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Breast schwannoma in a patient with diffuse large B-cell lymphoma: a case report
© Salihoglu et al.; licensee BioMed Central Ltd. 2012
Received: 10 August 2012
Accepted: 6 November 2012
Published: 17 December 2012
Schwannomas are mostly benign tumors arising from Schwann cells of the nerve sheaths. Breast schwannomas are very rare and account for only 2.6% of cases. As far as we know this is the first reported case of breast schwannoma discovered in a patient with diffuse large B-cell lymphoma. The breast schwannoma was evaluated with positron emission tomography and it exhibited moderate 18F-fluorodeoxyglucose uptake.
We present the case of a breast schwannoma in a 63-year-old Caucasian woman who was diagnosed with diffuse large B-cell lymphoma.
Imaging modalities including positron emission tomography-computed tomography failed to distinguish breast schwannoma from diffuse large B-cell lymphoma involvement of the breast.
KeywordsBreast Diffuse large B-cell lymphoma Positron emission tomography-computed tomography Schwannoma
Schwannoma is a slow-growing tumor arising from the nerve sheath of peripheral, cranial and autonomic nerves. It commonly occurs in the neck, head and extensor surfaces of the extremities [1, 2]. A schwannoma is usually solitary and presents several years before diagnosis . Breast-located schwannomas are unusual. Das Gupta et al. reported the percentage of schwannomas arising in the breast to be only 2.6% of all schwannomas . Diffuse large B-cell lymphoma (DLBCL) constitutes approximately 30% of all lymphomas and is the most common subtype throughout the world . We report here a case of schwannoma arising in the breast of a 63-year-old Caucasian woman treated for DLBCL. To the best of our knowledge this is the first reported case of schwannoma co-existing with DLBCL and detected by positron emission tomography (PET).
Schwannomas arise rarely within breast parenchyma . In the English language medical literature, 29 previous cases have been identified. According to Guido Bellezza et al. most patients were female and the mean age was 47 years. The tumors were most often located in the upper outer quadrant, and tumor size ranged from a few millimeters to 11cm . Our patient presented with a solitary lesion measuring two × one cm in diameter located in the lower inner quadrant. The patient had first noticed the mass 25 years ago. Manifestations of genetic syndromes such as neurofibromatosis types 1 and 2 or schwannomatosis were absent. This benign tumor of the breast may simulate clinically a malignant neoplasm . Taking the long history and the same size of the breast mass in both the initial CT and the interim PET analysis into account, we considered that the breast lesion was a benign one. However, there was still a possibility of residual lymphoma involvement. It is difficult to diagnose intramammary schwannoma on the basis of clinical and radiologic findings . Schwannoma was not diagnosed prior to surgery in our patient and a final diagnosis was established by histopathological examination of the excised mass. The ultrasonographic and mammographic characteristics of the mass in our case were similar to those described in the literature [6, 8, 9].
It is worth mentioning that we present here the first case of schwannoma of the breast detected on PET, thus far reported. There has been no documentation of the PET findings of intramammary schwannomas. Various schwannomas often have a high level of FDG uptake [10, 11]. Schwannomas originate from Schwann cells, which produce the myelin sheath of the peripheral nerves. Schwann cells transport glucose for axonal repolarization. This might be the cause of FDG uptake in schwannomas, although the precise mechanism of FDG accumulation in these benign tumors is not well defined .
Here we presented a patient with DLBCL who coincidentally happened to have a schwannoma in her breast. PET is a cornerstone procedure in lymphoma management. A PET-positive lesion does not necessarily indicate a diagnosis of lymphoma. False positive PET results are of paramount importance when deciding on the patient’s management. False positives occur in the setting of: inflammation, infection, and necrosis; granulomatous disease including sarcoidosis, thymic hyperplasia, and brown fat or with myeloid growth factor; and rituximab use [19, 20]. A diagnostic work-up (a biopsy), just like we did with our patient, should be performed in such patients with lymphoma who have suspected lesions on PET-CT. Schwannoma was a unforeseen diagnosis in the patient described above. PET-positive lesions must be carefully interpreted and rare entities such as schwannomas should be kept in mind in the differential diagnosis. Imaging modalities including PET-CT failed to distinguish breast schwannoma from DLBCL involvement of the breast.
Written informed consent was obtained from the patient’s son for publication of this manuscript and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Gupta RK, Naran S, Lallu S, Fauck R: Fine-needle aspiration cytology in neurilemoma (schwannoma) of the breast: report of two cases in a man and a woman. Diagn Cytopathol. 2001, 24: 76-77. 10.1002/1097-0339(200101)24:1<76::AID-DC1013>3.0.CO;2-J.View ArticlePubMedGoogle Scholar
- Bernardello F, Caneva A, Bresaola E, Mombello A, Zamboni G, Bonetti F, Iannucci A: Breast solitary schwannoma: fine needle aspiration biopsy and immunocytochemical analysis. Diagn Cytopathol. 1994, 10: 221-223. 10.1002/dc.2840100306.View ArticlePubMedGoogle Scholar
- Galant C, Mazy S, Berliere M, Mazy G, Wallon J, Marbaix E: Two schwannomas presenting as lumps in the same breast. Diagn Cytopathol. 1997, 16 (3): 281-284. 10.1002/(SICI)1097-0339(199703)16:3<281::AID-DC18>3.0.CO;2-H.View ArticlePubMedGoogle Scholar
- Das Gupta TK, Brasfield RD, Strong EW, Hajdu SI: Benign solitary schwannomas (neurilemomas). Cancer. 1969, 24: 355-366. 10.1002/1097-0142(196908)24:2<355::AID-CNCR2820240218>3.0.CO;2-2.View ArticlePubMedGoogle Scholar
- Armitage JO: How I treat patients with diffuse large B-cell lymphoma. Blood. 2007, 110 (1): 29-36. 10.1182/blood-2007-01-041871.View ArticlePubMedGoogle Scholar
- Bellezza G, Lombardi T, Panzarola P, Sidoni A, Cavaliere A, Giansanti M: Schwannoma of the breast: a case report and review of the literature. Tumori. 2007, 93 (3): 308-311.PubMedGoogle Scholar
- Gultekin SH, Cody HS, Hoda SA: Schwannoma of the breast. South Med J. 1996, 89: 238-239. 10.1097/00007611-199602000-00018.View ArticlePubMedGoogle Scholar
- Cho KS, Choi HY, Lee SW, Sung SH: Sonographic findings in solitary schwannoma of the breast. J Clin Ultrasound. 2001, 29: 99-101. 10.1002/1097-0096(200102)29:2<99::AID-JCU1005>3.0.CO;2-R.View ArticlePubMedGoogle Scholar
- Linda A, Machin P, Bazzocchi M, Zuiani C: Painful schwannoma of the breast completely removed by a vacuum-assisted device with symptom resolution. Breast J. 2008, 14 (5): 496-497. 10.1111/j.1524-4741.2008.00629.x.View ArticlePubMedGoogle Scholar
- Beaulieu S, Rubin B, Djang D, Conrad E, Turcotte E, Eary JF: Positron emission tomography of schwannomas: emphasizing its potential in preoperative planning. AJR Am J Roentgenol. 2004, 182 (4): 971-974.View ArticlePubMedGoogle Scholar
- De Waele M, Carp L, Lauwers P, Hendriks J, De Maeseneer M, Van Schil P, Blockx P: Paravertebral schwannoma with high uptake of fluorodeoxyglucose on positron emission tomography. Acta Chir Belg. 2005, 105 (5): 537-538.View ArticlePubMedGoogle Scholar
- Matsuki A, Kosugi S, Kanda T, Komukai S, Ohashi M, Umezu H, Mashima Y, Suzuki T, Hatakeyama K: Schwannoma of the esophagus: a case exhibiting high 18F-fluorodeoxyglucose uptake in positron emission tomography imaging. Dis Esophagus. 2009, 22 (4): E6-E10. 10.1111/j.1442-2050.2007.00712.x.View ArticlePubMedGoogle Scholar
- Fujiuchi N, Saeki T, Takeuchi H, Sano H, Takahashi T, Matsuura K, Shigekawa T, Misumi M, Nakamiya N, Okubo K, Osaki A, Sakurai T, Matsuda H: A false positive for metastatic lymph nodes in the axillary region of a breast cancer patient following mastectomy. Breast Cancer. 2011, 18 (2): 141-144. 10.1007/s12282-009-0125-9.View ArticlePubMedGoogle Scholar
- Akin M, Bozkirli B, Leventoglu S, Unal K, Kapucu LO, Akyurek N, Sare M: Liver schwannoma incidentally discovered in a patient with breast cancer. Bratisl Lek Listy. 2009, 110 (5): 298-300.PubMedGoogle Scholar
- Sadok Boudaya M, Dechaud C, Gossot D, Validire P, Magdeleinat P, Moretti JL: Benign schwannoma with high uptake of 18 fluorodeoxglucose (PET-Scan). Rev Mal Respir. 2009, 26 (1): 63-65. 10.1016/S0761-8425(09)70136-6.View ArticlePubMedGoogle Scholar
- Ahmed AR, Watanabe H, Aoki J, Shinozaki T, Takagishi K: Schwannoma of the extremities: the role of PET in preoperative planning. Eur J Nucl Med. 2001, 28 (10): 1541-1551. 10.1007/s002590100584.View ArticlePubMedGoogle Scholar
- Halac M, Cnaral F, Sait S, Ylmaz S, Kerim S, Sergülen D, Uslu I: FDG PET/CT findings in recurrent malignant schwannoma. Clin Nucl Med. 2008, 33 (3): 172-174. 10.1097/RLU.0b013e318162d922.View ArticlePubMedGoogle Scholar
- Chang CY, Fan YM, Bai CY, Cherng SC: Schwannoma mimicking lung cancer metastases demonstrated by PET/CT. Clin Nucl Med. 2006, 31 (10): 644-645. 10.1097/01.rlu.0000238130.18526.39.View ArticlePubMedGoogle Scholar
- Cheson BD: Role of functional imaging in the management of lymphoma. J Clin Oncol. 2011, 29 (14): 1844-1854. 10.1200/JCO.2010.32.5225.View ArticlePubMedGoogle Scholar
- Ozer O, Eskazan AE, Ar MC, Beköz H, Tabak F, Ongen G, Ferhanoglu B: Sarcoidosis mimicking lymphoma on positron emission tomography-computed tomography in two patients treated for lymphoma: two case reports. J Med Case Reports. 2009, 3: 7306-10.4076/1752-1947-3-7306.View ArticlePubMed CentralGoogle Scholar
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