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Pancreatectomy for metastasis to the pancreas from colorectal cancer and reconstruction of superior mesenteric vein: a case report

  • Efstratios Georgakarakos1Email author,
  • Hartmut Goertz1,
  • Joerg Tessarek1,
  • Karsten Papke2 and
  • Christoph Seidlmayer3
Journal of Medical Case Reports20115:424

https://doi.org/10.1186/1752-1947-5-424

Received: 23 November 2010

Accepted: 31 August 2011

Published: 31 August 2011

Abstract

Introduction

Tumors of the pancreatic head can infiltrate the superior mesenteric vein. In such cases, the deep veins of the lower limbs can serve as suitable autologous conduits for superior mesenteric vein reconstruction after its resection. Few data exist, however, describing the technique and the immediate patency of such reconstruction.

Case report

We present the case of a 70-year-old Caucasian man with a metachronous metastasis of colon cancer and infiltration of the uncinate pancreatic process, on the anterior surface of which the tumor was located. En bloc resection of the tumor was performed with resection of the superior mesenteric vein and reconstruction. A 10 cm segment of the superficial femoral vein was harvested for the reconstruction. The superficial femoral vein segment was inter-positioned in an end-to-end fashion. The post-operative conduit patency was documented ultrasonographically immediately post-operatively and after a six-month period. The vein donor limb presented subtle signs of post-operative venous hypertension with edema, which was managed with compression stockings and led to significant improvement after six months.

Conclusion

In cases of exploratory laparotomies with high clinical suspicion of pancreatic involvement, the potential need for vascular reconstruction dictates the preparation for leg vein harvest in advance. The superficial femoral vein provides a suitable conduit for the reconstruction of the superior mesenteric vein. This report supports the uncomplicated nature of this technique, since few data exist about this type of reconstruction.

Introduction

Though pancreatic metastases from colorectal cancer are very rare and the mid-term results of surgery have not been clearly defined yet, pancreatic resection has been suggested in selected patients with isolated metastases from colorectal cancer and/or limited extra-pancreatic disease [1, 2].

The most common unexpected finding at the time of pancreaticoduodenectomy in pancreatic carcinoma of the head and uncinate process is the invasion of the superior mesenteric vein (SMV) or superior mesenteric portal vein (SMV/PV) confluence, located anteriorly, laterally, or posterolaterally [3, 4]. The current literature suggests that portal vein and/or SMV invasion is not a contraindication to pancreatic resection, provided that these veins are not occluded [5]. In this report, we describe a case of resection of the SMV and restoration of its continuity by inter-position of an autologous superficial femoral vein (SFV) graft, since few data exist about SMV reconstruction with a SFV graft during pancreatectomy.

Case presentation

A 70-year-old Caucasian man with a history of right hemi-colectomy one year earlier (due to adenocarcinoma of the right colon) was admitted to our hospital with abdominal pain and unexplained weight loss. His laboratory values, X-rays, and computed tomography (CT) were not indicative of any distinctive pathology. Therefore, the general surgeons decided to proceed with an exploratory laparotomy, based on the patient's recent hemi-colectomy and the high clinical suspicion of a metachronous metastatic insult of the pancreas.

A metastatic tumor was identified in the uncinate process of the pancreas. During the dissection and preparation, the SMV involvement was identified on its anterior surface superiorly to the confluence of the middle colic vein at the level of the transverse mesocolon. No involvement of the superior mesenteric artery was identified. When it was decided that the tumor could be resected with a sufficient macroscopic margin, a duodenopancreatectomy was performed. Sufficient resection with healthy margins was documented by intra-operative histology. The tumor adhered only to the SMV, with the latter caudally divided at the point where the SMV emerged.

Accordingly, a right mid-thigh incision was performed, and an adequate SFV segment up to the junction with the profunda femoris vein was harvested. The duration from the vein preparation and harvest to skin closure was 15 to 20 minutes. During the venous reconstruction, a solution of 5000 U of heparin was delivered locally through the SMV. No valvulotomy was performed. The pancreatic head resection was immediately followed by the construction of a proximal anastomosis between a non-reversed SFV segment 3 cm to 4 cm in length and the central stump of the SMV in an end-to-end fashion (Figure 1). The peripheral anastomosis was created in a similar fashion. The duration of the creation of each anastomosis was 10 minutes. Intra-operatively, the patency of the reconstruction was confirmed by a continuous wave Doppler signal. The operation was completed with the creation of pancreatojejunostomy and a new ileotransversostomy.
Figure 1

Resection and reconstruction of the superior mesenteric vein with superficial vein segment. (A) Distal anastomosis. (B) Proximal anastomosis. The red vessel loop encircles the superior mesenteric artery.

The patient's post-operative instructions included the administration of a prophylactic dose of low-molecular-weight heparin, limb elevation, and application of compression stockings (class II). During the immediate post-operative and follow-up phase (six months), only mild edema of the leg was marked. The SFV inter-position graft showed good patency (Figure 2) on color duplex ultrasonography.
Figure 2

Ultrasonographic six-month follow-up evaluation of the superficial femoral vein inter-position graft showing good patency.

Discussion

Pancreatic resection is sometimes combined with reconstruction of the major veins with venous grafts [6]. The vein reconstruction can be applied more frequently than anticipated pre-operatively, since pre-operative imaging can present false estimation of the SMV/PV invasion and CT may not differentiate tumor invasion from inflammatory adhesion [4, 7]. The aforementioned examples justify the need for vascular intra-operative consultation, as in our case. From the surgical point of view, it is only when the neck of the pancreas has been divided that the degree of SMV involvement can be assessed to further proceed to SMV/PV resection and reconstruction [8].

Several types of conduits have been utilized for the reconstruction of the SMV, including mostly autogenous vein grafts and, in some cases, synthetic polytetrafluorethylene grafts. The avoidance of the infection risk regarding the pancreatoduodenectomy favors the autogenous conduits. Apart from the commonly used saphenous vein (SV) and SMV, autologous reconstructions with the internal jugular vein, left renal vein, and gonadal veins have also been reported. The SFV provides an excellent size match (7 mm to 12 mm in diameter and 40 to 50 cm in length) for the SMV/PV site compared with the SV [9]. Generally, the SV is preferred for SMV patching, whereas the SFV is preferred as an inter-position conduit. Lee et al. [4] suggested performing reconstruction of the SMV/PV with a vein patch when less than one-third of the vessel circumference is involved, whereas an inter-position fashion is the preferred option when there is a greater degree of vessel involvement. Careful preservation of the junction of the profunda femoris vein with the common femoral vein remains a key note for the prevention of excessive venous hypertension.

Immediately post-operatively and after six months, our patient had only mild edema and no discomfort. There seemed to be no significant difference in the measurement of the circumference of the harvested limb compared with the unharvested limb (thigh, proximal calf, mid-calf, and ankle). As long as the SFV harvest does not extend into the popliteal segment and the profunda femoral vein is preserved, the generation of severe venous hypertension and the consequent need for prophylactic fasciotomies is precluded. The minimal mid-term to late-term lower-limb venous morbidity could be attributed to the preservation of collaterals and the low incidence of mild reflux despite the venous outflow obstruction, provided that the venous valves are intact and competent. The deep vein harvest results in venous outflow obstruction. This in turn generates pooling of blood in the periphery and consequent poor apposition of the venous valve leaflets, leading to functional venous reflux, thus underscoring the clinical utility of compression stockings. These pathophysiologic features could explain why SFV harvest is so well tolerated in contrast to the valve damage caused by venous thrombosis.

Conclusion

The SFV can be an excellent conduit for SMV reconstruction because of its size and availability, good mid-term patency, and low peri-operative and post-operative venous morbidity. Surgeons should be aware of and prepared for the unexpected need to perform venous reconstruction with a SFV conduit. Adherence to technical perfection makes SFV an excellent conduit with minimal morbidity.

Consent

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Abbreviations

SFV: 

superficial femoral vein

SMV: 

superior mesenteric vein

SMV/PV: 

superior mesenteric portal vein.

Declarations

Authors’ Affiliations

(1)
Department of Vascular Surgery, St Bonifatius Hospital
(2)
Department of Radiology, St Bonifatius Hospital
(3)
Department of General Surgery, St Bonifatius Hospital

References

  1. Sperti C, Pasquali C, Berselli M, Frison L, Vicario G, Pedrazzoli S: Metastasis to the pancreas from colorectal cancer: is there a place for pancreatic resection?. Dis Colon Rectum. 2009, 52: 1154-1159. 10.1007/DCR.0b013e31819f7397.View ArticlePubMedGoogle Scholar
  2. Lasithiotakis K, Petrakis I, Georgiadis G, Paraskakis S, Chalkiadakis G, Chrysos E: Pancreatic resection for metastasis to the pancreas from colon and lung cancer, and osteosarcoma. JOP. 2010, 11: 593-596.PubMedGoogle Scholar
  3. Cusack JC, Fuhrman GM, Lee JE, Evans DB: Managing unsuspected tumor invasion of the superior mesenteric-portal venous confluence during pancreaticoduodenectomy. Am J Surg. 1994, 168: 352-354. 10.1016/S0002-9610(05)80164-3.View ArticlePubMedGoogle Scholar
  4. Lee DY, Mitchell EL, Jones MA, Landry GJ, Liem TK, Sheppard BC, Billingsley KG, Moneta GL: Techniques and results of portal vein/superior mesenteric vein reconstruction using femoral and saphenous vein during pancreaticoduodenectomy. J Vasc Surg. 2010, 51: 662-666. 10.1016/j.jvs.2009.09.025.View ArticlePubMedGoogle Scholar
  5. Ramacciato G, Mercantini P, Petrucciani N, Giaccaglia V, Nigri G, Ravaioli M, Cescon M, Cucchetti A, Del Gaudio M: Does portal-superior mesenteric vein invasion still indicate irresectability for pancreatic carcinoma?. Ann Surg Oncol. 2009, 16: 817-825. 10.1245/s10434-008-0281-8.View ArticlePubMedGoogle Scholar
  6. Siriwardana HP, Siriwardena AK: Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pancreatectomy for cancer. Br J Surg. 2006, 93: 662-673. 10.1002/bjs.5368.View ArticlePubMedGoogle Scholar
  7. Li B, Chen FZ, Ge XH, Cai MZ, Jiang JS, Li JP, Lu SH: Pancreatoduodenectoma with vascular reconstruction in treating carcinoma of the pancreatic head. Hepatobiliary Pancreat Dis Int. 2004, 3: 612-615.PubMedGoogle Scholar
  8. O'Sullivan AW, Heaton N, Rela M: Cancer of the uncinate process of the pancreas: surgical anatomy and clinicopathological features. Hepatobiliary Pancreat Dis Int. 2009, 8: 569-574.PubMedGoogle Scholar
  9. Smith ST, Clagett GP: Femoral vein harvest for vascular reconstructions: pitfalls and tips for success. Semin Vasc Surg. 2008, 21: 35-40. 10.1053/j.semvascsurg.2007.11.007.View ArticlePubMedGoogle Scholar

Copyright

© Georgakarakos et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.