From: Morgellons disease, illuminating an undefined illness: a case series
1. The large age spread, geographic spread and gender neutrality among patients suggest broad human susceptibility to the illness. |
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2. Rural abode or exposure to unhygienic conditions (third world travel or simply soil exposure) may be risk factors. |
3. Onset rate is moderately rapid, without recognizable prodrome, commonly preceded by a healthy state. |
4. Once ill, exercise capacity is significantly reduced. |
5. The illness is common among family members and close associates, both related genetically and unrelated (such as spouses). |
6. Most patients experience weight gain after disease onset. |
7. Micro-angiomas appear rapidly on skin after illness onset in most. |
8. Fever is recurrent in at least half of those affected. |
9. The first illness sign may be the sudden appearance of persistent itching. Ulcerative lesions follow in some cases. |
10. Once dermal symptoms begin, patients experience extrusion of unfamiliar material described variously as filamentous, "fuzz balls", black or white "flecks" or "rice grains". |
11. Numerous CNS effects occur, that includes bizarre cranial nerve phenomena, anxiety and emotional sequelae. The former tend to be transient. |
12. Numerous Peripheral Nervous System findings appear after illness onset. Unlike CNS effects, these are serious, permanent and progressive, and include sensory and motor nerves. |
13. All Morgellons have elevated heart rate (>72 BPM) and low body temperature by oral thermometry (<97.5 degrees F). |
14. Orthostatic intolerance is intermittent but common in most. |
15. Most have some formally diagnosable emotional illness that begins with or becomes apparent after Morgellons disease onset. |
16. Endocrine abnormality number and type is higher than background. Most common are Diabetes Type II, Hashimoto's Thyroiditis, hyperparathyroidism and adrenal hypofunction. |
17. Most have elevated fasting insulin levels accompanied by elevated TNF-alpha (insulin receptor blocker) [15, 16]. |
18. Common clinical laboratory abnormalities include: |
a. RBCs have abnormal morphology. On manual examination, RBCs were non-discoid, varied in color and size. |
b. Natural Killer Cell (CD 56 + CD 16) number and function are very low in most. |
c. A/G ratio and globulin level are frequently elevated. |
d. Sedimentation Rate and ANA are extremely low despite other common autoimmune-like conditions. |
e. Elevated cytokines include: TNF-alpha, IFN-gamma, IL-6, C Reactive Protein, Homocysteine and serum Leptin. |
19. Despite no fact-based Case Definition of Delusions of Parasitosis (DP), each of our 25 patients could have been given such an illness label as well. As pointed out by Trabert in a meta-analysis of 1,223 DP cases and others, most DP data were taken from isolated cases. Psychiatric-skewed labels were common such as "psychocutaneous disease", "acarophobia" and "monosymptomatic hypochondriasis" with no serious search for consistent physical abnormalities or microscopic parasitic agents [17]. |