Fig. 3From: Polymorphic ventricular tachycardia and cardiac arrest from abiraterone-induced hypokalemia: a case reportAdrenal steroid biosynthesis pathways. Abiraterone inhibits 17-α-hydroxylase and C17,20-lyase decreasing dihydroepiandrosterone and subsequent testosterone. Synthesis of cortisol, which feeds back to inhibit adrenocorticotropic hormone, is also diminished and leads to overproduction of adrenocorticotropic hormone decreased aldosteroneBack to article page