- Case report
- Open Access
- Open Peer Review
Vulvar lipoma: a case report
© Jayi et al.; licensee BioMed Central Ltd. 2014
- Received: 16 November 2013
- Accepted: 30 April 2014
- Published: 18 June 2014
Vulvar lipoma is a rare tumor localization and only a few cases have been reported. The clinical characteristics of vulvar lipoma are well known. However, it is important to distinguish lipomas from liposarcomas. We report a case of vulvar lipoma and discuss its clinical features, including diagnostic aspects, with emphasis on histopathological evaluation of all excised lesions. We also report and discuss patient management and treatment outcomes.
We report the case of a 27-year-old Moroccan woman. Our patient presented with a painless and slow-growing right vulvar mass that had evolved over one year, which had suddenly become uncomfortable when walking. A physical examination revealed a single soft and pasty mass in her left labium majus, which could be mobilized under her skin towards her mons pubis. The largest dimension of the mass measured 6cm. Magnetic resonance imaging showed a homogenous hyperintense mass with a well-defined contour in her left labium majus; a fat-suppressed magnetic resonance image demonstrated a marked signal intensity decrease. The mass was completely removed surgically. A histological examination revealed a circumscribed benign tumor composed of mature adipocytes, confirming the diagnosis of vulvar lipoma.
Vulvar lipomas must be differentiated from liposarcomas, which demonstrate very similar clinical and imaging profiles. The final diagnosis should be based on histopathological evaluation. A precise diagnosis should allow for appropriate surgical treatment.
- Surgical excision
Lipomas are widely disseminated benign mesenchymal neoplasms commonly found over the neck and upper back, shoulders, abdomen, buttocks, and proximal portions of the extremities . Vulva localizations are rare, and very few cases have been reported [2, 3]. In this paper, we report the case of a vulvar lipoma that was diagnosed in a 27-year-old woman. We discuss the clinical features and management options of this pathology with emphasis on the histopathological evaluation of all excised lesions. A review of the literature is also presented.
Lipomas are very common benign tumors in soft tissues derived from mesenchymal cells . They have been identified in various age groups ranging from infancy to late-age decades . They usually appear between 40 and 60 years of age . Nevertheless, their precise etiology and pathogenesis not completely elucidated. Trauma seems to be implicated in some cases [1, 4]. Our patient was in her third decade of life without any history of trauma.
Lipomas usually present as single or multiple painless slowly growing and mobile swelling soft tissue with a pasty characteristic. The tumor shows ill-defined, well-demarcated, or pedunculated aspects that are not adherent to the overlying skin. These characteristics allow correct diagnosis in most cases by clinical examination [1–6]. However, vulvar lipomas have to be differentiated from liposarcomas, which are rare but have a very similar clinical profile to lipoma, including cystic swellings of Bartholin’s gland and Nuck’s canal, and inguinal hernia, especially in children [1–3].
In developing countries, ultrasound is recommended instead of expensive imaging investigation because of its availability and cost-effectiveness . Vulvar lipoma ultrasound demonstrates a non-specific homogenous echogenic mass with lobular structures consistent with fat deposition [1, 6, 7]. Computed tomography and MRI are useful for evaluating tumor extensions and anatomical connections with surrounding structures [2, 6, 7]. MRI is a supportive tool to differentiate vulvar lipomas from liposarcomas [1, 3, 8]. However, Ohguri et al. showed that septal enhancement in contrast-enhanced MRI allows the differentiation of liposarcoma ; they found moderate or marked septal enhancement in 25% and 75%, respectively, of well-differentiated liposarcomas . Therefore, soft lipomatous lesions with thin septa that are not enhanced on MRI could be diagnosed as lipoma [3, 9].
Treatment for a lipoma without excision includes steroid injection and liposuction and is common. However, complete surgical excision is the treatment of choice for vulvar lipoma . Surgery also allows for excluding any malignant tumoral evolvement via a histological study [1, 2]. Typically, a histological study shows a thin peripheral capsule surrounding a lobular proliferation of adipocytes . Recurrence is possible; short-term recurrence should draw the attention of clinicians to possible malignant tumor evolvement. Indeed, authors have reported histological diagnosis difficulties that suggested a borderline adipose tumor .
Vulvar lipomas need to be differentiated from liposarcomas, which demonstrate very similar clinical and imaging profiles. The final diagnosis should be based on histopathological evaluation. A precise diagnosis should allow for appropriate surgical treatment.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
We thank Boujraf Said (Med Sc, Ph.D, Director of the Clinical Neurosciences Laboratory, Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy, University of Fez, Morocco) who revised the written English of the manuscript.
- Odoi AT, Owusu-Bempah A, Dassah ET, Darkey DE, Quayson SE: Vulvar lipoma: is it so rare?. Ghana Med J. 2011, 45: 125-127.PubMedPubMed CentralGoogle Scholar
- Jung HL, Seung MC: Large vulvar lipoma in an adolescent: a case report. J Korean Med Sci. 2008, 23: 744-746.View ArticleGoogle Scholar
- Jourjon R, Dohan A, Brouland JP, Guerrache Y, Fazel A, Soyer P: Angiolipoma of the labia majora: MR imaging findings with histopathological correlation. Clin Imaging. 2013, 37: 965-968.View ArticlePubMedGoogle Scholar
- Aust MC, Spies M, Kall S, Gohritz A, Boorboor P, Kolokythas P, Vogt PM: Lipomas after blunt soft tissue trauma: are they real? Analysis of 31 cases. Br J Dermatol. 2007, 157 (1): 92-99.View ArticlePubMedGoogle Scholar
- Salam GA: Lipoma excision. Am Fam Physician. 2002, 65 (5): 901-904.PubMedGoogle Scholar
- Jung-T O, Seung HC, Sung GA, Myung JK, Woo IY, Seok JH: Vulvar lipomas in children: an analysis of 7 cases. J Pediatr Surg. 2009, 44: 1920-1923.View ArticleGoogle Scholar
- Ogasawara Y, Ichimiya M, Nomura S, Muto M: Perineallipoma in a neonate. J Dermatol. 2001, 28: 165-167.View ArticlePubMedGoogle Scholar
- Ohguri T, Aoki T, Hisaoka M, Watanabe H, Nakamura K, Hashimoto H, Nakamura T, Nakata H: Differential diagnosis of benign peripheral lipoma from well-differentiated liposarcoma on MR imaging: is comparison of margins and internal characteristics useful?. AJR Am J Roentgenol. 2003, 180: 1689-1694.View ArticlePubMedGoogle Scholar
- Murphey MD, Carroll JF, Flemming DJ, Pope TL, Gannon FH, Kransdorf MJ: From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 2004, 24: 1433-1466.View ArticlePubMedGoogle Scholar
- Poncelet C, Boccara J, Walker-Combrouze F, Féraud O, Madelenat P: Atypical lipomatous tumour of the vulva. About one case. Gynécol Obstét Fertil. 2004, 32: 46-48.View ArticlePubMedGoogle Scholar
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