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Thyroid-stimulating hormone elevation misdiagnosed as subclinical hypothyroidism following non-convulsive status epilepticus: a case report
© Wada et al; licensee BioMed Central Ltd. 2011
Received: 25 April 2011
Accepted: 5 September 2011
Published: 5 September 2011
Non-convulsive status epilepticus is a form of epileptic seizure that occurs without convulsions. Recent reviews suggest that the diagnosis of non-convulsive status epilepticus remains difficult. Here, we report the case of a patient with thyroid-stimulating hormone elevation misdiagnosed as subclinical hypothyroidism following non-convulsive status epilepticus.
Our patient was a 68-year-old Japanese woman. The results of endocrine testing after her first episode of non-convulsive status epilepticus suggested latent subclinical hypothyroidism: she had elevated thyroid-stimulating hormone with normal levels of free tri-iodothyronine and free thyroxine. On examination, a diagnosis of thyroid disorder was not supported by other test results and our patient remained untreated. A follow-up examination revealed that her thyroid-stimulating hormone levels had spontaneously normalized. When she consulted another doctor for confusion, the transient increase in thyroid-stimulating hormone levels following non-convulsive status epilepticus was mistaken for subclinical hypothyroidism, and unfortunately treated with levothyroxine. Our patient then experienced levothyroxine-induced non-convulsive status epilepticus.
In this report, we suggested possible mechanisms for latent hypothyroid-like hormone abnormality following epileptic seizures and the possibility of provoking epileptic seizures by administering levothyroxine for misdiagnosed subclinical hypothyroidism.
Non-convulsive status epilepticus (NCSE) is a condition primarily diagnosed through electroencephalography (EEG). The differentiation of NCSE from other neurological and psychiatric disorders is necessary because of possible damage to many high-order functions including consciousness, emotion, thinking, and memory. Absence epilepsy was first described by Lennox in 1945 , and Gastaut and Roger reported non-convulsive complex partial status epilepticus in 1956 . Since then, these seizures and the associated neurological symptoms have been found to be linked, and it is now possible to determine whether they are paroxysmal or non-paroxysmal. A recent review suggested that the diagnosis of NCSE remains difficult, and a high index of suspicion is required to recognize and correctly diagnose this illusive condition . NCSE is a rare condition, reportedly affecting only 38 people per 100,000; however, the true incidence may be much higher . Although NCSE presents with various symptoms, it is much more difficult to distinguish NCSE onset compared to convulsive epilepsy.
In our patient, we observed transient thyroid-stimulating hormone (TSH) elevation following NCSE that was misdiagnosed as subclinical hypothyroidism. After administration of levothyroxine, our patient experienced levothyroxine-induced NCSE. In the present report, we consider the possibility of TSH elevation following NCSE, and the possibility of levothyroxine superinducing NCSE.
Our patient was a 68-year-old Japanese woman who had no history of major illness. Nine years before her admission, she had been taking daily triazolam prescribed by a local doctor for insomnia, and four years before admission, she attempted to sleep without taking this medication but was unable to. The next day, her conversation was unfocused and she was unable to relax. She was examined at our hospital's neurology department on the same day. Our patient seemed normal in appearance and showed no signs of automatism or convulsions. However, she exhibited marked disorientation and a euphoric mood. Her free tri-iodothyronine and free thyroxine (fT3 and fT4, respectively) levels were normal but her TSH levels were high (10.88 μIU/mL), and she was accordingly admitted to the neurology department with suspected Hashimoto's encephalopathy. However, our patient tested negative for anti-thyroid antibodies (A-TPO: Anti-Thyroid peroxidase, A-TG: Anti-Thyroglobulin, and A-MC: Anti-Microsome), her cerebrospinal fluid appeared normal, and there were no abnormalities on a thyroid ultrasound scan; therefore, her results did not support the diagnosis of Hashimoto's encephalopathy. Her EEG results showed continuous, irregular, generalized 3 Hz spike-and-wave complexes, and our patient was accordingly diagnosed as having NCSE (absence status epilepticus). After administration of 5 mg of diazepam intravenously, the 3 Hz spike-and-wave complexes disappeared. The next day, her orientation improved. She was discharged after 11 days and began taking zonisamide (200 mg/day).
Three years before admission, she experienced depression, which resolved with flunitrazepam alone. One year before admission, because her speech was slightly confused, she was investigated at an internal medicine clinic and was found to have a TSH level of 5.7 μIU/mL and an fT4 level of 1.0 ng/dL. At this time, our patient was diagnosed as having subclinical hypothyroidism and given 25 μg/day of levothyroxine. However, she did not adhere to this medication until 12 days before this admission.
On admission, a physical examination revealed no non-pitting edema, or any irregularities in the central nervous system, motor system, sense of balance, reflexes, sensory systems, or in the head, neck, or spine. Her biochemical and hematological findings were unremarkable. Endocrine analysis revealed the following: TSH 11.19 μIU/mL, fT4 1.04 ng/dL, fT3 2.61 pg/mL and prolactin (PRL) 30.74 ng/mL (her TSH and PRL levels were hence considerably elevated). A cranial MRI scan showed no gross lesions, and a pituitary MRI scan revealed no tumors. After admission, we supplemented her medication with a 10 mg/day diazepam suppository and 0.5 mg/day of oral clonazepam. Our patient's level of consciousness had greatly improved by the next day after this admission, and all evidence of paroxysmal discharge had disappeared (Figure 1B). Four days after this admission, further endocrine testing results showed normal levels of TSH (3.575 μIU/mL) and her PRL level had fallen (16.18 ng/mL). To determine the cause of the high TSH levels detected on admission, thorough endocrine examinations including thyroid ultrasound and anti-thyroid antibody tests were performed at our Division of Endocrinology, but there was no evidence of thyroid disorder. We therefore decided that in the absence of thyroid disorder, and because of the potential for further NCSE episodes, our patient did not require levothyroxine. Our patient was discharged from our department 12 days after this admission. There have been no further signs of NCSE recurrence to date.
Several cases have been reported where epileptic discharges induced endocrine abnormalities. Prolactin has been reported to increase following epileptic seizures , as have TSH levels. Apria et al.  reported that the pituitary gland can suddenly release TSH following electroconvulsive therapy. In addition, it is reported that ictal epileptic activity in the mesial temporal structures may propagate to the hypothalamus . Our patient had diffuse electrical discharges in the brain including the bilateral temporal lobe (Figure 1A), therefore NCSE might feasibly have induced elevation of TSH and PRL levels.
However, it should be verified whether physicians with little experience of NCSE are likely to start levothyroxine when they encounter patients whose laboratory data are similar to the findings from our patient. A review of studies on latent thyroid disorder by Surks et al. recommended treatment with levothyroxine for women aged 60 and older with TSH levels in the 4.5 to 10 μIU/mL range . This recommendation strongly supports the decision to use levothyroxine in our patient's case. However, though NCSE is rare, if it can induce abnormal levels of TSH, it is important to evaluate cognitive symptoms in detail.
In addition, there are several reports proposing a negative correlation between thyroid function and epileptic threshold. Jabbari and Huott reported a case of concurrent hyperthyroidism and epileptic seizure; as thyroid function improved, so did epileptic seizures and abnormal brain wave patterns . Maeda and Izumi reported on a patient who developed generalized convulsions emerging concurrently with Graves' disease . In the case of our patient, therefore, it seems that levothyroxine likely lowered the epileptic threshold, which provoked the NCSE before our patient was admitted to our department.
NCSE-induced hormone abnormality resulting in TSH elevation with normal fT3 and fT4 levels may be misdiagnosed as subclinical hypothyroidism. Particular attention is required because treatment of subclinical hypothyroidism with levothyroxine may result in a lowered epileptic threshold and consequent NCSE recurrence. Because some cases presenting with a high TSH with normal fT3 and fT4 levels may have NCSE as an underlying cause, particular caution is necessary when interpreting these particular endocrine abnormalities.
We present a case of TSH elevation misdiagnosed as subclinical hypothyroidism following non-convulsive status epilepticus. In this case report, we suggested the possible mechanisms of latent hypothyroid-like hormone abnormality following epileptic seizures and the possibility of provoking epileptic seizures by administering levothyroxine for misdiagnosed subclinical hypothyroidism.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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