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Mediastinal extension of a complicated pancreatic pseudocyst; a case report and literature review
© Sadat et al; licensee BioMed Central Ltd. 2007
Received: 16 February 2007
Accepted: 25 April 2007
Published: 25 April 2007
Mediastinal pancreatic pseudocyst is a rare complication of acute or chronic pancreatitis.
This case report describes the management of a difficult case of pancreatic pseudocyst with a mediastinal extension in a patient having chronic pancreatitis. Different management strategies were used until complete resolution of this complex pseudocyst occurred using open surgical cystogastrostomy.
Despite the availablity of different minimally invasive techniques to treat pancreatic pseudocysts, management of complex mediastinal pseudocyst may still require open surgical drainage procedures.
Mediastinal pancreatic pseudocyst is a rare complication of acute or chronic pancreatitis. Since its first description in 1951, approximately 50 cases have been reported in the world literature. We report a case of mediastinal pseudocyst associated with alcoholic pancreatitis successfully treated with cystogastrostomy.
Mediastinal Pseudocysts are caused by rupture of the pancreatic duct posteriorly into the retroperitoneal space and subsequent tracking of the fluid in to mediastinum. In the majority of patients, the pancreatic fluid enters the mediastinum through the esophageal or aortic hiatus  leading to pseudocyst formation in the posterior mediastinum. A fistulous track often connects the larger thoracic component to the abdominal part of the cyst. Other less frequent sites of entry into the mediastinum are the foramen of Morgagni, the inferior vena cava hiatus and direct penetration of the diaphragm [1, 2]. Mediastinal pseudocysts may rupture into the pleural space producing pleural effusion or may extend further into the neck.
The diagnosis of pancreatic pseudocysts should be suspected in the setting of pancreatitis. They are more likely to develop and liable to persist in patients with chronic pancreatitis as in our case. Mediastinal pseudocysts may have no specific symptoms or may be associated with back pain, dysphagia or oesophageal reflux. Our patient had marked gastro-oesophageal reflux symptoms that have been previously described with mediastinal pseudocysts. It is probably due to ineffectiveness of anti-reflux mechanisms of the diaphragmatic crura, widening of hiatus, and loss of gastro-oesophageal angle. As with our case, pleural effusion is present in majority of cases. It has been postulated that the pleural effusion is due to lymphatic obstruction due to peri-cystic inflammation.
Frequently, diagnosis of mediastinal pseudocyst is made on cross-sectional imaging. CT scan is the investigation of choice which demonstrates the presence of thick walled, cystic lesion in the posterior mediastinum. Additionally, MRI scan has been shown to be useful in demonstrating the fistulous tract extending to pancreas . Fluid from a mediastinal cyst under ultrasound guidance showing high amylase level can confirm the diagnosis of a mediastinal pseudocyst .
The ideal management of mediastinal pseudocysts is controversial and depends upon the exact location, underlying aetiology, ductal anatomy, size of the pseudocyst and expertise available. Pancreatic pseudocysts, irrespective of the location are initially treated conservatively. However, spontaneous regression of mediastinal cysts is rare .
Several treatment approaches have been described. Medical management has been anecdotally reported to be successful and is aimed at minimizing the pancreatic exocrine secretions. Somatostatin or its analogues have been used but this usually requires prolonged therapy . Total parenteral nutrition has also been reported to result in resolution of the cyst . Successful resolution of mediastinal pseudocysts with 5-months of therapy with the mucolytic agent bromhexine hydrochloride has also been reported .
Endoscopic interventions with their obvious advantages for the patient are increasingly used as the first modality of treatment. Endoscopic procedures are better tolerated by the patient and have the advantage of not precluding any future surgery, if required. Trans-gastric drainage and/or deployment of stent under EUS-guidance has been shown to highly successful . However, the pseudocyst has to be bulging in to the viscus for this to be possible. In our case, EUS-guided stent deployment was considered but was deemed inappropriate because cyst was not in close relationship with stomach. Trans-oesophageal stent deployment although has been reported in the literature was not considered in this case because of obvious theoretical risk of oesophageal perforation and/or stricture. There have also been reports of resolution of pseudocysts following transpapillary pancreatic stenting [2, 10]. ERCP especially has played a revolutionary role in managing the complications of chronic pancreatitis and in defining the ductal anatomy in up to 80% of all pancreatic pseudocysts. 
The surgical procedures described for pseudocysts are varied and range from or external or internal drainage to pancreatic resections. Surgery should be considered in symptomatic patients and if there are associated complications such as infection, obstruction, rupture, or hemorrhage. Approaches include cystogastrostomy or cystojejunostomy carry a low recurrence rate. Increasingly, surgical drainage procedures are been performed laparoscopically with low morbidity and faster recovery. In our case, laparoscopic approach was not used due to previous upper abdominal surgery.
Conflict of interests
The author(s) declare that they have no competing interests.
I would also like to thank Ms Isla Kuhn for helping with literature search and use of Cambridge University Medical library information services. Written consent was obtained from the patient for publication of case report.
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