| | | |
Pregnancy
| |
|---|
| |
Diagnosis PAH
|
3 months later
|
5th week
|
20th week
|
35th week
|
Delivery
|
3 months postpartum
|
|
NYHA
|
IV
|
III
|
III
|
III
|
III
|
III
|
IV
|
|
6-MWT m
|
229
|
423
|
454
|
396
|
276
| |
392
|
|
RVSP mmHg (Echo)
|
69
| |
normal
|
normal
|
40
| |
57
|
|
SPAP mmHg
|
72
|
57
| | | |
45
| |
|
MPAP mmHg
|
52
|
35
| | | |
21
| |
|
PAOP mmHg
|
10
|
8
| | | |
7
| |
|
CI L/min/m2
|
1.3
|
3.4
| | | |
4.3
| |
|
PVR dyn.sec.cm−5
|
1580
|
410
| | | |
250
| |
|
mVO2%
|
35
|
67
| | | |
69
| |
|
SLEDAI [14]
|
17
|
2
|
2
| | |
14
|
18
|
|
Phenprocoumon (INR)
| |
2.1
|
2.2
| | | |
2.1
|
|
LMWH (Dalteparin E/day)
| | | |
10,000
|
10,000
| | |
|
Prednisone (mg/day)
|
50
|
30
|
10
|
25
|
25
|
50
|
50
|
|
Hydroxychloroquine (mg/day)
|
200
|
200
|
200
|
200
|
200
|
200
|
200
|
|
Cyclophosphamide (mg/day)
|
100
|
100
| | | | | |
|
Azathioprine (mg/day)
| | |
100
|
100
|
100
|
100
|
150
|
|
Bosentan (mg/day)
|
250
|
250
| | | | |
250
|
|
Sildenafil (mg/day)
|
150
|
150
|
150
|
150
|
150
|
150
|
150
|
|
Inhaled iloprost (μg/day)
| | | | |
50
|
100
| |
- NYHA, New York Heart Association; 6-MWT, 6 minute walking test distance; RVSP, echocardiographic systolic right ventricular pressure over right atrial pressure; hemodynamic assessments by right heart catheterization: SPAP, systolic pulmonary arterial pressure; MPAP, mean pulmonary arterial pressure; PAOP, pulmonary arterial occlusive pressure; CI, cardiac index; PVR, pulmonary vascular resistance; mVO2, mixed venous oxygen saturation; SLEDAI, systemic lupus erythematosus disease activity index; LMWH, low molecular weight heparin.
