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Acute renal failure as a form of presentation of sarcoidosis in a young adult: a case report
© Rema et al.; licensee BioMed Central Ltd. 2014
Received: 25 August 2013
Accepted: 26 June 2014
Published: 13 August 2014
Sarcoidosis is a systemic granulomatous disease. Renal involvement is a rare initial presentation of this disease. Few articles on renal involvement as an initial presentation of sarcoidosis have been published in the literature.
A 26-year-old Caucasian woman presented with acute renal failure as an initial manifestation of sarcoidosis.
Renal involvement is an uncommon feature of sarcoidosis and it is essential to establish a fast and correct diagnosis because early therapy avoids progression to terminal renal failure.
Sarcoidosis is a systemic disease caused by noncaseating granulomas in multiple organs . Its etiology is unknown . In Caucasians, the prevalence is estimated to be 20 to 50 per 100,000 people . The incidence of the disease is 16.5/100,000 and 19/100,000 in men and women, respectively . Renal manifestations of sarcoidosis include changes in calcium metabolism, nephrocalcinosis and nephrolithiasis. Some studies have shown that granulomatous tubulointerstitial nephritis is associated with acute renal failure and may lead to hemodialysis. The standard treatment is based on corticosteroids. Failure to respond to corticosteroids or relapse after withdrawal may be associated with worsening of renal failure, requiring dialysis and even kidney transplantation .
The histopathology report indicated granulomatous tubulointerstitial nephritis compatible with the diagnosis of sarcoidosis.
In terms of follow-up, she has been followed under an out-patient regimen; her hemogram and renal function remain unchanged and are associated with no alterations in physical examination despite corticosteroid weaning.
Sarcoidosis is a multisystem disease of unknown etiology; the lungs and lymph nodes are most commonly involved (30 to 60% of cases). Hypercalcemia (2 to 10%) and hypercalciuria (6 to 30%) can cause nephrocalcinosis and nephrolithiasis. The prevalence of tubulointerstitial nephritis varies between 7 and 27%, and spite of chronic renal failure develops in less than 1% of cases according to different retrospective studies . The spectrum of renal involvement in sarcoidosis includes hypercalcemia, nephrocalcinosis and interstitial granulomas . Glomerular involvement in sarcoidosis is not common, although focal segmental sclerosis, membranous glomerulonephritis, mesangioproliferative glomerulonephritis, mesangiocapillary glomerulonephritis, immunoglobulin A nephropathy, and crescentic glomerulonephritis have all been described although their mechanisms are not known. Membranous nephropathy has been most commonly reported. Enhanced production of immunoglobulins may be involved in the pathogenesis of membranous glomerulonephritis, but neither an antigen nor a specific antibody has been identified .
Sarcoidosis is not only a pulmonary or renal disease but a systemic disease that can affect any organ in the body. The most common extrapulmonary organs affected are the eye and skin. Other than the lungs, neurological and cardiac involvement must be excluded. The heart can manifest with mechanical and/or conduction defects. Central nervous system manifestations may present with cranial nerve symptoms (for example, VII, IX, X), with signs of optic chiasm involvement (for example, papilledema, blurred vision), meningeal symptoms caused by aseptic meningitis, symptoms of stroke/transient ischemic attack, and paresthesias. Patients may present with ophthalmologic or neuro-ophthalmologic findings before the systemic manifestations of sarcoidosis are seen. Ocular symptoms include uveitis and keratitis sicca. Musculoskeletal symptoms include myositis, bony lesions, and polyarthritis. Head, neck, and upper respiratory tract symptoms include dry cough, tonsillitis and epiglottitis; cardiac symptoms include cor pulmonale caused by pulmonary fibrosis, complete heart block, ventricular tachycardia most common arrhythmia, myocarditis, pericarditis, and congestive heart failure .
The mainstay of treatment is based on corticosteroids with good success rates . In this case we can discuss whether nephrolithiasis was already in the context of a possible sarcoidosis because it is a common presentation of this multisystemic disease. It was essential to exclude possible infectious causes including tuberculosis in order to start treatment with corticosteroids. On further observation after 3 weeks of steroid therapy she presented with no anemia or leucopenia, and her renal function had normalized.
Although sarcoidosis usually presents with pulmonary and lymph nodes involvement, in the emergency of a young adult woman with acute renal failure it becomes imperative to focus on the correct diagnosis because early therapy is essential to avoid progression to terminal renal failure .
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
We thank Prof. Dr Rui Medeiros for his support and suggestions. Permission for the acknowledgement was obtained from Prof. Dr Rui Medeiros.
Sources of funding
There were no sources of funding for all the authors.
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