This article has Open Peer Review reports available.
Bleeding from ruptured hepatic metastases as a cause of syncope in an octogenarian: a case report
© Seetho et al; licensee BioMed Central Ltd. 2010
Received: 8 December 2009
Accepted: 26 June 2010
Published: 26 June 2010
Acute hemoperitoneum as a result of hemorrhage from liver metastases is an uncommon but serious condition. The use of appropriate imaging is important in the diagnosis and can have a profound impact on subsequent management. This case is important because the presentation was of recurrent syncopal episodes with an unusual underlying cause. This case highlights the need to consider this diagnosis in the differential in patients presenting with collapse in the acute setting.
We present the case of an 85-year-old Caucasian man who was admitted following a collapse episode and was found to be persistently hypotensive despite aggressive resuscitation. An acute intra-peritoneal bleed originating from hepatic metastases from an unknown primary was identified promptly with computed tomography imaging and was subsequently managed conservatively.
This case aims to convey key teaching points: (A) the need to consider intra-abdominal hemorrhage in the differential diagnosis when assessing patients with collapse; and (B) the use of appropriate imaging such as computed tomography can facilitate a prompt diagnosis and appropriate management steps can then be taken accordingly.
Spontaneous rupture of hepatic metastases leading to hemoperitoneum may initially present as collapse in the elderly and is a serious diagnosis. In this case report, we present a patient who was admitted following recurrent syncopal episodes with clinical features of persistent hypotension. A sudden fall in his hemoglobin level suggested that an acute bleed had led to his collapse. This was an important investigation finding in determining the cause of his syncopal episodes. The underlying diagnosis of acute hemorrhage from liver metastases was confirmed on computed tomography (CT) imaging.
An 85-year-old Caucasian man was admitted to hospital following three collapse episodes with transient loss of consciousness at home. Each episode was short-lived lasting several minutes. Apart from mild abdominal generalized discomfort, there were no other symptoms. There was no history of recent trauma. He had no history of similar episodes but was known to have severe aortic stenosis, type 2 diabetes, paroxysmal atrial fibrillation, hypertension and a previous duodenal ulcer bleed.
At that time, he was taking aspirin, bisoprolol, omeprazole and ramipril. He lived with his daughter and was independent with his activities of daily living. He had not smoked for 35 years and his alcohol consumption was minimal.
On examination, he was apyrexial, oxygen saturation was 100% on air. His blood pressure was 80/40 mmHg. He was persistently hypotensive despite aggressive fluid resuscitation. There was an ejection systolic murmur on cardiac auscultation. His venous pressure was not elevated and there was no leg edema. The lungs were clear on auscultation. Upper and lower limb pulses were equal bilaterally. Examination of his abdomen revealed mild epigastric discomfort, but there was no rebound or peritonism and bowel sounds were present. Per rectal examination was normal.
Initial blood results showed a hemoglobin of 11.3 (13-18 g/dL), white cell count of 11 (4-11 × 109/L), and platelets of 136 (150-450 × 109/L). Coagulation profile, renal function and liver function tests were within normal limits. His chest radiograph was normal and his electrocardiogram showed left ventricular hypertrophy. At admission, he was taken to the coronary care unit for cardiac monitoring because of the history of collapse with loss of consciousness which was thought to be related to his aortic stenosis. An urgent echocardiogram was performed which showed evidence of aortic stenosis, but no evidence of critical stenosis with good ejection fraction > 55% and good biventricular contraction.
A repeat full blood count showed that his hemoglobin had fallen to 4.9 g/dL and he was transfused with red cells, platelets and cryoprecipitate. The impression was that this patient had a possible dissecting thoracic aneurysm that was possibly extending into the abdomen. He was transferred to the intensive care unit.
Our patient had an esophageal gastro-duodenal endoscopy as he had been taking aspirin and had a past history of a duodenal ulcer. This did not show any evidence of bleeding. A rigid sigmoidoscopy was also normal.
Whilst on the intensive care ward, our patient's blood pressure subsequently improved and he did not require inotropic support. He had no further hypotensive episodes and improved during his stay on the ward. Given the advanced nature of his hepatic metastases, he did not wish to have further investigations to identify the primary source of the metastases and decided on conservative supportive treatment, as advised by the oncologists. He was referred to the Macmillan and Hospital Palliative Care Team. Subsequently, he died three months later. A post-mortem was not performed.
Tumor perforation and bleeding may occur as a complication of primary hepatocellular carcinoma . This complication is not uncommon in primary hepatocellular carcinoma . The significance of this case is that we describe acute rupture of hepatic metastases resulting in acute hemoperitoneum that initially presented as a syncopal episode. There are only a few reported cases in the literature of acute hemoperitoneum secondary to the rupture of liver metastases [3–9] originating from different sources. These sources include nasopharyngeal cancer , gastric cancer , lung cancer , renal cell carcinoma  and carcinoma of the liver .
Intra-peritoneal hemorrhage frequently presents with acute abdominal pain and can be life-threatening. CT is commonly used as an imaging modality in the investigations of these patients, but ultrasound and magnetic resonance imaging may also be used in the diagnosis . It should be noted that in this case, our patient presented following recurrent collapse episodes rather than with an acute abdomen. He did not wish for further investigations to identify the primary source given the advanced nature of the liver metastases. As such, the source of his liver metastases was not identified. He survived the acute bleeding episode with conservative management alone.
The literature reports laparotomy as a management option for metastatic hepatic hemorrhage but this would entail surgical risks for the patient [11, 12]. In hemoperitoneum occurring as a result of rupture of hepatocellular carcinoma, transcatheter arterial embolization has been previously described as a potential therapeutic option [1, 2].
In conclusion, a high index of suspicion is needed in the acute setting when considering the possibility of spontaneous hemoperitoneum in a patient who presents with syncope, especially with an acute abdomen. This is particularly important if there is a known history of neoplastic process. This case highlights an unusual source of intra-abdominal bleeding which was from liver metastatic disease. The use of appropriate CT imaging in this case facilitated the prompt diagnosis and subsequent management steps were then taken accordingly.
Written informed consent was obtained from our patient's next-of-kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Chedid AD, Klein PW, Tiburi MF: Spontaneous rupture of hepatocellular carcinoma with haemoperitoneum: a rare condition in Western countries. HPB. 2001, 3 (3): 227-230. 10.1080/136518201753242262.View ArticlePubMedPubMed CentralGoogle Scholar
- Abdel Samie A, Otto G, Theilmann L: Acute haemoperitoneum due to spontaneous tumour rupture as first manifestation of hepatocellular carcinoma. Z Gastroenterol. 2007, 45 (7): 615-619. 10.1055/s-2006-927404.View ArticlePubMedGoogle Scholar
- Schoedel KE, Dekker A: Hemoperitoneum in the setting of metastatic cancer to the liver. A report of two cases with review of the literature. Dig Dis Sci. 1992, 37 (1): 153-154. 10.1007/BF01308360.View ArticlePubMedGoogle Scholar
- Fidas-Kamini A, Busuttil A: Fatal intraperitoneal haemorrhage of hepatic origin. Postgrad Med J. 1986, 62: 1097-1100. 10.1136/pgmj.62.734.1097.View ArticlePubMedPubMed CentralGoogle Scholar
- Dewar GA, Griffin SM, van Hasselt CA: Fatal haemoperitoneum due to liver metastases from nasopharyngeal cancer. Aust N Z J of Surg. 1991, 61 (9): 723-725. 10.1111/j.1445-2197.1991.tb00332.x.View ArticleGoogle Scholar
- Yoshida H, Mamada Y, Taniai N: Ruptured metastatic liver tumour from an alpha-fetoprotein-producing gastric cancer. J Nippon Med Sch. 2005, 72 (4): 236-241. 10.1272/jnms.72.236.View ArticlePubMedGoogle Scholar
- Kadowaki T, Hamada H, Yokoyama A: Hemoperitoneum secondary to spontaneous rupture of hepatic metastasis from lung cancer. Intern Med. 2005, 44 (4): 290-293. 10.2169/internalmedicine.44.290.View ArticlePubMedGoogle Scholar
- Wong KT, Khir AS, Noori S: Fatal haemoperitoneum due to rupture of hepatic metastasis from renal cell carcinoma. Aust N Z J Surg. 1994, 64 (2): 128-129. 10.1111/j.1445-2197.1994.tb02160.x.View ArticlePubMedGoogle Scholar
- Tung CF, Chang CS, Chow WK: Hemoperitoneum secondary to spontaneous rupture of metastatic epidermoid carcinoma of liver: case report and review of the literature. Hepatogastroenterology. 2002, 49 (47): 1415-1417.PubMedGoogle Scholar
- Lucey BC, Varghese JC, Anderson SW: Spontaneous hemoperitoneum: a bloody mess. Emerg Radiol. 2007, 14 (2): 65-75. 10.1007/s10140-007-0594-0.View ArticlePubMedGoogle Scholar
- Lucha PA: Spontaneous hemoperitoneum. J Am Osteopath Assoc. 1996, 96 (6): 364-365.PubMedGoogle Scholar
- Suber WJ, Cunningham PL, Bloch RS: Massive spontaneous hemoperitoneum of unknown etiology: a case report. Am Surg. 1998, 64 (12): 1177-1778.PubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.