- Case report
- Open Access
- Open Peer Review
Stress-induced hemorrhagic gastric ulcer after successful Helicobacter pylori eradication: two case reports
© Moriya et al; licensee BioMed Central Ltd. 2011
- Received: 4 February 2010
- Accepted: 29 June 2011
- Published: 29 June 2011
Helicobacter pylori infection is a major cause of gastric ulcers, and Helicobacter pylori eradication drastically reduces ulcer recurrence. It has been reported, however, that severe physical stress is closely associated with gastric ulceration even in Helicobacter pylori -negative patients.
We report the cases of a 47-year-old Japanese man and a 69-year-old Japanese man who developed psychological stress-induced hemorrhagic gastric ulcers, in both of whom Helicobacter pylori had been successfully eradicated.
Our cases strongly suggest that not only physical but also psychological stress is still an important pathogenic factor for peptic ulceration and accordingly that physicians should pay attention to the possible presence of psychological stress in the management of patients with peptic ulcers.
- Peptic Ulcer
- Gastric Ulcer
- Psychological Stress
- Eradication Therapy
- Ulcer Recurrence
Since Selye  reported that stress induces gastrointestinal ulcers, stress has been a major pathogenic factor for peptic ulceration. It is now well-documented, however, that Helicobacter pylori (Hp) infection is a major cause of peptic ulcers and that Hp eradication drastically reduces ulcer recurrence, thereby understating or even excluding the importance of stress in ulcer formation.
On the other hand, there is increasing evidence that peptic ulcers can occur even in patients without chronic Hp infection or the use of non-steroidal anti-inflammatory drugs (NSAIDs). Chen et al.  examined 32 non-Hp and non-NSAID duodenal ulcer cases and reported that 15.6% of the cases were closely associated with psychophysical stress. In 2009, Wong et al.  revealed that patients with Hp-negative idiopathic bleeding ulcers, in the pathogenesis of which mental stress might play an important role, had a high risk of mortality and recurrent bleeding.
Along these lines, we report the cases of two patients with psychological stress-induced hemorrhagic gastric ulcers in whom Hp had been successfully eradicated. This case report surely provides clinically important information that psychological stress should also be considered in the management of patients with gastric ulcers.
A 69-year-old Japanese man visited our hospital seven years ago because of repeated tarry stools. In the previous year, he had developed a gastric ulcer and underwent Hp eradication therapy. He did not take NSAIDs or aspirin or drink alcohol, but he smoked an average of 20 cigarettes daily. Before he noticed tarry stools, he had been requested to edit a booklet for a community meeting. He was computer-illiterate and totally unaccustomed to such a task. He could manage to finish it by the deadline, but he developed tarry stools. He reported that his smoking pattern, including the number of cigarettes per day, was unchanged during the stressful period. Laboratory data demonstrated mild anemia (hemoglobin 11.1 g/dL), elevated BUN (33.1 mg/dL) and normal gastrin (25 pg/mL), suggesting the possible presence of gastrointestinal bleeding. Esophagogastroduodenoscopy revealed a recurrent gastric ulcer without active bleeding (Figure 1B). The absence of Hp infection was confirmed by negative 13C-urea breath test, histology and Hp antibody. The psychological assessment of the patient profile demonstrated that he was strict with regard to punctuality and had a strong sense of responsibility. These characteristics forced him to complete the task in which he was inexperienced by the deadline. It was therefore considered that his intense emotional stress resulted in his recurrent gastric ulcer.
Although it is well-established that Hp infection is the most important pathogenic factor in peptic ulceration, it has been reported that ulcer recurrence occurs even after Hp eradication. A meta-analysis of seven trials conducted in the United States showed that 20% of patients had recurrent ulcers within six months despite successful cure of Hp infection and no reported use of NSAIDs . A similar Japanese study revealed a recurrence rate of 3% 48 months after successful Hp eradication .
The mechanism by which ulcer recurrence takes place in Hp-negative patients remains to be clarified, but psychological stress may be associated with its recurrence. In fact, it should be noted that the incidence of bleeding gastric ulcers significantly increased after the Hanshin-Awaji earthquake in Japan . It has also been demonstrated that psychophysical stress contributed to duodenal ulcer formation among 15.7% of Hp-negative ulcer patients .
Since Selye  reported that stress produced the same symptoms, that is, peptic ulcer, adrenal hypertrophy and thymus atrophy, stress has been considered an important factor in the pathogenesis of ulcer formation. In fact, it has been well-documented that physical stress encountered in the intensive care unit can induce peptic ulcer bleeding among Hp-negative patients [8–10]. On the other hand, our two patients developed hemorrhagic gastric ulcers due to psychological stress rather than to physical pathologies. In other words, our findings strongly indicate that not only physical but also psychological stressors can cause ulcer bleeding in spite of Hp negativity.
In conclusion, our case reports suggest that psychological stress is still an important clinical factor for peptic ulceration. In the management of patients with peptic ulcer, physicians should pay attention to the possible presence of psychological stress as well as physical causes.
Written informed consent was obtained from the patients for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Selye H: A syndrome produced by diverse nocuous agents. Nature. 1936, 138: 32-33.View ArticleGoogle Scholar
- Chen TS, Chang FY: Clinical characteristics of Helicobacter pylori-negative duodenal ulcer disease. Hepatogastroenterology. 2008, 55: 1615-1618.PubMedGoogle Scholar
- Wong GL, Wong VW, Chan Y, Ching JY, Au K, Hui AJ, Lai LH, Chow DK, Siu DK, Lui YN, Wu JC, To KF, Hung LC, Chan HL, Sung JJ, Chan FK: High incidence of mortality and recurrent bleeding in patients with Helicobacter pylori-negative idiopathic bleeding ulcers. Gastroenterology. 2009, 137: 525-531. 10.1053/j.gastro.2009.05.006.View ArticlePubMedGoogle Scholar
- Friedman M, Rosenman RH: Association of specific overt behavior pattern with blood and cardiovascular findings; blood cholesterol level, blood clotting time, incidence of arcus senilis, and clinical coronary artery disease. J Am Med Assoc. 1959, 169: 1286-1296.View ArticlePubMedGoogle Scholar
- Laine L, Hopkins RJ, Girardi LS: Has the impact of Helicobacter pylori therapy on ulcer recurrence in the United States been overstated? A meta-analysis of rigorously designed trials. Am J Gastroenterol. 1998, 93: 1409-1415.PubMedGoogle Scholar
- Miwa H, Sakaki N, Sugano K, Sekine H, Higuchi K, Uemura N, Kato M, Murakami K, Kato C, Shiotani A, Ohkusa T, Takagi A, Aoyama N, Haruma K, Okazaki K, Kusugami K, Suzuki M, Joh T, Azuma T, Yanaka A, Suzuki H, Hashimoto H, Kawai T, Sugiyama T: Recurrent peptic ulcers in patients following successful Helicobacter pylori eradication: a multicenter study of 4,940 patients. Helicobacter. 2004, 9: 9-16. 10.1111/j.1083-4389.2004.00194.x.View ArticlePubMedGoogle Scholar
- Aoyama N, Kinoshita Y, Fujimoto S, Himeno S, Todo A, Kasuga M, Chiba T: Peptic ulcers after the Hanshin-Awaji earthquake: increased incidence of bleeding gastric ulcers. Am J Gastroenterol. 1998, 93: 311-316. 10.1111/j.1572-0241.1998.00311.x.View ArticlePubMedGoogle Scholar
- Schilling D, Haisch G, Sloot N, Jakobs R, Saggau W, Riemann JF: Low seroprevalence of Helicobacter pylori infection in patients with stress ulcer bleeding: a prospective evaluation of patients on a cardiosurgical intensive care unit. Intensive Care Med. 2000, 26: 1832-1836. 10.1007/s001340000724.View ArticlePubMedGoogle Scholar
- Halm U, Halm F, Thein D, Mohr FW, Mössner J: Helicobacter pylori infection: a risk factor for upper gastrointestinal bleeding after cardiac surgery?. Crit Care Med. 2000, 28: 110-113. 10.1097/00003246-200001000-00018.View ArticlePubMedGoogle Scholar
- Robert R, Gissot V, Pierrot M, Laksiri L, Mercier E, Prat G, Villers D, Vincent JF, Hira M, Vignon P, Charlot P, Burucoa C: Helicobacter pylori infection is not associated with an increased hemorrhagic risk in patients in the intensive care unit. Crit Care. 2006, 10: R77-10.1186/cc4920.View ArticlePubMedPubMed CentralGoogle Scholar
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