- Case report
- Open Access
- Open Peer Review
Inflammatory pseudotumor of the kidney: a case report
© Khallouk et al; licensee BioMed Central Ltd. 2011
- Received: 31 December 2010
- Accepted: 24 August 2011
- Published: 24 August 2011
Inflammatory pseudotumors, also known as inflammatory myofibroblastic tumors, are uncommon benign tumors of unknown etiology which may develop at several anatomical sites. In the urogenital tract, inflammatory pseudotumor usually affects the urinary bladder or the prostate. Inflammatory pseudotumor of the kidney is very rare. It is considered as a reactive inflammatory lesion that features very good prognosis.
We present the case of a 57-year-old Moroccan man who presented with a two-month history of gross hematuria and left lumbar pain. Imaging investigations revealed a left kidney mass and pathological examination of the nephrectomy specimen showed an inflammatory pseudotumor.
As the preoperative definitive diagnosis of such a tumor is not possible, surgery is advised because only pathological examination of the nephrectomy specimen can establish the diagnosis with certainty. From one case report and literature review, the authors suggest a diagnostic and therapeutic strategy for the management of this rare tumor.
- Renal Cell Carcinoma
- Radical Nephrectomy
- Fibrous Histiocytoma
- Latent Membrane Protein
- Inflammatory Myofibroblastic Tumor
Inflammatory pseudotumor is a rare benign condition of unknown cause. As far as we know, less than 20 cases have been reported in the English literature. It is important to report such rare benign renal tumors in order to determine their reliable characteristics and avoid performing unnecessary nephrectomies that increase the risk of chronic kidney disease. It can be seen in various organs. Originally described in the lungs, a renal location is extremely rare . As inflammatory pseudotumor of the kidney usually mimics renal cell carcinoma, the preoperative diagnosis remains difficult and it is only made through pathological examination of the tumor. We report a case of inflammatory pseudotumor of the kidney; our patient presented with a renal mass and was treated with radical nephrectomy.
The postoperative course was uneventful and our patient is disease-free after a follow-up of 14 months.
Renal inflammatory pseudotumor (RIP) is very rare. It affects individuals of both sexes and is seen in a wide range of age groups . First described in the lung which is the most common site of involvement, RIP has been described as a benign lesion that mimics malignancy . Differential diagnoses include malignant tumors such as renal cell carcinoma, sarcomatoid renal cell carcinoma, inflammatory fibrosarcoma, malignant fibrous histiocytoma, low grade neurogenic tumor, myxoid leiomyosarcoma and non-malignant tumors such as angiomyolipoma, xanthogranuloma pyelonephritis and plasma cell granuloma [4, 5]. The pathogenesis of RIP is still controversial. The inflammatory reaction may be secondary to trauma, surgery, infection or an autoimmune process. Some cases could be related to Epstein-Barr virus infection as some authors reported positivity for Epstein-Barr virus latent membrane protein, especially in the liver and spleen [6, 7].
Patients with RIP usually present with lumbar pain and hematuria. Physical examinations and radiological investigations are often inconclusive. RIP can be seen as a hypo- or heterogeneous echoic mass on sonography, a well-defined hypoechoic mass with intratumoral vascularity on enhanced power Doppler sonography, a low-attenuation mass on CT, and hypovascular lesion on magnetic resonance imaging (MRI) .
We initially approached our case as renal cell carcinoma due to our patient's symptoms (hematuria and left flank pain) together with CT findings. Some authors reported malignancy associated with inflammatory pseudotumors  and it is difficult to make a preoperative diagnosis because symptoms and imaging findings are not specific. It is therefore appropriate to presume the given renal mass to be a renal cell carcinoma and to perform nephrectomy (be it radical or partial). Most diagnoses have been made after surgical intervention .
Histological examination is of particular importance to ensure appropriate patient management because RIP can be confused with both reactive process and malignant tumor . RIP consist of a proliferation of spindle cells admixed with various amounts of lymphoplasmacytic infiltrate. Immunohistochemical studies support the myofibroblastic nature of this lesion, with consistent expression of vimentin and smooth muscle actin. These tumors are strongly positive for cluster of differentiation 34 molecule (CD34) reactivity. The architectural appearances vary and have been described as a patternless pattern .
RIP is an extremely rare neoplasm of uncertain biological potential. The preoperative diagnosis remains difficult, despite progress in medical imaging and often requires surgical exploration.
We report a case of RIP treated with radical nephrectomy because the tumor was presumed to be malignant. Histological examination of the specimen confirmed RIP. It is therefore mandatory to carry out good histological examination to make the diagnosis and to assure appropriate patient management.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Coffin CM, Watterson J, Priest JR, Dehner LP: Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol. 1995, 19 (8): 859-872. 10.1097/00000478-199508000-00001.View ArticlePubMedGoogle Scholar
- Park SB, Cho KS, Kim JK, Lee JH, Jeong AK, Kwon WJ, Kim HH: Inflammatory pseudotumor (myoblastic tumor) of the genitourinary tract. AJR Am J Roentgenol. 2008, 191 (4): 1255-1262. 10.2214/AJR.07.3663.View ArticlePubMedGoogle Scholar
- Ryu KH, Im CM, Kim MK, Kwon D, Park K, Ryu SB, Choi C: Inflammatory myofibroblastic tumor of the kidney misdiagnosed as renal cell carcinoma. J Korean Med Sci. 2010, 25 (2): 330-332. 10.3346/jkms.2010.25.2.330.View ArticlePubMedGoogle Scholar
- Tazi K, Ehirchiou A, Karmouni T, Maazaz K, el Khadir K, Koutani A, Ibn Attiya AI, Hachimi M, Lakrissa A: Inflammatory pseudotumors of the kidney: a case report. Ann Urol (Paris). 2001, 35 (1): 30-33.View ArticleGoogle Scholar
- Selvan DR, Philip J, Manikandan R, Helliwell TR, Lamb GH, Desmond AD: Inflammatory pseudotumor of the kidney. World J Surg Oncol. 2007, 5: 106-10.1186/1477-7819-5-106.View ArticlePubMedPubMed CentralGoogle Scholar
- Arber DA, Kamel OW, van de Rijn M, Davis RE, Medeiros LJ, Jaffe ES, Weiss LM: Frequent presence of the Epstein-Barr virus in inflammatory pseudotumor. Hum Pathol. 1995, 26 (10): 1093-1098. 10.1016/0046-8177(95)90271-6.View ArticlePubMedGoogle Scholar
- Brittig F, Ajtay E, Jaksó P, Kelényi G: Follicular dendritic reticulum cell tumor mimicking inflammatory pseudotumor of the spleen. Pathol Oncol Res. 2004, 10 (1): 57-60. 10.1007/BF02893411.View ArticlePubMedGoogle Scholar
- Tarhan F, Gül AE, Karadayi N, Kuyumcuoğlu U: Inflammatory pseudotumor of the kidney: a case report. Int Urol Nephrol. 2004, 36 (2): 137-140.View ArticlePubMedGoogle Scholar
- Gwynn ES, Clark PE: Inflammatory myofibroblastic tumor associated with renal cell carcinoma. Urology. 2005, 66 (4): 880-View ArticlePubMedGoogle Scholar
- Petrescu A, Berdan G, Hulea I, Gaitanidis R, Ambert V, Jinga V, Popescu M, Andrei F, Niculescu L: Renal inflammatory myofibroblastic tumor - a new case report. Rom J Morphol Embryol. 2007, 48 (4): 437-442.PubMedGoogle Scholar
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