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Hydatid cyst disease of the lung as an unusual cause of massive hemoptysis: a case report
© Tekinbas et al; licensee BioMed Central Ltd. 2009
Received: 13 July 2007
Accepted: 23 January 2009
Published: 23 January 2009
Echinococcosis and/or hydatidosis is one of the most important zoonotic diseases in the world. In Turkey, echinococcosis is an endemic disease, however, hydatid disease of the lung is uncommon and usually caused by Echinococcus granulosus.
In this report we describe a 17-year-old male patient who presented with massive hemoptysis due to hydatid disease of the lung.
Although it is one of the less common causes of massive hemoptysis, hydatid disease of the lung requires greater attention in countries, such as Turkey, in which hydatid cyst disease is common.
Echinococcosis and/or hydatidosis is one of the most important zoonotic diseases in the world. In Turkey, echinococcosis is an endemic disease and the annual incidence of hydatid disease is 4.9 cases per 100,000 inhabitants . However, hydatid disease of the lung is uncommon and usually caused by Echinococcus granulosus. In its adult stage, the parasite lives in the intestinal tract of carnivores such as dogs and cats, as well as in herbivores such as sheep. The head is composed of a double crown of hook-like structures, and the body is formed by three or four rings, the last of which bears the eggs. After being eliminated with feces, the eggs contaminate fields, irrigated land and wells. Herbivores ingest the eggs, which develop into larvae, or hydatids, within the viscera of these animals. The cycle is completed with the ingestion of the infected viscera by carnivores.
Humans contract the disease from water or food or by direct contact with dogs. Once the eggs reach the stomach, the hexacanth embryos are released. These pass through the intestinal wall and reach the tributary veins of the liver where they undergo a vesicular transformation and develop into hydatids. If they overcome the hepatic obstacle, they may become lodged in the lung, where they also transform into hydatids. If they advance beyond the lung, they may remain in any organ to which they are carried by the bloodstream. It has been shown that the embryos can reach the lung via the lymphatic vessels, bypassing the liver, and there is also evidence that the disease can be contracted through the bronchi .
On the first day of hospitalization, massive hemoptysis persisted. Increased respiratory failure and decreased Hb values (from 9.7 to 7.4 mg/dl) forced us to administer blood transfusion, after which surgery was indicated. The upper lobe bronchus of the right lung was completely obliterated while the anterior and posterior segments of the upper lobe were destroyed. In addition, one of the cysts in the lower lobe was ruptured. During surgery, lobectomy of the upper lobe of the right lung and cystectomy with capitonnage of the lower lobe cysts was performed. Capitonnage is obliteration of the pericystic cavity. The material obtained revealed hydatid cyst disease. Following medication with albendazole, the patient was discharged in a healthy condition on the eighth day postoperatively.
Hemoptysis in adults is most often caused by tuberculosis, bronchiectasis and trauma or bronchogenic carcinoma. Parasitic etiology is very rare. Small cysts are usually asymptomatic in hydatid disease. Coughing, chest pain and breathlessness are the common presenting symptoms. Hemoptysis as a presenting symptom is common in adult series, although massive hemoptysis is rare. The mechanism of hemoptysis may be due to pressure erosion of a bronchus or an obstructive effect with bronchial infection. There may be occasional rupture of cysts into the bronchus, resulting in massive hemoptysis. The underlying etiology for hemoptysis may be unknown in 20% of cases, but in cases with pulmonary hydatidosis, the clinical and radiological picture is so unique that it can be easily identified despite its rarity .
Diagnosis of an intact echinococcal cyst is usually based on a suspicion resulting from an unexpected finding on routine X-rays. Radiographically, the cyst appears as a homogeneous spherical opacity with definite edges. CT scanning and magnetic resonance imaging have added to the diagnosis of hydatid disease of the lung. Serological tests have limited diagnostic value. It is diagnosed by viewing the cystic membrane.
Hydatid cysts are typical, involving one lobe in 72% of cases, usually at the lung base [4–6]. In this case, multiple cysts were present in both lower and upper lobes of the right lung. The hydatid cyst not open to the pleura appears as a circular or oval image with well-defined limits, that can change according to its evolution. If the cyst ruptures, a radiological image of the pneumopericyst appears. If the content of the cyst is completely evacuated to the bronchial tree, a cavity similar to those observed in tuberculosis or pulmonary abscesses appears. However, if the content is only partially evacuated, a waterline image appears, commonly referred to as the Camelot sign . Rupture of cysts may cause an anaphylactic reaction.
The conventional treatment of hydatid cysts in all organs is surgery. Medical treatment with albendazole is also effective in selected patients. Praziquantel may be added to albendazole. Surgical methods related to pulmonary cysts include cystotomy and enucleation of the intact cyst, with or without capitonnage, for complicated or intact cysts. The current treatment of hydatid disease of the lung is complete excision of the cyst, including the germinative membrane, with the maximum preservation of lung tissue . Thoracotomy is the best procedure for removing a hydatid cyst, but video-assisted thoracic surgery is suggested for selected patients .
This case report suggests that when a patient presents with massive hemoptysis, zoonotic infections, especially hydatid disease of the lung, should always be considered alongside other common causes of massive hemoptysis. Although it is one of the less common causes of massive hemoptysis, hydatid disease of the lung requires greater attention in countries, such as Turkey, in which hydatid cyst disease is common.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Kilie D, Kaya I, Kamas A: Health Statistics. 2002, Ankara: Republic of Turkey Ministry of Health, Research Planning Coordination Council, 54-Google Scholar
- Burgos R, Varela A, Castedo E, Roda J, Montero CG, Serrano S, Tellez G, Ugarte J: Pulmonary hydatidosis: surgical treatment and follow-up of 240 cases. Eur J Cardiothorac Surg. 1999, 16: 628-635. 10.1016/S1010-7940(99)00304-8.View ArticlePubMedGoogle Scholar
- Bharti S, Bharti B: Hydatid disease of the lung – unusual cause of hemoptysis. Indian Pediatr. 2002, 39: 1062-1063.PubMedGoogle Scholar
- Mahmoud AAF: Helminthic disease of the lungs. Pulmonary Disease and Disorders. Edited by: Fishman AP. 1988, New York: McGraw-Hill, 1719-1733. 2Google Scholar
- Arora VK, Varma R: Right-sided chest pain with progressive dyspnea. Chest. 1991, 100: 811-812. 10.1378/chest.100.3.811.View ArticlePubMedGoogle Scholar
- Harlaftis NN, Aletras HA, Symbas PN: Hydatid disease of the lung. General Thoracic Surgery. Edited by: Shields TW. 2005, Philadelphia, PA: Lippincott Williams and Wilkins, 1: 1298-1308. 6Google Scholar
- Pasto M, Curull V, Minguella J, Jimenez MA, Sanjuas C, Broquetas J: Haemoptysis and a cavity in a young man. Eur Respir J. 1995, 8: 481-482. 10.1183/09031936.95.08030481.View ArticlePubMedGoogle Scholar
- Erdogan A, Ayten A, Demircan A: Methods of surgical therapy in pulmonary hydatid disease: is capitonnage advantageous?. ANZ J Surg. 2005, 75: 92-96. 10.1111/j.1445-2197.2005.03594.x.View ArticleGoogle Scholar
- Shabb BR, Ağabeyad F: Hydatid cysts of the lung. Minial Access Cardiothoracic Surgery. Edited by: Yim APC, Hazelrigg SR, Izzat MB, Landreneau RJ, Mack MJ, Naunheim KS. 2000, Philadelphia, PA: WB Saunders, 335-340.Google Scholar
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