- Case report
- Open Access
- Open Peer Review
Left ventricular systolic dysfunction in a patient with accidental hypothermia: a case report
© Mine et al.; licensee BioMed Central Ltd. 2012
- Received: 18 July 2012
- Accepted: 14 November 2012
- Published: 28 December 2012
Hypothermia is a relatively rare condition, and the effects of unintentional hypothermia on the heart are not known.
This report describes the case of an 88-year-old Japanese man found in a coma and presenting with heart failure associated with hypothermia. He experienced sinus arrest, junctional rhythm and left ventricular systolic dysfunction with prolonged ejection time. With rewarming and treatment of his heart failure, he completely recovered over a period of two weeks.
Prolonged ejection time might be a characteristic finding in hypothermia.
- Left Ventricular Ejection Fraction
- Ejection Time
- Ventricular Systolic Dysfunction
- Therapeutic Mild Hypothermia
- Sinus Arrest
Differential diagnosis of a decreased level of consciousness can be difficult, as a clinical history cannot be obtained from the affected patient. A broad set of diagnostics is usually obtained, including determination of blood count, glucose, liver function and carbon monoxide levels. Brain computed tomography and a spinal tap are also often performed. Hypothermia is included within the differential diagnosis of decreased level of consciousness.
In our report we describe a case of a man with coma and heart failure associated with hypothermia. Hypothermia has been reported to reduce left ventricular systolic [1–3] and diastolic  function, but findings specific for hypothermia have not been described. This case involved a patient with hypothermia with a prolonged ejection time and left ventricular systolic dysfunction.
An 88-year-old Japanese man presented to our emergency unit in a comatose condition with a body temperature below the lower limit of detection (<32°C when measured under the armpit; <34°C when measured at the tympanic membrane) and no external injures. He had a history of mild dementia and cerebral infarction without residual motor deficits. His medication regimen consisted of only aspirin. He was found lying in a room with a window wide open; the lowest ambient temperature recorded that night was 2°C. A physical examination showed a blood pressure of 80mmHg on palpation, a heart rate of 40 beats per minute, a respiratory rate of 10 breaths per minute, a Glasgow Coma Scale score of 4 points and an oxygen saturation (SpO2) of 96% on nasal oxygen at 3L/min. Warmed saline and inotropic support was administered, and our patient’s temperature normalized over three hours. His level of consciousness had normalized by the following day.
Additional file 1: Videos of echocardiogram. (MPEG 2 MB)
We concluded that our patient had experienced a coma and heart failure due to accidental hypothermia. Hypothermia can impair left ventricular contraction and may specifically result in prolongation of the ejection time. His impaired cardiac function and coma resolved in response to rewarming.
A decreased heart rate, Osborn waves and systolic or diastolic dysfunction can be seen in the context of hypothermia [1–4], and a decreased left ventricular systolic function may persist even after rewarming . However, the effects of unintentional hypothermia on the heart are unknown.
Ejection time is a hemodynamic parameter used to compute stroke volume  and is inversely proportional to heart rate . Lance and Spodick described the relationship between heart rate and left ventricular ejection time during postural change. According to their report, the ejection time is 0.32 to 0.34 seconds when the heart rate is 40 beats per minute . Teodorescu et al. reported that patients with heart failure and acute myocardial infarction showed significant decreases in ejection time. Moreover, ejection times are shorter than 0.25 seconds in patients with acute pulmonary edema or congestive heart failure . In our case, the ejection time was clearly prolonged (0.71 seconds), which is thought to be a characteristic finding of hypothermia-induced cardiac dysfunction. While the pathophysiology of hypothermia-induced prolongation of the ejection time and systolic dysfunction is unclear, calcium+ overload due to temperature-dependent dysfunction of ion transport may play a role . Aslami et al. showed that therapeutic mild hypothermia possibly improves oxygenation and ventilation in mechanically ventilated patients . Lung congestion and pleural effusions are considered to be due to left ventricular dysfunction. The possibility of conditions such as brain disease, trauma or metabolic disorders must be excluded in the differential diagnosis of patients in coma. Our findings indicate that the prolonged ejection time observed on echocardiography may be a marker of hypothermia as the etiology of unexplained comas. Although there is still a need to conduct large-scale prospective studies, our case illustrates the characteristics of impaired cardiac function in patients with unintentional hypothermia.
Our patient with hypothermia-induced coma and cardiac dysfunction presented with bradycardia, Osborn waves, systolic dysfunction and prolonged ejection time. These findings may be a characteristic finding of hypothermia-induced cardiac dysfunction. A review of additional cases is needed to determine if these signs would be helpful within the differential diagnosis of coma.
Written informed consent was obtained from the patient’s next of kin for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Filseth OM, How OJ, Kondratiev T, Gamst TM, Tveita T: Post-hypothermic cardiac left ventricular systolic dysfunction after rewarming in an intact pig model. Crit Care. 2010, 14 (6): R211-10.1186/cc9334.View ArticlePubMedPubMed CentralGoogle Scholar
- Nordmark J, Johansson J, Sandberg D, Granstam SO, Huzevka T, Covaciu L, Mörtberg E, Rubertsson S: Assessment of intravascular volume by transthoracic echocardiography during therapeutic hypothermia and rewarming in cardiac arrest survivors. Resuscitation. 2009, 80 (11): 1234-1239. 10.1016/j.resuscitation.2009.06.035.View ArticlePubMedGoogle Scholar
- Siniorakis E, Arvanitakis S, Roulia G, Voutas P, Karidis C: Myocardial damage after prolonged accidental hypothermia: a case report. J Med Case Rep. 2009, 3: 8459-10.4076/1752-1947-3-8459.View ArticlePubMedPubMed CentralGoogle Scholar
- Post H, Schmitto JD, Steendijk P, Christoph J, Holland R, Wachter R, Schöndube FW, Pieske B: Cardiac function during mild hypothermia in pigs: increased inotropy at the expense of diastolic dysfunction. Acta Physiol (Oxf). 2010, 199 (1): 43-52. 10.1111/j.1748-1716.2010.02083.x.View ArticleGoogle Scholar
- Lalani AV, Lee SJ: Echocardiographic measurement of cardiac output using the mitral valve and aortic root echo. Circulation. 1976, 54: 738-743. 10.1161/01.CIR.54.5.738.View ArticlePubMedGoogle Scholar
- Lance VQ, Spodick DH: Heart rate–left ventricular ejection time relations. Variations during postural change and cardiovascular challenges. Br Heart J. 1976, 38 (12): 1332-1338. 10.1136/hrt.38.12.1332.View ArticlePubMedPubMed CentralGoogle Scholar
- Teodorescu P, Guţiu I, Câmpeanu A, Pleşea O, Carp C: Value of systolic time intervals in the estimation of heart failure secondary to acute myocardial infarction. Med Interne. 1977, 15 (1): 19-25.PubMedGoogle Scholar
- Kondratiev TV, Wold RM, Aasum E, Tveita T: Myocardial mechanical dysfunction and calcium overload following rewarming from experimental hypothermia in vivo. Cryobiology. 2008, 56: 15-21. 10.1016/j.cryobiol.2007.09.005.View ArticlePubMedGoogle Scholar
- Aslami H, Binnekade JM, Horn J, Huissoon S, Juffermans NP: The effect of induced hypothermia on respiratory parameters in mechanically ventilated patients. Resuscitation. 2010, 81 (12): 1723-1725. 10.1016/j.resuscitation.2010.09.006.View ArticlePubMedGoogle Scholar
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