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Linear asymptomatic pneumatosis as an unexpected finding of computed tomography colonography: a case report
© Flor et al.; licensee BioMed Central Ltd. 2013
Received: 14 January 2013
Accepted: 20 June 2013
Published: 14 August 2013
We discuss asymptomatic colonic pneumatosis, an unexpected finding of computed tomography colonography that we must see as distinct from perforation. Among the papers detailing complications with computed tomography colonography, we found only one report focusing on linear pneumatosis.
We report the case of a 75-year-old Caucasian woman who had a high level of carcinoembryonic antigen, and who underwent computed tomography colonography. Our patient accidentally fell from a chair in the radiology department just before the examination, experiencing a right hip trauma. The examination was negative for colonic lesions but revealed the presence of some air bubbles in her right colon. Our patient remained asymptomatic throughout the procedure and afterwards; no intervention or treatment was necessary.
Radiologists should consider colonic linear pneumatosis among the potential complications of computed tomography colonography, even if it is a rare event, to avoid unnecessary therapy and anxiety for the patient.
Computed tomography colonography (CTC) is a valid alternative to optical colonoscopy (OC), sharing its high rates of accuracy in diagnosis of polyps and colon cancers [1–5]. Part of the success of the method is due to its low invasiveness, which is clearly lower than OC [6–8]. Complications are quite rare, and amongst these the most feared is intestinal perforation. The report we present here concentrates on an unexpected CTC imaging finding, which must be seen as distinct from perforation: intestinal pneumatosis.
We present the case of a 75-year-old Caucasian woman with an increase of carcinoembryonic antigen three months after an incomplete OC, who underwent CTC to exclude the presence of colonic lesions. The OC was incomplete and interrupted at her sigmoid colon because of inadequate bowel cleansing. Our patient was being followed-up for lung cancer. She had carried out intestinal preparation in the days preceding the CTC with a mild laxative associated with a low fiber diet. On the morning of the examination, just before taking the oral contrast medium for fecal tagging, our patient accidentally fell from a chair in the radiology department, experiencing a right hip trauma. Because of the persistent pain, she immediately underwent a pelvis X-ray, which excluded fractures.
Asymptomatic colonic pneumatosis is a rare potential CTC complication. Among papers discussing CTC complications, there is one report dealing with pneumatosis cystoides coli  and only one, by Pickhardt et al., focusing on linear pneumatosis. Pickhardt et al. described six cases of linear colonic pneumatosis in 5,368 patients who underwent CTC examination for screening purposes, with a prevalence of 0.11%. They reported that pneumatosis was always asymptomatic and correlated with the use of automated insufflators of carbon dioxide. Our case has some analogies with that report . Our patient was also asymptomatic; the pneumatosis was detected at the end of the examination, during the first review of the images, and represented a surprising finding due to the absolute absence of symptoms during the CTC and immediately after the procedure. Moreover, our patient judged the examination as absolutely not painful in her questionnaire after the CTC. This unexpected finding also occurred using a carbon dioxide automated insufflator for colonic distention. We have used this device for 15 months instead of room air insufflation: this is the only case of pneumatosis that occurred out of a total of almost 800 CTC examinations (0.1%) performed with the use of an automated insufflator. In almost 700 examinations performed with room air, a similar event had never occurred.
The cause of this event is unclear. Some authors [11–14] have postulated the role of different factors including intraluminal pressure, mucosal integrity, bacterial flora and intraluminal gas. Pickhardt et al. hypothesized a potential role for cathartic bowel preparation .
We cannot exclude that linear pneumatosis in our case resulted from the traumatic event, which may have caused an acute increase in intraluminal pressure and, subsequently, a mucosal laceration.
Kelly et al. described a case of portal venous air embolism and extensive pneumatosis cystoides intestinalis secondary to blunt abdominal trauma, diagnosed by conventional CT.
These findings are not the sole prerogative of CTC; it is likely that such asymptomatic findings occur more frequently on OC, but are not recognized without CT imaging.
Linear pneumatosis should not be confused with perforation and with so-called primary pneumatosis cystoides coli, which typically manifests itself as a cluster of air-filled cysts usually involving the left colon, and resembling polyposis on endoluminal evaluation.
Radiologists dealing with CTC have to consider linear colonic pneumatosis as a potential complication, even if it represents a rare event, to avoid unnecessary therapy and anxiety for the patient. We therefore suggest this unexpected imaging finding be included in the patient’s information sheet.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent in available for review by the Editor-in-Chief of this journal.
- Pickhardt PJ, Hassan C, Halligan S, Marmo R: Colorectal cancer: CT colonography and colonoscopy for detection–systematic review and meta-analysis. Radiology. 2011, 259: 393-405. 10.1148/radiol.11101887.View ArticlePubMedPubMed CentralGoogle Scholar
- Kim DH, Pickhardt PJ, Taylor AJ, Leung WK, Winter TC, Hinshaw JL, Gopal DV, Reichelderfer M, Hsu RH, Pfau PR: CT colonography versus colonoscopy for the detection of advanced neoplasia. N Engl J Med. 2007, 357: 1403-1412. 10.1056/NEJMoa070543.View ArticlePubMedGoogle Scholar
- Johnson CD, Chen MH, Toledano AY, Heiken JP, Dachman A, Kuo MD, Menias CO, Siewert B, Cheema JI, Obregon RG, Fidler JL, Zimmerman P, HortonK M, Coakley K, Iyer RB, Hara AK, Halvorsen RA, Casola G, Yee J, Herman BA, Burgart LJ, Limburg PJ: Accuracy of CT colonography for detection of large adenomas and cancers. N Engl J Med. 2008, 359: 1207-1217. 10.1056/NEJMoa0800996.View ArticlePubMedPubMed CentralGoogle Scholar
- Regge D, Laudi C, Galatola G, Della Monica P, Bonelli L, Angelelli G, Asnaghi R, Barbaro B, Bartolozzi C, Bielen D, Boni L, Borghi C, Bruzzi P, Cassinis MC, Galia M, Gallo TM, Grasso A, Hassan C, Laghi A, Martina MC, Neri E, Senore C, Simonetti G, Venturini S, Gandini G, Regge D, Laudi C, Galatola G, Della Monica P, Bonelli L: Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cancer. JAMA. 2009, 301: 2453-2461. 10.1001/jama.2009.832.View ArticlePubMedGoogle Scholar
- Graser A, Stieber P, Nagel D, Schäfer C, Horst D, Becker CR, Nikolaou K, Lottes A, Geisbüsch S, Kramer H, Wagner AC, Diepolder H, Schirra J, Roth HJ, Seidel D, Göke B, Reiser MF, Kolligs FT: Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population. Gut. 2009, 58: 241-248. 10.1136/gut.2008.156448.View ArticlePubMedGoogle Scholar
- Pickhardt PJ: The incidence of colonic perforation at CT colonography: review of the existing data and the implications for screening of asymptomatic adults. Radiology. 2006, 239: 313-316. 10.1148/radiol.2392052002.View ArticlePubMedGoogle Scholar
- Burling D, Halligan S, Slater A, Noakes MJ, Taylor SA: Potentially serious adverse events associated with CT colonography performed in symptomatic patients: a national survey of the UK. Radiology. 2006, 239: 464-471. 10.1148/radiol.2392051101.View ArticlePubMedGoogle Scholar
- Sosna J, Blachar A, Amitai M, Barmeir E, Peled N, Goldberg SN, Bar-Ziv J: Assessment of the risk of colonic perforation at CT colonography in a multi-center large cohort. Radiology. 2006, 239: 457-463. 10.1148/radiol.2392050287.View ArticlePubMedGoogle Scholar
- Hachlander T, Wenger H: Pneumatosis intestinalis coli – a rare find in CT-colonoscopy. Rofo. 2005, 177: 759-761. 10.1055/s-2004-813895.View ArticleGoogle Scholar
- Pickhardt PJ, Kim DH, Taylor AJ: Asymptomatic pneumatosis at CT colonography: a benign self-limited imaging finding distinct from perforation. AJR. 2008, 190: W112-W117. 10.2214/AJR.07.2843.View ArticlePubMedGoogle Scholar
- Pear BL: Pneumatosis intestinalis: a review. Radiology. 1998, 207: 13-19.View ArticlePubMedGoogle Scholar
- St Peter SD, Abbas MA, Kelly KA: The spectrum of pneumatosis intestinalis. Arch Surg. 2003, 138: 68-75. 10.1001/archsurg.138.1.68.View ArticlePubMedGoogle Scholar
- Soyer P, Martin-Grivaud S, Boudiaf M, Malzy P, Duchat F, Hamzi L, Pocard M, Vahedi K, Rymer R: Linear or bubbly: a pictorial review of CT features of intestinalis pneumatosis adults. J Radiol. 2008, 89: 1907-1920. 10.1016/S0221-0363(08)74786-3.View ArticlePubMedGoogle Scholar
- Ho LM, Paulson EK, Thompson WM: Pneumatosis intestinalis in the adult: benign to life-threatening causes. AJR. 2007, 188: 1604-1613. 10.2214/AJR.06.1309.View ArticlePubMedGoogle Scholar
- Kelly BS, Meyers P, Choe KA, Hurst J, Luchette FA: Traumatic pneumatosis cystoides intestinalis with portal venous air embolism. J Trauma. 1997, 42: 112-113. 10.1097/00005373-199701000-00020.View ArticlePubMedGoogle Scholar
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