18F-fluorodeoxyglucose positron emission tomography-positive sarcoidosis after chemoradiotherapy for Hodgkin’s disease: a case report
© Cherk et al; licensee BioMed Central Ltd. 2011
Received: 12 July 2010
Accepted: 29 June 2011
Published: 29 June 2011
The occurrence of granulomatous disease in the setting of Hodgkin's disease is rare; however, when it occurs it can pose significant clinical and diagnostic challenges for physicians treating these patients.
We report the case of a 33-year-old Caucasian woman of Mediterranean descent with newly diagnosed 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) scan-positive, early-stage Hodgkin's disease involving the cervical nodes who, despite having an excellent clinical response to chemotherapy, had a persistent 18F-FDG PET scan-positive study, which was suggestive of residual or progressive disease. A subsequent biopsy of her post-chemotherapy PET-positive nodes demonstrated sarcoidosis with no evidence of Hodgkin's disease.
This case highlights the fact that abnormalities observed on posttherapy PET/CT scans in patients with Hodgkin's disease are not always due to residual or progressive disease. An association between Hodgkin's disease and/or its treatment with an increased incidence of granulomatous disease appears to exist. Certain patterns of 18F-FDG uptake observed on PET/CT scans may suggest other pathologies, such as granulomatous inflammation, and because of the significant differences in prognosis and management, clinicians should maintain a low threshold of confidence for basing their diagnosis on histopathological evaluations when PET/CT results appear to be incongruent with the patient's clinical response.
The use of positron emission tomography (PET)/computed tomography (CT) to evaluate lymphoma, including Hodgkin's disease, continues to increase worldwide and is considered the standard of care when available for pretreatment staging and assessment of treatment response.
PET has been demonstrated to modify disease stage (usually upstage) in about 15% to 20% of patients and affect therapeutic management in about 5% to 15% of patients . PET is considered significantly more accurate than CT for the assessment of treatment response because of its ability to distinguish between metabolically active tumor or fibrosis in posttherapy residual masses, which are present in approximately two-thirds of patients with Hodgkin's disease.
Although PET/CT is a highly sensitive technique for detecting Hodgkin's disease, other conditions, such as infection, inflammation and granulomatous disease, may result in a false-positive scan. An increased incidence of granulomatous disease has been associated with Hodgkin's disease and/or its treatment [2–4]; hence a positive posttherapy PET/CT scan needs to be interpreted with caution, particularly if it is incongruent with the patient's clinical response.
Here we present the case of a patient with residual PET scan positivity following seemingly successful treatment of early-stage Hodgkin's disease which subsequently was confirmed to be due to granulomatous disease.
Subsequent investigations, including serum and urinary calcium levels and an ophthalmological review for ocular sarcoidosis, were normal. Her pulmonary function tests demonstrated a mild decrease in gas transfer (62% of predicted value) which was nonspecific and possibly related to prior radiotherapy. Her chest X-ray was normal. Cardiac magnetic resonance imaging was performed to evaluate a left anterior hemiblock pattern visualized on her electrocardiogram, which was negative for cardiac sarcoidosis. A nonsteroidal anti-inflammatory drug regimen was commenced for mild chest discomfort thought to be related to mediastinal lymphadenopathy, with good relief of symptoms. A course of corticosteroids was deemed unnecessary upon a respiratory physician's review, and the proposed management plan was one of close observation.
An association between sarcoidosis and Hodgkin's lymphoma has been raised previously in the literature, including several case reports and case series describing sarcoidosis preceding or occurring concurrently with Hodgkin's lymphoma [4, 5]. An association of sarcoidosis and lymphoma has also been described by Brincker, who found that patients with sarcoidosis have a five and one-half times higher incidence of developing lymphoma associated with their sarcoidosis . Sporadic case reports have described sarcoidosis following treatment of Hodgkin's lymphoma [3, 6, 7].
Sarcoidosis is a chronic multisystem disorder of unknown cause that typically affects young to middle-aged adults and causes non-necrotizing granulomas composed of epithelioid histocytes which replace the normal lymph node architecture and at times also infiltrate body organs such as the lungs. The prevalence of sarcoidosis is estimated to be between 10 to 20 per 100,000 population; however, the prevalence is not known with certainty and can vary greatly between geographical regions. Sarcoidosis is three to four times more common among African-Americans, who have a lifetime risk of 2.4% compared to a 0.85% risk among the Caucasian population in North America [8, 9].
Interestingly, sarcoidosis and Hodgkin's disease appear to have many immunological features in common, such as cutaneous anergy, peripheral lymphopenia and prominent infiltration of helper T cells at sites of involvement. It is possible that a similar underlying dysregulation in immune function or an immunosuppressive state predisposes individuals to both conditions.
Among the other hypotheses that have been postulated is that Hodgkin's disease itself or its treatment may contribute to the development of sarcoidosis through immunosuppression or other mechanisms, such as an idiosyncratic drug reaction. ABVD therapy is a commonly utilized regimen for the treatment of Hodgkin's disease. Bleomycin differs pharmacokinetically from other drugs in ABVD combination therapy and has a relatively higher tissue concentration in the skin, lungs, kidneys, peritoneum and lymphatics relative to hematopoietic tissues . Interestingly, sarcoidosis has a predilection for similar organs; hence a relationship between the two has been raised .
18F-FDG PET/CT is considered the standard tool for primary staging and assessment of treatment response in patients with Hodgkin's lymphoma because of its high overall sensitivity (> 95%) and specificity (> 90% pretreatment and 70% to 80% posttreatment) for detecting lymphoma [10–12]. False-positive results do occur, however, particularly following treatment (in up to 10% to 40% of cases) [12, 13], as a result of other concomitant conditions, such as infection, inflammation and granulomatous disease, all of which have the potential to cause increased 18F-FDG uptake during PET.
18F-FDG PET has been demonstrated to have high sensitivity (78% to 95%) for detecting granulomatous changes and inflammation, with evidence in the literature confirming its utility as a noninvasive means of monitoring treatment response in patients with sarcoidosis. In many centers, 18F-FDG PET has surpassed the traditionally used gallium-67 scan for the diagnosis and management of patients with sarcoidosis because of its higher sensitivity for detecting active sites of disease .
It is likely that an increasing number of cases of sarcoidosis will be detected in association with Hodgkin's lymphoma or its treatment because of the increasing use of 18F-FDG PET as the main imaging modality to stage and assess the progress of this disease. Although biopsy and histopathological evaluation comprise the only definitive technique to confirm granulomatous disease and exclude residual or recurrent lymphoma, clinical features and certain patterns of 18F-FDG uptake on PET scans often suggest an alternate diagnosis, such as granulomatous disease.
Bilateral pulmonary hilar and mediastinal nodal 18F-FDG uptake particularly, if not in an original site of disease on pretreatment PET scans, should raise the possibility of an alternate pathology to Hodgkin's lymphoma following chemotherapy. This is even more true in patients with early-stage Hodgkin's lymphoma, such as in the present case, in which the prognosis would be expected to be excellent and relapse or progressive disease following first-line chemotherapy would be considered unusual. Symmetry is an important diagnostic feature of metabolically active pulmonary hilar and mediastinal lymphadenopathy associated with sarcoidosis, which often differentiates it from alternate pathologies, such as lymphoma, on PET scans .
The lungs are the most common extranodal site of involvement with sarcoidosis, and changes can often be seen on CT scans, particularly if CT is performed at high resolution . Small, 1 mm to 5 mm pulmonary nodules with irregular borders predominantly found in the upper and middle lung zone are the most common and almost universal finding where there is pulmonary involvement . The presence of architectural distortion associated with these nodules is a key feature of pulmonary sarcoidosis, which helps to differentiate it from lymphoma . Pulmonary fibrosis occurs in 20% to 25% of patients with pulmonary sarcoidosis ; however, this usually takes years to develop and is not a particularly specific finding in Hodgkin's disease patients treated with bleomycin, as this drug itself is associated with pulmonary fibrosis.
Extrathoracic involvement can also occur with sarcoidosis and warrants consideration in situations in which the PET/CT findings are incongruent with the patient's clinical response. Examples of extrathoracic sites of disease include any nodal group within the body, skin, eyes, liver, spleen, muscles, bones and parotid glands.
Apart from Hodgkin's disease, granulomatous inflammation has also been associated with other neoplasms, such as T-cell lymphomas, seminomas of the testis, renal cell carcinoma and nasopharyngeal carcinoma, where the presence of granulomas in the tumor parenchyma has been attributed to the cytokine milieu of either the main tumor of other cells comprising the tumor background . It is therefore of vital importance to scrutinize granulomas closely on the basis of histological examinations in the setting of neoplasia to avoid the underdiagnosis of residual viable malignancy.
Differential diagnoses for granulomatous inflammation in patients with a history of neoplasia include foreign body reaction to necrotic tumors, associated systemic illness such as tuberculosis caused by immunosuppression or a direct reaction to one of the therapeutic agents given to the patient .
Abnormalities on PET/CT scans in patients treated for Hodgkin's disease are not always due to residual or progressive lymphoma, and clinicians should retain a high index of suspicion for alternative pathologies when PET/CT results appear incongruent with the patient's clinical presentation or response to therapy. An association appears to exist between Hodgkin's disease and/or its treatment with an increased incidence of granulomatous disease. Certain patterns of 18F-FDG uptake on PET scans may suggest granulomatous disease rather than lymphoma, and because of the differences in the prognosis and management of the two conditions, clinicians should maintain a low threshold for biopsy and histopathological correlation in these situations.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Juweid ME: Utility of positron emission tomography (PET) scanning in managing patients with Hodgkin lymphoma. Hematology Am Soc Hematol Educ Program. 2006, 259-265. 510-511Google Scholar
- Brincker H: The sarcoidosis-lymphoma syndrome. Br J Cancer. 1986, 54: 467-473. 10.1038/bjc.1986.199.View ArticlePubMedPubMed CentralGoogle Scholar
- de Hemricourt E, De Boeck K, Hilte F, Abib A, Kockx M, Vandevivere J, De Bock R: Sarcoidosis and sarcoid-like reaction following Hodgkin's disease: report of two cases. Mol Imaging Biol. 2003, 5: 15-19. 10.1016/S1536-1632(02)00123-3.View ArticlePubMedGoogle Scholar
- Karakantza M, Matutes E, MacLennan K, O'Connor NT, Srivastava PC, Catovsky D: Association between sarcoidosis and lymphoma revisited. J Clin Pathol. 1996, 49: 208-212. 10.1136/jcp.49.3.208.View ArticlePubMedPubMed CentralGoogle Scholar
- Ponticelli P, Arganini L, Cionini L: Hodgkin's disease associated with sarcoidosis: case report. Tumori. 1981, 67: 45-51.PubMedGoogle Scholar
- Merchant TE, Filippa DA, Yahalom J: Sarcoidosis following chemotherapy for Hodgkin's disease. Leuk Lymphoma. 1994, 13: 339-347. 10.3109/10428199409056299.View ArticlePubMedGoogle Scholar
- Subbiah V, Ly UK, Khiyami A, O'Brien T: Tissue is the issue: sarcoidosis following ABVD chemotherapy for Hodgkin's lymphoma. A case report. J Med Case Reports. 2007, 1: 148-10.1186/1752-1947-1-148.View ArticlePubMed CentralGoogle Scholar
- Rybicki BA, Major M, Popovich J, Maliarik MJ, Iannuzzi MC: Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization. Am J Epidemiol. 1997, 145: 234-241.View ArticlePubMedGoogle Scholar
- Thomas KW, Hunninghake GW: Sarcoidosis. JAMA. 2003, 289: 3300-3303. 10.1001/jama.289.24.3300.View ArticlePubMedGoogle Scholar
- Jerusalem G, Warland V, Najjar F, Paulus P, Fassotte MF, Fillet G, Rigo P: Whole-body 18F-FDG PET for the evaluation of patients with Hodgkin's disease and non-Hodgkin's lymphoma. Nucl Med Commun. 1999, 20: 13-20. 10.1097/00006231-199901000-00004.View ArticlePubMedGoogle Scholar
- Jerusalem G, Beguin Y, Fassotte MF, Najjar F, Paulus P, Rigo P, Fillet G: Whole-body positron emission tomography using 18F-fluorodeoxyglucose for posttreatment evaluation in Hodgkin's disease and non-Hodgkin's lymphoma has higher diagnostic and prognostic value than classical computed tomography scan imaging. Blood. 1999, 94: 429-433.PubMedGoogle Scholar
- Schaefer NG, Taverna C, Strobel K, Wastl C, Kurrer M, Hany TF: Hodgkin disease: diagnostic value of FDG PET/CT after first-line therapy. Is biopsy of FDG-avid lesions still needed?. Radiology. 2007, 244: 257-262. 10.1148/radiol.2441060810.View ArticlePubMedGoogle Scholar
- Crocchiolo R, Fallanca F, Giovacchini G, Ferreri AJ, Assanelli A, Verona C, Pescarollo A, Bregni M, Ponzoni M, Gianolli L, Fazio F, Ciceri F: Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin's lymphoma. Ann Hematol. 2009, 88: 1229-1236. 10.1007/s00277-009-0752-4.View ArticlePubMedGoogle Scholar
- Basu S, Zhuang H, Torigian DA, Rosenbaum J, Chen W, Alavi A: Functional imaging of inflammatory diseases using nuclear medicine techniques. Semin Nucl Med. 2009, 39: 124-145. 10.1053/j.semnuclmed.2008.10.006.View ArticlePubMedGoogle Scholar
- Nishino M, Lee KS, Itoh H, Hatabu H: The spectrum of pulmonary sarcoidosis: variations of high-resolution CT findings and clues for specific diagnosis. Eur J Radiol. 2010, 73: 66-73. 10.1016/j.ejrad.2008.09.038.View ArticlePubMedGoogle Scholar
- Koyama T, Ueda H, Togashi K, Umeoka S, Kataoka M, Nagai S: Radiologic manifestations of sarcoidosis in various organs. Radiographics. 2004, 24: 87-104. 10.1148/rg.241035076.View ArticlePubMedGoogle Scholar
- Brauner MW, Grenier P, Mompoint D, Lenoir S, de Crémoux H: Pulmonary sarcoidosis: evaluation with high-resolution CT. Radiology. 1989, 172: 467-471.View ArticlePubMedGoogle Scholar
- Itoh H, Nishino M, Hatabu H: Architecture of the lung: morphology and function. J Thorac Imaging. 2004, 19: 221-227. 10.1097/01.rti.0000142835.06988.b0.View ArticlePubMedGoogle Scholar
- Bhatia A, Kumar Y, Kathpalia AS: Granulomatous inflammation in lymph nodes draining cancer: a coincidence or a significant association!. Int J Med Med Sci. 2009, 1: 13-16.Google Scholar
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