- Case report
- Open Access
- Open Peer Review
Cold saline irrigation of the renal pelvis during Radiofrequency Ablation of a central renal neoplasm: a case report
© Morales et al; licensee BioMed Central Ltd. 2008
- Received: 21 March 2007
- Accepted: 07 February 2008
- Published: 07 February 2008
Thermal destruction mediated by radiofrequency ablation (RFA) is gaining attention as an alternative treatment for patients with renal cell carcinoma (RCC), particularly in those who are not candidates for open surgery. Treatment of central tumours is occasionally associated with complications such as ureteric stricture, injury to the psoas muscle, haematuria and vascular laceration.
We have used infusion of cold saline during RFA, through a retrograde ureteric catheter with its tip in the renal pelvis, in a patient with a central renal tumour.
We believe this process to have successfully avoided the risk of thermal injury.
- Renal Cell Carcinoma
- Radiofrequency Ablation
- Partial Nephrectomy
- Renal Pelvis
- Cold Saline
Thermal destruction mediated by radiofrequency ablation (RFA) is gaining attention as an alternative treatment for patients with renal cell carcinoma (RCC), particularly in those who are not candidates for open surgery . RFA carries less risk in the treatment of peripheral RCC. Treatment of centrally located tumours is occasionally associated with complications such as ureteric stricture, injury to the psoas muscle, haematuria and vascular laceration . However, protective measures can be taken to increase the safety of RFA when the electrode is located near the hilum of the kidney. We have used infusion of cold saline during RFA, through a retrograde ureteric catheter with its tip in the renal pelvis, in a patient with a central renal tumour in order to reduce the risk of thermal injury.
Asymptomatic renal tumours are being demonstrated with increasing frequency [3, 4]. Although partial nephrectomy is the standard therapy for small RCC , minimally invasive options associated with limited morbidity–such as probe-ablative procedures–are, however, being investigated in selected patients for whom invasive, nephron-sparing surgery (whether laparoscopic or open) is undesirable. The main probe-ablative techniques being investigated as alternatives to partial nephrectomy are cryoablation, radiofrequency ablation, and high-intensity focused ultrasound. Advances in imaging, ablative system technologies, and early evidence that in situ tumor ablation can yield comparable results to those achieved with tumor resection in selected cases, have sparked significant interest in these minimally invasive techniques.
RFA is an increasingly employed alternative treatment option, especially in patients with significant co-morbidities or those who refuse surgery . RFA of peripheral renal tumours is effective in achieving coagulation in most cases, because the kidneys are surrounded by fat, which prevents heat loss from the area being treated. In the case of central tumours, well-perfused tissue, vessels and the fluid-filled collecting system are found near the treatment area, potentially diminishing effectiveness and increasing the risk of complications. Ahrar et al.  reported four major complications, three of them in patients with solitary kidneys and central renal tumors. Additional procedures were necessary in these patients, such as insertion of a ureteric stent to deal with obstruction of the renal system by blood clot. Other complications associated with ablation of central renal tumors include injury, to the lumbar plexus, ureteral stricture, injury to psoas muscle and vascular laceration.
The treatment of renal lesions is complicated by heat loss, both conductive and convective. The kidney has a high blood flow, leading to substantial convective heat loss during renal RFA . Some authors have managed to increase ablation diameters by reducing blood flow to the treated area using embolization or clamping of the renal artery . The use and efficacy of generators of 200 W or greater and careful technique is helpful in achieving a satisfactory result .
As a new modality treatment of renal tumors, contra-indications to renal RFA are in evolution and are related with tumor in immediate proximity to a hollow viscus, renal pelvis or ureter. These contra-indications can be attempted to be reduced by the use of simultaneous irrigation with cold saline via ureteric catheter into the renal pelvis prior and during the ablation and in doing so, major complications may be avoided. This in keeping with previous reports were cooling systems were used to avoid complications of adjacent tissues in different organs. Dominique et al.  reported the feasibility of treating liver tumours close to a main biliary duct using intraductal cooling during RFA avoiding heat-induce damage and stenosis of biliary ducts. Similarly, Hiraki et al.. published the use of RFA of metastatic mediastinal lymph nodes during cooling and temperature monitoring of the tracheal mucosa to prevent thermal damage. RFA with retrograde saline irrigation of centrally located renal parenchymal lesions had been proved safe and efficient in animal studies by Margulis et al., which concluded that retrograde renal cooling helps protect the renal collecting system from injury during RFA without a decrease in expected lesion size. They also suggested that clinically retrograde renal cooling may decrease the risk of collecting system injury and subsequent complications during RFA. RFA with cooling system had been now reported in humans with the use of either normal saline or dextrose without significant differences in between them. [10, 11]
Although in our patient the biopsy revealed an Oncocytoma, it does not make any difference regarding the procedure itself as the lesion was close to the renal pelvis. We believe that using the ureteral irrigation catheter system we were able to prevent heat damage, either gross haematuria or ureteral stricture, as well as it may improve the impedance guarantying better ablation. This technique might be considered while performing RFA of central renal masses in order to avoid complications. It will be important for further evaluation of this technique in large clinical case series.
Peer review was divided on the merits of this manuscript, and importantly also on the safety of using cold Saline rather than Dextrose. This is an area of clinical controversy and we urge readers to remember that this is only a single case report and that clinical decision making should always be based on the best available evidence.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- McGovern FJ, Wood BJ, Goldberg N, Mueller PR: Radiofrequency ablation of renal cell carcinoma via image guided needle electrodes. J Urol. 1999, 161: 599-600. 10.1016/S0022-5347(01)61961-X.View ArticlePubMedGoogle Scholar
- Brown DB: Concepts, considerations, and concerns on the cutting edge of radiofrequency ablation. J Vasc Interv Radiol. 2005, 16: 597-613.View ArticlePubMedGoogle Scholar
- Homma Y, Kawabe K, Kitamura T, Nishimura Y, Shinohara M, Kondo Y, Saito I, Minowada S, Asakage Y: Increased incidental detection and reduced mortality in renal cancer: recent retrospective analysis at eight institutions. Int J Urol. 1995, 2: 77-80. 10.1111/j.1442-2042.1995.tb00428.x.View ArticlePubMedGoogle Scholar
- Jayson M, Sander H: Increased incidence of serendipitously discovered renal cell carcinoma. Urology. 1998, 51: 203-205. 10.1016/S0090-4295(97)00506-2.View ArticlePubMedGoogle Scholar
- Ahrar K, Matin S, Wood CG, Wallace MJ, Gupta S, Madoff DC, Rao S, Tannir NM, Jonasch E, Pisters LL, Rozner MA, Kennamer DL, Hicks ME: Percutaneous radiofrequency ablation of renal tumors: technique, complications, and outcomes. J Vasc Interv Radiol. 2005, 16: 679-88.View ArticlePubMedGoogle Scholar
- Chang I, Mikityansky I, Wray-Cahen D, Pritchard WF, Karanian JW, Wood BJ: Effects of perfusion on radiofrequency ablation in swine kidneys. Radiology. 2004, 231: 500-5. 10.1148/radiol.2312021248.View ArticlePubMedPubMed CentralGoogle Scholar
- Dominique E, El Otmany A, Goharin A, Attalah D, de Baere T: Intraductal cooling of the main bile ducts during intraoperative radiofrequency ablation. J Surg Onco. 2001, 76 (4): 297-300. 10.1002/jso.1049.View ArticleGoogle Scholar
- Hiraki T, Yasui K, Mimura H, Gobara H, Mukai T, Hase S, Fujiwara H, Tajiri N, Naomoto Y, Yamatsuji T, Shirakawa Y, Asami S, Nakatsuka H, Hanazaki M, Morita K, Tanaka N, Kanazawa S: Radiofrequency ablation of metastatic mediastinal lymph nodes during cooling and temperature monitoring of the tracheal mucosa to prevent thermal tracheal damge: initial experience. Radiology. 2005, 237: 1068-1074. 10.1148/radiol.2373050234.View ArticlePubMedGoogle Scholar
- Margulis V, Matsumoto ED, Taylor G, Shaffer S, Kabbani W, Cadeddu JA: Retrograde renal cooling during radio frequency ablation to protect from renal collecting system injury. J Urol. 2005, 174: 350-2. 10.1097/01.ju.0000161596.71457.1b.View ArticlePubMedGoogle Scholar
- Schultze D, Morris CS, Bhave AD, Worgan BA, Najarian KE: Radiofrequency ablation of renal transitional cell carcinoma with protective cold saline infusion. J Vasc Interv Radiol. 2003, 14: 489-492.View ArticlePubMedGoogle Scholar
- Wah TM, Koenig P, Irving HC, Gervais DA, Mueller PR: Radiofrequency ablation of a central renal tumor: protection of the collecting system with retrograde cold dextrose pyeloperfusion technique. J Vasc Interv Radiol. 2005, 16: 1551-1555.View ArticlePubMedGoogle Scholar
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