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Pontine extension of a tentorial schwannoma without cranial nerve involvement: a case report
Journal of Medical Case Reports volume 5, Article number: 597 (2011)
Intracranial schwannomas unrelated to the cranial nerves are uncommon. We report a new case of tentorial schwannoma unrelated to the cranial nerves, with extension into the pons. A literature review with discussion of the most relevant pathogenetic aspects is also performed.
A 42-year-old Caucasian man was admitted with right-sided paresthesias and weakness of his upper and lower extremities. The neurological examination revealed right hemiparesis and hemi-hypoesthesia. A brain magnetic resonance imaging scan revealed a cerebellopontine lesion, arising from the left free edge of the tentorium, and extending into his pons. A piecemeal removal was performed through a retrosigmoid approach. The lesion was not found to be associated with any cranial nerves. The histological examination revealed a schwannoma Antoni type A. His postoperative course was uneventful. At one year follow-up, the patient was neurologically intact and the magnetic resonance imaging of his brain performed at that time showed complete removal without signs of recurrence.
Tentorial schwannomas are rare clinical entities. Knowledge of their clinical, radiological and anatomical characteristics is very important for the correct diagnosis and management.
Schwannomas constitute about 8% of primary intracranial tumors and account for almost 80% to 90% of cerebellopontine angle tumors. Most cases are related to the eighth cranial nerve, and less commonly to other cranial nerves. Intracranial schwannomas not associated with cranial nerves are uncommon [1, 2]. To date, only 11 cases of intracranial schwannomas arising from the tentorium have been reported [1, 3–12].
We report a new case of a tentorial schwannoma unrelated to the cranial nerves, with extension into the pons. A literature review with the discussion of the most relevant pathogenetic aspects has also been performed.
A 42 year-old Caucasian man was admitted to our institution with a recent history of paresthesias and weakness of his right upper and lower extremities. The neurological examination revealed right hemiparesis and hemi-hypoesthesia. His cranial nerve functions were normal as was his brainstem auditory evoked response test. His personal and family histories were negative for neurofibromatosis. A brain magnetic resonance imaging (MRI) scan revealed a left cerebellopontine lesion, hypointense in T1-weighted images and hyperintense in T2-weighted images. A homogeneous contrast enhancement of the lesion was observed after gadolinium injection; the tumor appeared to be implanted on the left free edge of the tentorium, with extension into the pons. A 'dural tail' connecting the lesion to the tentorial edge was also present (Figure 1).
Surgery was performed using a retrosigmoid approach. After retraction of the hemispheric cerebellar lobe, a yellowish extra-axial lesion of the cerebellopontine angle was discovered. The tumor was strongly attached to the superior surface and the free edge of the tentorium, extending into the pons parenchyma. An endocapsular piecemeal removal was performed by means of an ultrasonic aspirator; the lesion appeared friable and vascularized. The cranial nerve complexes V, VII, VIII, IX, × and XI were all identified and preserved, and the mass was not found to be associated with these cranial nerves. The intraparenchymal portion was carefully dissected by the brain stem. After dissection from the surrounding structures, the lesion was mobilized and its implantation on the left free edge and superior surface of the tentorium exposed and resected. After tumor removal, the IV cranial nerve was exposed in its arachnoid cistern. At the end of the procedure, coagulation and resection of the implantation were achieved.
His postoperative course was uneventful and our patient fully recovered from his preoperative deficits.
Histological examination of the resected tumor revealed schwannoma Antoni type A (Figure 2A-D). A brain MRI scan performed one year after the surgical procedure revealed total removal of the lesion, without signs of recurrence (Figure 2A, B). At that time, our patient continued to be neurologically intact.
Intracranial schwannomas unrelated to the cranial nerves are uncommon, since the central nervous system is devoid of Schwann cells. In 1966, Gibson published the first case of intracerebral Schwann cell tumor in the temporal lobe of a six-year-old boy . Since that time, approximately 60 cases of schwannomas unrelated to the cranial nerves have been reported [14, 15]. Most intracranial schwannomas unrelated to the cranial nerves have been described as being adherent to the dura mater and have been thought to arise from this structure [4, 5, 16–18]; in 10 cases, a tentorial attachment has been demonstrated (Table 1[1, 3–11]). Interestingly, none of the patients of the reported cases had neurofibromatosis. Even in our case, the lesion arose from the tentorial dura, but an intraparenchymal extension into the pons was also present.
Typically, tentorial-based schwannomas appear on radiology as a heterogeneous enhancing cystic lesion, occasionally encased in the surrounding brain parenchyma, but without peritumoral edema; as in our case, a dural tail sign is often present .
Several surgical approaches have been reported to remove this kind of tumor (Table 1). In our case, we used a retrosigmoid approach. An alternative approach could be a subtemporal route, because of the tumor location in the middle incisural space. However, dealing with a left-sided lesion in a right-handed patient, we preferred a retrosigmoid approach to avoid a temporal venous infarction secondary to brain retraction, a complication reported as symptomatic in 2.6% to 13% of these approaches .
There are several hypotheses about the origin of intracranial schwannomas unrelated to the cranial nerves . Interestingly, some authors have suggested that these lesions could arise from Schwann cells normally present within the perivascular nerve plexuses surrounding arteries in the subarachnoid space, or from Schwann cells of meningeal branches of the trigeminal and anterior ethmoid nerves . The absence of cranial nerve deficits and the frequent presence of a unilateral headache strongly suggest a possible origin of the thin branches of the trigeminal ganglion or of the sensorial branches of the first division of the trigeminal nerve which supplies the tentorium. These branches were first described by Arnold in 1826 .
Although the absence of postoperative cranial nerves deficits has been advocated as proof that these lesions do not arise from cranial nerves, this observation has been questioned by some authors, since a lack of postoperative symptoms could be related to the compensative mechanism of ocular movements .
Tentorial schwannomas are rare clinical entities, but the knowledge of their clinical, radiological and anatomical characteristics is very important for a correct diagnosis and management.
Written informed consent was obtained from the patient for publication of this manuscript and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Anton T, Guttierez J, Rock J: Tentorial schwannoma: a case report and review of the literature. J Neurooncol. 2006, 76: 307-311. 10.1007/s11060-005-7286-y.
Bruni P, Esposito S, Greco R, Oddi G: Solitary intracerebral schwannoma in von Recklinghausen's disease. Surg Neurol. 1984, 22: 360-364. 10.1016/0090-3019(84)90140-X.
Chung KH, Cherian M, Chandran KN: Schwannoma with tentorial attachment in the cerebellopontine angle mimicking a meningioma. J Clin Neurosci. 2007, 14: 797-801. 10.1016/j.jocn.2006.05.008.
Du R, Dhoot J, McDermott MW, Gupta N: Cystic schwannoma of the anterior tentorial hiatus. Case report and review of the literature. Pediatr Neurosurg. 2003, 38: 167-173. 10.1159/000069094.
Oikawa A, Takeda N, Aoki N, Takizawa T, Sakoma T: Schwannoma arising from the tentorium at an unusual location: case report. Neurosurgery. 2002, 50: 1352-1355.
Flickinger FW, Yuh WT, Sato Y, Hart MN: MR findings of an unusual intracranial neuroma simulating a meningioma. J Comput Assist Tomogr. 1988, 12: 485-488. 10.1097/00004728-198805010-00025.
Jabbour P, Rizk T, Lahoud GA, Hourani R, Checrallah A, Samaha E, Nohra G, Moussa R, Okais N: Schwannoma of the tentorium cerebelli in a child. Case report. Pediatr Neurosurg. 2002, 36: 153-156. 10.1159/000048371.
Ozawa N, Nakayama K, Ohata K, Okamura T, Inoue Y: Tentorial schwannoma: a case report. Br J Radiol. 2003, 76: 421-424. 10.1259/bjr/20106153.
Calisaneller T, Ozen O, Altinors N, Caner H: Tentorium schwannoma mimicking meningioma: an unusual location. Turk Neurosurg. 2008, 18: 316-319.
Hayashi N, Kurimoto M, Nagai S, Sato H, Hori S, Endo S: Tentorial incision in a lateral-medial direction with minimal retraction of the temporal lobe in the subtemporal transtentorial approach to the middle tentorial incisural space. Minim Invasive Neurosurg. 2008, 51: 340-344. 10.1055/s-0028-1085452.
Nitta N, Shiino A, Ishida M, Okabe H, Nozaki K: Tentorial schwannoma in a 64-year-old female: case report. Neurol Med Chir (Tokyo). 2011, 51: 239-243. 10.2176/nmc.51.239.
Nagata T, Goto T, Ichinose T, Tsuyuguchi N, Ohata K: Tentorial schwannoma mimicking meningioma. Neurol Med Chir (Tokyo). 2011, 51: 382-385. 10.2176/nmc.51.382.
Gibson AA, Hendrick EB, Conen PE: Case reports. Intracerebral schwannoma. Report of a case. J Neurosurg. 1966, 24: 552-557. 10.3171/jns.1966.24.2.0552.
Haga Y, Shoji H, Oguro K, Mori S, Kawai T, Shinoda S, Masuzawa T, Saito K: Intracerebral Schwannoma--case report. Neurol Med Chir (Tokyo). 1997, 37: 551-555. 10.2176/nmc.37.551.
Huang PP, Zagzag D, Benjamin V: Intracranial schwannoma presenting as a subfrontal tumor: case report. Neurosurgery. 1997, 40: 194-197.
Frim DM, Ogilvy CS, Vonsattal JP, Chapman PH: Is intracerebral schwannoma a developmental tumor of children and young adults? Case report and review. Pediatr Neurosurg. 1992, 18: 190-194. 10.1159/000120661.
Ghosh S, Chandy MJ: Solitary ectopic intracerebral schwannoma. Br J Neurosurg. 1992, 6: 163-166. 10.3109/02688699209002921.
Horgan MA, Kernan JC, Delashaw JB, Schwartz MS, Kuether T: Schwannoma of the torcula presenting as an occipital mass. Case illustration. J Neurosurg. 1998, 89: 490-10.3171/jns.1998.89.3.0490.
Nakase H, Shin Y, Nakagawa I, Kimura R, Sakaki T: Clinical features of postoperative cerebral venous infarction. Acta Neurochir (Wien). 2005, 147: 621-626. 10.1007/s00701-005-0501-y. discussion 626
Feigin I, Ogata J: Schwann cells and peripheral myelin within human central nervous tissues: the mesenchymal character of Schwann cells. J Neuropathol Exp Neurol. 1971, 30: 603-612. 10.1097/00005072-197110000-00005.
Nelson E, Rennels M: Innervation of intracranial arteries. Brain. 1970, 93: 475-490. 10.1093/brain/93.3.475.
Uryvaev MY, Sudarikova TV, Trufanov IN, Gorskaya TV, Tsybul'kin AG: The fine branches of the human trigeminal nerve. Neurosci Behav Physiol. 2008, 38: 157-160. 10.1007/s11055-008-0023-1.
The authors declare that they have no competing interests.
DPI analyzed and interpreted the patient data, and was the major contributor in writing the manuscript. MM performed the surgical procedure. DBA performed the histological examination. MCF analyzed and interpreted radiological data. DCP analyzed and interpreted clinical data. CG performed the surgical procedure and critically reviewed the manuscript. All authors read and approved the final manuscript.
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D'Urso, P.I., Marino, M., Di Blasi, A. et al. Pontine extension of a tentorial schwannoma without cranial nerve involvement: a case report. J Med Case Reports 5, 597 (2011). https://doi.org/10.1186/1752-1947-5-597
- Schwann Cell
- Cranial Nerve
- Rare Clinical Entity
- Cranial Nerve Deficit
- Retrosigmoid Approach