- Case report
- Open Access
- Open Peer Review
Half-dose verteporfin photodynamic therapy for bullous variant of central serous chorioretinopathy: a case report
© Ng et al; licensee BioMed Central Ltd. 2011
- Received: 20 October 2010
- Accepted: 26 May 2011
- Published: 26 May 2011
Central serous chorioretinopathy is characterized by serous neurosensory detachment of the macula and it usually resolves spontaneously with good visual prognosis. In some patients, however, the serous retinal detachment might be very extensive and can result in bullous exudative retinal detachment. We evaluated the use of half-dose verteporfin photodynamic therapy for the treatment of bullous retinal detachment in idiopathic central serous chorioretinopathy.
We report the case of a 51-year-old Chinese man who presented with blurred vision in his right eye and superior visual field defect due to bullous variant of central serous chorioretinopathy. No improvement in vision and retinal detachment was noted after three months of observation and a short course of oral acetazolamide. He was then treated with half-dose verteporfin photodynamic therapy and his visual acuity improved from 20/70 to 20/25 within one month of treatment. Three months after photodynamic therapy, there was complete resolution of sub-retinal fluid and bullous retinal detachment. No recurrence of central serous chorioretinopathy was noted in three years of follow-up.
We report the beneficial effect of photodynamic therapy with half-dose verteporfin as a treatment option for bullous retinal detachment caused by central serous chorioretinopathy.
- Retinal Detachment
- Central Serous Chorioretinopathy
- Serous Retinal Detachment
- Exudative Retinal Detachment
Central serous chorioretinopathy (CSC) is characterized by serous neurosensory detachment of the macula and it usually resolves spontaneously with good visual prognosis. In some patients, however, the serous retinal detachment might be very extensive and a large amount of sub-retinal fluid can result in bullous exudative retinal detachment . Photodynamic therapy (PDT) with verteporfin has been shown to be effective in the treatment of CSC but the use of conventional dosage of verteporfin (6 mg/m2) might be associated with complications such as iatrogenic choroidal neovascularization, diffuse retinal epithelial atrophy and more severe retinal thinning [2–4]. We report the use of half-dose (3 mg/m2) verteporfin PDT for treating a patient with the severe bullous form of CSC.
Bullous CSC is an uncommon form of CSC associated with a large amount of sub-retinal fluid. The visual prognosis of bullous CSC is generally poorer than those limited to the macula, as recurrence is common even after initial complete regression . Traditional management options of bullous CSC include observation or thermal laser photocoagulation. However, previous studies have shown that the outcome of thermal laser photocoagulation is similar with the natural course of the disease in terms of disease duration and final visual acuity .
In recent years, PDT with verteporfin has been utilized for treating patients with CSC. However, full-dose PDT for treating CSC is not without complications, as retinal pigment epithelium atrophy, retinal thinning and choroidal neovascularization have been reported after PDT for chronic CSC [2–4]. In order to decrease the extent of collateral damage and the risk of adverse events, a reduced dose of verteporfin has been used to treat CSC, with the efficacy of PDT remained high [3, 5, 6].
To the best of our knowledge, the long-term outcome of half-dose PDT for bullous variant of CSC has not previously been reported. Our case demonstrated that this treatment is effective in reducing the bullous exudative retinal detachment and improving the patient's vision rapidly. Moreover, there was no evidence of any disease recurrence or complications after more than three years of follow-up. The reasons for the successful treatment outcome might be related to the idiopathic cause of the disease and intuition of early treatment in our patient. Although the longer term complications and recurrence rate remains unknown, half-dose verteporfin PDT for bullous CSC appeared to be an effective treatment option and might be considered as a management option for these patients.
Bullous exudative retinal detachment is an uncommon manifestation of CSC and can result in significant visual loss. Our patient demonstrated that half-dose verteporfin PDT is an effective treatment option for bullous CSC, resulting in rapid resolution of exudative retinal detachment and improvement in vision.
Written informed consent was obtained from the patient for publication of this manuscript and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Otsuka S, Ohba N, Nakao K: A long-term follow-up study of severe variant of central serous chorioretinopathy. Retina. 2002, 22 (1): 25-32. 10.1097/00006982-200202000-00005.View ArticlePubMedGoogle Scholar
- Yannuzzi LA, Slakter JS, Gross NE, Spaide RF, Costa DL, Huang SJ, Klancnik JM, Aisman A: Indocyanine green angiography-guided photodynamic therapy for treatment of chronic central serous chorioretinopathy: a pilot study. Retina. 2003, 23 (3): 288-298. 10.1097/00006982-200306000-00002.View ArticlePubMedGoogle Scholar
- Lai TY, Chan WM, Li H, Lai RY, Liu DT, Lam DS: Safety enhanced photodynamic therapy with half-dose verteporfin for chronic central serous chorioretinopathy: a short term pilot study. Br J Ophthalmol. 2006, 90 (7): 869-874. 10.1136/bjo.2006.090282.View ArticlePubMedPubMed CentralGoogle Scholar
- Shin JY, Woo SJ, Yu HG, Park KH: Comparison of efficacy and safety between half-fluence and full-fluence photodynamic therapy for chronic central serous chorioretinopathy. Retina. 2011, 31 (1): 119-126. 10.1097/IAE.0b013e3181e378f2.View ArticlePubMedGoogle Scholar
- Chan WM, Lai TY, Lai RY, Liu DT, Lam DS: Half-dose verteporfin photodynamic therapy for acute central serous chorioretinopathy: one-year results of a randomized controlled trial. Ophthalmology. 2008, 115 (10): 1756-1765. 10.1016/j.ophtha.2008.04.014.View ArticlePubMedGoogle Scholar
- Zhao MW, Zhou P, Xiao HX, Lv YS, Li CA, Liu GD, Li XX: Photodynamic therapy for acute central serous chorioretinopathy: the safe effective lowest dose of verteporfin. Retina. 2009, 29 (8): 1155-1161. 10.1097/IAE.0b013e3181a6c028.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.