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A multidisciplinary clinical treatment of locally advanced rectal cancer complicated with rectovesical fistula: a case report
© Zhan et al.; licensee BioMed Central Ltd. 2012
Received: 30 January 2012
Accepted: 17 September 2012
Published: 29 October 2012
Rectal cancer with rectovesical fistula is a rare and difficult to treat entity. Here, we describe a case of rectal cancer with rectovesical fistula successfully managed by multimodality treatment. To the best of our knowledge, this is the first such case report in the literature.
A 51-year-old Chinese man was diagnosed as having rectal cancer accompanied by rectovesical fistula. He underwent treatment with neoadjuvant radiochemotherapy combined with total pelvic excision and adjuvant chemotherapy, as recommended by a multimodality treatment team. Post-operative pathology confirmed the achievement of pathological complete response.
This case suggests that a proactive multidisciplinary treatment is needed to achieve complete cure of locally advanced rectal cancer even in the presence of rectovesical fistula.
Most colorectal cancers in the upper rectum or sigmoid colon invade the top of the bladder, and they are clinically treated with a relatively simple en-bloc resection of the invaded bladder. When the tumor is located in the anterior wall in the middle of the rectum it is likely to invade the bladder trigone, and when tumor is in the low rectum it is likely to invade the prostate and seminal vesicles. Thus, special handling is required for mid to low rectal cancer, especially in men.
A 51-year-old Asian man presented to our facility with issues of increased stool frequency (six to eight times a day) accompanied with tenesmus for more than a month. The stool was shapeless and occasionally mixed with small amounts of blood. He was admitted due to worsening of these symptoms and fecaluria accompanied with fever and severe body weight loss.
Given that our patient had incomplete intestinal obstruction, rectal bladder fistula, local hemorrhage and infection, radical resection of the tumor was not suitable. A multimodality treatment team consisting of surgeons, physicians, imaging scientists, pathologists and radiologists suggested conducting a transverse colostomy to bypass feces first, subsequently performing pre-operative neoadjuvant therapy when our patient became stable. A week after transverse colostomy, all his clinical symptoms disappeared and neoadjuvant chemotherapy was administrated using oxaliplatin 80mg once a week (50mg/m2) and capecitabine 1.5g twice a day (1000mg/m2) for four weeks, combined with 10MV X-ray intensity modulated radiation therapy (IMRT) of gross tumor volume (GTV) 50.6Gy/clinical target volume (CTV) 41.8Gy for 22 days.
According to the National Comprehensive Cancer Network (NCCN) guidelines, neoadjuvant therapy should be given for the treatment of locally advanced rectal cancer (LARC). However, for tumors that invade into the bladder trigone resulting in rectovesical fistula, the treatment becomes complicated. Therefore, a multidisciplinary clinical team is needed to find comprehensive solutions. All the symptoms such as fever, blood in the stool, fecaluria, and incomplete intestinal obstruction present in our patient resulted from the bladder fistula caused by local invasion of rectal cancer. After under going the operation to create a diverting stoma, all his symptoms disappeared within a week, which helped our patient undergo further treatment.
The incidence of fecaluria caused by rectovesical fistula is relatively low in rectal cancer invading the bladder. Since simple rectal resection would not remove residual tumor in the bladder, we administered neoadjuvant chemotherapy using a XELOX regimen combined with 50.6Gy of pre-operative radiation[4, 5]. The standard pre-operative treatment for locally invasive rectal cancer in our hospital included fractional radiation with cumulative 50.4Gy combined with oral administration of capecitabine. In addition to the standard pre-operative treatment, four weeks of oxaliplatin was also given in this case to enhance tumor killing and increase the sensitivity of radiation therapy. This treatment may also contribute to the control of distant metastasis caused by long-term pre-operative treatment. Reassessment after neoadjuvant therapy showed tumor shrinkage and absence of distant metastases. A reasonable therapeutic option could be the performance of a limited surgical procedure if cystoscopy excludes residual tumor in the bladder. Then, a strict urologic follow-up could show eventual vesical relapse and a secondary total cystectomy could be performed. However, we believe that pathological analysis is more accurate than cystoscopy for the diagnosis of residual tumor in the bladder. Considering the multiple enlarged lymph nodes and the good general condition of our patient to tolerate the operation, we performed TPE. Post-operative adjuvant therapy was carried out based on the opinion that post-operative adjuvant therapy is necessary even for a PCR of rectal cancer[2, 4, 5].
The findings from our patient’s case suggest that a proactive multidisciplinary treatment is needed to achieve complete cure for locally advanced rectal cancer complicated with rectovesical fistula.
Written informed consent was obtained from the patient for publication of this manuscript and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Lopez MJ, Barrios L: Evolution of pelvic exenteration. Surg Oncol Clin N Am. 2005, 14: 587-606. 10.1016/j.soc.2005.05.005.View ArticlePubMedGoogle Scholar
- National Comprehensive Cancer Network: Colon/Rectal Cancer Version v.2.http://www.nccn.org/professionals/physician_gls/PDF/colon/rectal.pdf,
- Sharma A, Sharp DM, Walker LG, Monson JR: Colorectal MDTs: the team's perspective. Colorectal Dis. 2008, 10: 63-68.View ArticlePubMedGoogle Scholar
- Bosset JF, Collette L, Calais G, Mineur L, Maingon P, Radosevic-Jelic L, Daban A, Bardet E, Beny A, Ollier JC: Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006, 355: 1114-1123. 10.1056/NEJMoa060829.View ArticlePubMedGoogle Scholar
- Gérard JP, Conroy T, Bonnetain F, Bouché O, Chapet O, Closon-Dejardin MT, Untereiner M, Leduc B, Francois E, Maurel J, Seitz JF, Buecher B, Mackiewicz R, Ducreux M, Bedenne L: Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol. 2006, 24: 4620-4625. 10.1200/JCO.2006.06.7629.View ArticlePubMedGoogle Scholar
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