- Case report
- Open Access
- Open Peer Review
Osteosarcoma in the distal femur two years after an ipsilateral femoral shaft fracture: a case report
© Dorrestijn and Jutte; licensee BioMed Central Ltd. 2011
- Received: 24 March 2010
- Accepted: 21 May 2011
- Published: 21 May 2011
The duration of symptoms preceding a definitive diagnosis of osteosarcoma is quite long. Pathological radiological signs are often evident by the time of diagnosis. Although several case reports have been published on osteosarcoma of the femur, to the best of our knowledge this report is the first one with such an unusual clinical course.
We describe the case of a 58-year-old Caucasian man who presented with a femoral shaft fracture. Two years post-trauma osteosarcoma in the ipsilateral distal femur was diagnosed. Was it coincidence? We think that the history of the trauma is crucial to answering this question.
This case report underlines the need to keep up awareness of pathological fractures in emergency medicine and trauma surgery. When radiographs do not raise any suspicion but the history of trauma or the physical examination does, we recommend further radiological and/or histological diagnostic examinations.
- Distal Femur
- Pathological Fracture
- Lateral Femoral Condyle
- Medial Femoral Condyle
The "symptom interval" is defined as the time from the first onset of symptoms or signs until a definitive diagnosis is made and treatment is initiated. In people with bone cancer, this interval can be quite long. For patients with osteosarcoma, a median symptom interval of 3.8 months (range 1.0-14.6) is reported for patients between ages 12 and 20 years . Both patient and professional delays contribute to this prolonged delay. A minority of patients with osteosarcoma present with pathological fractures. Guerra et al.  reported 20 such cases (11.4%) of 175 total patients in their series. The pathological nature of the fracture is commonly recognized on the basis of radiological signs. We report a case of osteosarcoma in the distal femur diagnosed two years after an ipsilateral femoral shaft fracture. Was it a pathological fracture or was it coincidence?
An exarticulation of the hip followed. Prior to the operation, the last radiographs were taken (Figure 5B). The histology showed a classic high-grade osteosarcoma (Enneking rating stage IIB). At the last follow-up examination, three years after undergoing amputation, the patient was alive without metastatic disease and was able to ambulate with crutches.
We present a rare case of a patient with osteosarcoma in the distal femur diagnosed two years after a fracture in the femoral shaft. In our patient, there were no clues of the pathological nature of the fracture; therefore, neither additional imaging studies nor a biopsy was performed initially. Retrospectively speaking, we did not see any signs of malignancy on the trauma radiographs either. Besides, most osteosarcomas originate in the metaphyseal region as mixed sclerotic and lytic lesions, although primarily sclerotic or lytic lesions also occur. Most osteosarcomas appear with destruction of the bony cortex and the formation of a soft-tissue mass .
In this case, the question is whether the presence of the femoral shaft fracture and the osteosarcoma in the same femur were coincidental. We do not think they were. Although no biopsy was performed at the fracture site, we believe the femoral shaft fracture had a pathological nature. Several facts speak for this. The patient stumbled in a local pub. Such a traumatic mechanism is unlikely to cause the femoral shaft fracture presented; therefore, we think a primary tumor existed at the site of the fracture and was spread distally by the insertion of the intramedullary nail. The initial trauma imaging studies did not reveal any signs of a pathological fracture, but the last radiographs (Figure 5B) showed lytic lesions in different fracture fragments. According to our hypothesis, the osteosarcoma in the distal femur would be an iatrogenic skip metastasis. Skip metastases are defined by the American Joint Committee on Cancer as "two or more discontinuous lesions in the same bone" . Another case of iatrogenic spread of bony metastasis was described by Currall et al. . They presented a case of synovial metastases with bony metastasis following total knee arthroplasty.
Regarding skip metastases, it is known that they tend to be less differentiated than the primary tumor . In our case, the histology of the distal femur biopsy showed an undifferentiated lesion. This finding supports our hypothesis that the lesion in the distal femur would be the skip lesion.
A prolonged union time of 13 months, despite bone grafting, is also quite unusual, especially in a case of intramedullary nailing. The mean reported union time for femoral shaft fractures caused by a fall is 11.1 weeks, and it is 10.4 weeks for intramedularry nailing . Even after bone grafting, the first bony callus was seen only seven months after pseudarthrosis repair in our patient. This observation might also speak for a pathologic fracture. Another option is that the lytic lesions at the fracture were skip metastases from a primary osteosarcoma in the distal femur; therefore, the appearance of a femoral shaft fracture and an osteosarcoma in the same femur could be coincidental.
Antegrade femoral nailing is the gold standard for surgical treatment of diaphyseal femoral shaft fractures because of decreased operative trauma and the possibility of early weight bearing . It has a high rate of union (99%) and a low rate of infection and malunion (<1%) [9, 10]. One of the complications in the surgical treatment of femoral shaft fractures is delayed union or nonunion. The nonunion in our case could be a result of the marked diastasis of the fracture fragments.
Facts supporting the suspicion of a primary tumor in the distal femur are the location and size of the lesion. The distal femur is a far more frequently affected site compared to the diaphyseal femur: 44% and 3%, respectively . In terms of size, the lesion in the distal femur of our patient had progressed much more than the lesions in the fracture fragments (Figure 5B). Another argument is that skip metastases in osteosarcomas are more often found proximal to the primary tumor .
Although we do not have histological proof for the femoral shaft fracture being pathological in our patient, we think the answer must be sought in the history of the trauma that caused this fracture. The absence of signs of malignancy on the first plain film radiographs and the later development of the osteosarcoma emphasize the importance of a detailed history of the trauma mechanism. An inadequate trauma mechanism can be an important clue for the pathological nature of a fracture.
This case report underlines the need to keep up awareness of pathological fractures in emergency medicine and trauma surgery. When radiographs do not raise any suspicion but the history of trauma or the physical examination do, we recommend further radiological and/or histological diagnostic examinations.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
We are grateful to Jurjen A Niewold for the work he initially did for this case report.
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