- Case report
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Herpes zoster encephalitis presenting as multiple cerebral hemorrhages – a rare presentation: a case report
© Saxena et al.; licensee BioMed Central Ltd. 2013
- Received: 1 January 2013
- Accepted: 29 April 2013
- Published: 18 June 2013
An infection by herpes zoster virus is a common and important cause of encephalitis. Herpes zoster virus encephalitis if not treated promptly can result in significant morbidity and mortality. The diagnosis of herpes zoster virus encephalitis is based on clinical history, examination, neuroradiological imaging (magnetic resonance imaging and/or computed tomography scan), cerebrospinal fluid analysis and identification of the pathogen in cerebrospinal fluid by polymerase chain reaction amplification and/or anti-herpes zoster virus immunoglobulin G antibody in cerebrospinal fluid. Although ischemic intracerebral infarcts in patients with herpes zoster virus encephalitis or vasculopathy are reported in the literature, multiple intracerebral hemorrhages as a complication of herpes zoster virus encephalitis in an immunocompetent individual are extremely rare.
A 40-year-old Indian man presented with an acute history of four episodes of seizures, fever, headache, drowsiness, focal neurological deficits and vesicular eruptions over the abdomen in a typical dermatomal distribution. His head computed tomography scan revealed multiple cerebral hemorrhages. Investigations (positive ratio between the cerebrospinal fluid/serum quotients for anti-herpes zoster virus immunoglobulin G and total immunoglobulin G antibodies) established its infective origin due to herpes zoster virus. He developed bilateral pneumonia during the hospital course. He had an excellent recovery following a 2 weeks’ course of intravenous acyclovir.
Herpes zoster virus encephalitis or vasculopathy is a rare cause of multiple intracerebral hemorrhages and must be considered in the differential diagnosis of patients presenting with an acute history of fever, altered consciousness, and focal neurologic deficits with history of a typical herpetic rash. Its prompt recognition and treatment could alter the course of illness.
- Herpes zoster virus
- Intracerebral hemorrhage
- Viral encephalitis
Herpes zoster virus (HZV) infection is associated with neurological complications such as encephalitis, aseptic meningitis, meningoencephalitis, acute cerebellar ataxia, leukoencephalopathy, cranial nerve palsies, Ramsay Hunt syndrome, postherpetic neuralgia, radiculitis and myelitis. The frequency of HZV as a cause of encephalitis is variable, ranging from as low as 5% to as high as 15% in different series [1, 2]. Cases of intracerebral hemorrhagic lesion in patients with herpes simplex virus (HSV) encephalitis are described in the literature [3, 4]. Herpes zoster vasculopathy presenting as intracerebral hemorrhage is a very rare entity . Although multifocal ischemic intracerebral infarcts in patients with HZV encephalitis or vasculopathy are reported in the literature, multiple intracerebral hemorrhages as a complication of HZV encephalitis in an immunocompetent individual are extremely rare [6, 7]. We report here an immunocompetent patient with multiple intracerebral hemorrhages as a complication of HZV encephalitis, who also had concurrent herpes zoster rash in a dermatomal distribution over his trunk and bilateral pneumonia.
His neurological examination revealed paucity of movement on the left side, and brisk deep tendon reflexes with left plantar extensor response. The pupils were equal and normally reactive to light. No signs of meningeal irritation were present. Fundus examination and other system examination revealed no abnormality. He had no history of seizures prior to the present incident. A history of hypertension and diabetes mellitus were not present.
Examination of peripheral blood smear failed to demonstrate any malarial parasite. The result of a rapid malaria antigen test (histidine-rich protein-II and plasmodium lactate dehydrogenase) was negative. The cerebrospinal fluid (CSF) examination revealed: lymphocytes (80/mm3) with presence of red blood cells (20/mm3), protein 90mg/dL, and glucose 108mg/dL. There was no organism in Gram and Ziehl–Neelsen staining of the CSF. His hemogram showed a total leukocyte count of 12,700/μL (with differential of 81% polymorphonuclear leukocytes, 12% lymphocytes, 7% monocytes). His platelet count, bleeding and coagulation profile were within normal limits. The results of the human immunodeficiency virus (HIV) tests were negative by both enzyme-linked immunosorbent assay (ELISA) and rapid HIV test for HIV-1 and HIV-2 antibodies.
He was empirically treated with intravenous acyclovir 500mg every 8 hours and antibiotics (intravenous ceftriaxone 2g every 12 hours) for the possible diagnosis of acute infective encephalitis or meningoencephalitis most likely viral in origin. He was given a loading dose of phenytoin sodium intravenously and then placed on 100mg intravenously every 8 hours to control seizures.
On day 5, mechanical ventilatory support was withdrawn and his GCS improved to 13 (E4V3M6). He was confused and dysarthric. His motor power in the left upper and lower limbs was 2 out of 5. He was found to have memory disturbances, behavioral changes, disorganized speech and apraxia during the hospital course. His neurologic function, motor power, mental status and speech partially recovered gradually during the hospital stay. Dexamethasone was given for a period of 7 days and acyclovir for 14 days (started on day 2 of hospitalization).
The viruses commonly responsible for causing encephalitis in immunocompetent patients are human HSV-1, HZV or varicella zoster virus, Epstein–Barr virus, mumps, measles, and enteroviruses . The neurological complications caused by HZV occur due to vasculitis affecting small or large vessels [8, 9]. HZV vasculopathy affects both immunocompetent and immunocompromised patients, and can be either unifocal or multifocal. HZV vasculopathy may involve large vessels in immunocompetent patients, ranging from necrotizing granulomatous arteritis to chronic vasculitis and thrombosis of cerebral vessels. HZV vasculopathy may involve small vessels and ependyma in immunocompromised patients, especially those with acquired immune deficiency syndrome or malignancy or the elderly [10, 11]. In our case, the patient was not immunocompromised and had no evidence of underlying malignancy. In a past report, both HZV deoxyribonucleic acid (DNA) and HZV-specific antigen were demonstrated in the media of cerebral arteries of a patient who died after HZV vasculopathy . Cerebral angiography in a patient of HZV encephalitis reported by Jain et al. revealed multiple short segments of narrowing and beading involving the small- and medium-sized vessels, suggestive of vasculitis . MRI angiography in our patient did not reveal any segmental narrowing or beading.
In a previous case series reported by Nagel et al., the detection of anti-HZV IgG antibody in CSF was a more sensitive indicator of HZV vasculopathy than detection of HZV DNA, which becomes detectable in CSF generally after 2 weeks [13, 14]. HZV IgG antibody becomes detectable in CSF generally after 2 weeks, which lasts for months. Hence, in our case a lumbar puncture was repeated on the 15th day of hospitalization for the detection of intrathecal anti-HZV IgG antibody. Similarly in an another study, it was found that testing for anti-HZV IgG antibody identified more cases of HZV vasculopathy .
An absence of history of head trauma, normal coagulation and hematological profile, and hemorrhages at unusual sites exclude the other possible causes like traumatic hemorrhage, coagulation or hematological disorders and hypertensive hemorrhage respectively. The resolution of the radiological lesions in the head CT scan repeated after 15 days ruled out the possibility of a brain tumor or metastases. No abnormal contrast enhancement of the lesions in the CT and MRI scans of his brain also make the diagnosis of brain tumor or metastases or arteriovenous malformations unlikely. In our patient, clinical presentation (fever, headache, seizures, focal neurologic deficits and typical vesicular eruptions), CSF findings, and the presence of anti-HZV IgG antibodies established the diagnosis of HZV encephalitis.
HZV encephalitis or vasculopathy is a rare cause of multiple intracerebral hemorrhages and must be considered in the differential diagnosis of patients presenting with an acute history of fever, altered consciousness, and focal neurologic deficits with history of a typical herpetic rash. Its prompt recognition and treatment could alter the course of illness.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-chief of this journal.
- Rantalaiho T, Farkkila M, Vaheri A, Koskiniemi M: Acute encephalitis from 1967 to 1991. J Neurol Sci. 2001, 184: 169-177. 10.1016/S0022-510X(01)00441-5.View ArticlePubMedGoogle Scholar
- Mailles A, Stahl JP: Infectious encephalitis in France in 2007: a national prospective study. Clin Infect Dis. 2009, 49: 1838-1847. 10.1086/648419.View ArticlePubMedGoogle Scholar
- Biswas A, Das SK, Roy T, Dhibar T, Ghorai SP: Acute intracerebral haematoma – an unusual presentation of herpes simplex encephalitis. J Assoc Physicians India. 2004, 52: 69-71.PubMedGoogle Scholar
- Gkrania-Klotsas E, Lever AM: Herpes simplex I encephalitis presenting as a brain haemorrhage with normal cerebrospinal fluid analysis: a case report. J Med Case Rep. 2008, 2: 387-10.1186/1752-1947-2-387.View ArticlePubMedPubMed CentralGoogle Scholar
- Jain R, Deveikis J, Hickenbottom S, Mukherji SK: Varicella-zoster vasculitis presenting with intracranial hemorrhage. AJNR Am J Neuroradiol. 2003, 24: 971-974.PubMedGoogle Scholar
- Amlie-Lefond C, Kleinschmidt-DeMasters BK, Mahalingam R, Davis LE, Gilden DH: The vasculopathy of varicella-zoster virus encephalitis. Ann Neurol. 1995, 37: 784-790. 10.1002/ana.410370612.View ArticlePubMedGoogle Scholar
- Nagel MA, Traktinskiy I, Azarkh Y, Kleinschmidt-DeMasters B, Hedley-Whyte T, Russman A, VanEgmond EM, Stenmark K, Frid M, Mahalingam R, Wellish M, Choe A, Cordery-Cotter R, Cohrs RJ, Gilden D: Varicella zoster virus vasculopathy: analysis of virus-infected arteries. Neurology. 2011, 77: 364-370. 10.1212/WNL.0b013e3182267bfa.View ArticlePubMedPubMed CentralGoogle Scholar
- Gilden D, Cohrs RJ, Mahalingam R, Nagel MA: Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatment. Lancet Neurol. 2009, 8: 731-740. 10.1016/S1474-4422(09)70134-6.View ArticlePubMedPubMed CentralGoogle Scholar
- Tavazzi E, Minoli L, Ferrante P, Scagnelli P, Del Bue S, Romani A, Ravaglia S, Marchioni E: Varicella zoster virus meningo-encephalo-myelitis in an immunocompetent patient. Neurol Sci. 2008, 29: 279-283.View ArticlePubMedPubMed CentralGoogle Scholar
- Kleinschmidt-DeMasters BK, Gilden DH: Varicella-Zoster virus infections of the nervous system: clinical and pathologic correlates. Arch Pathol Lab Med. 2001, 125: 770-780.PubMedGoogle Scholar
- Kleinschmidt-DeMasters BK, Amlie-Lefond C, Gilden DH: The patterns of varicella zoster virus encephalitis. Hum Pathol. 1996, 27: 927-938. 10.1016/S0046-8177(96)90220-8.View ArticlePubMedGoogle Scholar
- Gilden DH, Kleinschmidt-DeMasters BK, Wellish M, Hedley-Whyte ET, Rentier B, Mahalingam R: Varicella zoster virus, a cause of waxing and waning vasculitis: the New England Journal of Medicine case 5–1995 revisited. Neurology. 1996, 47: 1441-1446. 10.1212/WNL.47.6.1441.View ArticlePubMedGoogle Scholar
- Nagel MA, Forghani B, Mahalingam R, Wellish MC, Cohrs RJ, Russman AN, Katzan I, Lin R, Gardner CJ, Gilden DH: The value of detecting anti-VZV IgG antibody in CSF to diagnose VZV vasculopathy. Neurology. 2007, 68: 1069-1073. 10.1212/01.wnl.0000258549.13334.16.View ArticlePubMedGoogle Scholar
- Nagel MA, Cohrs RJ, Mahalingam R, Wellish MC, Forghani B, Schiller A, Safdieh JE, Kamenkovich E, Ostrow LW, Levy M, Greenberg B, Russman AN, Katzan I, Gardner CJ, Häusler M, Nau R, Saraya T, Wada H, Goto H, de Martino M, Ueno M, Brown WD, Terborg C, Gilden DH: The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology. 2008, 70: 853-860. 10.1212/01.wnl.0000304747.38502.e8.View ArticlePubMedPubMed CentralGoogle Scholar
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