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Primary mucinous adenocarcinoma in a defunctionalized urinary bladder: a case report
© Taneous et al; licensee BioMed Central Ltd. 2009
Received: 11 January 2009
Accepted: 30 November 2009
Published: 30 November 2009
Malignancies are rare in defunctionalized bladders and are thought to arise from metaplasia secondary to chronic inflammation. Transitional cell and squamous cell carcinomas are the most common but there are three reported cases of mucinous adenocarcinoma.
We report a 57-year-old Caucasian man presenting with penile discharge for 30 years following ileal conduit surgery for neurogenic bladder, and who was found to have primary mucinous adenocarcinoma of his defunctionalized bladder.
Although urinary diversion without cystectomy is less common in current urologic practice, there are many patients with longstanding defunctionalized bladders. While there are no established surveillance protocols, defunctionalized bladder patients with urethral discharge should be evaluated.
Primary adenocarcinoma of the urinary bladder accounts for approximately 0.5-2% of all bladder cancers . Patients generally present with hematuria, dysuria, suprapubic pain, and, less commonly, mucusuria. The histologic appearance of bladder adenocarcinoma can be enteric, signet ring, mucinous, clear cell, hepatoid and mixed types. The differential diagnosis includes glandular differentiation of transitional cell carcinoma and direct extension or metastatic spread of adenocarcinoma arising primarily from the colon, prostate, appendix or endometrium.
Predisposing factors for the development of primary adenocarcinoma of the bladder include schistosomiasis, exstrophy, persistent urachal remnants, and bladder augmentation by intestinal segments [1, 2]. Concomitant cystitis glandularis occurs in the majority of cases, but is not considered a definitive precursor lesion since adenocarcinoma can develop in the absence of cystitis glandularis and only a small number of bladders with cystitis glandularis actually develop malignancies .
The potential for adenocarcinoma to develop in the defunctionalized bladder that is left in-situ at the time of urinary diversion is rare [3–5]. We describe the fifth case of primary mucinous adenocarcinoma arising in a longstanding defunctionalized bladder.
A 57-year-old Caucasian man presented with profuse blood-streaked mucous drainage from his penis. Past medical history was significant for T12 spinal cord injury secondary to a motor vehicle accident in 1971. Due to urinary incontinence exacerbating his multiple decubitus ulcers and severe bilateral vesico-ureteral reflux, the patient underwent ileal conduit urinary diversion in 1975 with his bladder left in-situ.
Postoperatively, the patient underwent adjuvant radiation and chemotherapy, but developed metastatic intraperitoneal and pulmonary masses 18 months following diagnosis. He expired 29 months after diagnosis.
Historically, supravesical intestinal urinary diversion without cystectomy was a common procedure employed to control the sequelae of neurogenic bladder . Advances in medical management, intermittent catheterization, and augmentation procedures have significantly decreased, but not completely eliminated, the need for intestinal urinary diversion in neurogenic bladder patients.
The most common complaint of patients with defunctionalized bladders is urethral discharge, occurring in approximately 30% of patients . Patients with intact sensation will often complain of pain. Hematuria and infection, particularly pyocystis and urosepsis, are the most frequent indications for additional surgical intervention. There is general awareness of the increased risk of malignancy in the intestinal segments used in urinary diversion and both the intestine and urothelium following intestinal augmentation of the bladder. The potential for malignancy in the bladder that is left in-situ and defunctionalized by urinary diversion is less well recognized . When malignancy develops in the setting of a defunctionalized bladder, tumor types consist predominantly of squamous cell carcinoma and transitional carcinoma. Only six prior cases of primary adenocarcinoma in a defunctionalized, non-augmented bladder have been described: one signet ring adenocarcinoma , one enteric adenocarcinoma , and four mucinous adenocarcinomas [8–10].
Of the six adenocarcinomas in defunctionalized bladders, one patient had bladder dysfunction associated with prune belly syndrome , and five patients had neurogenic bladder dysfunction (three secondary to traumatic spinal cord injury [7–9], one patient with meningomyelocele , and one with imperforate anus and likely associated sacral abnormalities ). Our patient also had neurogenic bladder dysfunction secondary to traumatic spinal cord injury. Combining our patient with the three prior reported cases of mucinous adenocarcinoma in defunctionalized, non-augmented bladders, four were associated with cystitis glandularis [7–9] and one had intestinal metaplasia. The time interval from supravesical diversion to development of mucinous adenocarcinoma in these five patients ranged from 8 to 39 years (average 23.9 years). In contrast, squamous cell carcinoma, transitional cell carcinoma, and non-mucinous adenocarcinomas developed in defunctionalized bladders an average of 5 years after supravesical diversion . In 80% (four of five cases), the patients presented with mucoid or bloody urethral discharge; the remaining case presented with urosepsis. Four of the five mucinous adenocarcinomas in defunctionalized bladders have been highly aggressive, with either extensive disease at initial surgery or early recurrence/progression [7–9].
As large numbers of spinal cord injury patients with supravesical intestinal diversions approach 20 to 40 years postoperatively, malignancies in the defunctionalized bladders of these patients may become more frequent. There are currently no guidelines for bladder screening in these patients who appear to be at risk. Yap et al. recommend close follow-up with cystoscopy and bladder wash cytology on an annual or biennial basis in patients with a defunctionalized bladder . The development of mucoid urethral discharge or bleeding in patients with long-term defunctionalized bladders should raise the suspicion of malignancy and prompt evaluation. When performing urinary diversion for neurogenic bladder, prophylactic simple cystectomy should be considered to eliminate the possibility of future development of bladder carcinoma.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Burnett AL, Epstein JI, Marshall FF: Adenocarcinoma of urinary bladder: classification and management. Urology. 1991, 37: 315-321. 10.1016/0090-4295(91)80256-7.View ArticlePubMedGoogle Scholar
- Corica FA, Husmann DA, Churchill BM, Young RH, Pacelli A, Lopez-Beltran A, Bostwick DG: Intestinal metaplasia is not a strong risk factor for bladder cancer: study of 53 cases with long-term follow-up. Urology. 1997, 50: 427-431. 10.1016/S0090-4295(97)00294-X.View ArticlePubMedGoogle Scholar
- Austen M, Kalble T: Secondary malignancies in different forms of urinary diversion using isolated gut. J Urol. 2004, 172: 831-838. 10.1097/01.ju.0000134890.07434.8e.View ArticlePubMedGoogle Scholar
- Granados EA, Salvador J, Vicente J, Villavicencio H: Follow-up of the remaining bladder after supravesical urinary diversion. Eur Urol. 1996, 29: 308-311.PubMedGoogle Scholar
- Hanno PM, Tomaszewski JE: Bladder carcinoma after urinary diversion. JAMA. 1982, 248: 2885-2886. 10.1001/jama.248.21.2885.View ArticlePubMedGoogle Scholar
- Weiss AM, Jeandel R, Lugagne-Delpon PM, Kamalodine T, Barbanel C: Primary signet ring adenocarcinoma of a diverted neurogenic bladder. Ann Pathol. 1995, 15: 131-133.PubMedGoogle Scholar
- Vesth N, Kay L, Nordkild P: Adenocarcinoma in the defunctionalized bladder. Scand J Urol Nephrol. 1985, 19: 303-304. 10.3109/00365598509180276.View ArticlePubMedGoogle Scholar
- Djavan B, Litwiller SE, Milchgrub S, Roehrborn CG: Mucinous adenocarcinoma in defunctionalized bladders. Urology. 1995, 46: 107-110. 10.1016/S0090-4295(99)80173-3.View ArticlePubMedGoogle Scholar
- Young RH, Parkhurst EC: Mucinous adenocarcinoma of bladder. Case associated with extensive intestinal metaplasia of urothelium in patient with nonfunctioning bladder for twelve years. Urology. 1984, 24: 192-195. 10.1016/0090-4295(84)90429-1.View ArticlePubMedGoogle Scholar
- Yap RL, Weiser A, Ozer O, Pazona J, Schaeffer A: Adenocarcinoma arising from a defunctionalized bladder. J Urol. 2002, 167: 1782-1783. 10.1016/S0022-5347(05)65202-0.View ArticlePubMedGoogle Scholar
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