- Case report
- Open Access
- Open Peer Review
This article has Open Peer Review reports available.
Eosinophilic myocarditis mimicking acute coronary syndrome secondary to idiopathic hypereosinophilic syndrome: a case report
© Amini and Nielsen; licensee BioMed Central Ltd. 2010
Received: 5 November 2009
Accepted: 6 February 2010
Published: 6 February 2010
Eosinophilic myocarditis is a rare form of myocarditis. It is characterized pathologically by diffuse or focal myocardial inflammation with eosinophilic infiltration, often in association with peripheral blood eosinophilia. We report a case of eosinophilic myocarditis secondary to hypereosinophilic syndrome.
A 74-year-old Caucasian woman with a history of asthma, paroxysmal atrial fibrillation, stroke and coronary artery disease presented to the emergency department of our hospital with chest pain. Evaluations revealed that she had peripheral blood eosinophilia and elevated cardiac enzymes. Electrocardiographic findings were nonspecific. Her electrocardiographic finding and elevated cardiac enzymes pointed to a non-ST-elevated myocardial infarction. Echocardiogram showed a severe decrease in the left ventricular systolic function. Coronary angiogram showed nonobstructive coronary artery disease. She then underwent cardiac magnetic resonance imaging, which showed neither infiltrative myocardial diseases nor any evidence of infarction. This was followed by an endomyocardial biopsy which was consistent with eosinophilic myocarditis. Hematologic workup regarding her eosinophilia was consistent with hypereosinophilic syndrome. After being started on steroid therapy, her peripheral eosinophilia resolved and her symptoms improved. Her left ventricular ejection fraction, however, did not improve.
Eosinophilic myocarditis can present like an acute myocardial infarction and should be considered in the differential diagnosis of acute coronary syndrome in patients with a history of allergy, asthma or acute reduction of the left ventricular function with or without peripheral eosinophilia.
Löffler was first to report the association between eosinophilia and heart disease in his observation of endocarditis parietalis fibroplastica and peripheral eosinophilia . Regardless of the fact that eosinophilic myocarditis (EM) has been well described, due to its nonspecific clinical presentation and rapid fatal course, most of the cases are usually diagnosed on autopsy examination [2–7]. Endomyocardial biopsy remains the gold standard of diagnosis and the treatment guide in these cases.
A 74-year-old Caucasian American woman presented to the emergency room of the Cleveland Clinic with a one-month history of progressive exertional chest pain. The pain was dull and diffuse. It lasted for a few minutes after exertion and was associated with shortness of breath. Physical activity made it worse and improvement was noted with sublingual nitroglycerin. She denied any nausea, vomiting, sweating, light headedness or dizziness associated with these episodes.
Her medical history was significant for long-standing asthma and hypertension. She had a stroke nine months prior to this admission in the setting of paroxysmal atrial fibrillation with near complete resolution of her neurologic deficit. Her medical history was also significant for coronary artery disease (non-ST elevation myocardial infarction) after angioplasty and stenting to the right coronary artery with a bare-metal stent; the procedure was performed four months before she presented to the emergency room. She never smoked or drank, but she did have a history of allergy to iodine.
On arrival to our emergency department her blood pressure was 105/62 mmHg, pulse was 98 beats per minute, and she was in no acute distress at rest. Her estimated central venous pressure was about 10 cm H2O. Her lungs revealed no wheeze or rales but had decreased breath sounds in the bilateral bases. Cardiac examination revealed a regular heart with no murmur, rubs or gallop. She had 2+ bilateral edema of the lower extremities with normal peripheral pulses.
Due to these findings our patient was started on a daily treatment of 70 mg of prednisone at a tapering dose. She responded well to the treatment and her chest pain resolved. The pain was presumably due to the associated pericarditis and steady decrease in her cardiac enzyme markers. An extensive workup for the cause of her eosinophilia showed negative results. This workup included negative antinuclear antibodies, negative antineutrophil cytoplasmic antibodies, negative marrow exam for malignancy, negative CHIC2 studies, negative JAK2 mutation analysis, normal serum IL-5, and negative flow cytometry for immunophenotypically abnormal T-cells associated with lymphocytic hypereosinophilic syndrome. Her stool studies and parasite serologies for strongyloides and toxocara were also negative. No vasculitis was described in any tissue specimen. The patient was therefore discharged home.
Two months later she presented to an outside facility with monomorphic ventricular tachycardia and heart failure exacerbation. She was treated, and upon discharge from this hospital she received an implantable cardioverter-defibrillator. A follow-up examination with our cardiology department five months later showed that her symptoms had improved but her ejection fraction had remained at 25%.
Eosinophilic myocarditis is a rare form of myocarditis . It is characterized pathologically by diffuse or focal myocardial inflammation with eosinophilic infiltration, often in association with peripheral blood eosinophilia [8, 9]. If this disease is left untreated, it is potentially fatal [8, 10]. Eosinophilic myocarditis has been observed in 0.5% of unselected autopsy series and in more than 20% of explanted hearts from cardiac transplant recipients. The most common cause reported in these cases was related to medication [1, 11]. Studies have shown that EM occurs in up to 60% of patients with hypereosinophilic syndrome [12–14].
Drugs causing hypersensitivity myocarditis .
Pathogenesis includes both immediate (immunoglobulin E degranulation of mast cells and basophiles) and delayed hypersensitivity reactions (activation of T H and IL-5 production). Eosinophilic proteins lead to increased membrane permeability in target cells by creating membrane pores that lead to cell killing [8, 9]. Endomyocardial biopsy will show eosinophilic degranulation with extracellular deposition of major basic protein and eosinophilic cationic protein adjacent to thrombotic and necrotic lesions. It is not clear why eosinophils have an affinity for heart muscles .
Peripheral blood eosinophilia is not present in all cases, so the diagnosis of EM may not be suspected . Clinical presentation is also nonspecific and has a wide spectrum. Patients may present with fever, skin rash, sinus tachycardia, chest pain, shortness of breath, symptoms of heart failure, conduction delays, and ST and T abnormalities [10, 16]. Myocardial fibrosis can lead to fatal arrhythmias . The diagnosis of EM is often made at autopsy. If EM is clinically suspected, an endomyocardial biopsy should be done. However, a biopsy is not very sensitive (50%) as the infiltrate is often focal . If there is a high index of suspicion and the biopsy results are negative, a repeat biopsy should be performed.
The management of EM includes stopping the offending agent and starting standard treatment for heart failure. In addition, immunosuppressive therapy with a steroid, especially in patients with left ventricular failure, has been shown to improve symptoms [9, 18]. In a case report by Aggarwal et al., a combination of azathioprine and steroids has been used to prevent the recurrence of EM . In selected cases cardiac surgery (endocardectomy) and transplant have been performed .
Our patient with EM secondary to idiopathic hypereosinophilic syndrome presented with several misleading features, including symptoms of acute coronary syndrome, nonspecific electrocardiography changes, echocardiographic findings and increased cardiac enzymes. Negative workup with regard to coronary artery disease prompted us to look for infiltrative disease with cardiac magnetic resonance imaging and endomyocardial biopsy. The endomyocardial biopsy results led to the correct diagnosis and guided the patient's treatment. In patients with a history of allergy and asthma and presenting with chest pain or symptoms of heart failure, EM should be considered. Because of the disease's potentially fatal course if left untreated, endomyocardial biopsy should be performed and repeated if necessary.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The authors would like to express their gratitude to Dr Rene Rodriguez from the Department of Anatomic Pathology of Cleveland Clinic for providing the pathologic figures in this manuscript.
- Löffler W: Endocarditis parietalis fibroplastica mit Blut Eosinophilie, ein eigenartiges Krankheitsbild. Schweizerische Medizinische Wochenschrift. 1936, 18: 817-820.Google Scholar
- Oakley CM, Olsen GJ: Eosinophilia and heart disease. Br Heart J. 1977, 39 (3): 233-237. 10.1136/hrt.39.3.233.View ArticlePubMedPubMed CentralGoogle Scholar
- Herzog CA, Snover DC, Staley NA: Acute necrotising eosinophilic myocarditis. Br Heart J. 1984, 52 (3): 343-348. 10.1136/hrt.52.3.343.View ArticlePubMedPubMed CentralGoogle Scholar
- Tonnesen P, Teglbjaerg CS: An "unexpected" fatal case of the hypereosinophilic syndrome. Eur J Respir Dis. 1984, 65 (5): 389-393.PubMedGoogle Scholar
- Kim CH, Vlietstra RE, Edwards WD, Reeder GS, Gleich GJ: Steroid-responsive eosinophilic myocarditis: diagnosis by endomyocardial biopsy. Am J Cardiol. 1984, 53 (10): 1472-1473. 10.1016/S0002-9149(84)91473-5.View ArticlePubMedGoogle Scholar
- Isaka N, Araki S, Shibata M, Takebayashi S, Yada T, Konishi T, Nakano T: Reversal of coronary artery occlusions in allergic granulomatosis and angiitis (Churg-Strauss syndrome). Am Heart J. 1994, 128 (3): 609-613. 10.1016/0002-8703(94)90638-6.View ArticlePubMedGoogle Scholar
- Seshadri S, Narula J, Chopra P: Asymptomatic eosinophilic myocarditis: 2+2 = 4 or 5. Int J Cardiol. 1991, 31 (3): 348-349. 10.1016/0167-5273(91)90387-5.View ArticlePubMedGoogle Scholar
- Ginsberg F, Parrillo JE: Eosinophilic myocarditis. Heart Fail Clin. 2005, 1 (3): 419-429. 10.1016/j.hfc.2005.06.013.View ArticlePubMedGoogle Scholar
- Galiuto L, Enriquez-Sarano M, Reeder GS, Tazelaar HD, Li JT, Miller FA, Gleich GJ: Eosinophilic myocarditis manifesting as myocardial infarction: early diagnosis and successful treatment. Mayo Clin Proc. 1997, 72 (7): 603-610. 10.4065/72.7.603.View ArticlePubMedGoogle Scholar
- Al Ali AM, Straatman LPAllard MF, Ignaszewski AP: Eosinophilic myocarditis: case series and review of literature. Can J Cardiol. 2006, 22 (14): 1233-1237.View ArticlePubMedPubMed CentralGoogle Scholar
- Winters G, McManus BM: Myocarditis. Cardiovascular Pathology. Edited by: Silver MD, Gotlieb AI, Schoen FJ. 2001, New York: Churchill Livingstone, 256-3Google Scholar
- Weller PF, Bubley GJ: The idiopathic hypereosinophilic syndrome. Blood. 1994, 83 (10): 2759-2779.PubMedGoogle Scholar
- Take M, Sekiguchi M, Hiroe M, Hirosawa K, Mizoguchi H, Kijima M, Shirai T, Ishide T, Okubo S: Clinical spectrum and endomyocardial biopsy findings in eosinophilic heart disease. Heart Vessels Suppl. 1985, 1: 243-249. 10.1007/BF02072403.View ArticlePubMedGoogle Scholar
- Brito-Babapulle F: The eosinophilias, including the idiopathic hypereosinophilic syndrome. Br J Haematol. 2003, 121 (2): 203-223. 10.1046/j.1365-2141.2003.04195.x.View ArticlePubMedGoogle Scholar
- Barton M, Finkelstein Y, Opavsky MA, Ito S, Ho T, Ford-Jones LE, Taylor G, Benson L, Gold R: Eosinophilic myocarditis temporally associated with conjugate meningococcal C and hepatitis B vaccines in children. Pediatr Infect Dis J. 2008, 27 (9): 831-835. 10.1097/INF.0b013e31816ff7b2.View ArticlePubMedGoogle Scholar
- Taliercio CP, Olney BA, Lie JT: Myocarditis related to drug hypersensitivity. Mayo Clin Proc. 1985, 60 (7): 463-468.View ArticlePubMedGoogle Scholar
- Burke AP, Saenger J, Mullick F, Virmani R: Hypersensitivity myocarditis. Arch Pathol Lab Med. 1991, 115 (8): 764-769.PubMedGoogle Scholar
- Corradi D, Vaglio A, Maestri R, Legname V, Leonardi G, Bartoloni G, Buzio C: Eosinophilic myocarditis in a patient with idiopathic hypereosinophilic syndrome: insights into mechanisms of myocardial cell death. Hum Pathol. 2004, 35 (9): 1160-1163. 10.1016/j.humpath.2004.05.008.View ArticlePubMedGoogle Scholar
- Aggarwal A, Bergin P, Jessup P, Kaye D: Hypersensitivity myocarditis presenting as cardiogenic shock. J Heart Lung Transplant. 2001, 20 (11): 1241-1244. 10.1016/S1053-2498(01)00313-8.View ArticlePubMedGoogle Scholar
- Kounis NG, Zavras GM, Soufras GD, Kitrou MP: Hypersensitivity myocarditis. Ann Allergy. 1989, 62 (2): 71-74.PubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.