- Case report
- Open Access
- Open Peer Review
Neurocysticercosis as an important differential of seizures in pregnancy: two case reports
© Singhal et al; licensee BioMed Central Ltd. 2011
- Received: 5 November 2009
- Accepted: 26 May 2011
- Published: 26 May 2011
Seizures in pregnancy usually result from eclampsia, epilepsy or central nervous system disorders. Neurocysticercosis is a rare, but an important, cause of first-time convulsions in pregnancy.
We report the cases of two Indian women, aged 20 and 24 years old respectively, with neurocysticercosis presenting in the second trimester of pregnancy with convulsions. Both had marginally raised blood pressure with 1+ urine albumin and neither had a past history of convulsions. The neurocysticercosis was diagnosed on magnetic resonance imaging of the head, which showed spherical ring-enhancing lesions in the brain. In one woman, pregnancy was terminated due to spina bifida in the fetus and she was discharged on albendazole and phenytoin. The second woman was put on carbamazepine: she had an emergency Cesarean section at term for fetal distress and delivered a healthy baby. Her postnatal period was uneventful.
Neurocysticercosis should be considered in pregnant women presenting with seizures which cannot be explained by eclampsia, especially in early pregnancy.
- Endemic Area
- Spina Bifida
- Urine Albumin
Seizures in pregnancy usually result from eclampsia, epilepsy or central nervous system disorders. Neurocysticercosis, although rare, is an important cause of first-time convulsions in pregnancy. Del Brutto has proposed certain definitive and probable criteria for the diagnosis of neurocysticercosis: histology; imaging; epidemiology; serology; clinical symptoms; and follow-up scans . Magnetic response imaging (MRI) is superior to a computed tomography (CT) scan in diagnosis and follow-up studies . The signs and symptoms range from a single seizure to coma and death. It can be treated with minimal interruption to the course of the pregnancy and medical treatment is effective in most cases although surgery may be indicated for a few women . We report two cases of neurocysticercosis in women who presented with convulsions in the second trimester of their pregnancy.
A 20-year-old Indian woman who was an unbooked primigravida presented as an emergency at 27 weeks of gestation with generalised tonic clonic seizures over a six hour period. She had been unconsciousness for one hour. She was referred by a general practitioner with a diagnosis of eclampsia. There was no past history of seizures and she was not on any medication. On examination, she was in a grade III coma and her pulse and blood pressure were 92 beats/min and 130/90 mmHg, respectively. Her urine albumin was +1 and the liver function, renal function and fundus examinations were normal. An ultrasound showed a live 26-week-size fetus with spina bifida. An emergency MRI of our patient's head showed a 4-5 mm spherical ring-enhancing lesion in the frontal region of her brain. A diagnosis of neurocysticercosis was made on the basis of the MRI finding, symptoms and living in an endemic area. She was put on intravenous phenytoin and the pregnancy was terminated in view of the fetus' spina bifida with misoprostol. She aborted after 16 hours and regained consciousness after 24 hours: she was discharged on albendazole and phenytoin.
Convulsions during pregnancy reported to an obstetrician are mainly due to eclampsia. A complete and continuous evaluation is crucial to differentiate eclampsia from other disorders. When atypical features are present, or clinical status worsens, neuroimaging is important . In both these reported cases there was marginally raised blood pressure; +1 albuminuria; no past history of any seizures; and both women presented in the second trimester. Marginally raised blood pressure and +1 urine albumin may be present in acute stages of convulsions. In both women, the MRI was suggestive of neurocysticercosis.
The first case was misdiagnosed as eclampsia at periphery. There was a small possibility of eclampsia as her blood pressure was only 130/90 mmHg and only +1 urine albumin. Bearing this in the mind, an emergency MRI of the head was done which detected the spherical ring-enhancing lesion. The diagnosis of neurocysticercosis was made on the basis of MRI findings, symptoms and living in an endemic area. She presented in a very bad state with a grade III coma as she had multiple seizures over a period of six hours. The second woman was in quite good condition in spite of having suffered a seizure. Thus, the presentation may be variable from a single episode to multiple seizures.
Neurocysticercosis is usually misdiagnosed as eclampsia and can be differentiated by imaging studies as in these two cases. MRI is superior to a CT scan in such cases . During pregnancy, treatment of neurocysticercosis consists of anti-convulsant therapy. Anti-helminthic drugs should be delayed until post-partum .
Neurocysticercosis should be considered as a possible diagnosis in pregnant women presenting with seizures which cannot be explained by eclampsia, especially in early pregnancy.
Written informed consent was obtained from both patients for publication of these case reports and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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