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Table 1 Laboratory documents of 3 cases during admission

From: Fulminant coronavirus disease 2019 meningitis in Iranian infants: a case series 

Variables

At admission

During hospitalization

Before discharge

Case 1

 WBC (No.)

12,900

14,800

8400

 PMN (%)

71

68

42

 Lymphocyte (%)

23

24

57

 Platelets (count No.)

325,000

405,000

435,000

 ESR (mm/h)

26

105

7

 CRP (mg/L)

70

64

5

 CSF RBC (No.)

10

  

 CSF WBC (No.) (PMN%/lymphocyte%)

350 (20/80)

  

 CSF protein (mg/dL)

172

  

 CSF glucose (mg/dL)

76

  

 CSF gram stain

Negative

  

 CSF culture for bacteria

Negative

  

 CSF PCR for common bacterial germs of meningitis, HSV, and Candida

Negative

  

 Pharyngeal PCR for COVID-19

Positive

  

 CSF PCR for COVID-19

Not performed

  

 Blood culture (aerobes and anaerobes, and fungus)

Negative

  

 BUN (mg/dl)

13

  

 Creatinine (mg/dl)

0.3

  

 AST (IU/L)

23

  

 ALT (IU/L)

21

  

 Urine analysis

Normal

  

 Urine culture

Negative

  

Case 2

 WBC (No.)

18,800

20,500

14,000

 PMN (%)

68

81

39

 Lymphocyte (%)

23

13

49

 Platelets (count No.)

450,000

386,000

402,000

 ESR (mm/h)

7

7

5

 CRP (mg/L)

3.5

23

5

 CSF RBC (No.)

100

  

 CSF WBC (No.) (PMN%/lymphocyte%)

400 (30/70)

  

 CSF protein

28

  

 CSF Glucose

145

  

 CSF gram stain

Negative

  

 CSF culture for bacteria

Negative

  

 CSF PCR for common bacterial germs of meningitis, HSV, and Candida

Negative

  

 Pharyngeal PCR for COVID-19

Positive

  

 CSF PCR for COVID-19

Popsitive

  

 Blood culture (aerobes and anaerobes, and fungus)

Negative

  

 BUN (mg/dl)

15

  

 Creatinine (mg/dl)

0.4

  

 AST (IU/L)

20

  

 ALT (IU/L)

23

  

 Urine analysis

Normal

  

 Urine culture

Negative

  

Case 3

 WBC (No.)

14,300

11,000

4400

 PMN (%)

71

65

39

 Lymphocyte (%)

23

28

55

 Platelets (count No.)

82,000

230,000

230,000

 ESR (mm/h)

54

41

41

 CRP (mg/L)

14

34

9

 CSF RBC (No.)

110

  

 CSF WBC (No.) (PMN%/lymphocyte%)

0

  

 CSF Protein (mg/dL)

14

  

 CSF Glucose (mg/dL)

77

  

 CSF gram stain

Negative

  

 CSF culture for bacteria

Negative

  

 CSF PCR for common bacterial germs of meningitis, HSV, and Candida

Negative

  

 Pharyngeal PCR for COVID-19

Negative

  

 CSF PCR for COVID-19

Positive

  

 Blood culture (aerobes and anaerobes, and fungus)

Negative

  

 BUN (mg/dl)

10

  

 Creatinine (mg/dl)

0.5

  

 AST (IU/L)

19

  

 ALT (IU/L)

21

  

 Urine analysis

Normal

  

 Urine culture

Negative

  
  1. CSF and blood samples for aerobe, anaerobe, and fungus were collected and transported in sterile condition at admission time. Blood sample was obtained in sterile condition for common viral, bacterial, and fungal pathogens andPCR. CSF samples were obtained and transferred in sterile condition for COVID-19 infection test
  2. WBC white blood cells, PMN Polymorph nuclear neutrophils, ESR Erythrocyte sedimentation rate, BUN Blood urea nitrogen, AST Aspartate aminotransferase, ALT Alanin aminotransferase, PCR polymerase chain reaction, CRP C-reactive protein