Fractured neck of femur below long spinopelvic fixation for Charcot spine: a case report
© Quan and Wilde; licensee BioMed Central Ltd. 2013
Received: 2 April 2013
Accepted: 30 September 2013
Published: 30 December 2013
We present a case of a patient with a previously undescribed complication: intertrochanteric femoral neck insufficiency fracture after long-segment instrumented spinopelvic fusion to the ilium for Charcot spine.
A 42-year-old Caucasian man with post-traumatic complete T6 paraplegia presented to our institution after developing Charcot spinal arthropathy at L3 and L4 and symptoms of autonomic dysreflexia 21 years after his original spinal cord injury. Multiple anterior and posterior surgeries were required to eventually achieve stabilization of his thoracolumbar spine to his pelvis and resolution of symptoms. The most distal fixation point was two iliac wing screws bilaterally. At 10 weeks after the final spinal surgery and after posterior spinal bony consolidation had occurred, he sustained an intertrochanteric femoral neck fracture, distal to the iliac fixation, whilst bending forward in his wheelchair. His proximal femoral fracture was internally fixed with an intramedullary device.
Spinal Charcot’s arthropathy is a rare condition that may occur in patients with post-traumatic spinal cord injury. Although associated with high risk of complications, circumferential instrumented fusion in Charcot spine can restore spinal stability. Insufficiency fractures of the proximal femur are possible complications of long spinopelvic fusions.
After Charcot described the neuropathic joint in 1868  and Charcot spinal arthropathy was reported in a patient with tabes dorsalis in 1884 , the first report of Charcot spinal arthropathy in a patient with post-traumatic paraplegia appeared in 1978 . Since then, traumatic spinal cord injury has become the commonest cause of Charcot spinal arthropathy, however, this condition is rare with less than 90 cases reported . The mean time of development of Charcot spine after the initial spinal injury is usually greater than 10 years . The destructive process is triggered by loss of protective pain and proprioceptive sensation in the post-traumatic spinal cord-injured spine, resulting in abnormal motion and instability, leading to disc degeneration, facet joint destruction, and eventually causing vertebral destruction and fracture, subluxation, deformity, and dislocation. Symptoms include pain, further neurological deterioration, progressive deformity and impairment of sitting balance. There have been rare case reports of patients presenting with autonomic dysreflexia, an imbalance in reflex sympathetic discharge resulting in hypertension, headache and profuse sweating [4, 6]. Surgery is often indicated upon failure of non-operative management, although it is associated with high risk of complications, including infection, failure of fixation and need for revision surgery [7, 8]. The goals of surgery are to achieve a painless well-balanced spine, maintain sitting balance and obtain a solid fusion, thus restoring stability. Dual anterior and posterior surgery is usually recommended to obtain circumferential stabilization and fusion, especially in severe cases [7, 8]. Occasionally, patients may have a long pre-existing fusion mass with the Charcot arthropathy distal to this, and the posterior instrumentation needs to be extended to the sacrum or pelvis .
Long multisegmental posterior thoracolumbar fusions to the sacrum and pelvis are challenging operations associated with high complication rates including instrumentation prominence and failure and pseudarthrosis . However, successful fusion results in stiffening of the spine and leads to increased motion and biomechanical strain at caudal or rostral levels of the axial skeleton adjacent to the fusion . This in turn may cause degeneration, instability and insufficiency fracture, especially in patients with poor bone quality and longer fusion segments . Although uncommon, sacral insufficiency fractures just distal to S1 screws after multisegmental lumbosacral fusion have been reported in several case series . If symptoms do not improve with non-operative management, extension of instrumentation to the iliac wings is an effective salvage procedure. However, the biomechanical effects of long fusions and instrumentation to the ilium are unknown. To the best of our knowledge, no previous case of bony fracture immediately distal to iliac fixation has been reported. When the fusion ends in the ilium, the hip joint becomes the adjacent distal joint. We present a patient who sustained a comminuted intertrochanteric femoral neck fracture after a long multisegment spinopelvic fixation to the ilium for Charcot spine.
Plain X-rays showed severe bony reabsorption and destruction distal to the previous fusion coupled with new bone formation around the destroyed L4 vertebra (Figure 1). A computed tomography (CT) scan showed extensive endplate and osseous destruction of his L3 and L4 vertebral bodies, with gas vacuum phenomenon at this level. A magnetic resonance imaging scan confirmed the bony and soft tissue destruction at L3 and L4, as well as showing abnormal paravertebral soft tissue and a complex paraspinal 7cm diameter mass within his psoas muscle with associated multifocal and multilocular fluid collections, areas of dystrophic ossification and nonspecific soft tissue inflammatory changes.
The development of Charcot spine arthropathy is a rare occurrence but should be considered in every active patient with paraplegia presenting with back pain and/or deformity distal to the sensory level, change in neurological function and symptoms of autonomic dysreflexia . Surgery is indicated after failure of non-operative management for pain, neurological deterioration, progressive deformity, impairment of sitting balance and autonomic dysreflexia. This case highlights the many difficult issues faced in surgery for Charcot spine, which may involve dual surgical approaches, revising previous spinal instrumentation, extending an already long spinal fusion, and correction of deformity in the presence of suboptimal bone quality. Consequently, there is a high risk of associated complications, particularly with failure of instrumentation and adjacent distal level failure. In this case, the distal L5 and S1 screws implanted in the first procedure failed bilaterally by loosening within the bone, despite anterior surgery, reconstruction and stabilization. It is uncertain whether or not this might have been prevented with the use of polymethylmethacrylate augmentation of the pedicle screws. Nevertheless, revision surgery and extension of the long multisegmental posterior thoracolumbar fusions to the ilium with two screws bilaterally was performed.
Long rigid multisegmental fusions into the lumbosacral spine have been shown to significantly increase the stress and motion at more distal segments, predisposing these segments to degeneration and premature failure in the form of insufficiency fracture, especially in patients with osteoporosis [10, 11]. Sacral insufficiency fractures are potential complications following lumbosacral fusion. Extended spinopelvic fixation to the ilium may improve fusion rates and provide a significant biomechanical advantage to secure distal fixation of long instrumented fusions to the pelvis by protecting the S1 screws from pullout and decreasing lumbosacral motion . However, iliac wing screws have complication rates of up to 50%, including screw prominence and local irritation, screw loosening and breakage, and infection [14, 15]. We report a case of intertrochanteric femoral neck insufficiency fracture following spinopelvic fixation. It is likely that rigid multilevel instrumentation of the spine and the pelvis transferred stress to the adjacent distal joint, in this case the hip joint, which failed under increased strains of torsional loading.
Spinal Charcot’s arthropathy is a rare condition that may occur in patients with post-traumatic spinal cord injury. Although associated with high risk of complications, circumferential instrumented fusion in Charcot spine can restore spinal stability. Insufficiency fractures of the proximal femur are possible complications of long spinopelvic fusions. The biomechanical effects of long fusions and instrumentation to the ilium need to be further studied. Femoral neck insufficiency fractures are possible complications of spinal fusions to the pelvis.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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