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Chest pain with ST segment elevation in a patient with prosthetic aortic valve infective endocarditis: a case report
© Luther et al; licensee BioMed Central Ltd. 2011
Received: 11 April 2011
Accepted: 24 August 2011
Published: 24 August 2011
Acute ST-segment elevation myocardial infarction secondary to atherosclerotic plaque rupture is a common medical emergency. This condition is effectively managed with percutaneous coronary intervention or thrombolysis. We report a rare case of acute myocardial infarction secondary to coronary embolisation of valvular vegetation in a patient with infective endocarditis, and we highlight how the management of this phenomenon may not be the same.
A 73-year-old British Caucasian man with previous tissue aortic valve replacement was diagnosed with and treated for infective endocarditis of his native mitral valve. His condition deteriorated in hospital and repeat echocardiography revealed migration of vegetation to his aortic valve. Whilst waiting for surgery, our patient developed severe central crushing chest pain with associated anterior ST segment elevation on his electrocardiogram. Our patient had no history or risk factors for ischaemic heart disease. It was likely that coronary embolisation of part of the vegetation had occurred. Thrombolysis or percutaneous coronary intervention treatments were not performed in this setting and a plan was made for urgent surgical intervention. However, our patient deteriorated rapidly and unfortunately died.
Clinicians need to be aware that atherosclerotic plaque rupture is not the only cause of acute myocardial infarction. In the case of septic vegetation embolisation, case report evidence reveals that adopting the current strategies used in the treatment of myocardial infarction can be dangerous. Thrombolysis risks intra-cerebral hemorrhage from mycotic aneurysm rupture. Percutaneous coronary intervention risks coronary mycotic aneurysm formation, stent infections as well as distal septic embolisation. As yet, there remains no defined treatment modality and we feel all cases should be referred to specialist cardiac centers to consider how best to proceed.
Atherosclerotic plaque rupture within a coronary vessel can lead to rapid vessel occlusion and subsequent myocardial ischaemia and necrosis . Risk factors for the development of atherosclerosis include hypertension, diabetes mellitus, high cholesterol, a history of smoking, and a family history of atherosclerotic disease . Current treatment involves either percutaneous coronary intervention (PCI) to relieve the occlusion, or thrombolysis to dissolve the occlusion .
There are more rare causes of acute myocardial infarction (AMI). We present and discuss the case of a patient with AMI secondary to embolisation of vegetation sitting on a prosthetic aortic valve in a patient with confirmed aortic valve infective endocarditis (IE).
Coronary embolisation is a rare cause of AMI and needs to be considered in patients with atrial fibrillation, prosthetic heart valves, dilated cardiomyopathy, and IE, where either thrombus or vegetation can embolize into the coronary circulation. Although systemic embolisation can occur in up to 50% of cases of IE , coronary embolisation rate is about 0.3% . There appears to be an increased risk of embolisation with vegetations that are > 1 cm in diameter, as in our patient's case . Successful strategies that have been used to manage coronary embolisation in non-endocarditic patients include thrombolytics , PCI and thrombus aspiration .
There is no clear evidence available about the best treatment option for patients with coronary embolisation in the setting of acute IE . Thrombolytic treatment of septic coronary embolisation is associated with an increased risk of cerebral vascular hemorrhage due to bleeding from silent cerebral microinfarctions or mycotic aneurysms . Indeed AMI caused by septic embolisation is a relative contraindication to the use of thrombolytic agents. PCI involves coronary balloon angioplasty and stent deployment, and this risks mycotic aneurysm formation at the dilatation site. This occurs as the balloon crushes vegetation against the vessel wall . Implanting foreign stent material into an infective site can lead to stent infection, and this can require stent excision and debridement . In addition, PCI risks further distal vegetation embolisation . As reported in a previous case report, 'the impulse to follow conventional strategies for coronary reperfusion should be tempered by thoughts of possible consequences' .
Surgical intervention in left-sided IE is in fact recommended in the context of systemic embolisation . However, evidence of successful surgical intervention in the context of coronary embolisation is scarce, with a few case reports demonstrating success through coronary embolectomy .
This case report presents a common condition seen in an uncommon setting. AMI is common, and the management is well defined and performed by acute physicians and cardiologists. However, in the absence of risk factors for ischaemic heart disease, clinicians need to consider alternate causes of AMI.
This is especially important in the case of septic coronary embolisation in patients with IE, as adopting the current strategies used in the management of myocardial infarction can be dangerous. Where suspicion is high, care should be urgently transferred to specialist cardiac centers where both interventional and surgical skills are available to decide on how best to proceed.
Written informed consent was obtained from the patient's next-of-kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Rozenman Y, Rosenheck S, Nassar H, Welber S, Sapoznikov D, Lotan C, Mosseri M, Weiss AT, Gotsman MS: Acute myocardial infarction--the angiographic picture: new insights into the pathogenesis of myocardial infarction. Int J Cardiol. 1995, 49: s11-6.View ArticlePubMedGoogle Scholar
- Virmani R, Farb A, Burke AP: Risk factors in the pathogenesis of coronary artery disease. Compr Ther. 1998, 24: 519-529.PubMedGoogle Scholar
- Cohen M: High-risk acute coronary syndrome patients with non-ST-elevation myocardial infarction: definition and treatment. Cardiovasc Drugs Ther. 2008, 22: 407-418. 10.1007/s10557-008-6120-0.View ArticlePubMedGoogle Scholar
- Kraus PA, Lipman J: Coronary embolism causing myocardial infarction. Intensive Care Med. 1990, 16: 215-216. 10.1007/BF01724807.View ArticlePubMedGoogle Scholar
- Fabri J, Issa VS, Pomerantzeff PM, Grinberg M, Barretto AC, Mansur AJ: Time-related distribution, risk factors and prognostic influence of embolism in patients with left-sided infective endocarditis. Int J Cardiol. 2006, 110: 334-339. 10.1016/j.ijcard.2005.07.016.View ArticlePubMedGoogle Scholar
- Sanfilippo AJ, Picard MH, Newell JB, Rosas E, Davidoff R, Thomas JD, Weyman AE: Echocardiographic assessment of patients with infectious endocarditis: prediction of risk for complications. J Am Coll Cardiol. 1991, 18: 1191-1199. 10.1016/0735-1097(91)90535-H.View ArticlePubMedGoogle Scholar
- Quinn EG, Fergusson DJG: Coronary embolism following aortic and mitral valve replacement: successful management with abciximab and urokinase. Cathet Cardiovasc Diagn. 1998, 43: 457-459. 10.1002/(SICI)1097-0304(199804)43:4<457::AID-CCD24>3.0.CO;2-F.View ArticlePubMedGoogle Scholar
- Kiernan TJ, Flynn AMO, Kearney P: Coronary embolism causing myocardial infarction in a patient with mechanical aortic valve prosthesis. Int J Cardiol. 2006, 112: E14-E16. 10.1016/j.ijcard.2006.01.038.View ArticlePubMedGoogle Scholar
- Glazier JJ: Interventional treatment of septic coronary embolism: Sailing into uncharted and dangerous waters. J Interv Cardiol. 2002, 15: 305-307. 10.1111/j.1540-8183.2002.tb01109.x.View ArticlePubMedGoogle Scholar
- Hunter AJ, Girard DE: Thrombolytics in infectious endocarditis associated myocardial infarction. J Emerg Med. 2001, 21: 401-406. 10.1016/S0736-4679(01)00416-4.View ArticlePubMedGoogle Scholar
- Herzog CA, Henry TD, Zimmer SD: Bacterial endocarditis presenting as acute myocardial infarction: a cautionary note for the era of reperfusion. Am J Med. 1991, 90: 392-397.View ArticlePubMedGoogle Scholar
- Dieter RS: Coronary artery stent infection. Clin Cardiol. 2000, 23: 800-810. 10.1002/clc.4960231126.View ArticleGoogle Scholar
- Ural E, Bildirici U, Kahraman G, Komsuoğlu B: Coronary embolism complicating aortic valve endocarditis: treatment with successful coronary angioplasty. Int J Cardiol. 2007, 119: 377-379. 10.1016/j.ijcard.2006.07.180.View ArticlePubMedGoogle Scholar
- Chopra T, Kaatz GW: Treatment strategies for infective endocarditis. Exp Opin Pharmacother. 2010, 11: 345-360. 10.1517/14656560903496430.View ArticleGoogle Scholar
- Baek MJ, Kim HK, Yu CW, Na CY: Mitral valve surgery with surgical embolectomy for mitral valve endocarditis complicated by septic coronary embolism. Eur J Cardiothorac Surg. 2008, 33: 116-118. 10.1016/j.ejcts.2007.09.024.View ArticlePubMedGoogle Scholar
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