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Unilateral thalamic infarction presenting as vertical gaze palsy: a case report
© Khan et al; licensee BioMed Central Ltd. 2011
Received: 5 March 2011
Accepted: 31 October 2011
Published: 31 October 2011
Vertical gaze palsy is a recognized manifestation of midbrain lesions. It rarely is a consequence of unilateral thalamic infarction.
We report the case of a 48-year-old African-American woman who presented to our facility with vertical gaze palsy and evidence of left medial thalamic infarct on diffusion-weighted imaging without coexisting midbrain ischemia. The etiology of infarct was determined to be small vessel disease after extensive investigation.
This report suggests a possible role of the thalamus as a vertical gaze control center. Clinicoradiological studies are needed to further define the role of the thalamus in vertical gaze control.
Vertical gaze palsy is usually associated with lesions of the mesencephalic rostral interstitial nucleus of the medial longitudinal fasiculus, the interstitial nucleus of Cajal, the posterior commissure and the peri-aqueductal gray matter. Rarely, vertical gaze palsies can be a manifestation of paramedian thalamic infarction [1–3]. Here, we describe the case of a patient presenting with upward gaze palsy secondary to isolated medial thalamic infarct.
A transesophageal echocardiogram revealed an ejection fraction of 55% with no atrial or ventricular thrombus or intracardiac shunt. The etiology of stroke was thought to be due to small vessel disease secondary to uncontrolled diabetes and hypertension. Treatment with aspirin, simvastatin, and tight hypertension and diabetes control was initiated. No neuropsychological testing was performed.
This is a report of a rare acute left medial thalamic infarction manifesting as supranuclear upward gaze palsy and skew deviation. A few previous reports have described vertical gaze palsies in patients with unilateral or bilateral paramedian thalamic infarction, but attributed the gaze palsy to a coexisting midbrain lesion , identified primarily at autopsy. An important clinical feature in our patient was the skew deviation, which has been reported with thalamic infarctions .
The medial thalamus is supplied by perforating branches arising from the basilar communicating artery and posterior cerebral arteries. The midbrain is spared because the superior and inferior paramedian mesencephalic arteries arise separately from each other from the basilar communicating artery .
The supranuclear pathways involved in vertical gaze are not well understood. Studies on primates reveal that the frontal eye fields traverse the medial thalamus . Also, the internal medullary lamina has reciprocal connections with the frontal and supplementary eye fields. Interruption of supranuclear fibers as they traverse the medial thalamus en route to the pretectal and prerubral areas [3, 8] could possibly lead to vertical gaze paresis. The mechanism of vertical gaze paresis with unilateral lesions is uncertain but we can speculate on the possibility of decussation of the frontobulbar fibers in the medial thalamus, as suggested in a case series of thalamic infarctions presenting as vertical gaze palsies . The neuroimaging study results from our patient revealed no midbrain lesion. There has been a previous case reported of transient vertical gaze palsy with resolution of symptoms within three hours, highlighting the role of the thalamus in vertical gaze .
The combination of vertical gaze paresis and skew deviation, previously believed to be pointing to a brainstem lesion, may now be attributed to a broader spectrum of anatomical areas. However, more cases correlating MRI findings with clinical presentations as attempted by Weidauer et al. need to be studied in order to establish the role of the thalamus in vertical gaze as either a crossroads or an actual control center .
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Bogousslavsky J, Miklossy J, Deruaz JP, Regli F, Assal G: Unilateral left paramedian infarction of thalamus and midbrain: a clinico-pathological study. J Neurol Neurosurg Psychiatry. 1986, 49: 686-694. 10.1136/jnnp.49.6.686.View ArticlePubMedPubMed CentralGoogle Scholar
- Castaigne P, Lhermitte F, Buge A, Escourolle R, Hauw JJ, Lyon-Caen O: Paramedian thalamic and midbrain infarct: clinical and neuropathological study. Ann Neurol. 1981, 10: 127-148. 10.1002/ana.410100204.View ArticlePubMedGoogle Scholar
- Gentilini M, De Renzi E, Crisi G: Bilateral paramedian thalamic artery infarcts: report of eight cases. J Neurol Neurosurg Psychiatry. 1987, 50: 900-909. 10.1136/jnnp.50.7.900.View ArticlePubMedPubMed CentralGoogle Scholar
- van der Graaff MM, Vanneste JA, Davies GA: Unilateral thalamic infarction and vertical gaze palsy: cause or coincidence?. J Neuroophthalmol. 2000, 20: 127-129. 10.1097/00041327-200020020-00014.View ArticlePubMedGoogle Scholar
- Margolin E, Hanifan D, Berger MK, Ahmad OR, Trobe JD, Gebarski SS: Skew deviation as the initial manifestation of left paramedian thalamic infarction. J Neuroophthalmol. 2008, 28: 283-286. 10.1097/WNO.0b013e318183cb79.View ArticlePubMedGoogle Scholar
- Meissner I, Sapir S, Kokmen E, Stein SD: The paramedian diencephalic syndrome: a dynamic phenomenon. Stroke. 1987, 18: 380-385. 10.1161/01.STR.18.2.380.View ArticlePubMedGoogle Scholar
- Schlag J, Schlag-Rey M: Neurophysiology of eye movements. Adv Neurol. 1992, 57: 135-147.PubMedGoogle Scholar
- Guberman A, Stuss D: The syndrome of bilateral paramedian thalamic infarction. Neurology. 1983, 33: 540-546.View ArticlePubMedGoogle Scholar
- Clark JM, Albers GW: Vertical gaze palsies from medial thalamic infarctions without midbrain involvement. Stroke. 1995, 26: 1467-1470. 10.1161/01.STR.26.8.1467.View ArticlePubMedGoogle Scholar
- Blitshteyn S, Hentschel K, Czervionke LF, Eidelman BH: Transient vertical diplopia and nystagmus associated with acute thalamic infarction. Clin Imaging. 2006, 30: 54-56. 10.1016/j.clinimag.2005.07.033.View ArticlePubMedGoogle Scholar
- Weidauer S, Nichtweiss M, Zanella FE, Lanfermann H: Assessment of paramedian thalamic infarcts: MR imaging, clinical features and prognosis. Eur Radiol. 2004, 14: 1615-1626.View ArticlePubMedGoogle Scholar
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