patient surgical excision of the lesions was the ideal approach, in our opinion the treatment choice must be carefully evaluated on a case-by-case basis after an adequate analysis of clinical findings. Moreover, further studies (mainly randomized controlled trials) on this topic should be performed in order to draw up guidelines for clinicians and oral surgeons, although these cases are quite rare.
Written informed consent was obtained from the patient’s parents for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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